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Question 1
Correct
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As a response to low blood pressure, the baroreceptor reflex will facilitate vasoconstriction by activating which receptor?
Your Answer: Alpha1
Explanation:The rate of baroreceptor firing slows down when blood pressure falls too low. This causes an increase in sympathetic stimulation of the heart, resulting in an increase in cardiac output. It also causes vasoconstriction by activating alpha 1 receptors in smooth muscle, which causes sympathetic stimulation of peripheral vessels. Alpha2 receptors can be found in both the brain and the peripheral nervous system. They control sympathetic outflow in the brain stem. Beta1 receptors, which are found on the cell membrane of cardiac muscle cells, stimulate heart rate and myocardial contractility. The smooth muscle cell membrane contains beta2 receptors, which promote smooth muscle relaxation in the lungs causing bronchodilation, GI tract, and peripheral blood vessels.
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This question is part of the following fields:
- Cardiovascular
- Physiology
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Question 2
Incorrect
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An 82 year old man taking warfarin as a maintenance medication comes in to your clinic because of an infection. Which antibiotic is the safest choice for this patient?
Your Answer: Clarithromycin
Correct Answer: Cefalexin
Explanation:Alterations in the international normalized ratio (INR) brought about by the concurrent use of antibiotics and warfarin may result in either excessive clotting or excessive bleeding if they are deemed to have a high risk for interaction. As such, there should be careful consideration of the class of antibiotic to be used. Antibiotics from the following drug classes should generally be avoided as they have a high risk for interaction with warfarin, possible enhancing the anticoagulant effects of warfarin resulting in bleeding: Fluoroquinolones (e.g. ciprofloxacin, levofloxacin), Macrolides (e.g. clarithromycin, erythromycin, azithromycin), Nitroimidazoles (e.g. metronidazole), Sulphonamides (e.g. co-trimoxazole, a combination of trimethoprim and sulfamethoxazole), Trimethoprim, Tetracyclines (e.g. doxycycline). Low risk antibiotics that have low risk for interaction with warfarin includes cephalexin, from the cephalosporin class, and clindamycin which is a lincomycin.
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This question is part of the following fields:
- Cardiovascular
- Pharmacology
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Question 3
Correct
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EMLA cream is a topical local anaesthetic containing which of the following:
Your Answer: 50/50 mixture 2.5% lidocaine and 2.5% prilocaine
Explanation:EMLA cream, an effective topical local anaesthetic, is a 50/50 mixture of 2.5% prilocaine and 2.5% lidocaine.
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This question is part of the following fields:
- Anaesthesia
- Pharmacology
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Question 4
Incorrect
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A young boy is carried by his friends to the Emergency Department in an unconscious state. He is quickly moved into the resuscitation room. He was at a party with friends and has injected heroin. On examination, his GCS is 6/15, and he has bilateral pinpoint pupils and a very low respiratory rate of 6 breaths per minute. Which of the following is the first-line treatment for this patient?
Your Answer: Naloxone 0.2 mg IM
Correct Answer: Naloxone 0.8 mg IV
Explanation:Heroin is injected into the veins and is the most commonly abused drug. Acute intoxication with opioid overuse is the most common cause of death by drug overdose. The clinical features of opioid overdose are:1. Decreased respiratory rate2. Reduced conscious level or coma3. Decreased bowel sounds4. Miotic (constricted) pupils5. Cyanosis6. Hypotension7. Seizures8. Non-cardiogenic pulmonary oedema (with IV heroin usage)The main cause of death secondary to opioid overdose is respiratory depression, which usually occurs within 1 hour of the overdose. Vomiting is also common, and aspiration can occur.Naloxone is a short-acting, specific antagonist of mu(μ)-opioid receptors. It is used to reverse the effects of opioid toxicity. It can be given by a continuous infusion if repeated doses are required and the infusion rate is adjusted according to the vital signs. Initially, the infusion rate can be set at 60% of the initial resuscitative IV dose per hour.Naloxone has a shorter duration of action (6-24 hours) than most opioids, and so close monitoring according to the respiratory rate and depth of coma with repeated injections is necessary. When repeated doses are needed in opioid addicts, naloxone administration may precipitate a withdrawal syndrome with abdominal cramps, nausea and diarrhoea, but these usually settle within 2 hours.An initial dose of 0.4 to 2 mg can be given intravenously and can be repeated at 2 to 3-minute intervals to a maximum of 10mg. If the intravenous route is inaccessible, naloxone can be administered via an IO line, subcutaneously (SQ), IM, or via the intranasal (IN) route.
