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Question 1
Correct
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A 72-year-old man is brought by ambulance to the Accident and Emergency department. He is visibly distressed but gives a history of sudden onset central compressive chest pain radiating to his left upper limb. He is also nauseous and very sweaty. He has had previous myocardial infarctions (MI) in the past and claims the pain is identical to those episodes. ECG reveals an anterior ST elevation MI.
Which of the following is an absolute contraindication to thrombolysis?Your Answer: Brain neoplasm
Explanation:Relative and Absolute Contraindications to Thrombolysis
Thrombolysis is a treatment option for patients with ongoing cardiac ischemia and presentation within 12 hours of onset of pain. However, there are both relative and absolute contraindications to this treatment.
Absolute contraindications include internal or heavy PV bleeding, acute pancreatitis or severe liver disease, esophageal varices, active lung disease with cavitation, recent trauma or surgery within the past 2 weeks, severe hypertension (>200/120 mmHg), suspected aortic dissection, recent hemorrhagic stroke, cerebral neoplasm, and previous allergic reaction.
Relative contraindications include prolonged CPR, history of CVA, bleeding diathesis, anticoagulation, blood pressure of 180/100 mmHg, peptic ulcer, and pregnancy or recent delivery.
It is important to consider these contraindications before administering thrombolysis as they can increase the risk of complications. Primary percutaneous coronary intervention is the preferred treatment option, but if not available, thrombolysis can be a viable alternative. The benefit of thrombolysis decreases over time, and a target time of <30 minutes from admission for commencement of thrombolysis is typically recommended.
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This question is part of the following fields:
- Cardiology
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Question 2
Incorrect
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An 82-year-old man has been experiencing increasing shortness of breath, tiredness, intermittent chest pain and leg swelling for the past 6 months. He recently underwent an echocardiogram as an outpatient which revealed evidence of heart failure. As the FY1 on the Medical Assessment Unit, you have been tasked with taking the patient's medical history. He has a history of hypertension and gout and is currently taking diltiazem (calcium-channel blocker) 60 mg po bd, furosemide (diuretic) 20 mg po od, Spironolactone 25mg od, allopurinol 100 mg po od, paracetamol 1 g po qds prn, and lisinopril 20 mg po od. Considering his likely diagnosis of heart failure, which medication should be discontinued?
Your Answer: Allopurinol
Correct Answer: Diltiazem
Explanation:Medications for Heart Failure: Understanding their Effects
Heart failure is a complex condition that requires careful management, including the use of various medications. In this context, it is important to understand the effects of each drug and how they can impact the patient’s health. Here is a brief overview of some commonly used medications for heart failure and their effects:
Diltiazem: This calcium-channel blocker can be used to treat angina and hypertension. However, it is advisable to stop calcium-channel blockers in patients with heart disease, as they can reduce the contractility of the heart, exacerbating the condition.
Spironolactone: This drug can help alleviate leg swelling by reducing water retention. It is also one of the three drugs in heart failure that have been shown to reduce mortality, along with ACE inhibitors and b-blockers.
Allopurinol: This medication is used in the prevention of gout long term and has no detrimental effect on the heart.
Paracetamol: This drug does not have an effect on the heart.
Lisinopril: This ACE inhibitor is used in the treatment of hypertension and the prophylactic treatment of angina. Stopping this medication is likely to worsen heart failure. Like spironolactone and b-blockers, ACE inhibitors have been shown to reduce mortality in heart failure, although the mechanisms behind this effect are not fully understood.
In summary, understanding the effects of medications for heart failure is crucial for optimizing patient care and improving outcomes. Healthcare providers should carefully consider each drug’s benefits and risks and tailor treatment to the individual patient’s needs.
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This question is part of the following fields:
- Cardiology
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Question 3
Incorrect
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A 70-year-old man with a history of hyperlipidaemia, hypertension and angina arrives at the Emergency Department with severe chest pain that radiates down his left arm. He is sweating heavily and the pain does not subside with rest or sublingual nitroglycerin. An electrocardiogram (ECG) reveals ST segment elevation in leads II, III and avF.
