A 14 year old girl suffers from haemophilia A and chronic knee pain with progressive swelling and deformity over the last 4 years. Test results reveal a significantly reduced factor VIII activity. Which of the following is seen in the knee joint space after an acute painful episode?
An 8-year-old boy who recently migrated from Nigeria was seen in A&E department with a six-week history of progressive swelling of his jaw, fever, night sweats, and weight loss. His mother reported an episode of sore throat in the past which was treated with antibiotics, but he developed a rash subsequently. Other than that, there was no other significant past medical history. On examination, a painless, nontender 4x3cm mass was found that was fixed and hard. The only other examination finding of note was rubbery symmetrical cervical lymphadenopathy.Which of the following translocation would most likely be found on biopsy karyotyping?
A 14 year old girl suffers from haemophilia A and chronic knee pain with progressive swelling and deformity over the last 4 years. Test results reveal a significantly reduced factor VIII activity. Which of the following is seen in the knee joint space after an acute painful episode?
A 14 year-old girl is found to have haemophilia B. What pathological problem does she have?
A 6 month old infant has developed jaundice from breast milk. He is otherwise healthy with no signs of dehydration. His LFTs will most likely show which of the following pattern?
A child with jaundice and pale stools would most likely be evaluated by which of the following tests?
A 16-year-old female presents to the emergency department with recurrent epistaxis and a history of menorrhagia. The physician suspects Von Willebrand disease and requests for blood tests. Lab investigations reveal a prolonged bleeding time and thrombocytopenia. What is the most likely diagnosis?
A 15-year-old boy is diagnosed with aplastic anaemia after presenting with fatigue, dyspnoea and headaches. He lives on a farm and would usually play hide and seek with his siblings in the barn where the family store pesticides and other chemicals. Lab investigations reveal a significant leukopenia. Aplastic anaemia results due to failure of hematopoietic stem cells that give rise to progenitors of immune cells. In which area of the body are these cells primarily located?
A 16-year-old boy presents to the physician with a history of easy bruising and epistaxis since childhood. He recently had a dental extraction after which the bleeding lasted for 30 hours. His labs are sent and the reports are as follows: APTT: 36 secondsPT: 15 secondsFibrinogen: 2.5 g/lFactor VIIIC: 0.4 iu/ml (normal range 0.5-1.5)vWF antigen: 0.35 iu/ml (normal range 0.45-1.4)vWF ristocetin co-factor: 0.05 iu/ml (normal 0.45-1.35)PLT: 230 x 109/lBleeding time: 12 mins (normally up to 8 mins). Which of the following is the most likely diagnosis?
A 6 year old Somalian boy is admitted to the emergency department with dyspnoea. He looks distressed and has a heart rate of 180 bpm and a blood pressure of 130/90 mmHg. His respiratory rate is 37/min and his O2 saturation is 83% in room air. His temperature is 38C. His mother cannot speak English and neither does the child. The doctors observe that the boy has marked recession and a tracheal tug. He is crying and holding his chest. You immediately put the child on high flow oxygen, perform a chest X-ray and blood tests. The x-ray reveals bilateral pulmonary infiltrates. The blood results show:Hb:6g/dl, MCV:85fl, MCHC:36.0g/dl, WBC:19.6×109/l, neutrophils:15.3×109/l, PLT:350×109/l, CRP:50. His mother shows you that the child has been taking folic acid, hydroxyurea and Penicillin V daily, by pulling some tablets from her bag. What is the most probable diagnosis?