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  • Question 1 - What type of dysarthria is typically caused by damage to the lower motor...

    Correct

    • What type of dysarthria is typically caused by damage to the lower motor neurons related to a tumor?

      Your Answer: Flaccid dysarthria

      Explanation:

      Dysarthria is a speech disorder that affects the volume, rate, tone, of quality of spoken language. There are different types of dysarthria, each with its own set of features, associated conditions, and localisation. The types of dysarthria include spastic, flaccid, hypokinetic, hyperkinetic, and ataxic.

      Spastic dysarthria is characterised by explosive and forceful speech at a slow rate and is associated with conditions such as pseudobulbar palsy and spastic hemiplegia.

      Flaccid dysarthria, on the other hand, is characterised by a breathy, nasal voice and imprecise consonants and is associated with conditions such as myasthenia gravis.

      Hypokinetic dysarthria is characterised by slow, quiet speech with a tremor and is associated with conditions such as Parkinson’s disease.

      Hyperkinetic dysarthria is characterised by a variable rate, inappropriate stoppages, and a strained quality and is associated with conditions such as Huntington’s disease, Sydenham’s chorea, and tardive dyskinesia.

      Finally, ataxic dysarthria is characterised by rapid, monopitched, and slurred speech and is associated with conditions such as Friedreich’s ataxia and alcohol abuse. The localisation of each type of dysarthria varies, with spastic and flaccid dysarthria affecting the upper and lower motor neurons, respectively, and hypokinetic, hyperkinetic, and ataxic dysarthria affecting the extrapyramidal and cerebellar regions of the brain.

    • This question is part of the following fields:

      • Neurosciences
      10.8
      Seconds
  • Question 2 - What is an unexpected symptom in dissociative seizures? ...

    Incorrect

    • What is an unexpected symptom in dissociative seizures?

      Your Answer: Prolonged by restraint

      Correct Answer: Seizure duration under two minutes

      Explanation:

      Dissociative seizures, also known as pseudoseizures of functional seizures, are abnormal paroxysmal manifestations that resemble epileptic seizures but are not related to abnormal epileptiform discharges. They can be caused by physical factors such as hypoglycemia of cardiac dysfunction, but more commonly result from mental of emotional processes. Dissociative seizures are more common in females and tend to have an onset in late adolescence. Distinguishing between true seizures and pseudoseizures can be challenging, but a rise in serum prolactin levels after a seizure is a helpful diagnostic tool. Treatment options for psychogenic nonepileptic seizures are limited, with cognitive-behavioral therapy being the most studied and effective intervention.

    • This question is part of the following fields:

      • Classification And Assessment
      24.5
      Seconds
  • Question 3 - You are requested to assess a 40-year-old male patient who is currently admitted...

    Correct

    • You are requested to assess a 40-year-old male patient who is currently admitted to the hospital for treatment of severe depression. The nursing staff reports that he is experiencing tachycardia, hypertension, and has a fever of 38°C. Upon examination, you observe that the patient is confused and exhibiting myoclonus. What is the probable diagnosis?

      Your Answer: Serotonin syndrome

      Explanation:

      Serotonin syndrome is a serious condition that can be life-threatening and presents with a variety of symptoms affecting cognitive, autonomic, and somatic functions. It can be mistaken for neuroleptic malignant syndrome (NMS), but the presence of myoclonus can help differentiate between the two conditions. Treatment involves discontinuing medications and, in severe cases, using a serotonin antagonist. Benzodiazepines may also be used to manage agitation. Akathisia is a type of movement disorder, while hyperthermia can occur in both serotonin syndrome and NMS. Encephalopathy refers to a general dysfunction of the brain.

    • This question is part of the following fields:

      • Psychopharmacology
      16.2
      Seconds
  • Question 4 - Which of the following is excluded from the frontal assessment battery? ...

    Correct

    • Which of the following is excluded from the frontal assessment battery?

      Your Answer: Asking the patient to draw a clock

      Explanation:

      The Frontal Assessment Battery (FAB) is a quick and easy bedside test used to detect the dysexecutive syndrome. It consists of six subsets, including conceptualization, mental flexibility, motor programming, conflicting instructions, go-no go (inhibitory control), and prehension behavior. The test assesses a patient’s ability to perform tasks such as abstract reasoning, verbal fluency, and motor skills. The FAB can be completed in just a few minutes and is a useful tool for clinicians in evaluating patients with suspected executive dysfunction.

    • This question is part of the following fields:

      • Classification And Assessment
      16.2
      Seconds
  • Question 5 - What is an example of a drug that acts as an antagonist for...

    Incorrect

    • What is an example of a drug that acts as an antagonist for NMDA receptors?

      Your Answer: Donepezil

      Correct Answer: Memantine

      Explanation:

      Pharmacological management of dementia involves the use of acetylcholinesterase inhibitors (AChE inhibitors) and memantine. AChE inhibitors prevent the breakdown of acetylcholine, which is deficient in Alzheimer’s due to the loss of cholinergic neurons. Donepezil, galantamine, and rivastigmine are commonly used AChE inhibitors in the management of Alzheimer’s. However, gastrointestinal side effects such as nausea and vomiting are common with these drugs.

