-
Question 1
Incorrect
-
A 60-year-old patient complains of headaches which are worse in the morning and have been present for 2 months. They have been told by their GP it is probably 'tension headache'. Which of the following symptoms is suggestive of a more sinister pathology?
Your Answer: Pain gets worse as the day goes on
Correct Answer: Pain worse on bending down
Explanation:Indicators of a potentially serious headache are:
– Developing a headache for the first time after the age of 50
– Sudden and severe headache (often described as a thunderclap headache)
– Accompanying symptoms such as redness in the eye and seeing halos around lights
– Headache that gets worse with physical activity of straining (such as during a Valsalva maneuver)Cerebral Tumours
The most common brain tumours in adults, listed in order of frequency, are metastatic tumours, glioblastoma multiforme, anaplastic astrocytoma, and meningioma. On the other hand, the most common brain tumours in children, listed in order of frequency, are astrocytoma, medulloblastoma, and ependymoma.
-
This question is part of the following fields:
- Neurosciences
-
-
Question 2
Correct
-
What is the purpose of using the AUDIT questionnaire?
Your Answer: Alcohol misuse
Explanation:Alcohol screening tools are available to assist in the diagnosis of alcohol problems. One such tool is the AUDIT (Alcohol Use Disorders Identification Test), which consists of 10 questions and covers harmful use, hazardous use, and dependence. Another tool is the FAST (Fast Alcohol Screening Test), which has just 4 questions and was developed for use in a busy medical setting. The CAGE is a well-known 4 question screening tool, but recent research has questioned its value. Other tools include SASQ (Single alcohol screening questionnaire), PAT (Paddington Alcohol Test), MAST (Michigan Alcoholism Screening Test), and RAPS4 (Rapid Alcohol Problem Screen 4). These tools can help identify hazardous of harmful alcohol consumption and alcohol dependence.
-
This question is part of the following fields:
- Classification And Assessment
-
-
Question 3
Incorrect
-
Which of the following is classified as a mature defence?
Your Answer: Reaction formation
Correct Answer: Suppression
Explanation:Intermediate Mechanism: Rationalisation
Rationalisation is a defense mechanism commonly used by individuals to create false but credible justifications for their behavior of actions. It involves the use of logical reasoning to explain away of justify unacceptable behavior of feelings. The individual may not be aware that they are using this mechanism, and it can be difficult to identify in oneself.
Rationalisation is considered an intermediate mechanism, as it is common in healthy individuals from ages three to ninety, as well as in neurotic disorders and in mastering acute adult stress. It can be dramatically changed by conventional psychotherapeutic interpretation.
Examples of rationalisation include a student who fails an exam and blames the teacher for not teaching the material well enough, of a person who cheats on their partner and justifies it by saying their partner was neglectful of unaffectionate. It allows the individual to avoid taking responsibility for their actions and to maintain a positive self-image.
Overall, rationalisation can be a useful defense mechanism in certain situations, but it can also be harmful if it leads to a lack of accountability and an inability to learn from mistakes.
-
This question is part of the following fields:
- Classification And Assessment
-
-
Question 4
Incorrect
-
How can you differentiate between an obsession and a compulsion?
Your Answer: Hoarding useless items
Correct Answer: Repeatedly imagining violent scenes
Explanation:The question implies that obsessions are characterized by urges, images, of thoughts, while compulsions involve acts, either motor of mental. However, it is important to note that in order to be classified as an obsession of compulsion according to DSM-5 and ICD-11 criteria, the behavior must be time-consuming (taking more than 1 hour per day) of cause significant distress of impairment in important areas of functioning.
Obsessive-compulsive disorder (OCD) is a mental health condition characterized by the presence of either obsessions or compulsions, and often both. Obsessions are repetitive and persistent thoughts, images, of impulses that are intrusive and unwanted, while compulsions are repetitive behaviors of rituals that an individual feels driven to perform in response to an obsession of according to rigid rules. The symptoms can cause significant functional impairment and/of distress. To diagnose OCD, the essential features include the presence of persistent obsessions and/of compulsions that are time-consuming of result in significant distress of impairment in important areas of functioning. The symptoms cannot be attributed to another medical condition of the effects of a substance of medication on the central nervous system.
-
This question is part of the following fields:
- Classification And Assessment
-
-
Question 5
Incorrect
-
How does atomoxetine work in the body?
