MS-0489

A 67-year-old woman visits her GP for a routine hypertension check-up. She has been on amlodipine for a year and her blood pressure is under control, but she frequently experiences ankle swelling. The swelling is more pronounced towards the end of the day since she started taking amlodipine. The GP decides to switch her medication to a diuretic. Which diuretic targets the sodium-chloride transporter in the distal tubule?