      Memantine, on the other hand, is an NMDA receptor antagonist that blocks the effects of pathologically elevated levels of glutamate that may lead to neuronal dysfunction. It has a half-life of 60-100 hours and is primarily renally eliminated. Common adverse effects of memantine include somnolence, dizziness, hypertension, dyspnea, constipation, headache, and elevated liver function tests.

      Overall, pharmacological management of dementia aims to improve cognitive function and slow down the progression of the disease. However, it is important to note that these drugs do not cure dementia and may only provide temporary relief of symptoms.

    • This question is part of the following fields:

      • Psychopharmacology
      40.6
      Seconds
  • Question 6 - How can a group of genetic defects causing a single condition be described?...

    Incorrect

    • How can a group of genetic defects causing a single condition be described?

      Your Answer: Pleiotropy

      Correct Answer: Heterogeneity

      Explanation:

      Pleiotropy refers to a genetic phenomenon where a single gene has an impact on multiple observable traits. This occurs because the gene produces a product that is utilized by various cells. An instance of pleiotropy is the human condition known as PKU (phenylketonuria).

      Understanding Heterogeneity in Genetic Diseases

      Heterogeneity is a term used to describe the presence of different genetic defects that can cause the same disease. This phenomenon is commonly observed in genetic disorders, where multiple mutations can lead to the same clinical presentation. For instance, the ABO blood group system is an example of heterogeneity, where different combinations of alleles can result in the same blood type.

      Understanding heterogeneity is crucial for accurate diagnosis and treatment of genetic diseases. Identifying the specific genetic defect responsible for a particular disease can help tailor therapies and predict disease progression. However, the presence of heterogeneity can also complicate diagnosis and treatment, as different mutations may require different approaches.

      Overall, heterogeneity highlights the complexity of genetic diseases and underscores the need for personalized medicine approaches that take into account individual genetic variations.

    • This question is part of the following fields:

      • Genetics
      20.5
      Seconds
  • Question 7 - A child explains during a conversation that 'When I saw the man holding...

    Correct

    • A child explains during a conversation that 'When I saw the man holding a glass of wine, I knew my father was dead'.

      This is most indicative of what?

      Your Answer: Delusional perception

      Explanation:

      Borderline Learning Disability

      Borderline learning disability is a term used to describe individuals with an IQ between 70-85. This category is not officially recognized as a diagnosis by the ICD-11. It is estimated that approximately 15% of the population falls within this range (Chaplin, 2005). Unlike mild learning disability, borderline learning disability is not typically associated with deficits in adaptive functioning, such as grooming, dressing, safety, of money management.

    • This question is part of the following fields:

      • Classification And Assessment
      27.6
      Seconds
  • Question 8 - A male adolescent patient reports experiencing erectile dysfunction and premature ejaculation after starting...

    Incorrect

    • A male adolescent patient reports experiencing erectile dysfunction and premature ejaculation after starting antipsychotic medication. Which receptor site is responsible for the antipsychotic effect?

      Your Answer: Dopamine

      Correct Answer: alpha 1

      Explanation:

      Men may experience difficulties with achieving erections and ejaculation when taking medications that inhibit peripheral alpha 1-adrenoceptors. Antipsychotics can lead to disrupted sexual arousal due to their antimuscarinic effects. Impairment of both desire and arousal may occur as a result of dopaminergic blockade and hyperprolactinaemia. Selective serotonin reuptake inhibitor (SSRI) antidepressants, which increase serotonin activity, have been associated with anorgasmia.

    • This question is part of the following fields:

      • Psychopharmacology
      39.3
      Seconds
  • Question 9 - Which movement disorder is most likely to be managed through suppression? ...

    Correct

    • Which movement disorder is most likely to be managed through suppression?

      Your Answer: Stereotypies

      Explanation:

      Movement Disorders: Key Features

      Movement disorders refer to a range of conditions that affect voluntary muscle movements. These disorders can be caused by various factors, including neurological conditions, medication side effects, and metabolic imbalances. The following table outlines some of the key features of common movement disorders:

      Akinesia: Absence of loss of control of voluntary muscle movements, often seen in severe Parkinson’s disease.

      Bradykinesia: Slowness of voluntary movement, a core symptom of Parkinson’s disease.

      Akathisia: Subjective feeling of inner restlessness, often caused by antipsychotic medication use.

      Athetosis: Continuous stream of slow, flowing, writhing involuntary movements, often seen in cerebral palsy, stroke, and Huntington’s disease.

      Chorea: Brief, quasi-purposeful, irregular contractions that appear to flow from one muscle to the next, often seen in Huntington’s disease and Wilson’s disease.

      Dystonia: Involuntary sustained of intermittent muscle contractions that cause twisting and repetitive movements, abnormal postures, of both.

      Dyskinesia: General term referring to problems with voluntary movements and the presence of involuntary movements, often drug-induced.

      Myoclonus: A sequence of repeated, often non-rhythmic, brief shock-like jerks due to sudden involuntary contraction of relaxation of one of more muscles.