Your Answer: Nicotinic receptor partial agonist
Correct Answer: Noradrenaline reuptake inhibitor
Explanation:Mechanisms of Action of Different Drugs
Understanding the mechanisms of action of different drugs is crucial for medical professionals. It is a common topic in exams and can earn easy marks if studied well. This article provides a list of drugs and their mechanisms of action in different categories such as antidepressants, anti dementia drugs, mood stabilizers, anxiolytic/hypnotic drugs, antipsychotics, drugs of abuse, and other drugs. For example, mirtazapine is a noradrenaline and serotonin specific antidepressant that works as a 5HT2 antagonist, 5HT3 antagonist, H1 antagonist, alpha 1 and alpha 2 antagonist, and moderate muscarinic antagonist. Similarly, donepezil is a reversible acetylcholinesterase inhibitor used as an anti dementia drug, while valproate is a GABA agonist and NMDA antagonist used as a mood stabilizer. The article also explains the mechanisms of action of drugs such as ketamine, phencyclidine, buprenorphine, naloxone, atomoxetine, varenicline, disulfiram, acamprosate, and sildenafil.
-
This question is part of the following fields:
- Psychopharmacology
-
-
Question 6
Correct
-
How can the cognitive aspect of social capital be defined?
Your Answer: Values
Explanation:Social Capital: An Explanation for Inequalities in Morbidity and Mortality
The concept of social capital may provide insight into the observed disparities in morbidity and mortality based on occupational social class and material standard of living (McKenzie 2002). Social capital is considered the binding force of society, and it is believed that groups lacking in social capital may be at higher risk for mental illness.
Social capital is defined as the features of social life – networks, norms, and trust – that enable participants to act together more effectively to pursue shared objectives (Putnam, 1996). It is a characteristic of groups rather than individuals and can be divided into structural and cognitive components. Structural social capital includes roles, rules, behaviors, networks, and institutions that bond individuals in groups, bridge divides between societal groups, of vertically integrate groups with different levels of power and influence in a society, leading to social inclusion. Cognitive social capital refers to the values, attitudes, and beliefs that produce cooperative behavior (Colletta & Cullen, 2000).
In summary, social capital may offer an explanation for the observed inequalities in morbidity and mortality by occupational social class and material standard of living. It is a property of groups and can be broken down into structural and cognitive components.
-
This question is part of the following fields:
- Social Psychology
-
-
Question 7
Correct
-
An HIV+ patient in their 60s attends clinic in view of ongoing depression. You note a number of cutaneous lesions in the form of purple-red macules on their face and neck. These are also apparent on the mucous membranes. Which of the following would you most suspect?:
Your Answer: Kaposi's sarcoma
Explanation:Kaposi’s sarcoma is a type of tumor that is caused by human herpesvirus 8. When it is associated with AIDS, it typically appears as red to purple-red macules on the skin that quickly progress to papules, nodules, and plaques. These lesions tend to occur on the head, back, neck, trunk, and mucous membranes, and can also be found in the lymph nodes, stomach, intestines, and lungs in more advanced cases. Individuals with severe mental illness are at a higher risk of contracting and transmitting HIV, and are more likely to have HIV infection compared to the general population. Therefore, it is important to have a basic understanding of the symptoms of this condition.
HIV and Mental Health: Understanding the Relationship and Treatment Options
Human immunodeficiency virus (HIV) is a blood-borne virus that causes cellular immune deficiency, resulting in a decrease in the number of CD4+ T-cells. People with severe mental illness are at increased risk of contracting and transmitting HIV, and the prevalence of HIV infection among them is higher than in the general population. Antiretroviral drugs are used to manage HIV, but they are not curative.
Depression is the most common mental disorder in the HIV population, and it can result from HIV of the psycho-social consequences of having the condition. HIV-associated neurocognitive disorder (HAND) is the umbrella term for the spectrum of neurocognitive impairment induced by HIV, ranging from mild impairment through to dementia. Poor episodic memory is the most frequently reported cognitive difficulty in HIV-positive individuals.
Treatment options for mental health issues in people with HIV include atypical antipsychotics for psychosis, SSRIs for depression and anxiety, valproate for bipolar disorder, and antiretroviral therapy for HAND. It is important to avoid benzodiazepines for delirium and MAOIs for depression. Understanding the relationship between HIV and mental health and providing appropriate treatment options can improve the quality of life for people living with HIV.
-
This question is part of the following fields:
- Psychopharmacology
-
-
Question 8
Incorrect
-
Which component is excluded from the Papez circuit?
Your Answer: Thalamus
Correct Answer: Caudate nucleus
Explanation:The basal ganglia includes the caudate nucleus.
The Papez Circuit: A Neural Pathway for Emotion
James Papez was the first to describe a neural pathway in the brain that mediates the process of emotion. This pathway is known as the ‘Papez circuit’ and is located on the medial surface of the brain. It is bilateral, symmetrical, and links the cortex to the hypothalamus.
