Tricyclic Antidepressants for Neuropathic Pain

Tricyclic antidepressants (TCAs) were once commonly used for depression, but their side-effects and toxicity in overdose have led to a decrease in their use. However, they are still widely used in the treatment of neuropathic pain, where smaller doses are typically required. TCAs such as low-dose amitriptyline are commonly used for the management of neuropathic pain and the prophylaxis of headache, while lofepramine has a lower incidence of toxicity in overdose. It is important to note that some TCAs, such as amitriptyline and dosulepin, are considered more dangerous in overdose than others.

Common side-effects of TCAs include drowsiness, dry mouth, blurred vision, constipation, urinary retention, and lengthening of the QT interval. When choosing a TCA for neuropathic pain, the level of sedation may also be a consideration. Amitriptyline, clomipramine, dosulepin, and trazodone are more sedative, while imipramine, lofepramine, and nortriptyline are less sedative. It is important to work with a healthcare provider to determine the appropriate TCA and dosage for the individual’s specific needs.

Distinguishing Major Depressive Disorder from Other Conditions

Major depressive disorder is a psychiatric condition characterized by symptoms such as anhedonia, sadness, lack of concentration, sleep impairment, social withdrawal, and hopelessness. It is often triggered by a significant stressor, such as job loss. While severe depression can also be a component of adjustment disorder, the duration of symptoms beyond 6 months following a stressor suggests a diagnosis of major depressive disorder. Anhedonia, a significant lack of interest in once pleasurable activities, is a symptom rather than a diagnosis by itself and is often present in major depressive disorder. Drug abuse can be a cause or effect of depression, but in this case, the patient’s recent stressor makes drug-related depression less likely. The patient’s hand tremor, worsened by movement, is more likely related to essential tremor than Parkinson’s disease, which typically presents with a resting hand tremor, rigidity, and bradykinesia. Accurately distinguishing major depressive disorder from other conditions is crucial for effective treatment.

The probable diagnosis for this patient is conversion disorder, which is a psychiatric condition that involves the loss of motor or sensory function and is often caused by stress. There is no evidence of neurological disease in the patient’s history or clinical findings. The condition is likely triggered by recent domestic abuse and stress. The patient also exhibits a positive drop-arm test, which is a controlled drop of the arm to prevent it from hitting the face, and is an unconscious manifestation of psychological stress.

Acute stress disorder is a condition that occurs after life-threatening experiences, such as abuse, and is characterized by symptoms of hyperarousal, re-experiencing of the traumatic event, avoidance of stimuli, and distress. However, it does not involve physical weakness. It typically lasts between 3 days and 1 month.

Post-traumatic stress disorder is another condition that occurs after life-threatening experiences, such as abuse, and has similar symptoms to acute stress disorder. However, it lasts longer than 1 month.

Patients with somatisation disorder have multiple bodily complaints that last for months to years and persistent anxiety about their symptoms. However, based on this patient’s history and physical findings, conversion disorder is the most likely diagnosis.

Given the patient’s normal tone and reflexes and the absence of trauma to the neck or spine, it is highly unlikely that a spinal cord lesion is causing total arm paralysis.

Psychiatric Terms for Unexplained Symptoms

There are various psychiatric terms used to describe patients who exhibit symptoms for which no organic cause can be found. One such disorder is somatisation disorder, which involves the presence of multiple physical symptoms for at least two years, and the patient’s refusal to accept reassurance or negative test results. Another disorder is illness anxiety disorder, which is characterized by a persistent belief in the presence of an underlying serious disease, such as cancer, despite negative test results.

Conversion disorder is another condition that involves the loss of motor or sensory function, and the patient does not consciously feign the symptoms or seek material gain. Patients with this disorder may be indifferent to their apparent disorder, a phenomenon known as la belle indifference. Dissociative disorder, on the other hand, involves the process of ‘separating off’ certain memories from normal consciousness, and may manifest as amnesia, fugue, or stupor. Dissociative identity disorder (DID) is the most severe form of dissociative disorder and was previously known as multiple personality disorder.