      Parkinsonism: Syndrome characterized by tremor, rigidity, and bradykinesia.

      Tic: Sudden, repetitive, non-rhythmic, stereotyped motor movement of vocalization involving discrete muscle groups, often seen in Tourette’s syndrome.

      Tremor: Involuntary, rhythmic, alternating movement of one of more body parts, often seen in essential tremor, Parkinson’s disease, and alcohol withdrawal.

      Hemiballismus: Repetitive, but constantly varying, large amplitude involuntary movements of the proximal parts of the limbs, often seen in stroke and traumatic brain injury.

      Stereotypies: Repetitive, simple movements that can be voluntarily suppressed, often seen in autism and intellectual disability.

      It is important to consider the underlying conditions and factors that may contribute to movement disorders in order to properly diagnose and treat these conditions.

    • This question is part of the following fields:

      • Classification And Assessment
      13
      Seconds
  • Question 10 - Which drug experiences the most substantial first-pass metabolism? ...

    Incorrect

    • Which drug experiences the most substantial first-pass metabolism?

      Your Answer: Pregabalin

      Correct Answer: Imipramine

      Explanation:

      The First Pass Effect in Psychiatric Drugs

      The first-pass effect is a process in drug metabolism that significantly reduces the concentration of a drug before it reaches the systemic circulation. This phenomenon is related to the liver and gut wall, which absorb and metabolize the drug before it can enter the bloodstream. Psychiatric drugs are not exempt from this effect, and some undergo a significant reduction in concentration before reaching their target site. Examples of psychiatric drugs that undergo a significant first-pass effect include imipramine, fluphenazine, morphine, diazepam, and buprenorphine. On the other hand, some drugs undergo little to no first-pass effect, such as lithium and pregabalin.

      Orally administered drugs are the most affected by the first-pass effect. However, there are other routes of administration that can avoid of partly avoid this effect. These include sublingual, rectal (partly avoids first pass), intravenous, intramuscular, transdermal, and inhalation. Understanding the first-pass effect is crucial in drug development and administration, especially in psychiatric drugs, where the concentration of the drug can significantly affect its efficacy and safety.

    • This question is part of the following fields:

      • Psychopharmacology
      11
      Seconds
  • Question 11 - A teenage girl is referred by her GP due to concerns about her...

    Incorrect

    • A teenage girl is referred by her GP due to concerns about her academic performance and her atypical physical characteristics. She is observed to be shorter than her peers and have a neck with excess skin folds. Upon further examination, she displays a wide chest and signs of hypothyroidism. What condition do you suspect?

      Your Answer: Down's syndrome

      Correct Answer: Turner syndrome

      Explanation:

      Understanding Turner Syndrome

      Turner syndrome is a genetic disorder that affects only females. It occurs when one of the two X chromosomes is missing of partially missing. This happens randomly and does not increase the risk of the condition in future siblings. Although X-inactivation occurs in females, having only one X chromosome can cause issues as not all genes are inactivated in the inactivated X chromosome.

      The features of Turner syndrome include short stature, a webbed neck, a broad chest with widely spaced nipples, gonadal dysfunction leading to amenorrhea and infertility, congenital heart disease, and hypothyroidism. Despite these physical characteristics, girls with Turner syndrome typically have normal intelligence, with a mean full-scale IQ of 90. However, they may struggle with nonverbal, social, and psychomotor skills. It is important to understand the symptoms and effects of Turner syndrome to provide appropriate care and support for affected individuals.

    • This question is part of the following fields:

      • Psychological Development
      54.5
      Seconds
  • Question 12 - What is the other structure that, along with the putamen, comprises the lenticular...

    Correct

    • What is the other structure that, along with the putamen, comprises the lenticular nucleus?

      Your Answer: Globus pallidus

      Explanation:

      The Edinger-Westphal nucleus is the motor nucleus of the third cranial nerve, while the putamen and globus pallidus comprise the lenticular nucleus, which is part of the basal ganglia. The basal ganglia play a role in motor control and use the inhibitory neurotransmitter GABA. The components of the basal ganglia can be classified in various ways, with the corpus striatum (caudate nucleus, putamen, nucleus accumbens, and globus pallidus) and the striatum of neostriatum (caudate, putamen, and globus pallidus) being common groupings.

    • This question is part of the following fields:

      • Neurosciences
      24.4
      Seconds
  • Question 13 - Which statement about the glossopharyngeal nerve is false? ...

    Correct

    • Which statement about the glossopharyngeal nerve is false?

      Your Answer: Controls the muscles of mastication

      Explanation:

      The trigeminal nerve is responsible for controlling the muscles involved in chewing, while the glossopharyngeal nerves consist of both motor and sensory fibers that originate from nuclei in the medulla oblongata. The motor fibers of the glossopharyngeal nerves stimulate the pharyngeal muscles and parotid gland secretory cells, while the sensory fibers transmit impulses from the posterior third of the tongue, tonsils, and pharynx to the cerebral cortex.

      Overview of Cranial Nerves and Their Functions

      The cranial nerves are a complex system of nerves that originate from the brain and control various functions of the head and neck. There are twelve cranial nerves, each with a specific function and origin. The following table provides a simplified overview of the cranial nerves, including their origin, skull exit, modality, and functions.

