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  • Question 1 - A 51-year-old man passed away from a massive middle cerebral artery stroke. He...

    Correct

    • A 51-year-old man passed away from a massive middle cerebral artery stroke. He had no previous medical issues. Upon autopsy, it was discovered that his heart weighed 400 g and had normal valves and coronary arteries. The atria and ventricles were not enlarged. The right ventricular walls were normal, while the left ventricular wall was uniformly hypertrophied to 20-mm thickness. What is the probable reason for these autopsy results?

      Your Answer: Essential hypertension

      Explanation:

      Differentiating Cardiac Conditions: Causes and Risks

      Cardiac conditions can have varying causes and risks, making it important to differentiate between them. Essential hypertension, for example, is characterized by uniform left ventricular hypertrophy and is a major risk factor for stroke. On the other hand, atrial fibrillation is a common cause of stroke but does not cause left ventricular hypertrophy and is rarer with normal atrial size. Hypertrophic obstructive cardiomyopathy, which is more common in men and often has a familial tendency, typically causes asymmetric hypertrophy of the septum and apex and can lead to arrhythmogenic or unexplained sudden cardiac death. Dilated cardiomyopathies, such as idiopathic dilated cardiomyopathy, often have no clear precipitant but cause a dilated left ventricular size, increasing the risk for a mural thrombus and an embolic risk. Finally, tuberculous pericarditis is difficult to diagnose due to non-specific features such as cough, dyspnoea, sweats, and weight loss, with typical constrictive pericarditis findings being very late features with fluid overload and severe dyspnoea. Understanding the causes and risks associated with these cardiac conditions can aid in their proper diagnosis and management.

    • This question is part of the following fields:

      • Cardiology
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  • Question 2 - Examine the cardiac catheter data provided below for a patient. Which of the...

    Incorrect

    • Examine the cardiac catheter data provided below for a patient. Which of the following clinical scenarios is most consistent with the given information?

      Anatomical site Oxygen saturation (%) Pressure (mmHg) End systolic/End diastolic
      Superior vena cava 74 -
      Inferior vena cava 72 -
      Right atrium 73 5
      Right ventricle 74 20/4
      Pulmonary artery 74 20/5
      Pulmonary capillary wedge pressure - 15
      Left ventricle 98 210/15
      Aorta 99 125/75

      Your Answer: A 77-year-old man who presents with dyspnoea ten years after a porcine mitral valve replacement

      Correct Answer: A 17-year-old boy who presents after an episode of exercise-induced syncope

      Explanation:

      Left Ventricular Pressure and Cardiac Conditions

      Left ventricular pressures that exhibit a sharp decline between the LV and aortic systolic pressures are indicative of hypertrophic cardiomyopathy. This condition is consistent with the catheter data obtained from the patient. However, the data are not consistent with other cardiac conditions such as cyanotic congenital heart disease, post-MI VSD or mitral regurgitation, mitral stenosis, or mitral regurgitation. Although aortic stenosis may also present with a left ventricular outflow obstruction, it is not typically associated with exercise-induced syncope. These findings suggest that the patient’s symptoms are likely due to hypertrophic cardiomyopathy.

    • This question is part of the following fields:

      • Cardiology
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  • Question 3 - A final-year medical student is taking a history from a 63-year-old patient as...

    Incorrect

    • A final-year medical student is taking a history from a 63-year-old patient as a part of their general practice attachment. The patient informs her that she has a longstanding heart condition, the name of which she cannot remember. The student decides to review an old electrocardiogram (ECG) in her notes, and from it she is able to see that the patient has atrial fibrillation (AF).
      Which of the following ECG findings is typically found in AF?

      Your Answer:

      Correct Answer: Absent P waves

      Explanation:

      Common ECG Findings and Their Significance

      Electrocardiogram (ECG) is a diagnostic tool used to evaluate the electrical activity of the heart. It records the heart’s rhythm and detects any abnormalities. Here are some common ECG findings and their significance:

      1. Absent P waves: Atrial fibrillation causes an irregular pulse and palpitations. ECG findings include absent P waves and irregular QRS complexes.

      2. Long PR interval: A long PR interval indicates heart block. First-degree heart block is a fixed prolonged PR interval.

      3. T wave inversion: T wave inversion can occur in fast atrial fibrillation, indicating cardiac ischaemia.

      4. Bifid P wave (p mitrale): Bifid P waves are caused by left atrial hypertrophy.

      5. ST segment elevation: ST segment elevation typically occurs in myocardial infarction. However, it may also occur in pericarditis and subarachnoid haemorrhage.

      Understanding these ECG findings can help healthcare professionals diagnose and treat various cardiac conditions.

    • This question is part of the following fields:

      • Cardiology
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  • Question 4 - An overweight 46-year-old Caucasian male patient attends for the results of a health...

    Incorrect

    • An overweight 46-year-old Caucasian male patient attends for the results of a health check arranged by your surgery. He smokes 12 cigarettes a day and is trying to cut down. Alcohol intake is 8 units per week. He tells you that his father underwent a ‘triple bypass’ aged 48 years. His results are as follows:
      Total cholesterol : HDL ratio 6
      HbA1c: 39 mmol/mol
      Urea and electrolytes: normal
      Estimated glomerular filtration rate (eGFR): 97 ml/min/1.73m2
      Liver function tests: normal
      Blood pressure (daytime average on 24-h ambulatory monitor): 140/87
      Body mass index (BMI): 25
      His QRISK2 10-year cardiovascular risk is calculated at 22.7%.
      In addition to assisting with smoking cessation and providing lifestyle advice, what is the most appropriate means of managing his risk?

      Your Answer:

      Correct Answer: Commence atorvastatin 20 mg once a night and start a calcium channel blocker, review after three months

      Explanation:

      Treatment Plan for a Patient with High Cholesterol and Hypertension

      Introduction:
      This patient has high cholesterol and hypertension, both of which require immediate attention. In this treatment plan, we will discuss the appropriate medications and monitoring for this patient.

