MSRA-2076

A 55-year-old man has an HbA1c of 54 mmol/mol after 3 months of lifestyle changes, following a previous reading of HbA1c of 52 mmol/mol. You suggest that he should begin taking metformin standard release in addition to lifestyle interventions. He has normal renal function and no other medical issues. You inform him of the possibility of gastrointestinal discomfort.

What is the typical duration before considering increasing the dosage to alleviate these symptoms for this patient?