Factitious disorder, also known as Munchausen’s syndrome, involves the intentional production of physical or psychological symptoms. Finally, malingering is the fraudulent simulation or exaggeration of symptoms with the intention of financial or other gain. Understanding these psychiatric terms can help healthcare professionals better diagnose and treat patients with unexplained symptoms.

Complications of Haloperidol: Acute Dystonia, Neuroleptic Malignant Syndrome, Serotonin Syndrome, and Meningitis

Haloperidol is an anti-psychotic medication commonly used to treat schizophrenia. However, it can also cause various complications. Acute dystonia is a condition where the patient experiences muscle spasms in different muscle groups, which can occur shortly after taking haloperidol. Treatment for acute dystonia involves administering anticholinergics.

Neuroleptic malignant syndrome is another complication that can occur as a result of taking anti-psychotic medication, particularly high-potency ones like haloperidol. Symptoms include abnormal vital signs, such as high fever, and treatment involves discontinuing the medication and managing symptoms with cooling measures and medications like dantrolene or bromocriptine.

Serotonin syndrome is a condition that can occur when a patient takes multiple doses or an overdose of medications like selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or serotonin agonists like sumatriptans. Symptoms include muscular twitching, agitation, confusion, hyperthermia, sweating, hypertension, tachycardia, and diarrhea.

Meningitis, on the other hand, is not a complication of haloperidol. It is an inflammation of the protective membranes surrounding the brain and spinal cord, usually caused by a bacterial or viral infection.

Finally, malignant hyperthermia is a condition that can manifest with similar symptoms to neuroleptic malignant syndrome, but it usually occurs during anesthesia administration and is caused by an inherited autosomal dominant disorder of the ryanodine receptor gene in the skeletal muscle. Treatment involves using dantrolene and providing supportive care.

When a patient presents with symptoms of hypomania in primary care, it is important to refer them to the community mental health team for confirmation of the diagnosis before prescribing any medication. Quetiapine is often used as a first-line treatment for acute bipolar disorder, but it should not be prescribed until the diagnosis is confirmed. SSRIs are not recommended for depressive episodes in bipolar disorder, and olanzapine and fluoxetine should only be used in rare circumstances for acute depression. Lithium is a common medication for bipolar disorder, but it should not be prescribed until the diagnosis is confirmed. Routine referral to the community mental health team is advised for patients presenting with hypomania in primary care, and urgent referral may be necessary if the patient is at risk of self-harm or harm to others. Referral may also be necessary if the patient demonstrates poor judgment in areas such as employment, personal relationships, finances, driving, sexual activity, or drug use.

Understanding Bipolar Disorder

Bipolar disorder is a mental health condition that is characterized by alternating periods of mania/hypomania and depression. It typically develops in the late teen years and has a lifetime prevalence of 2%. There are two recognized types of bipolar disorder: type I, which involves mania and depression, and type II, which involves hypomania and depression.

Mania and hypomania both refer to abnormally elevated mood or irritability, but mania is more severe and can include psychotic symptoms for 7 days or more. Hypomania, on the other hand, involves decreased or increased function for 4 days or more. The presence of psychotic symptoms suggests mania.

Management of bipolar disorder may involve psychological interventions specifically designed for the condition, as well as medication. Lithium is the mood stabilizer of choice, but valproate can also be used. Antipsychotic therapy, such as olanzapine or haloperidol, may be used to manage mania/hypomania, while fluoxetine is the antidepressant of choice for depression. It is important to address any co-morbidities, as there is an increased risk of diabetes, cardiovascular disease, and COPD in individuals with bipolar disorder.

If symptoms suggest hypomania, routine referral to the community mental health team (CMHT) is recommended. However, if there are features of mania or severe depression, an urgent referral to the CMHT should be made. Understanding bipolar disorder and its management is crucial for healthcare professionals to provide appropriate care and support for individuals with this condition.