According to Papez, information about emotion passes through several structures in the brain, including the hippocampus, the Mammillary bodies of the hypothalamus, the anterior nucleus of the thalamus, the cingular cortex, and the entorhinal cortex. Finally, the information passes through the hippocampus again, completing the circuit.
The Papez circuit was one of the first descriptions of the limbic system, which is responsible for regulating emotions, motivation, and memory. Understanding the Papez circuit and the limbic system has important implications for understanding and treating emotional disorders such as anxiety and depression.
-
This question is part of the following fields:
- Neurosciences
-
-
Question 9
Incorrect
-
Which of these is a feature of Balint's syndrome?
Your Answer: Left-right disorientation
Correct Answer: Simultagnosia
Explanation:Simultagnosia is a condition where an individual is unable to focus on more than one aspect of a complex scene at a time. This condition, along with optic ataxia and oculomotor apraxia, is part of Balint’s syndrome.
Gerstmann syndrome is characterized by four symptoms: dysgraphia/agraphia, dyscalculia/acalculia, finger agnosia, and left-right disorientation. This syndrome is linked to a lesion in the dominant parietal lobe, specifically the left side of the angular and supramarginal gyri. It is rare for an individual to present with all four symptoms of the tetrad.
-
This question is part of the following fields:
- Neurosciences
-
-
Question 10
Incorrect
-
What combination of symptoms and signs would strongly indicate the presence of tuberous sclerosis?
Your Answer: Developmental delay, epicanthic folds, and single palmar crease
Correct Answer: Seizures, developmental delay, and skin lesions
Explanation:Tuberous Sclerosis: A Neurocutaneous Syndrome with Psychiatric Comorbidity
Tuberous sclerosis is a genetic disorder that affects multiple organs, including the brain, and is associated with significant psychiatric comorbidity. This neurocutaneous syndrome is inherited in an autosomal dominant pattern with a high penetrance rate of 95%, but its expression can vary widely. The hallmark of this disorder is the growth of multiple non-cancerous tumors in vital organs, including the brain. These tumors result from mutations in one of two tumor suppressor genes, TSC1 and TSC2. The psychiatric comorbidities associated with tuberous sclerosis include autism, ADHD, depression, anxiety, and even psychosis.
-
This question is part of the following fields:
- Genetics
-
-
Question 11
Incorrect
-
What is the heuristic that best explains a junior psychiatrist's misdiagnosis of a simple case of depression as a rare mental health condition they recently read about?
Your Answer: The framing effect
Correct Answer: Availability
Explanation:Heuristics: Cognitive Shortcuts that can Lead to Diagnostic Errors
In the 1970s, Tversky and Kahneman proposed that humans use cognitive heuristics, of mental shortcuts, to simplify complex decision-making processes. However, these heuristics can also lead to systematic errors. One such heuristic is the representativeness bias, where individuals judge the likelihood of an event based on how closely it resembles a stereotype. For example, a person described as shy and detail-oriented may be more likely to be perceived as a librarian than a farmer.
Another heuristic is the availability bias, where individuals favor recent and readily available information over more accurate but less accessible information. This can lead to overestimating the frequency of certain events, such as violent crime. The anchoring-and-adjustment bias occurs when individuals lock onto salient features in a patient’s initial presentation and fail to adjust their impression in light of new information.
The framing effect is another bias where individuals react differently to a choice depending on how the information is presented. For example, a pharmaceutical company may present a drug as having a 95% cure rate, making it seem superior to a drug with a 2.5% failure rate. Base rate neglect occurs when individuals ignore underlying incident rates of population-based knowledge, leading to unnecessary testing of treatment.
Confirmation bias is a tendency to interpret information to fit preconceived diagnoses, rather than considering alternative explanations. The conjunction rule is the incorrect belief that the probability of multiple events being true is greater than a single event. Finally, diagnostic momentum occurs when clinicians continue a course of action initiated by previous clinicians without considering new information.
Overall, while heuristics can be useful in simplifying complex decision-making processes, they can also lead to diagnostic errors if not used appropriately. It is important for clinicians to be aware of these biases and actively work to avoid them in their practice.
-
This question is part of the following fields:
- Social Psychology
-
-
Question 12
Incorrect
-
A 32-year-old teacher has been referred by the doctor with persistent feelings of sadness. She now describes experiencing a sense of disconnection and feels like she is watching herself in a surreal state. What is the most probable diagnosis?