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This question is part of the following fields:
- CNS Pharmacology
- Pharmacology
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Question 5
Incorrect
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A 32-old woman comes for a follow-up visit after being discharged on medications for her newly diagnosed epilepsy. She now complains of a tremor in her arm when she holds a tray in her hand. You examine the patient and notice she has developed postural tremors. Which of the following medications for epilepsy is most likely responsible for this tremor?
Your Answer: Phenytoin
Correct Answer: Sodium valproate
Explanation:A postural tumour is observed when a person maintains a position against gravity, such as holding the arms outstretched. (The patient holding her tray against gravity) Sodium valproate is the most commonly prescribed medication for epilepsy. It is commonly associated with tremors as valproate-induced tremors occur in around 6-45% of patients. The tremors are commonly postural, but a resting tremor may also occur.Approximately 25% of patients taking sodium valproate are found to develop a tremor within 3-12 months of initiating therapy.
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This question is part of the following fields:
- CNS Pharmacology
- Pharmacology
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Question 6
Correct
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Which of the following is NOT typically associated with eosinophilia:
Your Answer: Whooping cough
Explanation:An eosinophil leucocytosis is defined as an increase in blood eosinophils above 0.4 x 109/L.It is most frequently due to:Allergic diseases (e.g. bronchial asthma, hay fever, atopic dermatitis, urticaria)Parasites (e.g. hookworm, ascariasis, tapeworm, schistosomiasis)Skin diseases (e.g. psoriasis, pemphigus, urticaria, angioedema)Drug sensitivity
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This question is part of the following fields:
- Immune Responses
- Pathology
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Question 7
Correct
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A patient presents to your clinic with fever of unknown origin. His blood results shows a markedly elevated C-Reactive Protein (CRP) level.Which of these is responsible for mediating the release of CRP?
Your Answer: IL-6
Explanation:C-reactive protein (CRP) is an acute phase protein produced by the liver hepatocytes. Its production is regulated by cytokines, particularly interleukin 6 (IL-6) and it can be measured in the serum as a nonspecific marker of inflammation. Although a high CRP suggest an acute infection or inflammation, it does not identify the cause or location of infection.
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This question is part of the following fields:
- General Pathology
- Pathology
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Question 8
Correct
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Regarding iron deficiency anaemia, which of the following statements is INCORRECT:
Your Answer: Dietary insufficiency is the most common cause of iron deficiency anaemia in adult men in the UK.
Explanation:Blood loss from the gastrointestinal (GI) tract is the most common cause of iron deficiency anaemia in adult men and postmenopausal women.
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This question is part of the following fields:
- Haematology
- Pathology
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Question 9
Incorrect
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Which of the following is NOT a typical clinical feature of beta-thalassaemia major:
Your Answer: Gallstones
Correct Answer: Increased bleeding tendency
Explanation:Features include:- severe anaemia (becoming apparent at 3 – 6 months when the switch from gamma-chain to beta-chain production takes place)- failure to thrive- hepatosplenomegaly (due to excessive red cell destruction, extramedullary haemopoiesis and later due to transfusion related iron overload)- expansion of bones (due to marrow hyperplasia, resulting in bossing of the skull and cortical thinning with tendency to fracture)- increased susceptibility to infections (due to anaemia, iron overload, transfusion and splenectomy)- osteoporosis- hyperbilirubinaemia and gallstones- hyperuricaemia and gout- other features of haemolytic anaemia- liver damage and other features of iron overload
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This question is part of the following fields:
- Haematology
- Pathology
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Question 10
Incorrect
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Regarding an avulsion fracture, a sudden contraction of which muscle may lead to fracture of the head of the fibula?
Your Answer: Semimembranosus
Correct Answer: Biceps femoris
Explanation:Avulsion fractures of the fibular head are rare and are so-called the arcuate signal. The “arcuate signal” is used to describe an avulsed bone fragment related to the insertion site of the tendon of the biceps femoris associated with the arcuate complex, which consists of the fabellofibular, popliteofibular, and arcuate ligaments. Such lesions are typically observed in direct trauma to the knee with excessive varus and internal rotation forces or indirect trauma with the same direction of the force.
