MS-3391

MS-3391

A 50-year-old male is admitted to the renal ward after presenting with lethargy, swelling and two episodes of haematuria. Bloods revealed the following:

Hb 150 g/L Male: (135-180)
Female: (115 – 160)
Platelets 200 * 109/L (150 – 400)
WBC 11.8 * 109/L (4.0 – 11.0)
Neuts 4.5 * 109/L (2.0 – 7.0)
Lymphs 3.0 * 109/L (1.0 – 3.5)
Mono 0.8 * 109/L (0.2 – 0.8)
Eosin 4.0 * 109/L (0.0 – 0.4)

ESR 130 mm/hr Men: < (age / 2)
Women: < ((age + 10) / 2) He was found to have high circulating levels for perinuclear antineutrophil cytoplasmic antibody (pANCA). What is the main target of this antibody within the cell?