Your Answer: Derealisation
Correct Answer: Depersonalisation
Explanation:Depersonalisation is classified as a neurotic disorder in the ICD-10 and is characterized by feelings of detachment of distance from one’s own experiences and emotions. Derealisation, on the other hand, is a perceptual phenomenon in which the external world seems unreal. Dissociative fugue is a dissociative state that can lead to wandering and getting lost in another location. Hypochondriasis is a condition in which an individual excessively worries about having a serious illness, despite no evidence of a medical condition. Finally, somatisation is a chronic condition in which multiple physical complaints are present across various systems, but no physical cause can be identified, leading to frequent medical visits.
-
This question is part of the following fields:
- Descriptive Psychopathology
-
-
Question 13
Incorrect
-
Which nuclei in the hypothalamus are responsible for the production and release of dopamine that is transported to the pituitary gland through the infundibulum?
Your Answer: Dorsomedial
Correct Answer: Arcuate
Explanation:Functions of the Hypothalamus
The hypothalamus is a vital part of the brain that plays a crucial role in regulating various bodily functions. It receives and integrates sensory information about the internal environment and directs actions to control internal homeostasis. The hypothalamus contains several nuclei and fiber tracts, each with specific functions.
The suprachiasmatic nucleus (SCN) is responsible for regulating circadian rhythms. Neurons in the SCN have an intrinsic rhythm of discharge activity and receive input from the retina. The SCN is considered the body’s master clock, but it has multiple connections with other hypothalamic nuclei.
Body temperature control is mainly under the control of the preoptic, anterior, and posterior nuclei, which have temperature-sensitive neurons. As the temperature goes above 37ºC, warm-sensitive neurons are activated, triggering parasympathetic activity to promote heat loss. As the temperature goes below 37ºC, cold-sensitive neurons are activated, triggering sympathetic activity to promote conservation of heat.
The hypothalamus also plays a role in regulating prolactin secretion. Dopamine is tonically secreted by dopaminergic neurons that project from the arcuate nucleus of the hypothalamus into the anterior pituitary gland via the tuberoinfundibular pathway. The dopamine that is released acts on lactotrophic cells through D2-receptors, inhibiting prolactin synthesis. In the absence of pregnancy of lactation, prolactin is constitutively inhibited by dopamine. Dopamine antagonists result in hyperprolactinemia, while dopamine agonists inhibit prolactin secretion.
In summary, the hypothalamus is a complex structure that regulates various bodily functions, including circadian rhythms, body temperature, and prolactin secretion. Dysfunction of the hypothalamus can lead to various disorders, such as sleep-rhythm disorder, diabetes insipidus, hyperprolactinemia, and obesity.
-
This question is part of the following fields:
- Neurosciences
-
-
Question 14
Correct
-
A client is referred to your clinic by their physician due to a recent decline in their mood. The client reports difficulty swallowing pills and shares that during their last visit with a psychiatrist, they were given an antidepressant in the form of a patch. Can you identify which antidepressant was previously prescribed to this client?
Your Answer: Selegiline
Explanation:Alternative Routes of Administration for Antidepressants
While most antidepressants are taken orally, there are a few alternative routes of administration available. However, it is important to note that these non-oral preparations should only be used when absolutely necessary, as they may not have a UK licence.
One effective alternative route is sublingual administration of fluoxetine liquid. Buccal administration of selegiline is also available. Crushed amitriptyline has been shown to be effective when administered via this route.
Intravenous administration is another option, with several antidepressants available in IV preparations, including citalopram, escitalopram, mirtazapine, amitriptyline, clomipramine, and allopregnanolone (which is licensed in the US for postpartum depression). Ketamine has also been shown to be effective when administered intravenously.
Intramuscular administration of flupentixol has been shown to have a mood elevating effect, but amitriptyline was discontinued as an IM preparation due to the high volumes required.
Transdermal administration of selegiline is available, and suppositories containing amitriptyline, clomipramine, imipramine, and trazodone have been manufactured by pharmacies, although there is no clear data on their effectiveness. Sertraline tablets and doxepin capsules have also been given rectally.
-
This question is part of the following fields:
- Psychopharmacology
-
-
Question 15
Correct
-
What drug states are capable of eliciting a biological response?
Your Answer: A drug unbound in the plasma
Explanation:The biological response to a drug can only be triggered by the portion of the drug that is not bound.
Drug Distribution in the Body
After being absorbed, drugs can distribute to different parts of the body, such as fat, plasma, muscle, brain tissue, and glands like the thyroid. However, for a drug to have an effect, it must be present in the plasma in an unbound state. This means that the drug molecules are not attached to any other molecules and are free to interact with their target receptors. The concentration of unbound drug in the plasma is what determines the drug’s effectiveness and potential side effects. Therefore, understanding a drug’s distribution in the body is crucial for determining the appropriate dosage and monitoring its effects.
