MSFinals-0757
A 50-year-old man with a long-standing history of extensive psoriasis affecting the trunk, arms, buttock and nail beds is seen for review in Dermatology Outpatients. He has previously completed a course of phototherapy, with minimal improvement, and has shown no benefit on methotrexate for the past 12 months.
What is the next most appropriate step in the management of this patient?