What is the leading cause of death within the first hour after the onset of symptoms in this patient?Your Answer: Emboli from a left ventricular thrombus
Correct Answer: Arrhythmia
Explanation:After experiencing an inferior-wall MI, the most common cause of death within the first hour is a lethal arrhythmia, such as ventricular fibrillation. This can be caused by various factors, including ischaemia, toxic metabolites, or autonomic stimulation. If ventricular fibrillation occurs within the first 48 hours, it may be due to transient causes and not affect long-term prognosis. However, if it occurs after 48 hours, it is usually indicative of permanent dysfunction and associated with a worse long-term prognosis. Other complications that may occur after an acute MI include emboli from a left ventricular thrombus, cardiac tamponade, ruptured papillary muscle, and pericarditis. These complications typically occur at different time frames after the acute MI and present with different symptoms.
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This question is part of the following fields:
- Cardiology
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Question 4
Incorrect
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A 75-year-old man presents to his General Practitioner with chest pain. The man reports the pain as crushing in nature, exacerbated by exertion, particularly when climbing stairs in his home. The pain is typically relieved by rest, but he has experienced several episodes while watching television in the past two weeks. He has no other medical history and is generally in good health.
What is the most suitable course of action?Your Answer: Prescribe glyceryl trinitrate (GTN) spray, two puffs sublingual, and send home
Correct Answer: Refer to hospital for admission for observation and urgent elective angiogram
Explanation:Appropriate Management for a Patient with Unstable Angina
Unstable angina is a serious condition that requires urgent medical attention. In the case of a patient displaying textbook signs of unstable angina, such as crushing chest pain occurring at rest, admission to the hospital is necessary. Sending the patient home with only glyceryl trinitrate (GTN) spray is not appropriate, as the patient is at high risk of having a myocardial infarction (MI). Instead, the patient should be seen by Cardiology for consideration of an urgent elective angiogram.
Prescribing ramipril and simvastatin is not indicated unless there is evidence of hypertension. Lifestyle advice, including exercise recommendation, is also not appropriate for a patient with unstable angina. The immediate problem should be addressed first, which is the need for an angiogram.
It is important to differentiate between unstable and stable angina. Unstable angina presents with symptoms at rest, indicating a significant worsening of the patient’s cardiac disease. On the other hand, stable angina only presents with symptoms on exertion.
Sending the patient for percutaneous coronary intervention (PCI) is not necessary unless there is evidence of an MI. The pain experienced due to angina will alleviate itself most commonly at rest, unless the angina is unstable. Therefore, an urgent elective angiogram is the appropriate management for a patient with unstable angina.
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This question is part of the following fields:
- Cardiology
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Question 5
Correct
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A 65 year old man with a BMI of 29 was diagnosed with borderline hypertension during a routine check-up with his doctor. He is hesitant to take any medications. What dietary recommendations should be given to help lower his blood pressure?
Your Answer: Consume a diet rich in fruits and vegetables
Explanation:Tips for a Hypertension-Friendly Diet
Maintaining a healthy diet is crucial for managing hypertension. Here are some tips to help you make the right food choices:
1. Load up on fruits and vegetables: Consuming a diet rich in fruits and vegetables can reduce blood pressure by 2-8 mmHg in hypertensive patients. It can also aid in weight loss, which further lowers the risk of hypertension.
2. Limit cholesterol intake: A reduction in cholesterol is essential for patients with ischaemic heart disease, and eating foods that are low in fat and cholesterol can reduce blood pressure.
3. Moderate alcohol consumption: Men should have no more than two alcoholic drinks daily to lower their risk of hypertension.
4. Eat oily fish twice a week: Eating more fish can help lower blood pressure, but having oily fish twice weekly is advised for patients with ischaemic heart disease, not hypertension alone.
5. Watch your sodium intake: Restricting dietary sodium is recommended and can lower blood pressure. A low sodium diet contains less than 2 g of sodium daily. Aim for a maximum of 7 g of dietary sodium daily.
By following these tips, you can maintain a hypertension-friendly diet and reduce your risk of complications.
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This question is part of the following fields:
- Cardiology
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Question 6
Incorrect
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A 25-year-old man with a known harsh ejection systolic murmur on cardiac examination collapses and passes away during a sporting event. His father and uncle also died suddenly in their forties. The reason for death is identified as an obstruction of the ventricular outflow tract caused by an abnormality in the ventricular septum.