-
This question is part of the following fields:
- Psychopharmacology
-
-
Question 16
Incorrect
-
A 25-year-old woman is part of a group trying to decide on a restaurant for dinner. When the group suggests a popular Italian restaurant, the other 4 members all say they want to go there. The woman is hesitant, but ultimately agrees with the group's choice.
Which group process is at play here?Your Answer: Groupthink
Correct Answer: Conformity
Explanation:Social Influence Phenomena
Conformity is a social influence phenomenon where individuals tend to adopt the attitudes, beliefs, and behaviors of a group, aligning themselves with group norms. The bystander effect is another social influence phenomenon where individuals fail to offer help to a victim when others are present. The likelihood of help decreases as the number of bystanders increases. Groupthink occurs when a group makes poor decisions due to group pressures that lead to a decline in mental efficiency, reality testing, and moral judgment. Polarization is the tendency for a group to make decisions that are more extreme than the initial inclinations of its members. Deindividuation is the loss of self-awareness in groups, often leading to violent acts in situations such as football hooliganism.
-
This question is part of the following fields:
- Social Psychology
-
-
Question 17
Correct
-
What is the term used to describe an agonist that produces effects below the maximum level at a receptor?
Your Answer: A partial agonist
Explanation:Agonists and Antagonists in Pharmacology
In pharmacology, an agonist is a substance that binds to a receptor and triggers a biological response. On the other hand, an antagonist is a substance that blocks the effects of an agonist. A partial agonist produces a response but cannot produce the maximum response even at high doses.
Competitive antagonists bind to the receptor in a reversible way without affecting the biological response. They make the agonist appear less potent. Inverse agonists, on the other hand, have opposite effects from those of full agonists. They are not the same as antagonists, which block the effect of both agonists and inverse agonists.
Full agonists display full efficacy at a receptor. Some substances can act as an agonist at certain receptors and as an antagonist at others. Such a substance is called an agonist-antagonist. Understanding the differences between agonists and antagonists is crucial in drug development and treatment.
-
This question is part of the following fields:
- Psychopharmacology
-
-
Question 18
Incorrect
-
One of Bion's fundamental group assumptions is:
Your Answer: Universality
Correct Answer: Pairing
Explanation:Bion, a psychoanalyst, was fascinated by group dynamics and believed that groups had a collective unconscious that functioned similarly to that of an individual. He argued that this unconsciousness protected the group from the pain of reality. Bion identified two types of groups: the ‘working group’ that functioned well and achieved its goals, and the ‘basic assumption group’ that acted out primitive fantasies and prevented progress. Bion then described different types of basic assumption groups, including ‘dependency,’ where the group turns to a leader to alleviate anxiety, ‘fight-flight,’ where the group perceives an enemy and either attacks of avoids them, and ‘pairing,’ where the group believes that the solution lies in the pairing of two members. These dynamics can be observed in various settings, such as when strangers come together for the first time of when doctors in different specialties criticize one another.
-
This question is part of the following fields:
- Social Psychology
-
-
Question 19
Correct
-
What is the preferred antidepressant for individuals experiencing depression after a heart attack?
Your Answer: Sertraline
Explanation:Sertraline is the preferred medication for treating post-MI depression as it has minimal impact on heart rate, blood pressure, and the QTc interval. Tricyclics are not recommended due to their potential to cause postural hypotension, increased heart rate, and QTc interval prolongation. Fluoxetine may be used with caution as it has a slight effect on heart rate but does not significantly affect blood pressure of the QTc interval. Trazodone should be used with care as it can cause significant postural hypotension and QTc interval prolongation in post-MI patients. Venlafaxine should be avoided in these patients as it can increase blood pressure, particularly at higher doses.
-
This question is part of the following fields:
- Psychopharmacology
-
-
Question 20
Correct
-
A concerned parent of a 25-year-old daughter with schizophrenia wants to know what the biggest challenge is for individuals living with this condition and how it affects their overall quality of life.
Your Answer: People with schizophrenia live with the stigma of the illness and are often seen as dangerous by society
Explanation:Norman Sartorius highlights the iatrogenic stigma of mental illness as the main obstacle to a better life for those suffering from mental disorders. NICE guidelines on schizophrenia also acknowledge the stigma associated with the condition, which is often seen as dangerous and best dealt with away from society. However, research has shown that the fear of violence arising from people with schizophrenia is misplaced. Other factors that may contribute to feelings of exclusion and isolation include compulsory treatment under mental health legislation, medication side effects, and less careful use of diagnostic labels.