      Treatment Plan for a Patient with High Cholesterol and Hypertension

      Medications:
      The patient will start taking atorvastatin 20 mg once a night to address their high cholesterol. After three months, their cholesterol and full lipid profile will be rechecked, and the therapy will be titrated to maintain a total cholesterol of <5. If necessary, the dose may be increased to 40 mg once a night. For hypertension, the patient will start taking a calcium channel blocker as they are over the age of 55. The blood pressure will be monitored regularly, and if it rises above 150/90, additional treatment may be necessary. Monitoring:
      The patient’s cholesterol and full lipid profile will be rechecked after three months of treatment with atorvastatin. The aim is to see a 40% reduction in non-HDL cholesterol. If this is not achieved, a discussion of adherence, lifestyle measures, and the possibility of increasing the dose will take place.

      The patient’s blood pressure will also be monitored regularly. If it rises above 150/90, additional treatment may be necessary.

      Conclusion:
      This treatment plan addresses both the patient’s high cholesterol and hypertension. By starting atorvastatin and a calcium channel blocker, we can reduce their risk of developing cardiovascular disease. Regular monitoring will ensure that the patient’s cholesterol and blood pressure are under control.

    • This question is part of the following fields:

      • Cardiology
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  • Question 5 - What hormone does the heart produce under stressed conditions? ...

    Incorrect

    • What hormone does the heart produce under stressed conditions?

      Your Answer:

      Correct Answer: B-type natriuretic peptide (BNP)

      Explanation:

      The cardiovascular system relies on a complex network of hormones and signaling molecules to regulate blood pressure, fluid balance, and other physiological processes. Here are some key players in this system:

      B-type natriuretic peptide (BNP): This hormone is secreted by the ventricle in response to stretch, and levels are elevated in heart failure.

      Angiotensin II: This hormone is produced mostly in the lungs where angiotensin-converting enzyme (ACE) concentrations are maximal.

      C-type natriuretic peptide: This signaling molecule is produced by the endothelium, and not the heart.

      Nitric oxide: This gasotransmitter is released tonically from all endothelial lined surfaces, including the heart, in response to both flow and various agonist stimuli.

      Renin: This enzyme is released from the kidney, in response to reductions in blood pressure, increased renal sympathetic activity or reduced sodium and chloride delivery to the juxtaglomerular apparatus.

      Understanding the roles of these hormones and signaling molecules is crucial for managing cardiovascular health and treating conditions like heart failure.

    • This question is part of the following fields:

      • Cardiology
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  • Question 6 - What term describes a lack of pulses but regular coordinated electrical activity on...

    Incorrect

    • What term describes a lack of pulses but regular coordinated electrical activity on an ECG?

      Your Answer:

      Correct Answer: Pulseless electrical activity (PEA)

      Explanation:

      Causes of Pulseless Electrical Activity

      Pulseless Electrical Activity (PEA) occurs when there is a lack of pulse despite normal electrical activity on the ECG. This can be caused by poor intrinsic myocardial contractility or a variety of remediable factors. These factors include hypoxemia, hypovolemia, severe acidosis, tension pneumothorax, pericardial tamponade, hyperkalemia, hypocalcemia, poisoning with a calcium channel blocker, or hypothermia. Additionally, PEA may be caused by a massive pulmonary embolism. It is important to identify and address the underlying cause of PEA in order to improve patient outcomes.

    • This question is part of the following fields:

      • Cardiology
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  • Question 7 - A 55-year-old man is experiencing chest pain and shortness of breath three weeks...

    Incorrect

    • A 55-year-old man is experiencing chest pain and shortness of breath three weeks after a myocardial infarction that was treated with percutaneous coronary intervention (PCI) for a proximal left anterior descending artery occlusion. On examination, he has a loud friction rub over the praecordium, bilateral pleural effusions on chest x-ray, and ST elevation on ECG. What is the most probable diagnosis?

      Your Answer:

      Correct Answer: Dressler's syndrome

      Explanation:

      Dressler’s Syndrome

      Dressler’s syndrome is a type of pericarditis that typically develops between two to six weeks after a person has experienced an anterior myocardial infarction or undergone heart surgery. This condition is believed to be caused by an autoimmune response to myocardial antigens. In simpler terms, the body’s immune system mistakenly attacks the heart tissue, leading to inflammation of the pericardium, which is the sac that surrounds the heart.

      The symptoms of Dressler’s syndrome can vary from person to person, but they often include chest pain, fever, fatigue, and shortness of breath. In some cases, patients may also experience a cough, abdominal pain, or joint pain. Treatment for this condition typically involves the use of nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce inflammation and manage pain. In severe cases, corticosteroids may be prescribed to help suppress the immune system.

    • This question is part of the following fields:

      • Cardiology
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  • Question 8 - A man in his early 60s is undergoing treatment for high blood pressure....

    Incorrect

    • A man in his early 60s is undergoing treatment for high blood pressure. During a dental check-up, his dentist informs him that he has gingival hyperplasia. Which medication is the most probable culprit for this condition?

      Your Answer:

      Correct Answer: Nifedipine

      Explanation:

      Drugs Associated with Gingival Hyperplasia

      Gingival hyperplasia is a condition characterized by an overgrowth of gum tissue, which can lead to discomfort, difficulty in maintaining oral hygiene, and even tooth loss. There are several drugs that have been associated with this condition, including Phenytoin, Ciclosporin, and Nifedipine. These drugs are commonly used to treat various medical conditions, such as epilepsy, organ transplant rejection, and hypertension.

      According to Medscape, drug-induced gingival hyperplasia is a well-known side effect of these medications. The exact mechanism by which these drugs cause gingival hyperplasia is not fully understood, but it is believed to be related to their effect on the immune system and the production of collagen in the gums.

      It is important for healthcare providers to be aware of this potential side effect when prescribing these medications, and to monitor patients for any signs of gingival hyperplasia. Patients who are taking these drugs should also be advised to maintain good oral hygiene and to visit their dentist regularly for check-ups and cleanings.

      In summary, Phenytoin, Ciclosporin, and Nifedipine are drugs that have been associated with gingival hyperplasia. Healthcare providers should be aware of this potential side effect and monitor patients accordingly, while patients should maintain good oral hygiene and visit their dentist regularly.

    • This question is part of the following fields:

      • Cardiology
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  • Question 9 - A 48-year-old man presents to the Emergency Department with chest tightness. His blood...