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This question is part of the following fields:
- Anatomy
- Lower Limb
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Question 11
Correct
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Which of the following pathogens causes tetanus:
Your Answer: Clostridium tetani
Explanation:Tetanus is caused by Clostridium tetani, a bacterium. Tetanus can cause mild spasms to severe whole-body contractions, suffocation, and heart attack. Gas gangrene and food poisoning are both caused by Clostridium perfringens. Pseudomembranous colitis is caused by Clostridium difficile. Urinary tract infections, respiratory infections, dermatitis, soft tissue infections, bacteraemia, bone and joint infections, gastrointestinal infections, and a variety of systemic infections are all caused by Pseudomonas aeruginosa. Pharyngitis, skin infections, acute rheumatic fever, scarlet fever, poststreptococcal glomerulonephritis, toxic shock–like syndrome, and necrotizing fasciitis can all be caused by Streptococcus pyogenes infection.
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This question is part of the following fields:
- Microbiology
- Pathogens
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Question 12
Correct
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All of the following statements are considered true regarding likelihood ratios, except:
Your Answer: If less than one, indicates that the information increases the likelihood of the suspected diagnosis
Explanation:The Likelihood Ratio (LR) is the likelihood that a given test result would be expected in a patient with the target disorder compared to the likelihood that that same result would be expected in a patient without the target disorder.The LR is used to assess how good a diagnostic test is and to help in selecting an appropriate diagnostic tests or sequence of tests. They have advantages over sensitivity and specificity because they are less likely to change with the prevalence of the disorder, they can be calculated for several levels of the symptom/sign or test, they can be used to combine the results of multiple diagnostic test and they can be used to calculate post-test probability for a target disorder.A LR greater than 1 produces a post-test probability which is higher than the pre-test probability. An LR less than 1 produces a post-test probability which is lower than the pre-test probability. When the pre-test probability lies between 30 and 70 per cent, test results with a very high LR (say, above 10) rule in disease. An LR below 1 produces a post-test probability les than the pre-test probability. A very low LR (say, below 0.1) virtually rules out the chance that the patient has the disease.
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This question is part of the following fields:
- Evidence Based Medicine
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Question 13
Correct
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Which of the following blood groups is the least common in the UK:
Your Answer: AB
Explanation:Blood group O is the most common in the UK (46 %), followed by group A (42 %), group B (9 %) and finally group AB (3 %).Blood group O has no antigens, but both anti-A and anti-B antibodies and thus is the universal donor. Blood group AB has both A and B antigens but no antibodies and thus is the universal recipient.Blood group A has A antigens and anti-B antibodies and blood group B has B antigens and anti-A antibodies.
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This question is part of the following fields:
- Immune Responses
- Pathology
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Question 14
Correct
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You review a patient with urinary sepsis and decide to start her on gentamicin.Which statement about gentamicin is true?
Your Answer: Ototoxicity is a dose-related effect
Explanation:Gentamicin, an aminoglycoside antibiotic, acts by binding to the 30S subunit of the bacterial ribosome inhibiting the binding of aminoacyl-tRNA, and thus prevents initiation of protein synthesis.Gentamicin is given by injection because it is NOT absorbed orally. It is excreted in the kidneys by glomerular filtrationGentamicin is not to be used for the treatment of Neisseria meningitidis, Neisseria gonorrhoea, or Legionella pneumophila.There is a risk of patient going into shock from lipid A endotoxin release.Two of its most notable side effects are hearing loss reversible nephrotoxicity and which are both dose-related and levels should be monitored in patients.
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This question is part of the following fields:
- Infections
- Pharmacology
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Question 15
Correct
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Regarding the brachioradialis muscle, which of the following statements is true?