      The first cranial nerve, the olfactory nerve, originates from the telencephalon and exits through the cribriform plate. It is a sensory nerve that controls the sense of smell. The second cranial nerve, the optic nerve, originates from the diencephalon and exits through the optic foramen. It is a sensory nerve that controls vision.

      The third cranial nerve, the oculomotor nerve, originates from the midbrain and exits through the superior orbital fissure. It is a motor nerve that controls eye movement, pupillary constriction, and lens accommodation. The fourth cranial nerve, the trochlear nerve, also originates from the midbrain and exits through the superior orbital fissure. It is a motor nerve that controls eye movement.

      The fifth cranial nerve, the trigeminal nerve, originates from the pons and exits through different foramina depending on the division. It is a mixed nerve that controls chewing and sensation of the anterior 2/3 of the scalp. It also tenses the tympanic membrane to dampen loud noises.

      The sixth cranial nerve, the abducens nerve, originates from the pons and exits through the superior orbital fissure. It is a motor nerve that controls eye movement. The seventh cranial nerve, the facial nerve, also originates from the pons and exits through the internal auditory canal. It is a mixed nerve that controls facial expression, taste of the anterior 2/3 of the tongue, and tension on the stapes to dampen loud noises.

      The eighth cranial nerve, the vestibulocochlear nerve, originates from the pons and exits through the internal auditory canal. It is a sensory nerve that controls hearing. The ninth cranial nerve, the glossopharyngeal nerve, originates from the medulla and exits through the jugular foramen. It is a mixed nerve that controls taste of the posterior 1/3 of the tongue, elevation of the larynx and pharynx, and swallowing.

      The tenth cranial nerve, the vagus nerve, also originates from the medulla and exits through the jugular foramen. It is a mixed nerve that controls swallowing, voice production, and parasympathetic supply to nearly all thoracic and abdominal viscera. The eleventh cranial nerve, the accessory nerve, originates from the medulla and exits through the jugular foramen. It is a motor nerve that controls shoulder shrugging and head turning.

      The twelfth cranial nerve, the hypoglossal nerve, originates from the medulla and exits through the hypoglossal canal. It is a motor nerve that controls tongue movement. Overall, the cranial nerves play a crucial role in controlling various functions of the head and neck, and any damage of dysfunction can have significant consequences.

    • This question is part of the following fields:

      • Neurosciences
      98.3
      Seconds
  • Question 14 - What factor is most likely to worsen a patient's psoriasis? ...

    Incorrect

    • What factor is most likely to worsen a patient's psoriasis?

      Your Answer: Valproate

      Correct Answer: Lithium

      Explanation:

      Lithium – Pharmacology

      Pharmacokinetics:
      Lithium salts are rapidly absorbed following oral administration and are almost exclusively excreted by the kidneys unchanged. Blood samples for lithium should be taken 12 hours post-dose.

      Ebstein’s:
      Ebstein’s anomaly is a congenital malformation consisting of a prolapse of the tricuspid valve into the right ventricle. It occurs in 1:20,000 of the general population. Initial data suggested it was more common in those using lithium but this had not held to be true.

      Contraindications:
      Addison’s disease, Brugada syndrome, cardiac disease associated with rhythm disorders, clinically significant renal impairment, untreated of untreatable hypothyroidism, low sodium levels.

      Side-effects:
      Common side effects include nausea, tremor, polyuria/polydipsia, rash/dermatitis, blurred vision, dizziness, decreased appetite, drowsiness, metallic taste, and diarrhea. Side-effects are often dose-related.

      Long-term use is associated with hypothyroidism, hyperthyroidism, hypercalcemia/hyperparathyroidism, irreversible nephrogenic diabetes insipidus, and reduced GFR.

      Lithium-induced diabetes insipidus:
      Treatment options include stopping lithium (if feasible), keeping levels within 0.4-0.8 mmol/L, once-daily dose of the drug taken at bedtime, amiloride, thiazide diuretics, indomethacin, and desmopressin.

      Toxicity:
      Lithium salts have a narrow therapeutic/toxic ratio. Risk factors for lithium toxicity include drugs altering renal function, decreased circulating volume, infections, fever, decreased oral intake of water, renal insufficiency, and nephrogenic diabetes insipidus. Features of lithium toxicity include GI symptoms and neuro symptoms.

      Pre-prescribing:
      Before prescribing lithium, renal function, cardiac function, thyroid function, FBC, and BMI should be checked. Women of childbearing age should be advised regarding contraception, and information about toxicity should be provided.

      Monitoring:
      Lithium blood levels should be checked weekly until stable, and then every 3-6 months once stable. Thyroid and renal function should be checked every 6 months. Patients should be issued with an information booklet, alert card, and record book.

    • This question is part of the following fields:

      • Psychopharmacology
      25.2
      Seconds
  • Question 15 - Which of the following factors does not increase the risk of developing SIADH?...

    Incorrect

    • Which of the following factors does not increase the risk of developing SIADH?