    Incorrect

    • A 48-year-old man presents to the Emergency Department with chest tightness. His blood pressure is 200/105 mmHg and heart rate is 70 bpm. His femoral pulses cannot be felt. Echocardiography reveals cardiomegaly and a left-ventricular ejection fraction of 34%. The patient also has a N-terminal pro-brain natriuretic peptide (NT-proBNP) of 25,000 pg/mL. As a result of the patient’s hypertension and high levels of NT-proBNP, he undergoes coronary angiography to exclude cardiac ischaemia. There is no evidence of myocardial ischaemia, but there are significant arterial findings.
      Which of the following is most likely to be seen on coronary angiography of this patient?

      Your Answer:

      Correct Answer: Stenotic arteries

      Explanation:

      Differentiating Arterial Conditions: Understanding the Symptoms and Causes

      When it comes to arterial conditions, it is important to understand the symptoms and causes in order to make an accurate diagnosis. Here, we will explore several potential conditions and how they may present in a patient.

      Stenotic Arteries:
      Coarctation of the aorta is a potential condition to consider in younger adults with poorly controlled hypertension. Symptoms may include weak or absent femoral pulses, heart failure, and left-ventricular hypertrophy. Angiography may reveal stenosis in the middle and proximal segments of the left anterior descending artery, as well as in the left circumflex artery.

      Thickened Arteries:
      Atherosclerosis, or the build-up of plaque in the arteries, is a risk factor for heart attacks and stroke. However, it is unlikely to explain persistently high blood pressure or an absent femoral pulse.

      Aortic Aneurysm:
      While chronic high blood pressure can increase the risk of an aortic aneurysm, sudden, intense chest or back pain is a more common symptom. Additionally, a patient with an aneurysm would likely have low blood pressure and an elevated heart rate, which is inconsistent with the vitals seen in this presentation.

      Calcified Arteries:
      Calcification of arteries is caused by elevated lipid content and increases with age. While it can increase the risk of heart attack and stroke, it would not explain the absence of a femoral pulse or extremely high blood pressure.

      Patent Foramen Ovale:
      This condition, which predisposes patients to paradoxical emboli, is typically diagnosed on an echocardiogram and is unlikely to cause hypertension. It should be considered in patients who have had a stroke before the age of 50.

      In summary, understanding the symptoms and causes of arterial conditions is crucial for accurate diagnosis and treatment.

    • This question is part of the following fields:

      • Cardiology
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  • Question 10 - A 50-year-old male smoker presents with a 6-hour history of gradual-onset central chest...

    Incorrect

    • A 50-year-old male smoker presents with a 6-hour history of gradual-onset central chest pain. The chest pain is worse on inspiration and relieved by leaning forward. He reports recently suffering a fever which he attributed to a viral illness. He has no significant past medical history; however, both his parents suffered from ischaemic heart disease in their early 60s. An electrocardiogram (ECG) reveals PR depression and concave ST-segment elevation in most leads. He is haemodynamically stable.
      What is the most appropriate management?

      Your Answer:

      Correct Answer: Ibuprofen

      Explanation:

      Treatment Options for Acute Pericarditis: Understanding the Clinical Scenario

      Acute pericarditis can be caused by a variety of factors, including infection, inflammation, and metabolic issues. The condition is typically characterized by gradual-onset chest pain that worsens with inspiration and lying flat, but improves with leaning forward. ECG findings often show concave ST-segment elevation and PR depression in certain leads, along with reciprocal changes in others.

      Understanding Treatment Options for Acute Pericarditis

    • This question is part of the following fields:

      • Cardiology
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  • Question 11 - A 57-year-old man arrives at the Emergency Department with sudden onset central crushing...

    Incorrect

    • A 57-year-old man arrives at the Emergency Department with sudden onset central crushing chest pain. The patient reports feeling pain in his neck and jaw as well. He has no significant medical history, but he does smoke occasionally and consumes up to 60 units of alcohol per week. An ECG is performed, revealing widespread ST elevation indicative of an acute coronary syndrome. At what point do the microscopic changes of acute MI become visible?

      Your Answer:

      Correct Answer: 12-24 hours after the infarct

      Explanation:

      The Pathological Progression of Myocardial Infarction: A Timeline of Changes

      Myocardial infarction, commonly known as a heart attack, is a serious medical condition that occurs when blood flow to the heart is blocked, leading to tissue damage and potentially life-threatening complications. The pathological progression of myocardial infarction follows a predictable sequence of events, with macroscopic and microscopic changes occurring over time.

      Immediately after the infarct occurs, there are usually no visible changes to the myocardium. However, within 3-6 hours, maximal inflammatory changes occur, with the most prominent changes occurring between 24-72 hours. During this time, coagulative necrosis and acute inflammatory responses are visible, with marked infiltration by neutrophils.

      Between 3-10 days, the infarcted area begins to develop a hyperaemic border, and the process of organisation and repair begins. Granulation tissue replaces dead muscle, and dying neutrophils are replaced by macrophages. Disintegration and phagocytosis of dead myofibres occur during this time.

      If a patient survives an acute infarction, the infarct heals through the formation of scar tissue. However, scar tissue does not possess the usual contractile properties of normal cardiac muscle, leading to contractile dysfunction or congestive cardiac failure. The entire process from coagulative necrosis to the formation of well-formed scar tissue takes 6-8 weeks.

      In summary, understanding the timeline of changes that occur during myocardial infarction is crucial for early diagnosis and effective treatment. By recognising the macroscopic and microscopic changes that occur over time, healthcare professionals can provide appropriate interventions to improve patient outcomes.

    • This question is part of the following fields:

      • Cardiology
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  • Question 12 - A 68-year-old man presents to the Cardiology Clinic with worsening central crushing chest...

    Incorrect

    • A 68-year-old man presents to the Cardiology Clinic with worsening central crushing chest pain that only occurs during physical activity and never at rest. He is currently taking bisoprolol 20 mg per day, ramipril, omeprazole, glyceryl trinitrate (GTN), and atorvastatin. What is the most suitable course of action?