What is the accurate diagnosis for this condition?Your Answer: Ventricular septal defect
Correct Answer: Hypertrophic cardiomyopathy
Explanation:Types of Cardiomyopathy and Congenital Heart Defects
Cardiomyopathy is a group of heart diseases that affect the structure and function of the heart muscle. There are different types of cardiomyopathy, each with its own causes and symptoms. Additionally, there are congenital heart defects that can affect the heart’s structure and function from birth. Here are some of the most common types:
1. Hypertrophic cardiomyopathy: This is an inherited condition that causes the heart muscle to thicken, making it harder for the heart to pump blood. It can lead to sudden death in young athletes.
2. Restrictive cardiomyopathy: This is a rare form of cardiomyopathy that is caused by diseases that restrict the heart’s ability to fill with blood during diastole.
3. Dilated cardiomyopathy: This is the most common type of cardiomyopathy, which causes the heart chambers to enlarge and weaken, leading to heart failure.
4. Mitral stenosis: This is a narrowing of the mitral valve, which can impede blood flow between the left atrium and ventricle.
In addition to these types of cardiomyopathy, there are also congenital heart defects, such as ventricular septal defect, which is the most common congenital heart defect. This condition creates a direct connection between the right and left ventricles, affecting the heart’s ability to pump blood effectively.
Understanding the different types of cardiomyopathy and congenital heart defects is important for proper diagnosis and treatment. If you experience symptoms such as chest pain, shortness of breath, or fatigue, it is important to seek medical attention promptly.
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This question is part of the following fields:
- Cardiology
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Question 7
Incorrect
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A 56-year-old, 80 kg woman arrives at the Emergency Department complaining of chest pain that began 5 hours ago. She has no known allergies and is not taking any regular medications. Her electrocardiogram shows T-wave inversion in lateral leads but no ST changes, and her serum troponin level is significantly elevated. What is the appropriate combination of drugs to administer immediately?
Your Answer: Aspirin 300 mg, clopidogrel 75 mg, fondaparinux 2.5 mg
Correct Answer: Aspirin 300 mg, prasugrel 60 mg, fondaparinux 2.5 mg
Explanation:For patients with different combinations of medications, the appropriate treatment plan may vary. In general, aspirin should be given as soon as possible and other medications may be added depending on the patient’s condition and the likelihood of undergoing certain procedures. For example, if angiography is not planned within 24 hours of admission, a loading dose of aspirin and prasugrel with fondaparinux may be given. If PCI is planned, unfractionated heparin may be considered. The specific dosages and medications may differ based on the patient’s individual needs and risk factors.
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This question is part of the following fields:
- Cardiology
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Question 8
Incorrect
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A woman is evaluated in the Emergency Department for acute-onset shortness of breath. The doctor notices that the patient’s jugular veins distend when she inspires, even while sitting upright.
Which of the following processes could explain this observation?Your Answer: The patient has venous insufficiency
Correct Answer: The patient has constrictive pericarditis
Explanation:Understanding the Relationship between Neck Veins and Various Medical Conditions
The appearance of neck veins can provide valuable information about a patient’s health. Here are some examples of how different medical conditions can affect the appearance of neck veins:
1. Constrictive pericarditis: This condition restricts the heart’s ability to expand, leading to higher pressures within the right heart. This can cause jugular venous distension, which is more pronounced during inspiration (Kussmaul’s sign).
2. Dehydration: A decrease in intravascular blood volume can cause flattened neck veins.
3. Venous insufficiency: Incompetent venous valves can lead to venous stasis and pooling of blood in the lower extremities. This can cause syncope due to decreased venous return to the heart.
4. Budd-Chiari syndrome and hepatic vein thrombosis: These conditions involve blood clots in the hepatic vein or inferior vena cava, which prevent blood from returning to the right heart from the abdomen and lower extremities. This decreases the pressure in the right heart and allows blood to drain more easily from the jugular and neck veins, resulting in flattened neck veins.
Understanding the relationship between neck veins and various medical conditions can aid in diagnosis and treatment.
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This question is part of the following fields:
- Cardiology
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Question 9
Incorrect
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During a Cardiology Ward round, a 69-year-old woman with worsening shortness of breath on minimal exertion is examined by a medical student. While checking the patient's jugular venous pressure (JVP), the student observes that the patient has giant v-waves. What is the most probable cause of a large JVP v-wave (giant v-wave)?
