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  • Question 1 - Salivary glands produce saliva which is mostly water, but it also contains a...

    Incorrect

    • Salivary glands produce saliva which is mostly water, but it also contains a range of essential chemicals such as mucus, electrolytes, antibiotic agents, and enzymes.Which of the following is a carbohydrate-digesting enzyme found in saliva?

      Your Answer: Carboxypeptidase

      Correct Answer: Amylase

      Explanation:

      The acinar cells of the parotid and submandibular glands release amylase. Amylase begins starch digestion before food is even eaten, and it works best at a pH of 7.4.

    • This question is part of the following fields:

      • Gastrointestinal Physiology
      • Physiology
      11.9
      Seconds
  • Question 2 - Atracurium is used as a muscle relaxant during endotracheal intubation. This drug’s mechanism...

    Incorrect

    • Atracurium is used as a muscle relaxant during endotracheal intubation. This drug’s mechanism of action is best described by which of the following?

      Your Answer: Muscarinic acetylcholine receptor antagonist

      Correct Answer: Nicotinic acetylcholine receptor antagonist

      Explanation:

      Atracurium is a non-depolarizing neuromuscular blocker that is used to help with intubation and controlled ventilation by causing muscle relaxation and paralysis. At the neuromuscular junction’s post-synaptic membrane, atracurium competes with acetylcholine for nicotinic (N2) receptor binding sites. This prevents the receptors from being stimulated by acetylcholine. Muscle paralysis occurs gradually due to the competitive blockade.

    • This question is part of the following fields:

      • Anaesthesia
      • Pharmacology
      45.2
      Seconds
  • Question 3 - In a ward round, you come across a patient's treatment chart prescribed an...

    Incorrect

    • In a ward round, you come across a patient's treatment chart prescribed an antibiotic to fight his infection. This antibiotic is an inhibitor of cell wall synthesis. Which of the following antimicrobial drugs is prescribed to this patient?

      Your Answer: Clarithromycin

      Correct Answer: Benzylpenicillin

      Explanation:

      Penicillins and cephalosporins are the major antibiotics that inhibit bacterial cell wall synthesis. They inactivate transpeptidases that help cross-link peptidoglycans in cell walls. Isoniazid decreases the synthesis of mycolic acids in mycobacterium.Clarithromycin binds to the 50S subunit of ribosomes and inhibits protein synthesis. Metronidazole and the other 5-nitroimidazole agents inhibit nucleic acid synthesis by forming toxic free radical metabolites in the bacterial cell that damage DNA. Tetracycline bind to 30S and prevent attachment of aminoacyl-tRNA.

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      20.8
      Seconds
  • Question 4 - A 30-year-old man presents with diarrhoea, fever, vomiting, and abdominal cramps. A stool...

    Incorrect

    • A 30-year-old man presents with diarrhoea, fever, vomiting, and abdominal cramps. A stool culture was ordered and showed growth of Salmonella spp.Among the following serotypes of Salmonella spp., which is considered to be the most common cause of salmonella gastroenteritis?

      Your Answer: Serotype A

      Correct Answer: Serotype D

      Explanation:

      A common cause of gastroenteritis, Salmonella enteritidis, and Salmonella typhi, which causes enteric fever, are both group D. Therefore, serotype D Salmonella species are most commonly associated with gastroenteritis.

    • This question is part of the following fields:

      • Microbiology
      • Specific Pathogen Groups
      11.2
      Seconds
  • Question 5 - By what mechanism does Vibrio cholerae causes diarrhoea? ...

    Correct

    • By what mechanism does Vibrio cholerae causes diarrhoea?