Switching from Fluoxetine to Sertraline: Recommended Approach

When switching from fluoxetine to sertraline, it is important to follow a recommended approach to minimize the risk of adverse effects. Here are some options and their respective explanations:

1. Reduce fluoxetine gradually over two weeks, and wait 4-7 days after stopping fluoxetine before starting sertraline. This approach is recommended because fluoxetine has a long half-life, and a washout period is necessary before starting another SSRI. Gradual withdrawal is also recommended for doses over 20 mg.

2. Reduce fluoxetine gradually over two weeks, then start sertraline as soon as fluoxetine has stopped. This approach is not recommended because a washout period is necessary before starting another SSRI.

3. Reduce fluoxetine to 20 mg, and cross-taper with low-dose sertraline for two weeks. This approach is not recommended because fluoxetine has a long half-life, and a washout period is necessary before starting another SSRI.

4. Stop fluoxetine immediately, and start sertraline the following day. This approach is not recommended because fluoxetine has a long half-life, and a washout period is necessary before starting another SSRI. Gradual withdrawal is also recommended for doses over 20 mg.

5. Stop fluoxetine immediately, wait 4-7 days, then start sertraline. This approach is not recommended because gradual withdrawal is recommended for doses over 20 mg. Abruptly stopping fluoxetine can lead to adverse effects.

In summary, reducing fluoxetine gradually over two weeks and waiting for a washout period before starting sertraline is the recommended approach. It is important to consult with a healthcare provider before making any changes to medication.

Understanding the Relationship Between Depression and Anxiety: A Clinical Perspective

Depression and anxiety are two common mental health conditions that often co-occur. However, it is important to distinguish between the two and determine which is the primary diagnosis, as this will guide treatment. In cases where depression is the underlying main diagnosis, patients may develop secondary symptoms such as anxiety and panic attacks. On the other hand, in cases where anxiety is the primary diagnosis, patients may also experience secondary depressive symptoms.

One key factor in determining the primary diagnosis is the temporal development of symptoms. In cases where depressive symptoms clearly started first, a correct diagnosis of depression is important, as treating the underlying disorder can also improve secondary anxiety symptoms. Symptoms of depression include low mood, anhedonia, and anergia.

Generalized anxiety disorder is characterized by uncontrollable and irrational worry or anxiety about a wide range of issues and situations, while agoraphobia is an excessive fear of being in a situation where a person cannot freely escape or where help may not be available. Panic disorder is diagnosed when a person has recurrent, severe panic attacks without an obvious precipitant.

In cases where anxiety is secondary to depression, it is important to address the underlying depressive symptoms in order to improve the abnormal anxiety. Symptoms of abnormal anxiety and depression frequently present co-morbidly, and careful history-taking is necessary to determine which is the primary diagnosis. By understanding the relationship between depression and anxiety, clinicians can provide more effective treatment for their patients.

Dementia vs Delirium: Understanding the Differences

Dementia and delirium are two conditions that can affect cognitive abilities and behavior. While they share some similarities, there are also important differences between them.

Dementia is a group of neurodegenerative disorders that cause a progressive decline in cognition and/or behavior from previous levels of functioning. It is characterized by a slow, insidious progression and is rarely reversible. Memory loss, executive functioning problems, speech and language difficulties, social interaction loss, personality changes, and visuospatial problems are some of the areas of loss associated with dementia. Mobility and gait disturbances are also common.

Delirium, on the other hand, is an acute confusional state characterized by a relatively rapid onset and variable, fluctuating progression. It may cause a global reduction in cognitive abilities but is usually reversible if the underlying cause is promptly identified. Common causes include sepsis, medications, metabolic derangement, and causes of raised intracranial pressure.

While there are some similarities between dementia and delirium, there are also some differences. For example, dementia is never associated with a persistent fluctuating level of consciousness, which is a feature of delirium. Visual hallucinations are present in both delirium and dementia, particularly Lewy body dementia. Impaired memory and dysarthria are also present in both conditions, as is urinary incontinence.

