MRCP2-4373

MRCP2-4373

A 30-year-old woman with cystic fibrosis attends the respiratory clinic with her partner. They are considering starting a family but have concerns about the impact of her asthma on pregnancy. She has had a few exacerbations in the past year but is currently well-controlled on inhaled corticosteroids. She works as a teacher. During her last exacerbation, a blood gas analysis showed a pH of 7.35 and a PaO2 of 70 mmHg on room air.
Investigations:

Haemoglobin 135 g/l 115–155 g/l
White cell count (WCC) 8.5 × 109/l 4–11 × 109/l
Platelets 250 × 109/l 150–400 × 109/l
Sodium (Na+) 142 mmol/l 135–145 mmol/l
Potassium (K+) 4.2 mmol/l 3.5–5.0 mmol/l
Creatinine 80 µmol/l 50–120 µmol/l
FEV1 85% of that predicted

What advice should be given to the couple regarding pregnancy?