MSFinals-0375
A 68-year-old retired ship dockland worker presents to the Medical Outpatient Department with a history of difficulty breathing, hoarse voice, weight loss and occasional night sweats. He also complains of difficulty in swallowing, although this happens very infrequently. He has also noticed that, in the past month, he has become easily tired when performing his daily activities.
On examination, there is unilateral dullness to percussion at the right lung base, decreased breath sounds on the right side, asymmetrical chest wall expansion and scoliosis are observed. A chest X-ray demonstrates diffuse pleural thickening on the right side and decreased right lung volume. A positron emission tomography (PET) scan and video-assisted thoracoscopy (VAT) are performed to obtain the pleural biopsy, and a histopathological diagnosis is made.
Which of the treatments could achieve the best possible outcome in this patient?