-
This question is part of the following fields:
- Stigma And Culture
-
-
Question 21
Incorrect
-
Which developmental theory proposes a sequence of challenges of conflicts, with the advancement through each stage referred to as epigenesis?
Your Answer: Piaget
Correct Answer: Erikson
Explanation:The psychosocial theory of development, as described by Erikson, involves eight stages that continue into adulthood and require the resolution of a crisis at each stage. Bowlby is known for attachment theory and maternal deprivation, while Freud focused on psychosexual development. Kohlberg studied moral development, and Piaget developed the cognitive model of development.
-
This question is part of the following fields:
- Advanced Psychological Processes And Treatments
-
-
Question 22
Correct
-
A child called Jack has developed a fear of dogs after he was chased by a dog in the park. The parent addresses this by exposing Jack to a friendly dog. Initially Jack reacted nervously and cried at the sight of the dog but over a period of 15 minutes, he settled in the company of this dog.
What could be the reason for the improvement in Jack's fear of dogs?Your Answer: Extinction
Explanation:In psychology, the spacing effect suggests that humans are more likely to remember of learn items in a list when they are studied a few times over a long period of time (spaced presentation) rather than repeatedly in a short period of time, which is known as massed practice.
Classical Conditioning: A Learning Theory by Ivan Pavlov
Classical conditioning is a learning theory developed by Ivan Pavlov. It suggests that events that occur together are associated and acquire a similar meaning. Unlike operant conditioning, which focuses on responses to behavior, classical conditioning looks at responses to stimuli. In classical conditioning, animals behave as if they have learned to associate a stimulus with a significant event. Pavlov demonstrated that innate responses, such as a dog salivating when it sees food, can be associated with a neutral stimulus, such as ringing a bell, so that ringing the bell can cause salivation even in the absence of food.
Important terms used in classical conditioning include stimulus generalization and discrimination, higher order conditioning, spontaneous recovery, and aversive conditioning. Extinction is the laboratory analogue of exposure therapy for anxiety disorders, while Counterconditioning involves pairing a feared conditioned stimulus with a positive outcome. Incubation occurs in fear responses, and reciprocal inhibition is a technique that aims to replace an undesired response with a desired one by counterconditioning. Some stimuli are more prone to conditioning than others, which is referred to as stimulus/biological preparedness.
-
This question is part of the following fields:
- Social Psychology
-
-
Question 23
Correct
-
A 45-year-old woman has been referred to your outpatient clinic by her psychiatrist. Her family are concerned that she has recently started binge eating. Her psychiatrist changed her medication two weeks prior.
Which of the following treatments is she most likely to have been started on by her psychiatrist?:Your Answer: Pramipexole
Explanation:Pramipexole, a dopamine agonist used to treat Parkinson’s disease, has been linked to the development of pathological gambling, which is disproportionately common in patients with Parkinson’s disease. While levodopa treatment alone is not associated with pathological gambling, all dopamine agonists have been implicated, with pramipexole being the most common due to its high selectivity for D3 receptors in the limbic system. Quetiapine is unlikely to cause pathological gambling, and amantadine, a weaker dopamine agonist than pramipexole, is also less likely to be implicated. Memantine, an NMDA antagonist that reduces glutamate excitability, may have some potential in treating pathological gambling.
-
This question is part of the following fields:
- Psychopharmacology
-
-
Question 24
Incorrect
-
What is the accurate statement about the dispensation of medication in older adults?
Your Answer: There is a relative reduction of body fat to body water
Correct Answer: As people age, the half-life of a lipid soluble drug increases
Explanation:Prescribing medication for elderly individuals requires consideration of their unique pharmacokinetics and pharmacodynamics. As the body ages, changes in distribution, metabolism, and excretion can affect how medication is absorbed and processed. For example, reduced gastric acid secretion and motility can impact drug absorption, while a relative reduction of body water to body fat can alter the distribution of lipid soluble drugs. Additionally, hepatic metabolism of drugs decreases with age, and the kidneys become less effective, leading to potential accumulation of certain drugs.
In terms of pharmacodynamics, receptor sensitivity tends to increase during old age, meaning smaller doses may be needed. However, older individuals may also take longer to respond to treatment and have an increased incidence of side-effects. It is important to start with a lower dose and monitor closely when prescribing medication for elderly patients, especially considering the potential for interactions with other medications they may be taking.
-
This question is part of the following fields:
- Psychopharmacology
-
-
Question 25
Correct
-
Upon examination of a 24-year-old man admitted to A&E with vomiting blood and exhibiting a pill rolling tremor and a brown ring around the iris, one would anticipate the presence of certain blood results.