      Your Answer: Increases Cl- secretory channels in crypt cells

      Explanation:

      Cholera is a severe diarrheal illness caused by the Vibrio cholerae bacteria infecting the bowel. Ingesting cholera-infected food or drink is the a way to contract the disease. In the intestinal crypt cells, the toxigenic bacterium Vibrio cholera activates adenylate cyclase and raises cyclic adenosine monophosphate (cAMP). cAMP stimulates the Cl-secretory channels in crypt cells, resulting in the secretion of chloride with sodium ions and water. The toxin it produces causes the body to secrete massive amounts of water, resulting in diarrhoea and significant fluid and electrolyte loss.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      8.9
      Seconds
  • Question 6 - A 56-year-old female visits her cardiologist complaining of a condition that has started...

    Incorrect

    • A 56-year-old female visits her cardiologist complaining of a condition that has started since he started her on amiodarone for atrial arrhythmia. The cardiologist recognised that she is experiencing a side effect of amiodarone. Which one of the following conditions will this woman NOT have?

      Your Answer: Hypothyroidism

      Correct Answer: Xanthopsia

      Explanation:

      Amiodarone is a class III potassium channel blocker used to treat multiple types of arrhythmias. Side effects include:1. pulmonary fibrosis2. blue discolouration of the skin3. phototoxicity4. corneal deposits5. hepatic necrosis6. thyroid dysfunction7. sleep disturbances8. peripheral neuropathy. Xanthopsia is a condition where the patient complains of seeing yellow lines and is seen in digoxin overdose.

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      24.6
      Seconds
  • Question 7 - All of the muscles of the tongue (other than the palatoglossus) are innervated...

    Correct

    • All of the muscles of the tongue (other than the palatoglossus) are innervated by which of the following nerves:

      Your Answer: Hypoglossal nerve

      Explanation:

      All of the muscles of the tongue are innervated by the hypoglossal nerve, except for the palatoglossus, which is innervated by the vagus nerve.

    • This question is part of the following fields:

      • Anatomy
      • Head And Neck
      11.1
      Seconds
  • Question 8 - A patient is referred for lung function tests on account of a history...

    Correct

    • A patient is referred for lung function tests on account of a history of breathlessness and cough.Which statement about lung volumes is correct?

      Your Answer: The tidal volume is the volume of air drawn in and out of the lungs during normal breathing

      Explanation:

      The tidal volume(TV) is the amount of air that moves in and out of the lungs with each respiratory cycle. In a healthy male, the usual volume is 0.5 L (,7 ml/kg body mass).The vital capacity(VC) is the maximum amount of air that can be exhaled following maximal inspiration. The usual volume in a healthy male is 4.5 L.The residual volume(RV) is the amount of air remaining in the lungs after maximum expiration. The usual volume in a healthy male is 1.0 L.The inspiratory reserve volume(IRV) is the maximum amount of air that can be breathed in forcibly after normal inspiration. The usual volume in a healthy male is 3.0 L.The expiratory reserve volume(ERV) is the volume of air that can be breathed out forcibly after normal expiration. The usual volume in a healthy male is 1.0 L.Total lung capacity(TLC) is the volume of air the lungs can accommodate. TLC = RV+VC. The usual volume in a healthy male is 5.5 L.

    • This question is part of the following fields:

      • Physiology
      • Respiratory Physiology
      40.6
      Seconds
  • Question 9 - Which of the following cytokines is important for the maintenance of granulomatous inflammation:...

    Incorrect

    • Which of the following cytokines is important for the maintenance of granulomatous inflammation:

      Your Answer: IL-12

      Correct Answer: TNF-alpha

      Explanation:

      Granulomatous inflammation is a distinctive pattern of chronic inflammation that is encountered in a limited number of infectious and some non-infectious conditions. Briefly, a granuloma is a cellular attempt to contain an offending agent that is difficult to eradicate. In this attempt, there is often strong activation of T lymphocytes leading to macrophage activation, which can cause injury to normal tissues. IL-1 is important in initiating granuloma formation, IL-2 can cause them to enlarge and TNF-α maintains them.

    • This question is part of the following fields:

      • Inflammatory Responses
      • Pathology
      46.1
      Seconds
  • Question 10 - Which of the following statements accurately describes the flexor digitorum superficialis muscle? ...

    Correct

    • Which of the following statements accurately describes the flexor digitorum superficialis muscle?