Your Answer: It assists with supination of the forearm at the radioulnar joints
Explanation:Brachioradialis is a fusiform muscle located in the lateral part of the posterior forearm. Along with extensor carpi radialis brevis and extensor carpi radialis longus, it comprises the radial group of forearm muscles, which belong to the superficial layer of posterior forearm muscles. Although anatomically part of the posterior forearm muscles, which are known to be forearm extensors, brachioradialis’ fibre orientation enables it to rather flex the forearm, and aids in supination of the forearm at the radioulnar joint.The brachioradialis muscle originates from the upper two-thirds of the lateral supracondylar ridge of humerus and the anterior surface of the lateral intermuscular septum of the arm. It slides over the lateral surface of the elbow joint, entering the anterolateral cubital area. The muscle fibres course inferiorly down the radial part of the anterior forearm, forming a thick tendon in approximately the middle of the forearm. This tendon then traverses the remainder of the forearm, inserting near the wrist, just proximal to the styloid process of radius.Brachioradialis is innervated by the radial nerve (from the root values C5-C6) that stems from the posterior cord of the brachial plexus. Blood supply to the brachioradialis muscle comes from branches of the radial artery, radial recurrent artery and the radial collateral branch of the deep brachial artery.
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This question is part of the following fields:
- Anatomy
- Upper Limb
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Question 16
Correct
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All of the following typically occurs as part of normal inspiration except:
Your Answer: Contraction of the internal intercostal muscles
Explanation:Passive inspiration is a result of contraction of the diaphragm (depressing the diaphragm) and the external intercostal muscles (elevating the ribs). In inspiration, several movements occur. These are:1. elevation of the sternal ends of the ribs (‘pump handle’ movement), 2. elevation of the lateral shafts of the ribs (‘bucket handle’ movement) 3. depression of the diaphragm. These result in expansion of the thorax in an anteroposterior, transverse and vertical direction respectively. There is an increased intrathoracic volume and decreased intrathoracic pressure and air is drawn into the lungs.
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This question is part of the following fields:
- Anatomy
- Thorax
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Question 17
Incorrect
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Which statement about cross-sectional studies is true?
Your Answer: They can only study a single outcome
Correct Answer: They can be used to assess the prevalence of a condition
Explanation:Cross-sectional studies can be used to assess the prevalence of a condition.Cross-sectional studies CANNOT be used to differentiate between cause and effect or establish the sequence of events.They can be used to study multiple outcomes but are NOT suitable for studying rare diseases.
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This question is part of the following fields:
- Evidence Based Medicine
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Question 18
Correct
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Which of the following movements does the iliacus muscle produce?
Your Answer: Flexion of the thigh at the hip joint
Explanation:The iliacus flexes the thigh at the hip joint when the trunk is stabilised. It flexes the trunk against gravity when the body is supine.
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This question is part of the following fields:
- Abdomen
- Anatomy
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Question 19
Incorrect
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Regarding cross-sectional studies, which of the following statements is CORRECT:
Your Answer: They are useful for considering trends over time.
Correct Answer: They are particularly suitable for estimating point prevalence.
Explanation:Cross-sectional studies aim to provide data about population health, normal ranges of biological parameters, and disease prevalence or severity by observing the entire population, or a representative subset, at a single point in time. Cross-sectional studies are relatively simple and quick to perform and can be used to study multiple outcomes, but are subject to confounding and recall bias and are not suitable for studying rare diseases. Cross-sectional studies cannot be used to assess causation or to consider trends over time.
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This question is part of the following fields:
- Evidence Based Medicine
- Study Methodology
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Question 20
Correct
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This anatomic part lies at the heart of the tooth.
Your Answer: The pulp cavity
Explanation:Within the central portion of the tooth lies the dental pulp. The pulp chamber provides mechanical support and functions as a barrier from external stimuli and the oral microbiome. The dental pulp is a unique tissue that is richly innervated and has an extensive microvascular network. Maintaining its vitality increases both the mechanical resistance of the tooth and the long-term survival. The junctional epithelium forms a band around the tooth at the base of the gingival sulcus, sealing off the periodontal tissues from the oral cavity.
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This question is part of the following fields:
- Anatomy
- Head And Neck
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Question 21
Incorrect
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Pressure across the wall of a flexible tube (the transmural pressure) increases wall tension and extends it.Which law best describes transmural pressure?
Your Answer: Fick’s law
Correct Answer: Laplace’s law
Explanation:The transmural pressure (pressure across the wall of a flexible tube) can be described by Laplace’s law which states that:Transmural pressure = (Tw) / rWhere:T = Wall tensionw = Wall thicknessr = The radiusA small bubble with the same wall tension as a larger bubble will contain higher pressure and will collapse into the larger bubble if the two meet and join.Fick’s law describes the rate of diffusion in a solutionPoiseuille’s law is used to calculate volume of flow rate in laminar flowDarcy’s law describes the flow of a fluid through a porous medium.Starling’s law describes cardiac haemodynamics as it relates to myocyte contractility and stretch.