Your Answer: Low plasma ceruloplasmin
Explanation:The presence of a distinct brown ring encircling the iris is a clear indication of a Kayser-Fleischer ring, which is a telltale sign of Wilson’s disease. Vomiting of blood is a common symptom of esophageal varices, a complication that arises from liver failure, which is a common occurrence in individuals with Wilson’s disease.
Understanding Wilson’s Disease: Causes, Symptoms, and Management
Wilson’s disease, also known as hepatolenticular degeneration, is a genetic disorder that affects copper storage in the body. This condition is caused by a defect in the ATP7B gene, which leads to the accumulation of copper in the liver and brain. The onset of symptoms usually occurs between the ages of 10 and 25, with liver disease being the most common presentation in children and neurological symptoms in young adults.
The excessive deposition of copper in the tissues can cause a range of symptoms, including hepatitis, cirrhosis, basal ganglia degeneration, speech and behavioral problems, asterixis, chorea, dementia, Kayser-Fleischer rings, sunflower cataract, renal tubular acidosis, haemolysis, and blue nails. Diagnosis is based on reduced serum ceruloplasmin, reduced serum copper, and increased 24-hour urinary copper excretion.
The traditional first-line treatment for Wilson’s disease is penicillamine, which chelates copper. Trientine hydrochloride is an alternative chelating agent that may become first-line treatment in the future. Tetrathiomolybdate is a newer agent that is currently under investigation.
In summary, Wilson’s disease is a genetic disorder that affects copper storage in the body, leading to a range of symptoms that can affect the liver, brain, and eyes. Early diagnosis and treatment are essential to prevent complications and improve outcomes.
-
This question is part of the following fields:
- Classification And Assessment
-
-
Question 26
Incorrect
-
What is the accurate statement about the concept of the 'sick role'?
Your Answer: Society does not support the sick person to be exempt from the normal social roles during the course of the illness
Correct Answer: Sick persons are not considered responsible for their illnesses
Explanation:The concept of the sick role pertains to an implicit agreement between an individual who falls ill and the community they belong to.
The Sick Role and Illness Behavior
Mechanic and Volkart (1961) introduced the term illness behavior to describe how individuals perceive, evaluate, and respond to symptoms of physical dysfunction. Meanwhile, Talcott Parsons (1951) introduced the concept of the sick role as a temporary form of deviant behavior that is medically sanctioned.
According to Parsons, a sick person experiences conflicting desires to recover from the illness and to enjoy the secondary gains of attention and exemption from normal duties. The sick role is characterized by several rules, including the exemption of the sick person from their normal social roles, which is legitimized by society through the physician. The severity of the illness determines the strength of the exemption.
Additionally, sick persons are not held responsible for their illnesses, as they are beyond personal control. However, they have a duty to try to get well, as sickness is considered undesirable by society. Seeking competent technical help and cooperating with caregivers are also expected of sick persons.
In summary, the sick role and illness behavior are important concepts in understanding how individuals respond to physical dysfunction and how society legitimizes and responds to illness.
-
This question is part of the following fields:
- Social Psychology
-
-
Question 27
Correct
-
Who is the neurologist that created a map of the cortex surface with specific areas?
Your Answer: Korbinian Brodmann
Explanation:The Cerebral Cortex and Neocortex
The cerebral cortex is the outermost layer of the cerebral hemispheres and is composed of three parts: the archicortex, paleocortex, and neocortex. The neocortex accounts for 90% of the cortex and is involved in higher functions such as thought and language. It is divided into 6-7 layers, with two main cell types: pyramidal cells and nonpyramidal cells. The surface of the neocortex is divided into separate areas, each given a number by Brodmann (e.g. Brodmann’s area 17 is the primary visual cortex). The surface is folded to increase surface area, with grooves called sulci and ridges called gyri. The neocortex is responsible for higher cognitive functions and is essential for human consciousness.
-
This question is part of the following fields:
- Neurosciences
-
-
Question 28
Correct
-
What is an example of declarative memory?
Your Answer: Episodic
Explanation:Memory Forms
Memory is the ability to store, retain, and retrieve information. There are different forms of memory, including sensory memory, short-term/working memory, and long-term memory.
Sensory memory is the capacity for briefly retaining the large amounts of information that people encounter daily. It includes echoic memory (gathered through auditory stimuli), iconic memory (gathered through sight), and haptic memory (acquired through touch).
