MRCP2-4235
A 48-year-old man is referred to the hospital due to increasing shortness of breath. He has a history of HIV and is under the care of local GUM consultants but is not currently on any antiretroviral treatment. He reports experiencing worsening shortness of breath for the past two weeks, with breathlessness occurring even with minimal exercise. He also has a non-productive cough and has been feeling lethargic for the past week. Upon examination, he is afebrile, has a blood pressure of 120/89 mmHg, and a slightly elevated heart rate of 110 bpm. His respiratory rate is 18 at rest, and his oxygen saturation is 98% on air. However, when he mobilizes to the toilet, he becomes very tachypnoeic, and his saturations drop to 90%. Blood tests reveal a low hemoglobin level of 110 g/l, normal platelet count of 201 * 109/l, and a slightly elevated white blood cell count of 9.6 * 109/l with neutrophils at 4.5 * 109/l. His electrolyte levels are within normal range, with a slightly elevated CRP level of 70 mg/l. His liver function tests show a slightly elevated bilirubin level of 5 µmol/l, normal ALP level of 89 u/l, and slightly elevated ALT level of 43 u/l, with a low albumin level of 34 g/l. An ABG test shows a pH of 7.35, pO2 of 7.7, pCO2 of 4.6, HCO3- of 21, BE of -3, and lactate level of 2.2. His chest x-ray reveals fine bilateral reticular nodular shadowing. What is the most appropriate treatment for this patient?