      Your Answer: It flexes the middle phalanges of the medial four fingers at the proximal interphalangeal joints

      Explanation:

      Flexor digitorum superficialis is the largest muscle of the anterior compartment of the forearm. It belongs to the superficial flexors of the forearm, together with pronator teres, flexor carpi radialis, flexor carpi ulnaris and palmaris longus. Some sources alternatively classify this muscle as an independent middle/intermediate layer of the anterior forearm, found between the superficial and deep groups.Flexor digitorum superficialis is innervated by muscular branches of the median nerve, derived from roots C8 and T1 that arises from the medial and lateral cords of the brachial plexus. The skin that overlies the muscle is supplied by roots C6-8 and T1.The primary arterial blood supply to the flexor digitorum superficialis is derived from the ulnar artery and its anterior recurrent branch. In addition to branches of the ulnar artery, the anterior and lateral surfaces of the muscle are supplied by branches of the radial artery; and its posterior surface also receives branches from the median artery.The main function of flexor digitorum superficialis is flexion of the digits 2-5 at the proximal interphalangeal and metacarpophalangeal joints. Unlike the flexor digitorum profundus, flexor digitorum superficialis has independent muscle slips for all four digits. This allows it to flex the digits individually at their proximal interphalangeal joints. In addition, flexor digitorum superficialis aids the aids flexion of the wrist.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      15.5
      Seconds
  • Question 11 - Regarding benzylpenicillin, which of the following statements is CORRECT: ...

    Correct

    • Regarding benzylpenicillin, which of the following statements is CORRECT:

      Your Answer: If meningococcal disease is suspected, benzylpenicillin should be given before transfer to hospital.

      Explanation:

      Benzylpenicillin (although inactivated by bacterial beta-lactamases) is effective for many streptococcal (including pneumococcal), gonococcal, and meningococcal infections and also for anthrax, diphtheria, gas gangrene, leptospirosis, and treatment of Lyme disease. If meningococcal disease (meningitis with non-blanching rash or meningococcal septicaemia) is suspected, benzylpenicillin should be given before transfer to hospital, so long as this does not delay the transfer; benzylpenicillin is no longer the drug of first choice for pneumococcal meningitis. Although benzylpenicillin is effective in the treatment of tetanus, metronidazole is preferred. Benzylpenicillin is inactivated by gastric acid and absorption from the gastrointestinal tract is poor and therefore it must be given by injection.

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      11.1
      Seconds
  • Question 12 - Regarding acute myeloid leukaemia (AML), which of the following statements is CORRECT: ...

    Correct

    • Regarding acute myeloid leukaemia (AML), which of the following statements is CORRECT:

      Your Answer: AML becomes increasingly common with age.

      Explanation:

      Acute myeloid leukaemia (AML) is the most common form of acute leukaemia in adults and becomes increasingly common with age, with a median onset of 65 years. It forms only a minor fraction (10 – 15%) of childhood leukaemia. The clinical features of AML typically presents with clinical features secondary to leukaemic infiltration of bone marrow and extramedullary sites: Anaemia (lethargy, pallor and breathlessness)Thrombocytopaenia (petechiae, bruising, epistaxis, haemorrhage) – often profoundNeutropenia (infections)HepatosplenomegalyGingival infiltrationCentral nervous system involvement in AML is uncommon.Leukaemia cutis is the infiltration of neoplastic leukocytes in the skin. It occurs in approximately 10% of patients with AML.Haematological investigations reveal a normochromic normocytic anaemia with thrombocytopenia in most cases. The total white cell count is usually increased and blood film examination typically shows a variable number of blast cells. The bone marrow is hypercellular and typically contains many blast cells.. The prognosis for patients with AML has been improving steadily, particularly for those under 60 years of age, and approximately one-third of patients of this group can expect to achieve long-term cure. For the elderly, the situation is poor and less than 10% of those over 70 years of age achieve long-term remission.CML is commonly associated with the Philadelphia chromosome. The Philadelphia chromosome is present in only 1% of adults AML cases.Lymphadenopathy is rare in AML.