      Your Answer: Low baseline sodium levels

      Correct Answer: Male gender

      Explanation:

      Hyponatremia in Psychiatric Patients

      Hyponatremia, of low serum sodium, can occur in psychiatric patients due to the disorder itself, its treatment, of other medical conditions. Symptoms include nausea, confusion, seizures, and muscular cramps. Drug-induced hyponatremia is known as the syndrome of inappropriate antidiuretic hormone hypersecretion (SIADH), which results from excessive secretion of ADH and fluid overload. Diagnosis is based on clinically euvolaemic state with low serum sodium and osmolality, raised urine sodium and osmolality. SSRIs, SNRIs, and tricyclics are the most common drugs that can cause SIADH. Risk factors for SIADH include starting a new drug, and treatment usually involves fluid restriction and sometimes demeclocycline.

    • This question is part of the following fields:

      • Psychopharmacology
      105.9
      Seconds
  • Question 16 - What is the meaning of a drug's half-life? ...

    Correct

    • What is the meaning of a drug's half-life?

      Your Answer: Drugs which follow first order kinetics have a fixed half life

      Explanation:

      The half-life of a drug is the time taken for its concentration to fall to one half of its value. Drugs with long half-lives may require a loading dose to achieve therapeutic plasma concentrations rapidly. It takes about 4.5 half-lives to reach steady state plasma levels. Most drugs follow first order kinetics, where a constant fraction of the drug in the body is eliminated per unit time. However, some drugs may follow zero order kinetics, where the plasma concentration of the drug decreases at a constant rate, despite the concentration of the drug. For drugs with nonlinear kinetics of dose-dependent kinetics, the relationship between the AUC of CSS and dose is not linear, and the kinetic parameters may vary depending on the administered dose.

    • This question is part of the following fields:

      • Psychopharmacology
      38
      Seconds
  • Question 17 - You are evaluating a 28-year-old male patient who has been referred to you...

    Correct

    • You are evaluating a 28-year-old male patient who has been referred to you by his primary care physician. He has a history of hyper-sexuality and reports that he engages in masturbation up to 8 times a day. He states that he is constantly preoccupied with sexual thoughts and is attracted to post-pubescent girls around the age of 16. He has a prior conviction for indecent exposure and grooming offenses. What is the most effective antidepressant treatment for his paraphilic disorder?

      Your Answer: Sertraline

      Explanation:

      Sertraline and other selective serotonin reuptake inhibitors (SSRIs) are effective in treating paraphilias by reducing libido and delaying orgasm. While all serotonergic antidepressants have sexual effects, they are most common with SSRIs. Although these effects are typically considered side effects, they can be beneficial in treating paraphilias.

      Sexual side effects are prevalent with many antidepressants, with SSRIs having the highest incidence at 60-70%. Venlafaxine has a 70% incidence, duloxetine has a 46% incidence, monoamine oxidase inhibitors (MAOIs) have a 40% incidence, tricyclic antidepressants (TCAs) have a 30% incidence (but are more common with clomipramine), mirtazapine has a 25% incidence, reboxetine has a 5-10% incidence, and the incidence with trazodone is unknown.

      Cyproterone acetate (Androcur) is an effective treatment for hypersexuality as an anti-androgen that reduces testosterone to pre-pubescent levels. These findings are based on the Maudsley Guidelines, 11th edition, page 210.

    • This question is part of the following fields:

      • Psychopharmacology
      66.5
      Seconds
  • Question 18 - Can you provide an instance of a pareidolic illusion? ...

    Correct

    • Can you provide an instance of a pareidolic illusion?

      Your Answer: An elderly man is able to see the face of his grandchild in the clouds as they pass over him

      Explanation:

      The man’s longing for his girlfriend and the traveller’s thirst create affect illusions, distorting their perceptions. The woman who hears her mother when she sees the door open experiences a reflex hallucination, while the man who hears his wife’s voice describing something outside of his surroundings experiences an extracampine hallucination.

      Altered Perceptual Experiences

      Disorders of perception can be categorized into sensory distortions and sensory deceptions. Sensory distortions involve changes in the intensity, spatial form, of quality of a perception. Examples include hyperaesthesia, hyperacusis, and micropsia. Sensory deceptions, on the other hand, involve new perceptions that are not based on any external stimulus. These include illusions and hallucinations.

      Illusions are altered perceptions of a stimulus, while hallucinations are perceptions in the absence of a stimulus. Completion illusions, affect illusions, and pareidolic illusions are examples of illusions. Auditory, visual, gustatory, olfactory, and tactile hallucinations are different types of hallucinations. Pseudohallucinations are involuntary and vivid sensory experiences that are interpreted in a non-morbid way. They are different from true hallucinations in that the individual is able to recognize that the experience is an internally generated event.

      Understanding the different types of altered perceptual experiences is important in the diagnosis and treatment of various mental health conditions.

    • This question is part of the following fields:

      • Classification And Assessment
      41.4
      Seconds
  • Question 19 - What gene is thought to increase the likelihood of individuals developing frontotemporal dementia?...

    Incorrect

    • What gene is thought to increase the likelihood of individuals developing frontotemporal dementia?