Short-term memory is the ability to keep a small amount of information available for a short period of time. Atkinson and Shiffrin’s multistore model (1968) suggests the existence of a short-term storehouse with limited capacity. Baddeley and Hitch (1974) further developed the concept of short-term memory, which eventually became known as Baddeley’s multi-storehouse model (2000). This model includes the central executive, visuospatial sketchpad, phonological buffer/loop, and episodic buffer.
Long-term memory includes declarative (of explicit) memories, which can be consciously retrieved, and nondeclarative (of implicit) memories, which cannot. Declarative memory includes episodic memory (stores personal experiences) and semantic memory (stores information about facts and concepts). Non-declarative memory includes procedural memory (recalls motor and executive skills), associative memory (storage and retrieval of information through association with other information), and non-associative memory (refers to newly learned behavior through repeated exposure to an isolated stimulus).
Overall, memory is a complex and essential cognitive function that plays a crucial role in learning, reasoning, and understanding.
-
This question is part of the following fields:
- Social Psychology
-
-
Question 29
Correct
-
A 35-year-old man was at a concert when a firework exploded nearby. He was standing at the time and the force of the blast threw him to the ground. He suffered a broken arm and multiple cuts. Several people were killed and many others were injured.
After four months, he experiences nightmares about the incident, struggles to sleep, has avoided going to concerts since, and jumps at sudden sounds. He often finds himself unable to stop thinking about what happened.
What is the probable diagnosis?Your Answer: Post-traumatic stress disorder
Explanation:Post-traumatic stress disorder (PTSD) is a condition that develops in response to an exceptionally threatening of catastrophic event of situation, such as the one described above. It is only diagnosed if symptoms arise within six months of the traumatic event. The symptoms of PTSD can be categorized into three groups: re-experiencing the traumatic event (such as through nightmares of vivid thoughts), persistent avoidance of stimuli associated with the trauma, and persistent symptoms of increased arousal (such as difficulty sleeping of concentrating).
Agoraphobia is a fear of being in situations of places from which escape is difficult, leading to avoidance of many situations and confinement to the home. This fear is typically triggered by situations such as crowds, public places, of traveling alone of away from home.
Generalized anxiety disorder is characterized by persistent anxiety that is not limited to any specific environmental circumstance. To receive this diagnosis, a patient must experience symptoms of anxiety on most days for several weeks of months, with evidence of impairment in important areas of functioning. However, this diagnosis is not appropriate for the scenario described above, as the anxiety is related to a specific event of trigger.
Panic disorder involves sudden onset of severe anxiety, with at least three panic attacks experienced over a three-week period. Symptoms may include sweating, palpitations, shortness of breath, nausea, trembling, chest pain of discomfort, dizziness of lightheadedness, chills of hot flushes, fear of losing control of dying, paraesthesia, feeling of choking, and derealization or depersonalization.
Social phobia is characterized by a marked fear of social situations in which embarrassment may occur, leading to avoidance of these situations.
-
This question is part of the following fields:
- Diagnosis
-
-
Question 30
Correct
-
Which Piagetian stage is accurately paired with the corresponding developmental period?
Your Answer: Preoperational - 2-7 years
Explanation:Piaget’s Stages of Development and Key Concepts
Piaget developed four stages of development that describe how children think and acquire knowledge. The first stage is the Sensorimotor stage, which occurs from birth to 18-24 months. In this stage, infants learn through sensory observation and gain control of their motor functions through activity, exploration, and manipulation of the environment.
The second stage is the Preoperational stage, which occurs from 2 to 7 years. During this stage, children use symbols and language more extensively, but they are unable to think logically of deductively. They also use a type of magical thinking and animistic thinking.
The third stage is the Concrete Operational stage, which occurs from 7 to 11 years. In this stage, egocentric thought is replaced by operational thought, which involves dealing with a wide array of information outside the child. Children in this stage begin to use limited logical thought and can serialise, order, and group things into classes on the basis of common characteristics.
The fourth and final stage is the Formal Operations stage, which occurs from 11 through the end of adolescence. This stage is characterized by the ability to think abstractly, to reason deductively, to define concepts, and also by the emergence of skills for dealing with permutations and combinations.
Piaget also developed key concepts, including schema, assimilation, and accommodation. A schema is a category of knowledge and the process of obtaining that knowledge. Assimilation is the process of taking new information into an existing schema, while accommodation involves altering a schema in view of additional information.
Overall, Piaget’s stages of development and key concepts provide a framework for understanding how children learn and acquire knowledge.
-
This question is part of the following fields:
- Psychological Development
-
00
Correct
00
Incorrect
00
:
00
:
00
Session Time
00
:
00
Average Question Time (
Mins)