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This question is part of the following fields:
- Basic Cellular Physiology
- Physiology
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Question 22
Incorrect
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Regarding non-Hodgkin lymphoma (NHL), which of the following statements is CORRECT:
Your Answer: NHL is less common than Hodgkin lymphoma.
Correct Answer: There is a much greater predilection to disseminate to extranodal sites than in Hodgkin lymphoma.
Explanation:Non-Hodgkin’s lymphoma (NHL) refers to a group of lymphoproliferative malignancies (about 85% of B-cell and 15% of T or NK (natural killer) cell origin) with different behavioural patterns and treatment responses. This group of malignancies encompasses all types of lymphoma without Reed-Sternberg cells being present. The Reed-Sternberg cell is classically seen in Hodgkin’s lymphoma.NHL is five times as common as Hodgkin’s lymphoma. The peak incidence of NHL is in the 50-70 years age group, it affects men and women equally, but affects the Caucasian population more commonly than black and Asian ethnic groups.The following are recognised risk factors for NHL:Chromosomal translocations and molecular rearrangementsEpstein-Barr virus infectionHuman T-cell leukaemia virus type-1 (HTLV-1)Hepatitis CCongenital and acquired immunodeficiency statesAutoimmune disorders, e.g. Sjogren’s syndrome and Hashimoto’s thyroiditisThe most common clinical features at presentation are:Lymphadenopathy (typically asymmetrical and painless)Weight lossFatigueNight sweatsHepatosplenomegalyFor clinical purposes, NHL is divided into three groups: indolent, high-grade, and lymphoblastic.Indolent (low-grade) NHL:The cells are relatively matureDisease follows an indolent course without treatmentOften acceptable to follow a ‘watch and wait’ strategyLocal radiotherapy often effectiveRelatively good prognosis with median survival of 10 yearsHigh-grade NHL:Cells are immatureDisease progresses rapidly without treatmentSignificant number of patients can be cured with intensive combination chemotherapy regimensApproximately 40% cure rateLymphoblastic NHL:Cells are very immature and have a propensity to involve the CNSTreatment and progression are similar to that of acute lymphoblastic leukaemia (ALL)
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This question is part of the following fields:
- Haematology
- Pathology
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Question 23
Correct
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Which of these organisms is commonly spread by droplet transmission?
Your Answer: Neisseria meningitidis
Explanation:Droplets are airborne particles greater than 5 µm in size. Droplet transmission occurs during talking, coughing and sneezing where respiratory droplets are generated.Examples of organisms transmitted by the droplet route include:Neisseria meningitidisRespiratory syncytial virusParainfluenza virusBordetella pertussisInfluenza virusPoliovirus and Rotavirus are transmitted by the faeco-oral routeHepatitis B is transmitted by Sexual routeStaphylococcus aureus is transmitted by direct contact
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This question is part of the following fields:
- Microbiology
- Principles Of Microbiology
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Question 24
Incorrect
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Which of the following nerves supply the superficial head of the flexor pollicis brevis muscle?
Your Answer: The palmar digital branch of the median nerve
Correct Answer: The recurrent branch of the median nerve
Explanation:The two heads of the flexor pollicis brevis usually differ in their innervation. The superficial head of flexor pollicis muscle receives nervous supply from the recurrent branch of the median nerve, whereas the deep head receives innervation from the deep branch of the ulnar nerve, derived from spinal roots C8 and T1.
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This question is part of the following fields:
- Anatomy
- Upper Limb
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Question 25
Correct
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A patient presents with a laceration on his hand and wrist that has cut the nerve that innervates opponens pollicis.The opponens pollicis muscle is innervated by which of the following nerves? Select ONE answer only.
Your Answer: The recurrent branch of the median nerve
Explanation:Opponens pollicis is a small, triangular muscle that forms part of the thenar eminence. It originates from the flexor retinaculum and the tubercle of trapezium bone and inserts into the whole length of the first metacarpal bone on its radial side.Opponens pollicis is innervated by the recurrent branch of the median nerve and receives its blood supply from the superficial palmar arch.The main action of opponens pollicis is to flex the first metacarpal bone at the carpometacarpal joint, which opposes the thumb towards the centre of the palm. It also medially rotates the first metacarpal bone at the carpometacarpal joint.