      Your Answer: Presenilin-1

      Correct Answer: Progranulin

      Explanation:

      Genes Associated with Dementia

      Dementia is a complex disorder that can be caused by various genetic and environmental factors. Several genes have been implicated in different forms of dementia. For instance, familial Alzheimer’s disease, which represents less than 1-6% of all Alzheimer’s cases, is associated with mutations in PSEN1, PSEN2, APP, and ApoE genes. These mutations are inherited in an autosomal dominant pattern. On the other hand, late-onset Alzheimer’s disease is a genetic risk factor associated with the ApoE gene, particularly the APOE4 allele. However, inheriting this allele does not necessarily mean that a person will develop Alzheimer’s.

      Other forms of dementia, such as familial frontotemporal dementia, Huntington’s disease, CADASIL, and dementia with Lewy bodies, are also associated with specific genes. For example, C9orf72 is the most common mutation associated with familial frontotemporal dementia, while Huntington’s disease is caused by mutations in the HTT gene. CADASIL is associated with mutations in the Notch3 gene, while dementia with Lewy bodies is associated with the APOE, GBA, and SNCA genes.

      In summary, understanding the genetic basis of dementia is crucial for developing effective treatments and preventive measures. However, it is important to note that genetics is only one of the many factors that contribute to the development of dementia. Environmental factors, lifestyle choices, and other health conditions also play a significant role.

    • This question is part of the following fields:

      • Genetics
      22.1
      Seconds
  • Question 20 - What is the most common subtype of Creutzfeldt-Jakob disease (CJD) that is responsible...

    Incorrect

    • What is the most common subtype of Creutzfeldt-Jakob disease (CJD) that is responsible for the majority of cases?

      Your Answer: fCJD

      Correct Answer: sCJDMM1 and sCJDMV1

      Explanation:

      CJD has several subtypes, including familial (fCJD), iatrogenic (iCJD), sporadic (sCJD), and new variant (vCJD). The most common subtype is sCJD, which makes up 85% of cases. sCJD can be further classified based on the MV polymorphisms at codon 129 of the PRNP gene, with sCJDMM1 and sCJDMV1 being the most prevalent subtypes. fCJD is the most common subtype after sCJD, while vCJD and iCJD are rare and caused by consuming contaminated food of tissue contamination from other humans, respectively.

    • This question is part of the following fields:

      • Neurosciences
      12.9
      Seconds
  • Question 21 - A junior colleague calls you about a patient on one of the pediatric...

    Correct

    • A junior colleague calls you about a patient on one of the pediatric wards. They have fallen over and sustained a head injury. They tell you that the patient is orientated in time, place, and person, is opening their eyes when spoken to, and obeys commands such as put you finger to your nose. What is the patients Glasgow Coma Scale score?

      Your Answer: 14

      Explanation:

      The total score of E3 V5 M6 is 14.

      The Glasgow Coma Scale is used to assess the depth of coma and impaired consciousness. Scores range from 3 to 15, with impaired consciousness rated as mild, moderate, of severe. The scale assesses eye opening response, verbal response, and motor response, with specific criteria for scoring each behavior. The final score is a combination of these three scores.
      Scoring Guide;
      Eye opening response
      4 Spontaneous opening
      3 Opens to verbal stimuli
      2 Opens to pain
      1 No response
      Verbal response
      5 Orientated
      4 Confused conversation
      3 Inappropriate words
      2 Incoherent
      1 No response
      Motor response
      6 Obeys commands
      5 Purposeful movement to painful stimuli
      4 Withdraws in response to pain
      3 Flexion in response to pain (decorticate posturing)
      2 Extension in response to pain (decerebrate posturing)
      1 No response

    • This question is part of the following fields:

      • Classification And Assessment
      34.8
      Seconds
  • Question 22 - Which statement accurately describes the FAST questionnaire for alcohol misuse? ...

    Incorrect

    • Which statement accurately describes the FAST questionnaire for alcohol misuse?

      Your Answer: The maximum score is 20

      Correct Answer: May be stopped after first question depending on the answer

      Explanation:

      Alcohol screening tools are available to assist in the diagnosis of alcohol problems. One such tool is the AUDIT (Alcohol Use Disorders Identification Test), which consists of 10 questions and covers harmful use, hazardous use, and dependence. Another tool is the FAST (Fast Alcohol Screening Test), which has just 4 questions and was developed for use in a busy medical setting. The CAGE is a well-known 4 question screening tool, but recent research has questioned its value. Other tools include SASQ (Single alcohol screening questionnaire), PAT (Paddington Alcohol Test), MAST (Michigan Alcoholism Screening Test), and RAPS4 (Rapid Alcohol Problem Screen 4). These tools can help identify hazardous of harmful alcohol consumption and alcohol dependence.

    • This question is part of the following fields:

      • Classification And Assessment
      30.5
      Seconds
  • Question 23 - In Freud's topographical model of the mind, which term was not included in...

    Correct

    • In Freud's topographical model of the mind, which term was not included in his description?