      Your Answer:

      Correct Answer: Commence isosorbide mononitrate and arrange an outpatient angiogram

      Explanation:

      Management of Stable Angina: Adding Isosorbide Mononitrate and Arranging Outpatient Angiogram

      For a patient with stable angina who is already taking appropriate first-line medications such as bisoprolol and GTN, the next step in management would be to add a long-acting nitrate like isosorbide mononitrate. This medication provides longer-term vasodilation compared to GTN, which is only used when required. This can potentially reduce the frequency of angina symptoms.

      An outpatient angiogram should also be arranged for the patient. While stable angina does not require an urgent angiogram, performing one on a non-urgent basis can provide more definitive management options like stenting if necessary.

      Increasing the dose of ramipril or statin is not necessary unless there is evidence of worsening hypertension or high cholesterol levels, respectively. Overall, the management of stable angina should be tailored to the individual patient’s needs and risk factors.

    • This question is part of the following fields:

      • Cardiology
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  • Question 13 - A 57-year-old male with a known history of rheumatic fever and frequent episodes...

    Incorrect

    • A 57-year-old male with a known history of rheumatic fever and frequent episodes of pulmonary oedema is diagnosed with pulmonary hypertension. During examination, an irregularly irregular pulse was noted and auscultation revealed a loud first heart sound and a rumbling mid-diastolic murmur. What is the most probable cause of this patient's pulmonary hypertension?

      Your Answer:

      Correct Answer: Mitral stenosis

      Explanation:

      Cardiac Valve Disorders: Mitral Stenosis, Mitral Regurgitation, Aortic Regurgitation, Pulmonary Stenosis, and Primary Pulmonary Hypertension

      Cardiac valve disorders are conditions that affect the proper functioning of the heart valves. Among these disorders are mitral stenosis, mitral regurgitation, aortic regurgitation, pulmonary stenosis, and primary pulmonary hypertension.

      Mitral stenosis is a narrowing of the mitral valve, usually caused by rheumatic fever. Symptoms include palpitations, dyspnea, and hemoptysis. Diagnosis is aided by electrocardiogram, chest X-ray, and echocardiography. Management may be medical or surgical.

      Mitral regurgitation is a systolic murmur that presents with a sustained apex beat displaced to the left and a left parasternal heave. On auscultation, there will be a soft S1, a loud S2, and a pansystolic murmur heard at the apex radiating to the left axilla.

      Aortic regurgitation presents with a collapsing pulse with a wide pulse pressure. On palpation of the precordium, there will be a sustained and displaced apex beat with a soft S2 and an early diastolic murmur at the left sternal edge.

      Pulmonary stenosis is associated with a normal pulse, with an ejection systolic murmur radiating to the lung fields. There may be a palpable thrill over the pulmonary area.

      Primary pulmonary hypertension most commonly presents with progressive weakness and shortness of breath. There is evidence of an underlying cardiac disease, meaning the underlying pulmonary hypertension is more likely to be secondary to another disease process.

    • This question is part of the following fields:

      • Cardiology
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  • Question 14 - A 72-year-old man is brought by ambulance to Accident and Emergency. He presents...

    Incorrect

    • A 72-year-old man is brought by ambulance to Accident and Emergency. He presents with central crushing chest pain and has ST-segment elevation present on an electrocardiogram (ECG). You are at a District General Hospital without access to percutaneous coronary intervention (PCI), and you will not be able to transfer the patient across for PCI in time.
      Which of the following is an absolute contraindication to thrombolysis?

      Your Answer:

      Correct Answer: Brain neoplasm

      Explanation:

      Relative and Absolute Contraindications to Thrombolysis

      Thrombolysis is a treatment option for patients with ongoing cardiac ischemia and presentation within 12 hours of onset of pain. However, it is important to consider both relative and absolute contraindications before administering thrombolysis.

      Cerebral neoplasm is the only absolute contraindication, while advanced liver disease, severe hypertension (not meeting absolute contraindication values), active peptic ulceration, and pregnancy or recent delivery are all relative contraindications.

      Primary PCI is the preferred treatment option if available, but thrombolysis can be used as an alternative if necessary. The benefit of thrombolysis decreases over time, and a target time of less than 30 minutes from admission is recommended. Thrombolysis should not be given if the onset of pain is more than 24 hours after presentation.

      It is important to carefully consider contraindications before administering thrombolysis to ensure patient safety and optimal treatment outcomes.

    • This question is part of the following fields:

      • Cardiology
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  • Question 15 - A typically healthy and fit 35-year-old man presents to Accident and Emergency with...

    Incorrect

    • A typically healthy and fit 35-year-old man presents to Accident and Emergency with palpitations that have been ongoing for 4 hours. He reports no chest pain and has a National Early Warning Score (NEWS) of 0. Upon examination, the only notable finding is an irregularly irregular pulse. An electrocardiogram (ECG) confirms that the patient is experiencing atrial fibrillation (AF). The patient has no significant medical history and is not taking any regular medications. Blood tests (thyroid function tests (TFTs), full blood count (FBC), urea and electrolytes (U&Es), liver function tests (LFTs), and coagulation screen) are normal, and a chest X-ray (CXR) is unremarkable.

      What is the most appropriate course of action for this patient?

      Your Answer:

      Correct Answer: IV flecainide

      Explanation:

      Treatment options for acute atrial fibrillation

      Atrial fibrillation (AF) is a common arrhythmia that can lead to serious complications such as stroke and heart failure. When a patient presents with acute AF, it is important to determine the underlying cause and choose the appropriate treatment. Here are some treatment options for acute AF:

      Treatment options for acute atrial fibrillation

      Initial investigation

      The patient should be investigated for any reversible causes of AF such as hyperthyroidism and alcohol. Blood tests and a chest X-ray should be performed to rule out any underlying conditions.

      Medical cardioversion

      If no reversible causes are found, medical cardioversion is the most appropriate treatment for haemodynamically stable patients who have presented within 48 hours of the onset of AF.

      Anticoagulation therapy

      If the patient remains in persistent AF for more than 48 hours, their CHA2DS2 VASc score should be calculated to determine the risk of emboli. If the score is high, anticoagulation therapy should be started.

      Trial of b-blocker

      Sotalol is often used in paroxysmal AF as a ‘pill in the pocket’ regimen. However, in acute first-time presentations without significant cardiac risk factors, cardioversion should be attempted first.