In summary, understanding the differences between dementia and delirium is important for proper diagnosis and treatment. While both conditions can affect cognitive abilities and behavior, they have distinct features that can help differentiate them.

Personality Disorders: Types and Characteristics

Personality disorders are a group of mental health conditions that affect the way individuals think, feel, and behave. There are several types of personality disorders, each with its own set of characteristics.

Borderline Personality Disorder: This disorder is characterized by impulsive behavior, intense mood swings, and unpredictable behavior. Individuals with this disorder may struggle with maintaining stable relationships and may have difficulty regulating their emotions.

Avoidant Personality Disorder: People with this disorder tend to be socially inhibited and may avoid social situations due to a fear of rejection. They may also struggle with feelings of inadequacy and low self-esteem.

Dependent Personality Disorder: Individuals with this disorder may have an excessive need for nurture and may struggle with making decisions on their own. They may also have low self-confidence and be overly submissive in relationships.

Schizoid Personality Disorder: People with this disorder tend to be socially isolated and may have limited emotional expression. They may prefer to be alone and may struggle with forming close relationships.

Schizotypal Personality Disorder: This disorder is characterized by odd thought patterns and interpersonal awkwardness. Individuals with this disorder may also have an unusual appearance or behavior.

Overall, personality disorders can significantly impact an individual’s daily life and relationships. It is important to seek professional help if you or someone you know may be struggling with a personality disorder.

White kite, bright light, tight fight – these are examples of clang associations, where words are linked by their similar sounds or rhymes. It is a symptom often seen in individuals with schizophrenia or bipolar disorder. However, this patient is not currently displaying any signs of psychosis or mania. It is important to note that aphasic speech, where the patient loses the ability to form language, and echolalia, where they repeat words or phrases of others, are different from clang associations.

Thought disorders can manifest in various ways, including circumstantiality, tangentiality, neologisms, clang associations, word salad, Knight’s move thinking, flight of ideas, perseveration, and echolalia. Circumstantiality involves providing excessive and unnecessary detail when answering a question, but eventually returning to the original point. Tangentiality, on the other hand, refers to wandering from a topic without returning to it. Neologisms are newly formed words, often created by combining two existing words. Clang associations occur when ideas are related only by their similar sounds or rhymes. Word salad is a type of speech that is completely incoherent, with real words strung together into nonsensical sentences. Knight’s move thinking is a severe form of loosening of associations, characterized by unexpected and illogical leaps from one idea to another. Flight of ideas is a thought disorder that involves jumping from one topic to another, but with discernible links between them. Perseveration is the repetition of ideas or words despite attempts to change the topic. Finally, echolalia is the repetition of someone else’s speech, including the question that was asked.

When treating patients with clozapine, it is important to monitor for agranulocytosis, a rare but potentially fatal side-effect. Patients should report flu-like symptoms and undergo regular blood tests. In this case, the patient’s sore throat and fever may indicate agranulocytosis, so a full blood count is necessary. While an ECG should be done before starting antipsychotic treatment, it is not the most important test in this scenario. Blood glucose should be monitored to exclude organic causes and hyperglycemia caused by antipsychotics. Liver function and urea/electrolytes should also be monitored regularly, but are not the most important tests to conduct immediately in this case.

The administration of glucose IV is not necessary as the patient is not experiencing hypoglycemia. Simply providing regular high strength IM B vitamin replacement is insufficient as the patient also requires a benzodiazepine regimen for alcohol withdrawal. A stat dose of bisoprolol is not appropriate as the patient’s sinus tachycardia is a result of alcohol withdrawal and will not be effectively treated with bisoprolol.