      Your Answer: Subconscious system

      Explanation:

      Freud’s Topographical Model of the Mind

      Freud’s topographical model of the mind, introduced in his book The Interpretation of Dreams, divides the mind into three regions: the conscious system, the preconscious system, and the unconscious system.

      The conscious system refers to the part of the mind that is aware. The preconscious system is the information that is known and can potentially be brought into consciousness. Finally, the unconscious system is believed to be outside conscious awareness and operates on primary process thinking, which is aimed at wish fulfillment. It is governed by the pleasure principle, has no concept of time, denies the existence of negatives, and allows the existence of contradictions, making it irrational.

    • This question is part of the following fields:

      • Social Psychology
      21
      Seconds
  • Question 24 - What is the term used by Freud to describe the process through which...

    Incorrect

    • What is the term used by Freud to describe the process through which people release their aggressive impulses?

      Your Answer: Sublimation

      Correct Answer: Catharsis

      Explanation:

      Theories of aggression can be categorized into three main perspectives: psychodynamic, sociological/drive, and cognitive and learning. Psychodynamic theory, proposed by Freud, suggests that aggression arises from a primary instinct called thanatos, which aims for destruction and death. Sociobiological/drive theory, proposed by Lorenz, suggests that aggression is instinctual and necessary for survival, and that stronger genes are selected through aggression. Cognitive and learning theory, proposed by Berkowitz, Rotter, Bandura, and Anderson, suggests that aggression can be learned through observational learning and is influenced by environmental factors. Bandura’s work introduced the concept of reciprocal determinism, which suggests that behavior is influenced by both the environment and the individual’s behavior. Rotter’s social learning theory emphasizes the interaction between the individual and their environment, while Anderson and Bushman’s general aggression model considers the role of social, cognitive, developmental, and biological factors on aggression.

    • This question is part of the following fields:

      • Social Psychology
      34
      Seconds
  • Question 25 - What is the lowest daily amount of sertraline that is effective for treating...

    Correct

    • What is the lowest daily amount of sertraline that is effective for treating depression in adults?

      Your Answer: 50 mg

      Explanation:

      Antidepressants: Minimum Effective Doses

      According to the Maudsley 13th, the following are the minimum effective doses for various antidepressants:

      – Citalopram: 20 mg/day
      – Fluoxetine: 20 mg/day
      – Fluvoxamine: 50 mg/day
      – Paroxetine: 20 mg/day
      – Sertraline: 50 mg/day
      – Mirtazapine: 30 mg/day
      – Venlafaxine: 75 mg/day
      – Duloxetine: 60 mg/day
      – Agomelatine: 25 mg/day
      – Moclobemide: 300 mg/day
      – Trazodone: 150 mg/day

      Note that these are minimum effective doses and may vary depending on individual factors and response to treatment. It is important to consult with a healthcare professional before starting of changing any medication regimen.

    • This question is part of the following fields:

      • Psychopharmacology
      13
      Seconds
  • Question 26 - Which statement about Wilson's disease is accurate? ...

    Incorrect

    • Which statement about Wilson's disease is accurate?

      Your Answer: It is associated with degeneration of the limbic system

      Correct Answer: In Wilson's disease the total serum copper is usually low

      Explanation:

      Understanding Wilson’s Disease: Causes, Symptoms, and Management

      Wilson’s disease, also known as hepatolenticular degeneration, is a genetic disorder that affects copper storage in the body. This condition is caused by a defect in the ATP7B gene, which leads to the accumulation of copper in the liver and brain. The onset of symptoms usually occurs between the ages of 10 and 25, with liver disease being the most common presentation in children and neurological symptoms in young adults.

      The excessive deposition of copper in the tissues can cause a range of symptoms, including hepatitis, cirrhosis, basal ganglia degeneration, speech and behavioral problems, asterixis, chorea, dementia, Kayser-Fleischer rings, sunflower cataract, renal tubular acidosis, haemolysis, and blue nails. Diagnosis is based on reduced serum ceruloplasmin, reduced serum copper, and increased 24-hour urinary copper excretion.

      The traditional first-line treatment for Wilson’s disease is penicillamine, which chelates copper. Trientine hydrochloride is an alternative chelating agent that may become first-line treatment in the future. Tetrathiomolybdate is a newer agent that is currently under investigation.

      In summary, Wilson’s disease is a genetic disorder that affects copper storage in the body, leading to a range of symptoms that can affect the liver, brain, and eyes. Early diagnosis and treatment are essential to prevent complications and improve outcomes.

    • This question is part of the following fields:

      • Classification And Assessment
      29.5
      Seconds
  • Question 27 - What is the likely diagnosis when a patient exhibits a normal accommodation reflex...

    Incorrect

    • What is the likely diagnosis when a patient exhibits a normal accommodation reflex but an absent light reflex during a pupil examination?

      Your Answer: Horner's pupil

      Correct Answer: Argyll Robertson pupil

      Explanation:

      Argyll Robertson Pupil: Accommodation Retained

      The Argyll Robertson pupil is a notable topic in medical exams, as it is associated with tertiary syphilis, which is a crucial differential diagnosis for various psychiatric conditions like mood disorders, dementia, and psychosis. This type of pupil reacts poorly to light but normally to near stimuli, such as accommodation and convergence. They are typically small and irregular in shape, but they do not usually affect visual acuity. Mydriatic agents are not effective in dilating the Argyll Robertson pupil. Although this type of pupil is often considered pathognomonic of tertiary syphilis, it has also been observed in diabetes.