    • This question is part of the following fields:

      • Haematology
      • Pathology
      26.1
      Seconds
  • Question 13 - Which of the following statements is correct about the extensor digitorum muscle? ...

    Correct

    • Which of the following statements is correct about the extensor digitorum muscle?

      Your Answer: It extends the medial four digits at the metacarpophalangeal joints

      Explanation:

      Extensor digitorum is a long muscle located in the posterior compartment of the forearm. Together with the extensor carpi ulnaris and extensor digiti minimi, extensor carpi radialis longus and brevis as well as the brachioradialis, it belongs to the group of superficial extensors of the forearm. These muscles can be easily palpated in the lateral aspect of the posterior forearm, especially during the extension of hand when they are contracted.Extensor digitorum runs from the lateral epicondyle of humerus to the medial four phalanges of the hand. In this way, it generates the pull for the extension of the four medial fingers in their metacarpophalangeal and both interphalangeal joints. Extensor digitorum also participates in the extension of the wrist.Extensor digitorum is innervated by posterior interosseous nerve which is a continuation of a deep branch of radial nerve (root value C7 and C8).Extensor digitorum is vascularized by the branches of three different arteries: (1) posterior interosseous artery, (2) radial recurrent artery, and (3) anterior interosseous artery. Anterior and posterior interosseous arteries are the branches of the common interosseous artery that arises from the ulnar artery. The radial recurrent artery is a branch of the radial artery.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      18.6
      Seconds
  • Question 14 - A 35 year old patient presents to ED having sustained an injury to...

    Correct

    • A 35 year old patient presents to ED having sustained an injury to his right hand whilst playing cricket. He is unable to fully straighten his right middle finger as the distal phalanx remains flexed. Which of the following structures within the digit was most likely injured:

      Your Answer: Insertion of terminal extensor digitorum tendon

      Explanation:

      Damage to the insertion of the terminal extensor digitorum tendon would result in loss of extension at the distal interphalangeal joint causing a fixed flexion deformity, called the Mallet deformity.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      22.9
      Seconds
  • Question 15 - If a patient dislocated his right shoulder and has been referred to the...

    Correct

    • If a patient dislocated his right shoulder and has been referred to the orthopaedic outpatient department for a follow-up after a successful reduction, which of the following is the most important position for him to avoid holding his arm in until he is seen in the clinic?

      Your Answer: Arm at 90 degrees to side with palm up

      Explanation:

      The arm should be placed in a poly-sling that should be worn for about two weeks. A physiotherapist may give gentle movements for the arm to help in reducing stiffness and in relieving the pain. It is important that the patient must avoid positions that could cause re-dislocation.The most important position to avoid is the arm being held out at 90 degrees to the side with the palm facing upwards, especially if a force is being applied.

    • This question is part of the following fields:

      • Anatomy
      • Upper Limb
      250.2
      Seconds
  • Question 16 - You review a 50-year-old man that is requesting the seasonal influenza vaccination.Which of...

    Correct

    • You review a 50-year-old man that is requesting the seasonal influenza vaccination.Which of the following single clinical risk groups is NOT eligible to receive the seasonal influenza vaccination? Select ONE answer only.

      Your Answer: Patients over the age of 50

      Explanation:

