MSFinals-6665
A 63-year-old man presents to his GP with a complaint of increasing blood in his urine over the past two weeks. He denies any pain or difficulty while urinating but reports feeling fatigued and possibly losing some weight over the last few months. He has a history of smoking with a 48 pack-year history. On examination, he has a heart rate of 70 bpm, blood pressure of 155/78 mmHg, oxygen saturation of 97% on air, and a temperature of 37.0ºC. There is tenderness in the left renal angle, and a palpable mass is felt on the left side. His abdomen is soft without anterior tenderness. Digital rectal exam reveals a non-enlarged and non-tender prostate. The urine dip results show leucocytes ++, blood +++, protein +, nitrites negative, glucose trace, and ketones negative. What is the most likely diagnosis?