      Intravenous adenosine

      This treatment may transiently block the atrioventricular (AV) node and is commonly used in atrial flutter. However, it is not recommended for use in acute AF presentation in an otherwise well patient.

      In conclusion, the appropriate treatment for acute AF depends on the underlying cause and the patient’s risk factors. It is important to choose the right treatment to prevent serious complications.

    • This question is part of the following fields:

      • Cardiology
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  • Question 16 - Which congenital cardiac defect is correctly matched with its associated syndrome from the...

    Incorrect

    • Which congenital cardiac defect is correctly matched with its associated syndrome from the following options?

      Your Answer:

      Correct Answer: Turner syndrome and coarctation of the aorta

      Explanation:

      Common Cardiovascular Abnormalities Associated with Genetic Syndromes

      Various genetic syndromes are associated with cardiovascular abnormalities. Turner syndrome is linked with coarctation of the aorta, aortic stenosis, bicuspid aortic valve, aortic dilation, and dissection. Marfan syndrome is associated with aortic root dilation, mitral valve prolapse, mitral regurgitation, and aortic dissection. Kartagener syndrome can lead to bicuspid aortic valve, dextrocardia, bronchiectasis, and infertility. However, congenital adrenal hyperplasia is not associated with congenital cardiac conditions. Finally, congenital rubella syndrome is linked with patent ductus arteriosus, atrial septal defect, and pulmonary stenosis.

    • This question is part of the following fields:

      • Cardiology
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  • Question 17 - A 68-year-old man presents with severe epigastric pain and nausea. He reports not...

    Incorrect

    • A 68-year-old man presents with severe epigastric pain and nausea. He reports not having a bowel movement in 3 days, despite normal bowel habits prior to this. The patient has a history of coronary stents placed after a heart attack 10 years ago. He has been asymptomatic since then and takes aspirin for his cardiac condition and NSAIDs for knee arthritis. He has not consumed alcohol in the past 5 years due to a previous episode of acute gastritis.

      On examination, there is mild tenderness over the epigastrium but no guarding. Bowel sounds are normal. An erect CXR and abdominal X-ray are unremarkable. Blood gases and routine blood tests (FBC, U&E, LFTs) are normal, with a normal amylase. Upper GI endoscopy reveals gastric erosions.

      What is the most important differential diagnosis to consider for this patient?

      Your Answer:

      Correct Answer: Myocardial infarction

      Explanation:

      Possible Diagnoses for a Patient with Epigastric Pain and History of Cardiac Stents

      Introduction:
      A patient with a history of cardiac stents presents with epigastric pain. The following are possible diagnoses that should be considered.

      Myocardial Infarction:
      Due to the patient’s history of cardiac stents, ruling out a myocardial infarction (MI) is crucial. An electrocardiogram (ECG) should be performed early to treat any existing cardiac condition without delay.

      Duodenal Ulcer:
      A duodenal ulcer would have likely been visualized on an oesophagogastroduodenoscopy (OGD). However, a normal erect CXR and absence of peritonitis exclude a perforated duodenal ulcer.

      Acute Gastritis:
      Given the patient’s history of aspirin and NSAID use, as well as the gastric erosions visualized on endoscopy, acute gastritis is the most likely diagnosis. However, it is important to first exclude MI as a cause of the patient’s symptoms due to their history of MI and presentation of epigastric pain.

      Pancreatitis:
      Pancreatitis is unlikely, given the normal amylase. However, on occasion, this can be normal in cases depending on the timing of the blood test or whether the pancreas has had previous chronic inflammation.

      Ischaemic Bowel:
      Ischaemic bowel would present with more generalized abdominal pain and metabolic lactic acidosis on blood gas. Therefore, it is less likely to be the cause of the patient’s symptoms.

    • This question is part of the following fields:

      • Cardiology
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  • Question 18 - A 27-year-old intravenous drug user presents with a systolic murmur that is most...

    Incorrect

    • A 27-year-old intravenous drug user presents with a systolic murmur that is most audible at the fifth costal cartilage on the left sternal edge. What is the most probable anatomical site of the disease causing the murmur?

      Your Answer:

      Correct Answer: Tricuspid valve

      Explanation:

      Auscultation of Heart Murmurs and Associated Cardiac Structures

      When listening to heart sounds, the location of the murmur can provide clues about the underlying cardiac structure involved. A pansystolic murmur heard at the left sternal margin at the fifth costal cartilage suggests tricuspid regurgitation, likely caused by infective endocarditis in an intravenous drug user. A ventricular septal defect can be auscultated as a pansystolic murmur, while an atrial septal defect is associated with an ejection systolic murmur and split second heart sound over the pulmonary area. Abnormalities of the mitral valve are heard in the fifth intercostal space at the mid-clavicular line, and the aortic valve can be auscultated at the second intercostal space in the right sternal edge. Understanding the relationship between heart murmurs and associated cardiac structures can aid in diagnosis and management of cardiac conditions.

    • This question is part of the following fields:

      • Cardiology
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  • Question 19 - A 30-year-old woman patient presents with a subacute history of lethargy and low-grade...

    Incorrect

    • A 30-year-old woman patient presents with a subacute history of lethargy and low-grade fever. Among other findings, full clinical examination reveals retinal haemorrhages with pale centres, painful red raised lesions on the hands and feet and subcentimetre, non-tender, raised papules on the palms and soles of the feet.
      What is the underlying condition?

      Your Answer:

      Correct Answer: Endocarditis

      Explanation:

      Clinical Signs and Diagnosis of Subacute Bacterial Endocarditis

      Subacute bacterial endocarditis (SBE) is a condition caused by Streptococcus viridans, an oral commensal, and presents with malaise, weakness, and low-grade fever. Diagnosis is often delayed due to non-specific presentation, but it should be suspected in any febrile or unwell patient with a new or changing murmur. The three classic clinical signs of SBE are finger clubbing, Roth spots, and Osler’s nodes, along with Janeway lesions, which are subcentimeter, non-tender, raised papules on the palms and soles of the feet. Confirmation of SBE usually requires three separate sets of blood cultures taken in a 24-hour period, ideally during times the patient is febrile.