Alcohol withdrawal occurs when an individual who has been consuming alcohol chronically suddenly stops or reduces their intake. Chronic alcohol consumption enhances the inhibitory effects of GABA in the central nervous system, similar to benzodiazepines, and inhibits NMDA-type glutamate receptors. However, alcohol withdrawal leads to the opposite effect, resulting in decreased inhibitory GABA and increased NMDA glutamate transmission. Symptoms of alcohol withdrawal typically start at 6-12 hours and include tremors, sweating, tachycardia, and anxiety. Seizures are most likely to occur at 36 hours, while delirium tremens, which includes coarse tremors, confusion, delusions, auditory and visual hallucinations, fever, and tachycardia, peak at 48-72 hours.

Patients with a history of complex withdrawals from alcohol, such as delirium tremens, seizures, or blackouts, should be admitted to the hospital for monitoring until their withdrawals stabilize. The first-line treatment for alcohol withdrawal is long-acting benzodiazepines, such as chlordiazepoxide or diazepam, which are typically given as part of a reducing dose protocol. Lorazepam may be preferable in patients with hepatic failure. Carbamazepine is also effective in treating alcohol withdrawal, while phenytoin is said to be less effective in treating alcohol withdrawal seizures.

Managing Acute Opioid Withdrawal in Heroin Users

Managing acute opioid withdrawal in patients who are actively using heroin can be challenging. However, a good way to manage this is by titrating codeine to effect. Codeine can be given in doses of 30-60 mg and repeated every 30 minutes until the symptoms begin to subside. It is important to note that most trusts will have a local policy on this matter.

If a patient normally takes methadone, it is crucial to contact their dispensing pharmacy to confirm their dose before administering codeine. Codeine can be used in the meantime to alleviate symptoms of opioid withdrawal. By following this approach, healthcare professionals can effectively manage acute opioid withdrawal in heroin users.

The mechanism of action of duloxetine involves inhibiting the reuptake of both serotonin and noradrenaline, making it a member of the antidepressant class known as serotonin and noradrenaline reuptake inhibitors. When selecting an antidepressant, patient preference, previous sensitization, overdose risk, and cost are all factors to consider. SSRIs are typically the first-line treatment due to their favorable risk-to-benefit ratio and comparable efficacy to other antidepressants.

Understanding Serotonin and Noradrenaline Reuptake Inhibitors

Serotonin and noradrenaline reuptake inhibitors (SNRIs) are a type of antidepressant medication that work by increasing the levels of serotonin and noradrenaline in the brain. These neurotransmitters are responsible for regulating mood, emotions, and anxiety levels. By inhibiting the reuptake of these chemicals, SNRIs help to maintain higher levels of serotonin and noradrenaline in the synaptic cleft, which can lead to improved mood and reduced anxiety.

Examples of SNRIs include venlafaxine and duloxetine, which are commonly used to treat major depressive disorders, generalised anxiety disorder, social anxiety disorder, panic disorder, and menopausal symptoms. These medications are relatively new and have been found to be effective in treating a range of mental health conditions. SNRIs are often preferred over other types of antidepressants because they have fewer side effects and are less likely to cause weight gain or sexual dysfunction.

Overall, SNRIs are an important class of medication that can help to improve the lives of people struggling with mental health conditions. By increasing the levels of serotonin and noradrenaline in the brain, these medications can help to regulate mood and reduce anxiety, leading to a better quality of life for those who take them.

Thought disorders can manifest in various ways, including circumstantiality, tangentiality, neologisms, clang associations, word salad, Knight’s move thinking, flight of ideas, perseveration, and echolalia. Circumstantiality involves providing excessive and unnecessary detail when answering a question, but eventually returning to the original point. Tangentiality, on the other hand, refers to wandering from a topic without returning to it. Neologisms are newly formed words, often created by combining two existing words. Clang associations occur when ideas are related only by their similar sounds or rhymes. Word salad is a type of speech that is completely incoherent, with real words strung together into nonsensical sentences. Knight’s move thinking is a severe form of loosening of associations, characterized by unexpected and illogical leaps from one idea to another. Flight of ideas is a thought disorder that involves jumping from one topic to another, but with discernible links between them. Perseveration is the repetition of ideas or words despite attempts to change the topic. Finally, echolalia is the repetition of someone else’s speech, including the question that was asked.