    • This question is part of the following fields:

      • Classification And Assessment
      55.2
      Seconds
  • Question 28 - What brain structure is involved in the reward system and receives dopaminergic input...

    Correct

    • What brain structure is involved in the reward system and receives dopaminergic input from the ventral tegmental area through the mesolimbic dopamine pathway?

      Your Answer: Nucleus accumbens

      Explanation:

      Brain Anatomy

      The brain is a complex organ with various regions responsible for different functions. The major areas of the cerebrum (telencephalon) include the frontal lobe, parietal lobe, occipital lobe, temporal lobe, insula, corpus callosum, fornix, anterior commissure, and striatum. The cerebrum is responsible for complex learning, language acquisition, visual and auditory processing, memory, and emotion processing.

      The diencephalon includes the thalamus, hypothalamus and pituitary, pineal gland, and mammillary body. The thalamus is a major relay point and processing center for all sensory impulses (excluding olfaction). The hypothalamus and pituitary are involved in homeostasis and hormone release. The pineal gland secretes melatonin to regulate circadian rhythms. The mammillary body is a relay point involved in memory.

      The cerebellum is primarily concerned with movement and has two major hemispheres with an outer cortex made up of gray matter and an inner region of white matter. The cerebellum provides precise timing and appropriate patterns of skeletal muscle contraction for smooth, coordinated movements and agility needed for daily life.

      The brainstem includes the substantia nigra, which is involved in controlling and regulating activities of the motor and premotor cortical areas for smooth voluntary movements, eye movement, reward seeking, the pleasurable effects of substance misuse, and learning.

    • This question is part of the following fields:

      • Neurosciences
      40.1
      Seconds
  • Question 29 - What is the term used in Piaget's theory of child development to describe...

    Incorrect

    • What is the term used in Piaget's theory of child development to describe the process of modifying a schema based on new information?

      Your Answer: Assimilation

      Correct Answer: Accommodation

      Explanation:

      Piaget’s Stages of Development and Key Concepts

      Piaget developed four stages of development that describe how children think and acquire knowledge. The first stage is the Sensorimotor stage, which occurs from birth to 18-24 months. In this stage, infants learn through sensory observation and gain control of their motor functions through activity, exploration, and manipulation of the environment.

      The second stage is the Preoperational stage, which occurs from 2 to 7 years. During this stage, children use symbols and language more extensively, but they are unable to think logically of deductively. They also use a type of magical thinking and animistic thinking.

      The third stage is the Concrete Operational stage, which occurs from 7 to 11 years. In this stage, egocentric thought is replaced by operational thought, which involves dealing with a wide array of information outside the child. Children in this stage begin to use limited logical thought and can serialise, order, and group things into classes on the basis of common characteristics.

      The fourth and final stage is the Formal Operations stage, which occurs from 11 through the end of adolescence. This stage is characterized by the ability to think abstractly, to reason deductively, to define concepts, and also by the emergence of skills for dealing with permutations and combinations.

      Piaget also developed key concepts, including schema, assimilation, and accommodation. A schema is a category of knowledge and the process of obtaining that knowledge. Assimilation is the process of taking new information into an existing schema, while accommodation involves altering a schema in view of additional information.

      Overall, Piaget’s stages of development and key concepts provide a framework for understanding how children learn and acquire knowledge.

    • This question is part of the following fields:

      • Psychological Development
      8.5
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  • Question 30 - Which of the following is an example of an extracampine hallucination? ...

    Correct

    • Which of the following is an example of an extracampine hallucination?

      Your Answer: A patient hears their brother shouting at them from another country

      Explanation:

      Altered Perceptual Experiences

      Disorders of perception can be categorized into sensory distortions and sensory deceptions. Sensory distortions involve changes in the intensity, spatial form, of quality of a perception. Examples include hyperaesthesia, hyperacusis, and micropsia. Sensory deceptions, on the other hand, involve new perceptions that are not based on any external stimulus. These include illusions and hallucinations.

      Illusions are altered perceptions of a stimulus, while hallucinations are perceptions in the absence of a stimulus. Completion illusions, affect illusions, and pareidolic illusions are examples of illusions. Auditory, visual, gustatory, olfactory, and tactile hallucinations are different types of hallucinations. Pseudohallucinations are involuntary and vivid sensory experiences that are interpreted in a non-morbid way. They are different from true hallucinations in that the individual is able to recognize that the experience is an internally generated event.

      Understanding the different types of altered perceptual experiences is important in the diagnosis and treatment of various mental health conditions.

    • This question is part of the following fields:

      • Classification And Assessment
      32
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Neurosciences (4/5) 80%
Classification And Assessment (6/10) 60%
Psychopharmacology (4/9) 44%
Genetics (0/2) 0%
Psychological Development (0/2) 0%
Social Psychology (1/2) 50%
Passmed