      While Janeway lesions may be found in systemic lupus erythaematosus (SLE), the combination of the three described findings is unique to SBE. Tuberculosis does not present with the above constellation of findings but would be expected to present with chronic cough, haemoptysis, fever, and night sweats. Subacute meningococcal septicaemia typically gives a non-blanching petechial rash in the context of fulminating sepsis and does not present subacutely as described here. Rheumatoid arthritis (RA) patients may have subcutaneous rheumatoid nodules on the extensor surfaces of the limbs, but RA does not give the findings described.

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      • Cardiology
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  • Question 20 - A 28-year-old man presents with chest pain, 5/10 in intensity, which is aggravated...

    Incorrect

    • A 28-year-old man presents with chest pain, 5/10 in intensity, which is aggravated by breathing deeply and improved by leaning forward. The chest pain is not radiating. He has a mild fever but denies nausea, vomiting, cough or haemoptysis. He has self-medicated for a common cold and sore throat 5 days previously. On the electrocardiogram (ECG), there is diffuse, mild ST segment elevation (on leads II, aVF and V2–V6) and PR depression.
      Which of the following findings is most likely to be observed on physical examination?

      Your Answer:

      Correct Answer: Triphasic systolic and diastolic rub

      Explanation:

      Common Heart Murmurs and Their Characteristics

      Pericarditis: Triphasic Systolic and Diastolic Rub
      Pericarditis is characterized by pleuritic chest pain that improves by leaning forward. A pericardial friction rub, with a scratchy, rubbing quality, is the classic cardiac auscultatory finding of pericarditis. It is often a high-pitched, triphasic systolic and diastolic murmur due to friction between the pericardial and visceral pericardium during ventricular contraction, ventricular filling, and atrial contraction.

      Mitral Regurgitation: High-Pitched Apical Pan-Systolic Murmur Radiating to the Axilla
      A high-pitched apical pan-systolic murmur radiating to the axilla is heard in mitral regurgitation.

      Coarctation of the Aorta: Continuous Systolic and Diastolic Murmur Obscuring S2 Sound and Radiating to the Back
      A continuous systolic and diastolic murmur obscuring S2 sound and radiating to the back is heard in coarctation of the aorta.

      Mitral Stenosis: Apical Opening Snap and Diastolic Rumble
      An apical diastolic rumble and opening snap are heard in mitral stenosis.

      Aortic Regurgitation: Soft-Blowing Early Diastolic Decrescendo Murmur, Loudest at the Third Left Intercostal Space
      A soft-blowing early diastolic decrescendo murmur, loudest at the second or third left intercostal space, is heard in aortic regurgitation.

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      • Cardiology
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  • Question 21 - A 72-year-old woman visits her GP for a routine check-up. During the examination,...

    Incorrect

    • A 72-year-old woman visits her GP for a routine check-up. During the examination, she seems generally healthy but slightly fatigued and experiences some breathlessness at rest. Her pulse is irregularly irregular and measures 72 bpm, while her blood pressure is 126/78 mmHg. Upon further examination, no concerning issues are found. The patient has no significant medical history and is not taking any regular medications.
      What is the probable reason for this woman's development of atrial fibrillation (AF)?

      Your Answer:

      Correct Answer: Lone AF

      Explanation:

      Management of Atrial Fibrillation: The ABCD Approach

      Atrial fibrillation (AF) is a common arrhythmia that can be classified as paroxysmal, persistent, or permanent. Treatment options for AF depend on the classification and can be categorized into rate control, rhythm control, and anticoagulation. The ABCD approach is a useful tool for managing AF.

      A – Anticoagulation: Patients with AF are at an increased risk for thromboembolic disease, and anticoagulation should be considered in high-risk patients where the benefit outweighs the risk of hemorrhage.

      B – Better symptom control: Rate control is aimed at controlling the ventricular response rate to improve symptoms. Rhythm control is aimed at restoring and maintaining sinus rhythm to improve symptoms.

      C – Cardiovascular risk factor management: Management of underlying cardiovascular risk factors such as hypertension, diabetes, and hyperlipidemia can help reduce the risk of AF recurrence and complications.

      D – Disease management: Management of underlying conditions associated with AF, such as valvular heart disease and heart failure, can help improve AF outcomes.

      In summary, the ABCD approach to managing AF involves anticoagulation, better symptom control, cardiovascular risk factor management, and disease management. This approach can help improve outcomes and reduce the risk of complications in patients with AF.

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      • Cardiology
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  • Question 22 - A 57-year-old male with a history of hypertension for six years presents to...

    Incorrect

    • A 57-year-old male with a history of hypertension for six years presents to the Emergency department with complaints of severe chest pain that radiates to his back, which he describes as tearing in nature. He is currently experiencing tachycardia and hypertension, with a blood pressure reading of 185/95 mmHg. A soft early diastolic murmur is also noted. The ECG shows ST elevation of 2 mm in the inferior leads, and a small left-sided pleural effusion is visible on chest x-ray. Based on the patient's clinical history, what is the initial diagnosis that needs to be ruled out?

      Your Answer:

      Correct Answer: Aortic dissection

      Explanation:

      Aortic Dissection in a Hypertensive Patient

      This patient is experiencing an aortic dissection, which is a serious medical condition. The patient’s hypertension is a contributing factor, and the pain they are experiencing is typical for this condition. One of the key features of aortic dissection is radiation of pain to the back. Upon examination, the patient also exhibits hypertension, aortic regurgitation, and pleural effusion, which are all consistent with this diagnosis. The ECG changes in the inferior lead are likely due to the aortic dissection compromising the right coronary artery. To properly diagnose and treat this patient, it is crucial to thoroughly evaluate their peripheral pulses and urgently perform imaging of the aorta. Proper and timely medical intervention is necessary to prevent further complications and ensure the best possible outcome for the patient.

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      • Cardiology
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  • Question 23 - A 7-year-old girl comes to the clinic complaining of headaches, particularly during times...

    Incorrect

    • A 7-year-old girl comes to the clinic complaining of headaches, particularly during times of stress or physical activity. She has no significant medical history. During her neurological exam, no abnormalities are found. However, a systolic murmur is heard along the length of her left sternal edge and spine. Her chest is clear and her blood pressure is 156/88 mmHg in her left arm and 104/68 mmHg in her left leg. An ECG reveals sinus rhythm with evidence of left ventricular hypertrophy. What is the most likely diagnosis?