      Patients with hypertension are only eligible for the seasonal influenza vaccination if they have co-existent cardiac complications.The UK national policy is that the seasonal influenza vaccine should be offered to the following groups:All those aged 65 years and olderChildren aged 2 to 15 yearsResidents of nursing and residential homes for the elderly (and other long-stay facilities)Carers of persons whose welfare may be at risk if the carer falls illAll those aged 6 months or older in a clinical risk groupThe following table outlines the clinical risk groups that are considered eligible for the vaccine:CategoryExamples of eligible groupsRespiratory diseaseCOPDInterstitial lung diseaseCystic fibrosisAsthma (requiring oral or inhaled steroids)Heart diseaseCongenital heart diseaseChronic heart failureCoronary heart disease (requiring medication and/or follow-up)Hypertension with cardiac complicationsKidney diseaseChronic kidney diseaseNephrotic syndromeRenal transplant patientsLiver diseaseLiver cirrhosisChronic hepatitisBiliary atresiaNeurological diseaseCerebrovascular accidentTransient ischaemic attackEndocrine diseaseType 1 and 2 diabetesImmunosuppressionPatients undergoing chemotherapyPatients taking immunosuppressive drug therapy (including systemic steroids)Asplenia or splenic dysfunctionHIV infectionPregnancyAll pregnant women

    • This question is part of the following fields:

      • Microbiology
      • Principles Of Microbiology
      6.2
      Seconds
  • Question 17 - A 56-year-old male with a 10-year history of Diabetes Mellitus and Hypertension was...

    Correct

    • A 56-year-old male with a 10-year history of Diabetes Mellitus and Hypertension was rushed to the Emergency Department due to sudden onset crushing chest pain. ECG showed an ST-elevation myocardial infarct in the left anterior descending artery territory. The patient's condition was stabilised and managed with angioplasty, but he sustained significant myocardial damage. Which one of the following statements best agrees with the myocardial healing process?

      Your Answer: The left ventricle will likely hypertrophy first to maintain cardiac output

      Explanation:

      Following a myocardial infarction scar tissue formation will take place at the site of the damaged muscle. This places increased load on the rest of the myocardium causing it to hypertrophy. The left ventricle will hypertrophy first as it is pumping blood against a greater afterload as compared to the right ventricle. There are three types of cells in the body with regards to the cell cycle: 1. permanent2. labile3. stable cellsPermanent cells do not re-enter the cell cycle and remain in G0. If there is a pool of stem cells the stem cells will enter the cell cycle to form more cells. Myocardial cells are a type of permanent cell and there is no pool of stem cells in the heart muscle. The anterior wall will not hypertrophy as it is formed by the right atrium and ventricle and both of these hypertrophy after the left ventricle.

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      27.8
      Seconds
  • Question 18 - Nifedipine commonly causes which of the following adverse effects? ...

    Incorrect

    • Nifedipine commonly causes which of the following adverse effects?

      Your Answer: Precipitation of heart failure

      Correct Answer: Ankle oedema

      Explanation:

      Most common adverse effects of Nifedipine include:Peripheral oedema (10-30%)Dizziness (23-27%)Flushing (23-27%)Headache (10-23%)Heartburn (11%)Nausea (11%)

    • This question is part of the following fields:

      • Cardiovascular
      • Pharmacology
      10.6
      Seconds
  • Question 19 - Aside from the inability to extend the leg above the knee, which of...

    Incorrect

    • Aside from the inability to extend the leg above the knee, which of the following clinical symptoms should you anticipate seeing in a patient who had a pelvic and right leg injury as well as femoral nerve damage?

      Your Answer: Loss of sensation over the lateral leg and foot

      Correct Answer: Loss of sensation over the anterior thigh

      Explanation:

      The femoral nerve runs down the front of the leg from the pelvis. It gives the front of the thigh and a portion of the lower leg sensation. Extension of the leg at the knee joint, flexion of the thigh at the hip are produced by muscles that is primarily innervated by the femoral nerve.

    • This question is part of the following fields:

      • Anatomy
      • Lower Limb
      25.8
      Seconds
  • Question 20 - A patient is sent in by her GP with suspected ectopic pregnancy. Tubal...

    Correct

    • A patient is sent in by her GP with suspected ectopic pregnancy. Tubal ectopic pregnancies occur most commonly in which part of the uterine tube:

      Your Answer: Ampulla

      Explanation:

      Ectopic pregnancy most commonly occurs in the ampulla (70% of cases).

    • This question is part of the following fields:

      • Abdomen
      • Anatomy
      14.1
      Seconds
  • Question 21 - Which of the following nerves is most important for eversion of the foot:...