Section 5 (2) of the MHA allows a doctor to detain a patient for up to 72 hours for assessment. This can be used for both informal patients in mental health hospitals and general hospitals. During this time, the patient is assessed by an approved mental health professional and a doctor with Section 12 approval. The patient can refuse treatment, but it can be given in their best interests or in an emergency. Section 2 and 3 can only be used if they are the least restrictive method for treatment and allow for detention for up to 28 days and 6 months, respectively. Section 135 allows police to remove a person from their home for assessment, while Section 136 allows for the removal of an apparently mentally disordered person from a public place to a place of safety for assessment. Since the patient in this scenario is already in hospital, neither Section 135 nor Section 136 would apply.

Language Disturbances in Mental Health

Neologism is the term used to describe the creation of new words. This phenomenon can occur in individuals with schizophrenia or brain injury. Clanging, on the other hand, is the use of rhyming words in speech. Pressured speech is characterized by rapid speech that is difficult to interrupt and is often seen in individuals experiencing mania or hypomania. Circumstantiality refers to speech that may wander from the topic for periods of time before finally returning to answer the question that was asked. Lastly, word salad is a type of speech that is completely disorganized and not understandable, which may occur in individuals who have suffered a stroke affecting Wernicke’s area.

In summary, language disturbances are common in individuals with mental health conditions. These disturbances can range from the creation of new words to completely disorganized speech. these language disturbances can aid in the diagnosis and treatment of mental health conditions.

The most significant risk factor for psychotic disorders is a person’s family history.

Understanding the Epidemiology of Schizophrenia

Schizophrenia is a psychotic disorder that affects a significant portion of the population. The strongest risk factor for developing this condition is having a family history of the disorder. Individuals with a parent who has schizophrenia have a relative risk of 7.5. Additionally, monozygotic twins have a 50% chance of developing schizophrenia, while siblings have a 10% chance. In contrast, individuals without relatives with schizophrenia have a 1% chance of developing the disorder.

Aside from family history, other factors can increase the risk of developing schizophrenia. Black Caribbean ethnicity has a relative risk of 5.4, while migration and living in an urban environment have relative risks of 2.9 and 2.4, respectively. Cannabis use also increases the risk of developing schizophrenia, with a relative risk of 1.4.

Understanding the epidemiology of schizophrenia is crucial in identifying individuals who may be at risk of developing the disorder. By recognizing these risk factors, healthcare professionals can provide early interventions and support to prevent or manage the onset of schizophrenia.

The correct answer is borderline personality disorder, which is characterized by a history of self-harm and intense relationships that alternate between idealization and devaluation. Symptoms also include mood swings and the possibility of paranoid thoughts and hallucinations.

Paranoid personality disorder is not the correct answer, as it primarily involves difficulty trusting others and interpreting situations as threatening. While the patient in question does exhibit some paranoia, their other symptoms are more indicative of borderline personality disorder.

Schizoid personality disorder is also not the correct answer, as it involves difficulty forming close relationships and a preference for solitude. The patient in question has close relationships with others.

Schizophrenia is not the correct answer either, as it primarily involves delusions, hallucinations, and disordered thinking.

Personality disorders are a set of personality traits that are maladaptive and interfere with normal functioning in life. It is estimated that around 1 in 20 people have a personality disorder, which are typically categorized into three clusters: Cluster A, which includes Odd or Eccentric disorders such as Paranoid, Schizoid, and Schizotypal; Cluster B, which includes Dramatic, Emotional, or Erratic disorders such as Antisocial, Borderline (Emotionally Unstable), Histrionic, and Narcissistic; and Cluster C, which includes Anxious and Fearful disorders such as Obsessive-Compulsive, Avoidant, and Dependent.