      Your Answer:

      Correct Answer: Coarctation of the aorta

      Explanation:

      Coarctation of the Aorta and its Interventions

      Coarctation of the aorta is a condition where the aorta narrows, usually distal to the left subclavian artery. This can cause an asymptomatic difference in upper and lower body blood pressures and can lead to left ventricular hypertrophy. The severity of the restriction varies, with severe cases presenting early with cardiac failure, while less severe cases can go undiagnosed into later childhood.

      Interventions for coarctation of the aorta include stenting, excision and graft placement, and using the left subclavian artery to bypass the coarctation. An atrial septal defect and hypertrophic occlusive cardiomyopathy would not cause a blood pressure difference between the upper and lower body. Stress headaches and a flow murmur are not appropriate diagnoses for a child with hypertension, which should be thoroughly investigated for an underlying cause.

      In contrast, transposition of the great arteries is a major cyanotic cardiac abnormality that presents in infancy. It is important to diagnose and treat coarctation of the aorta to prevent complications such as left ventricular hypertrophy and cardiac failure.

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      • Cardiology
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  • Question 24 - A 70-year-old male presents with abdominal pain.

    He has a past medical history...

    Incorrect

    • A 70-year-old male presents with abdominal pain.

      He has a past medical history of stroke and myocardial infarction. During examination, there was noticeable distension of the abdomen and the stools were maroon in color. The lactate level was found to be 5 mmol/L, which is above the normal range of <2.2 mmol/L.

      What is the most probable diagnosis for this patient?

      Your Answer:

      Correct Answer: Acute mesenteric ischaemia

      Explanation:

      Acute Mesenteric Ischaemia

      Acute mesenteric ischaemia is a condition that occurs when there is a disruption in blood flow to the small intestine or right colon. This can be caused by arterial or venous disease, with arterial disease further classified as non-occlusive or occlusive. The classic triad of symptoms associated with acute mesenteric ischaemia includes gastrointestinal emptying, abdominal pain, and underlying cardiac disease.

      The hallmark symptom of mesenteric ischaemia is severe abdominal pain, which may be accompanied by other symptoms such as nausea, vomiting, abdominal distention, ileus, peritonitis, blood in the stool, and shock. Advanced ischaemia is characterized by the presence of these symptoms.

      There are several risk factors associated with acute mesenteric ischaemia, including congestive heart failure, cardiac arrhythmias (especially atrial fibrillation), recent myocardial infarction, atherosclerosis, hypercoagulable states, and hypovolaemia. It is important to be aware of these risk factors and to seek medical attention promptly if any symptoms of acute mesenteric ischaemia are present.

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      • Cardiology
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  • Question 25 - A 70-year-old man presents with severe breathlessness which started this morning and has...

    Incorrect

    • A 70-year-old man presents with severe breathlessness which started this morning and has become gradually worse. The patient denies coughing up any phlegm. He has a history of essential hypertension. On examination, the patient has a blood pressure of 114/75 mmHg and a respiratory rate of 30 breaths per minute. His temperature is 37.1°C. His jugular venous pressure (JVP) is 8 cm above the sternal angle. On auscultation there are fine bibasal crackles and a third heart sound is audible. The patient is an ex-smoker and used to smoke 5–10 cigarettes a day for about 10 years.
      What is the most likely diagnosis?

      Your Answer:

      Correct Answer: Pulmonary oedema

      Explanation:

      Differentiating Pulmonary Oedema from Other Cardiac and Respiratory Conditions

      Pulmonary oedema is a condition characterized by the accumulation of fluid in the lungs due to left ventricular failure. It presents with symptoms such as shortness of breath, raised jugular venous pressure, and a third heart sound. Bi-basal crackles are also a hallmark of pulmonary oedema. However, it is important to differentiate pulmonary oedema from other cardiac and respiratory conditions that may present with similar symptoms.

      Tricuspid regurgitation is another cardiac condition that may present with a raised JVP and a third heart sound. However, it is characterized by additional symptoms such as ascites, a pulsatile liver, peripheral oedema, and a pansystolic murmur. Pneumonia, on the other hand, is a respiratory infection that presents with a productive cough of yellow or green sputum and shortness of breath. Bronchial breath sounds may also be heard upon auscultation.

      Pulmonary embolus is a condition that presents with chest pain, shortness of breath, and signs of an underlying deep vein thrombosis. Pericardial effusion, on the other hand, is characterized by the accumulation of fluid in the pericardial sac surrounding the heart. It may eventually lead to cardiac tamponade, which presents with hypotension, shortness of breath, and distant heart sounds. However, bi-basal crackles are not a feature of pericardial effusion.

      In summary, it is important to consider the specific symptoms and characteristics of each condition in order to accurately diagnose and differentiate pulmonary oedema from other cardiac and respiratory conditions.

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      • Cardiology
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  • Question 26 - A 60-year-old woman undergoes cardiac catheterisation. A catheter is inserted in her right...

    Incorrect

    • A 60-year-old woman undergoes cardiac catheterisation. A catheter is inserted in her right femoral vein in the femoral triangle and advanced through the iliac veins and inferior vena cava to the right side of the heart so that right chamber pressures can be recorded.
      What two other structures pass within the femoral triangle?

      Your Answer:

      Correct Answer: Femoral artery, femoral nerve

      Explanation:

      Anatomy of the Femoral Triangle

      The femoral triangle is a triangular area on the anterior aspect of the thigh, formed by the crossing of various muscles. Within this area, the femoral vein, femoral artery, and femoral nerve lie medial to lateral (VAN). It is important to note that the inguinal lymph nodes and saphenous vein are not part of the femoral triangle. Understanding the anatomy of the femoral triangle is crucial for medical professionals when performing procedures in this area.

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      • Cardiology
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  • Question 27 - A 60-year-old man is seen at cardiology outpatients 6 weeks after an anterior...

    Incorrect

    • A 60-year-old man is seen at cardiology outpatients 6 weeks after an anterior myocardial infarction. His wife complains that she cannot sleep at night due to his constant coughing and throat clearing.
      Which medication is likely causing these symptoms?