    Incorrect

    • Which of the following nerves is most important for eversion of the foot:

      Your Answer: Deep fibular nerve

      Correct Answer: Superficial fibular nerve

      Explanation:

      Eversion of the foot is primarily produced by the fibularis longus and fibularis brevis, both innervated by the superficial fibular nerve. The fibularis tertius, innervated by the deep fibular nerve, also assists in this action.

    • This question is part of the following fields:

      • Anatomy
      • Lower Limb
      7.5
      Seconds
  • Question 22 - A 67-year-old woman complains of general malaise, nausea, and vomiting. She is perplexed...

    Correct

    • A 67-year-old woman complains of general malaise, nausea, and vomiting. She is perplexed and declares that everything 'looks yellow.' Her potassium level is 6.8 mmol/l, according to a blood test.Which of the drugs listed below is most likely to be the cause of her symptoms?

      Your Answer: Digoxin

      Explanation:

      Because digoxin has a narrow therapeutic index, it can cause toxicity both during long-term therapy and after an overdose. Even when the serum digoxin concentration is within the therapeutic range, it can happen.Acute digoxin toxicity usually manifests itself within 2-4 hours of an overdose, with serum levels peaking around 6 hours after ingestion and life-threatening cardiovascular complications following 8-12 hours.Chronic digoxin toxicity is most common in the elderly or those with impaired renal function, and it is often caused by a coexisting illness. The clinical signs and symptoms usually appear gradually over days to weeks.The following are characteristics of digoxin toxicity:Nausea and vomitingDiarrhoeaAbdominal painConfusionTachyarrhythmias or bradyarrhythmiasXanthopsia (yellow-green vision)Hyperkalaemia (early sign of significant toxicity)Some precipitating factors are as follows:Elderly patientsRenal failureMyocardial ischaemiaHypokalaemiaHypomagnesaemiaHypercalcaemiaHypernatraemiaAcidosisHypothyroidismSpironolactoneAmiodaroneQuinidineVerapamilDiltiazem

    • This question is part of the following fields:

      • Cardiovascular Pharmacology
      • Pharmacology
      24
      Seconds
  • Question 23 - A 12-year-old boy presents to the ED with symptoms suggesting an anaphylactic reaction.Which...

    Incorrect

    • A 12-year-old boy presents to the ED with symptoms suggesting an anaphylactic reaction.Which of these statements about anaphylaxis is true?

      Your Answer: Prior exposure to the antigen is not required for it to occur

      Correct Answer: The immunoglobulin-antigen complex binds to Fc receptors on the surface of mast cells.

      Explanation:

      Anaphylaxis is an example of a type I hypersensitivity reaction. It is IgE mediated. It requires a prior exposure to the antigen. The initial exposure sensitizes the body to the antigen and a second exposure to that antigen leads to an anaphylactic reaction.Massive calcium influx into the cells leads to mast cell degranulation. The Immunoglobulin antigen complex binds to Fc receptors on the surface of mast cells. The result is mast cell degranulation and release of histamine, proteoglycans and serum proteases from cytoplasmic granules.

    • This question is part of the following fields:

      • General Pathology
      • Pathology
      31
      Seconds
  • Question 24 - You review the arterial blood gas (ABG) of a patient with lactic acidosis.Which...

    Correct

    • You review the arterial blood gas (ABG) of a patient with lactic acidosis.Which SINGLE statement regarding lactic acidosis is true?