Paranoid individuals exhibit hypersensitivity and an unforgiving attitude when insulted, a reluctance to confide in others, and a preoccupation with conspiratorial beliefs and hidden meanings. Schizoid individuals show indifference to praise and criticism, a preference for solitary activities, and emotional coldness. Schizotypal individuals exhibit odd beliefs and magical thinking, unusual perceptual disturbances, and inappropriate affect. Antisocial individuals fail to conform to social norms, deceive others, and exhibit impulsiveness, irritability, and aggressiveness. Borderline individuals exhibit unstable interpersonal relationships, impulsivity, and affective instability. Histrionic individuals exhibit inappropriate sexual seductiveness, a need to be the center of attention, and self-dramatization. Narcissistic individuals exhibit a grandiose sense of self-importance, lack of empathy, and excessive need for admiration. Obsessive-compulsive individuals are occupied with details, rules, and organization to the point of hampering completion of tasks. Avoidant individuals avoid interpersonal contact due to fears of criticism or rejection, while dependent individuals have difficulty making decisions without excessive reassurance from others.

Personality disorders are difficult to treat, but a number of approaches have been shown to help patients, including psychological therapies such as dialectical behavior therapy and treatment of any coexisting psychiatric conditions.

When it comes to discontinuing medication, it’s important to note the specific drug being used. Abruptly stopping a salbutamol inhaler or paracetamol is unlikely to cause any adverse effects. However, stopping a selective serotonin reuptake inhibitor (SSRI) like citalopram can lead to discontinuation symptoms. Gastrointestinal side-effects, such as diarrhoea, are commonly seen in SSRI discontinuation syndrome. To avoid this, it’s recommended to gradually taper off SSRIs. Blunted affect is not likely to occur as a result of sudden discontinuation, but emotional lability and mood swings may be observed. Cyanopsia, or blue-tinted vision, is not a known symptom of SSRI discontinuation, but it can be a side effect of other drugs like sildenafil. While hypertension has been reported in some cases, it’s less common than gastrointestinal symptoms. Weight loss, rather than weight gain, is often reported upon sudden discontinuation of SSRIs.

Selective serotonin reuptake inhibitors (SSRIs) are commonly used as the first-line treatment for depression. Citalopram and fluoxetine are the preferred SSRIs, while sertraline is recommended for patients who have had a myocardial infarction. However, caution should be exercised when prescribing SSRIs to children and adolescents. Gastrointestinal symptoms are the most common side-effect, and patients taking SSRIs are at an increased risk of gastrointestinal bleeding. Patients should also be aware of the possibility of increased anxiety and agitation after starting a SSRI. Fluoxetine and paroxetine have a higher propensity for drug interactions.

The Medicines and Healthcare products Regulatory Agency (MHRA) has issued a warning regarding the use of citalopram due to its association with dose-dependent QT interval prolongation. As a result, citalopram and escitalopram should not be used in patients with congenital long QT syndrome, known pre-existing QT interval prolongation, or in combination with other medicines that prolong the QT interval. The maximum daily dose of citalopram is now 40 mg for adults, 20 mg for patients older than 65 years, and 20 mg for those with hepatic impairment.

When initiating antidepressant therapy, patients should be reviewed by a doctor after 2 weeks. Patients under the age of 25 years or at an increased risk of suicide should be reviewed after 1 week. If a patient responds well to antidepressant therapy, they should continue treatment for at least 6 months after remission to reduce the risk of relapse. When stopping a SSRI, the dose should be gradually reduced over a 4 week period, except for fluoxetine. Paroxetine has a higher incidence of discontinuation symptoms, including mood changes, restlessness, difficulty sleeping, unsteadiness, sweating, gastrointestinal symptoms, and paraesthesia.

When considering the use of SSRIs during pregnancy, the benefits and risks should be weighed. Use during the first trimester may increase the risk of congenital heart defects, while use during the third trimester can result in persistent pulmonary hypertension of the newborn. Paroxetine has an increased risk of congenital malformations, particularly in the first trimester.