      Your Answer:

      Correct Answer: Perindopril

      Explanation:

      Common Side-Effects of Cardiovascular Medications

      Cardiovascular medications are commonly prescribed to manage various heart conditions. However, they can also cause side-effects that can affect a patient’s quality of life. Here are some common side-effects of popular cardiovascular medications:

      Perindopril: This medication can cause a dry, persistent cough, as well as hyperkalaemia, fatigue, dizziness, and hypotension.

      Amiodarone: Side-effects of this medication include dizziness, visual disturbance, unco-ordination, tremors, paraesthesia, deranged liver function tests (LFTs), deranged thyroid function tests (TFTs), and lung fibrosis.

      Atenolol: β-blockers like atenolol can cause fatigue, Raynaud’s phenomenon, bronchospasm, change in bowel habit, and sexual dysfunction.

      Atorvastatin: Statins like atorvastatin can cause myopathy/myositis, derangement of glucose control, and deranged LFTs.

      Candesartan: Angiotensin receptor blockers like candesartan can cause dizziness, headache, hyperkalaemia, and first-dose orthostatic hypotension. They are often prescribed to patients who are intolerant of ACE inhibitors due to dry cough.

      In conclusion, patients taking cardiovascular medications should be aware of these potential side-effects and report any concerns to their healthcare provider.

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      • Cardiology
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  • Question 28 - An 82-year-old woman is brought to the Emergency Department after experiencing a sudden...

    Incorrect

    • An 82-year-old woman is brought to the Emergency Department after experiencing a sudden loss of consciousness while grocery shopping. Upon examination, she is fully alert and appears to be in good health.

      Her vital signs are normal, with a CBG of 5.8 mmol/l. However, her cardiovascular system shows an irregular, low volume heart rate of 90-110 beats per minute, and her blood pressure is 145/120 mmHg while lying down and standing up. Her JVP is raised by 5 cm, and her apex beat is displaced to the mid-axillary line, with diffuse heart sounds. A loud pansystolic murmur is heard at the apex, radiating to the axilla and at the lower left sternal edge, along with a mid-diastolic rumble best heard at the apex. There are occasional bibasal crackles in her chest, which clear up with coughing. Additionally, she has mild peripheral edema up to the mid-calf.

      Based on these clinical findings, what is the most likely cause of her collapse?

      Your Answer:

      Correct Answer: Mixed mitral valve disease

      Explanation:

      This patient exhibits features of mixed mitral valve disease, which can be challenging to diagnose due to contradictory signs. She has a mid-diastolic rumble, low-volume pulse, and atrial fibrillation, indicating mitral stenosis. However, she also has a displaced apex beat and a pan-systolic murmur, indicating mitral regurgitation. Mixed aortic valve disease is also common in these patients. Aortic stenosis and mixed aortic valve disease are unlikely diagnoses based on the clinical findings, while mitral stenosis and mitral regurgitation alone do not fully explain the examination results.

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      • Cardiology
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  • Question 29 - You are requested by a nurse to assess a 66-year-old woman on the...

    Incorrect

    • You are requested by a nurse to assess a 66-year-old woman on the Surgical Assessment Unit who is 1-day postoperative, having undergone a laparoscopic cholecystectomy procedure for cholecystitis. She has a medical history of type II diabetes mellitus and chronic kidney disease. Blood tests taken earlier in the day revealed electrolyte imbalances with hyperkalaemia.
      Which of the following ECG changes is linked to hyperkalaemia?

      Your Answer:

      Correct Answer: Peaked T waves

      Explanation:

      Electrocardiogram (ECG) Changes Associated with Hypo- and Hyperkalaemia

      Hypo- and hyperkalaemia can cause significant changes in the ECG. Hypokalaemia is associated with increased amplitude and width of the P wave, T wave flattening and inversion, ST-segment depression, and prominent U-waves. As hypokalaemia worsens, it can lead to frequent supraventricular ectopics and tachyarrhythmias, eventually resulting in life-threatening ventricular arrhythmias. On the other hand, hyperkalaemia is associated with peaked T waves, widening of the QRS complex, decreased amplitude of the P wave, prolongation of the PR interval, and eventually ventricular tachycardia/ventricular fibrillation. Both hypo- and hyperkalaemia can cause prolongation of the PR interval, but only hyperkalaemia is associated with flattening of the P-wave. In hyperkalaemia, eventually ventricular tachycardia/ventricular fibrillation is seen, while AF can occur in hypokalaemia.

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      • Cardiology
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  • Question 30 - A 75-year-old man presents to his General Practitioner with chest pain. The man...

    Incorrect

    • A 75-year-old man presents to his General Practitioner with chest pain. The man reports the pain as crushing in nature, exacerbated by exertion, particularly when climbing stairs in his home. The pain is typically relieved by rest, but he has experienced several episodes while watching television in the past two weeks. He has no other medical history and is generally in good health.
      What is the most suitable course of action?

      Your Answer:

      Correct Answer: Refer to hospital for admission for observation and urgent elective angiogram

      Explanation:

      Appropriate Management for a Patient with Unstable Angina

      Unstable angina is a serious condition that requires urgent medical attention. In the case of a patient displaying textbook signs of unstable angina, such as crushing chest pain occurring at rest, admission to the hospital is necessary. Sending the patient home with only glyceryl trinitrate (GTN) spray is not appropriate, as the patient is at high risk of having a myocardial infarction (MI). Instead, the patient should be seen by Cardiology for consideration of an urgent elective angiogram.

      Prescribing ramipril and simvastatin is not indicated unless there is evidence of hypertension. Lifestyle advice, including exercise recommendation, is also not appropriate for a patient with unstable angina. The immediate problem should be addressed first, which is the need for an angiogram.

      It is important to differentiate between unstable and stable angina. Unstable angina presents with symptoms at rest, indicating a significant worsening of the patient’s cardiac disease. On the other hand, stable angina only presents with symptoms on exertion.

      Sending the patient for percutaneous coronary intervention (PCI) is not necessary unless there is evidence of an MI. The pain experienced due to angina will alleviate itself most commonly at rest, unless the angina is unstable. Therefore, an urgent elective angiogram is the appropriate management for a patient with unstable angina.

    • This question is part of the following fields:

      • Cardiology
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