      Your Answer: Type A lactic acidosis is typically due to tissue hypoxia

      Explanation:

      Lactic acidosis is defined as a pH 5 mmol/L. It is a common finding in critically ill patients and is often associated with other serious underlying pathologies. The anion gap is raised in lactic acidosis.There are major adverse consequences of severe acidaemia, which affect all body systems, and there is an associated increase in mortality of critically ill patients with a raised lactate. The mortality associated with lactic acidosis despite full supportive treatment remains at 60-90%.Acquired lactic acidosis is classified into two subtypes:Type A is due to tissue hypoxiaType B is due to non-hypoxic processes affecting the production and elimination of lactateLactic acidosis can be extreme after a seizure but usually resolves spontaneously within a few hours.Left ventricular failure typically results in tissue hypoperfusion and a type A lactic acidosis.Some causes of type A and type B lactic acidosis are shown below:Type A lactic acidosisType B lactic acidosisShock (including septic shock)Left ventricular failureSevere anaemiaAsphyxiaCardiac arrestCO poisoningRespiratory failureSevere asthma and COPDRegional hypoperfusionRenal failureLiver failureSepsis (non-hypoxic sepsis)Thiamine deficiencyAlcoholic ketoacidosisDiabetic ketoacidosisCyanide poisoningMethanol poisoningBiguanide poisoning

    • This question is part of the following fields:

      • Physiology
      • Renal Physiology
      31.7
      Seconds
  • Question 25 - A 24-year-old athlete drinks a 500 ml hypertonic sports drink before an endurance...

    Incorrect

    • A 24-year-old athlete drinks a 500 ml hypertonic sports drink before an endurance event he participates in.Which of the following effects will this cause?

      Your Answer: The intracellular fluid becomes more dilute

      Correct Answer: The interstitial fluid becomes more concentrated

      Explanation:

      Osmosis is the passive movement of water across a semipermeable membrane from a region of low solute concentration to a region of higher solute concentration.When hypertonic fluid is ingested:The plasma becomes CONCENTRATED. The cells lose water and shrinkThe intracellular fluid becomes more concentrated.Water and ions move freely from the plasma into the interstitial fluid and the interstitial fluid becomes more concentrated. The increased osmotic potential draws water out of the cells.

    • This question is part of the following fields:

      • Basic Cellular Physiology
      • Physiology
      21
      Seconds
  • Question 26 - Which of the following is NOT a common clinical manifestation of sickle cell...

    Incorrect

    • Which of the following is NOT a common clinical manifestation of sickle cell disease?

      Your Answer: Aplastic crisis

      Correct Answer: Iron deficiency

      Explanation:

      Signs and symptoms of Sickle cell disease(SCD):Acute and chronic pain: The most common clinical manifestation of SCD is vaso-occlusive crisis; pain crises are the most distinguishing clinical feature of SCDBone pain: Often seen in long bones of extremities, primarily due to bone marrow infarctionAnaemia: Universally present, chronic, and haemolytic in natureAplastic crisis: Serious complication due to infection with parvovirus B19 (B19V)Splenic sequestration: Characterized by the onset of life-threatening anaemia with rapid enlargement of the spleen and high reticulocyte countInfection: Organisms that pose the greatest danger include encapsulated respiratory bacteria, particularly Streptococcus pneumoniae; adult infections are predominantly with gram-negative organisms, especially SalmonellaGrowth retardation, delayed sexual maturation, being underweightHand-foot syndrome: This is a dactylitis presenting as bilateral painful and swollen hands and/or feet in childrenAcute chest syndrome: Young children present with chest pain, fever, cough, tachypnoea, leucocytosis, and pulmonary infiltrates in the upper lobes; adults are usually afebrile, dyspnoeic with severe chest pain, with multilobar/lower lobe diseasePulmonary hypertension: Increasingly recognized as a serious complication of SCDAvascular necrosis of the femoral or humeral head: Due to vascular occlusionCentral nervous system (CNS) involvement: Most severe manifestation is strokeOphthalmologic involvement: Ptosis, retinal vascular changes, proliferative retinitisCardiac involvement: Dilation of both ventricles and the left atriumGastrointestinal involvement: Cholelithiasis is common in children; liver may become involvedGenitourinary involvement: Kidneys lose concentrating capacity; priapism is a well-recognized complication of SCDDermatologic involvement: Leg ulcers are a chronic painful problem

    • This question is part of the following fields:

      • Haematology
      • Pathology
      380.3
      Seconds
  • Question 27 - Regarding gentamicin, which of the following statements is INCORRECT: ...