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This question is part of the following fields:
- Anatomy
- Upper Limb
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Question 26
Correct
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Regarding the abductor digiti minimi, which of the following statements is false?
Your Answer: It assists with flexion of the fifth finger at the middle phalanx
Explanation:Abductor digiti minimi is a short intrinsic muscle of the hand. It belongs to the group of muscles collectively called hypothenar muscles due to their acting on the 5th finger. Besides abductor digiti minimi, other hypothenar muscles include flexor digiti minimi brevis and opponens digiti minimi.The main function of abductor digiti minimi involves abduction of the 5th finger, as well as flexion of its proximal phalanx. Along with other hypothenar muscles, this muscle forms the hypothenar eminence on the medial side of the palm.Like other hypothenar muscles, abductor digiti minimi receives nervous supply from the deep branch of the ulnar nerve, derived from root values C8 and T1.Abductor digiti minimi receives arterial blood supply from the palmar branch of ulnar artery, palmar digital artery, as well as branches of the ulnar side of the superficial palmar arch. The venous blood from the muscle is drained via the venous networks of the palm into the deep veins of the arm (vv. ulnares).
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This question is part of the following fields:
- Anatomy
- Upper Limb
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Question 27
Correct
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All of the following statements regarding metronidazole are correct except:
Your Answer: Metronidazole reduces the anticoagulant effect of warfarin.
Explanation:The anticoagulant effect of warfarin is enhanced by metronidazole. If use of both cannot be avoided, one must consider appropriately reducing the warfarin dosage. With alcohol, metronidazole can cause a disulfiram-like reaction, with symptoms like flushing, headaches, dizziness, tachypnoea and tachycardia, nausea and vomiting. The common side effects of metronidazole include a metallic taste and gastrointestinal irritation, in particular nausea and vomiting. These side effects are more common at higher doses. This drug has high activity against anaerobic bacteria and protozoa, and is well absorbed orally. For severe infections, the intravenous route is normally reserved.
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This question is part of the following fields:
- Infections
- Pharmacology
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Question 28
Correct
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An increased anion gap metabolic acidosis is typically caused by which of the following?
Your Answer: Propylene glycol overdose
Explanation:Causes of a raised anion gap acidosis can be remember using the mnemonic MUDPILES:-Methanol-Uraemia (in renal failure)-Diabetic ketoacidosis-Propylene glycol overdose-Infection/Iron overdose/Isoniazid/Inborn errors of metabolism-Lactic acidosis-Ethylene glycol overdose-Salicylate overdose
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This question is part of the following fields:
- Physiology
- Renal
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Question 29
Incorrect
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An ambulance transports a 37-year-old woman who is having a seizure. She is moved to resuscitation and given a benzodiazepine dose, which quickly ends the seizure. You later learn that she has epilepsy and is usually treated with carbamazepine to control her seizures.What is carbamazepine's main mechanism of action?
Your Answer: GABA reuptake inhibitor
Correct Answer: Sodium channel blocker
Explanation:Carbamazepine is primarily used to treat epilepsy, and it is effective for both focal and generalised seizures. It is not, however, effective in the treatment of absence or myoclonic seizures. It’s also commonly used to treat neuropathic pain, as well as a second-line treatment for bipolar disorder and as a supplement for acute alcohol withdrawal.Carbamazepine works as a sodium channel blocker that preferentially binds to voltage-gated sodium channels in their inactive state. This prevents an action potential from firing repeatedly and continuously.
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This question is part of the following fields:
- CNS Pharmacology
- Pharmacology
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Question 30
Incorrect
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The ECG of a patient presenting with a history of intermittent palpitations has a prolonged QT interval.Which of these can cause prolongation of the QT interval on the ECG?
Your Answer: Hyperkalaemia
Correct Answer: Hypomagnesaemia
Explanation:The causes of a prolonged QT interval include:HypomagnesaemiaHypothermiaHypokalaemia HypocalcaemiaHypothyroidism Jervell-Lange-Nielsen syndrome (autosomal dominant)Romano Ward syndrome (autosomal recessive)Ischaemic heart diseaseMitral valve prolapseRheumatic carditisErythromycinAmiodaroneQuinidineTricyclic antidepressantsTerfenadineMethadoneProcainamideSotalol
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This question is part of the following fields:
- Cardiovascular Physiology
- Physiology
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