    Correct

    • Regarding gentamicin, which of the following statements is INCORRECT:

      Your Answer: Gentamicin typically causes acute glomerulonephritis in toxicity.

      Explanation:

      Gentamicin is the aminoglycoside of choice in the UK and is used widely for the treatment of serious infections. It has a broad spectrum but is inactive against anaerobes and has poor activity against haemolytic streptococci and pneumococci. When used for the blind therapy of undiagnosed serious infections it is usually given in conjunction with a penicillin or metronidazole (or both). The main toxic effects are nephrotoxicity and ototoxicity due to damage to the vestibulocochlear nerve (CN VIII).Gentamicin is contraindicated in myasthenia gravis and should be used with caution in renal disease which may result in accumulation and a greater risk of toxic side effects.

    • This question is part of the following fields:

      • Infections
      • Pharmacology
      26.6
      Seconds
  • Question 28 - For which of the following class of drugs can neostigmine be used as...

    Correct

    • For which of the following class of drugs can neostigmine be used as a reversal agent?

      Your Answer: Non-depolarising muscle relaxants

      Explanation:

      Neostigmine is used specifically for reversal of nondepolarizing (competitive) blockade and is anticholinesterase. It acts within one minute of intravenous injection, and the effects last for 20 to 30 minutes. After this time period, a second dose may then be necessary.

    • This question is part of the following fields:

      • Anaesthesia
      • Pharmacology
      29.2
      Seconds
  • Question 29 - Regarding control of hospital acquired infection (HAI), which of the following statements is...

    Correct

    • Regarding control of hospital acquired infection (HAI), which of the following statements is CORRECT:

      Your Answer: Chlorhexidine is an anti-staphylococcal agent.

      Explanation:

      Chlorhexidine is an anti-staphylococcal agent. Cleaning is the removal of foreign material from areas or objects to a point at which they are visually free from debris.  Disinfection is the reduction in the number of infectious particles. Isopropyl alcohol is not effective against C. difficile spores. Autoclaving is a method of sterilisation.

    • This question is part of the following fields:

      • Microbiology
      • Principles
      15.1
      Seconds
  • Question 30 - Regarding carbohydrate, which of the following statements is INCORRECT: ...

    Incorrect

    • Regarding carbohydrate, which of the following statements is INCORRECT:

      Your Answer: Glycogen is derived from animal sources.

      Correct Answer: Most dietary carbohydrate is in the form of disaccharides.

      Explanation:

      Carbohydrates are the main energy source of most diets. They provide 17 kJ (4 kcal) of energy per gram. Most dietary carbohydrate is in the form of polysaccharides. The principal ingested polysaccharides are starch which is derived from plant sources and glycogen which is derived from animal sources. Dietary fibre consists of indigestible carbohydrate (found in plant foods) such as cellulose, lignin and pectin.

    • This question is part of the following fields:

      • Gastrointestinal
      • Physiology
      26.6
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Gastrointestinal Physiology (0/1) 0%
Physiology (3/6) 50%
Anaesthesia (1/2) 50%
Pharmacology (4/8) 50%
Infections (2/3) 67%
Microbiology (2/3) 67%
Specific Pathogen Groups (0/1) 0%
Gastrointestinal (1/2) 50%
Cardiovascular Pharmacology (1/2) 50%
Anatomy (6/8) 75%
Head And Neck (1/1) 100%
Respiratory Physiology (1/1) 100%
Inflammatory Responses (0/1) 0%
Pathology (2/5) 40%
Upper Limb (4/4) 100%
Haematology (1/2) 50%
Principles Of Microbiology (1/1) 100%
General Pathology (1/2) 50%
Cardiovascular (0/1) 0%
Lower Limb (0/2) 0%
Abdomen (1/1) 100%
Renal Physiology (1/1) 100%
Basic Cellular Physiology (0/1) 0%
Principles (1/1) 100%
Passmed