Your Answer: Cardiac tamponade
Correct Answer: Tricuspid regurgitation
Explanation:Lachmann test
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This question is part of the following fields:
- Cardiology
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Question 10
Incorrect
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A 30-year-old woman with rheumatic fever has ongoing shortness of breath following her infection. You suspect she may have mitral stenosis.
What is the most suitable surface anatomical landmark to listen for this murmur?Your Answer: Fifth intercostal space, mid-axillary line
Correct Answer: At the apex beat
Explanation:Surface Locations for Cardiac Auscultation
Cardiac auscultation is a crucial part of a physical examination to assess the heart’s function. The surface locations for cardiac auscultation are essential to identify the specific valve sounds. Here are the surface locations for cardiac auscultation:
1. Apex Beat: The mitral valve is best heard over the palpated apex beat. If it cannot be felt, then it should be assumed to be in the fifth intercostal space, mid-clavicular line.
2. Fifth Intercostal Space, Mid-Axillary Line: This location is too lateral to hear a mitral valve lesion in a non-dilated ventricle.
3. Second Intercostal Space, Left of the Sternum: The pulmonary valve is located in the second intercostal space, left of the sternum.
4. Fourth Intercostal Space, Left of the Sternum: The tricuspid valve is located in the fourth intercostal space, left of the sternum.
5. Xiphisternum: The xiphisternum is not used as a marker for cardiac auscultation, though it is used to guide echocardiography for certain standard views.
Knowing the surface locations for cardiac auscultation is crucial to identify the specific valve sounds and assess the heart’s function accurately.
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This question is part of the following fields:
- Cardiology
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Question 11
Incorrect
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A 57-year-old man arrives at the Emergency Department with sudden onset central crushing chest pain. The patient reports feeling pain in his neck and jaw as well. He has no significant medical history, but he does smoke socially and consumes up to 60 units of alcohol per week. An ECG is performed, revealing widespread ST elevation indicative of an acute coronary syndrome.
What is the earliest point at which the microscopic changes of acute MI become apparent?Your Answer:
Correct Answer: 12-24 hours after the infarct
Explanation:The Pathological Progression of Myocardial Infarction: A Timeline of Changes
Myocardial infarction, commonly known as a heart attack, is a serious medical condition that occurs when blood flow to the heart is blocked, leading to tissue damage and potentially life-threatening complications. The pathological progression of myocardial infarction follows a predictable sequence of events, with macroscopic and microscopic changes occurring over time.
Immediately after the infarct occurs, there are usually no visible changes to the myocardium. However, within 3-6 hours, maximal inflammatory changes occur, with the most prominent changes occurring between 24-72 hours. During this time, coagulative necrosis and acute inflammatory responses are visible, with marked infiltration by neutrophils.
Between 3-10 days, the infarcted area begins to develop a hyperaemic border, and the process of organisation and repair begins. Granulation tissue replaces dead muscle, and dying neutrophils are replaced by macrophages. Disintegration and phagocytosis of dead myofibres occur during this time.
If a patient survives an acute infarction, the infarct heals through the formation of scar tissue. However, scar tissue does not possess the usual contractile properties of normal cardiac muscle, leading to contractile dysfunction or congestive cardiac failure. The entire process from coagulative necrosis to the formation of well-formed scar tissue takes 6-8 weeks.
In summary, understanding the timeline of changes that occur during myocardial infarction is crucial for early diagnosis and effective treatment. By recognising the macroscopic and microscopic changes that occur over time, healthcare professionals can provide appropriate interventions to improve patient outcomes.
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This question is part of the following fields:
- Cardiology
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Question 12
Incorrect
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A man in his early 40s comes to you with a rash. Upon examination, you notice that he has eruptive xanthoma. What is the most probable diagnosis?
Your Answer:
Correct Answer: Familial hypertriglyceridaemia
Explanation:Eruptive Xanthoma and its Association with Hypertriglyceridaemia and Diabetes Mellitus
Eruptive xanthoma is a skin condition that can occur in individuals with hypertriglyceridaemia and uncontrolled diabetes mellitus. Hypertriglyceridaemia is a condition characterized by high levels of triglycerides in the blood, which can be caused by a number of factors including genetics, diet, and lifestyle. Eruptive xanthoma is a type of xanthoma that appears as small, yellowish bumps on the skin, often in clusters.
Of the conditions listed, familial hypertriglyceridaemia is the most likely to be associated with eruptive xanthoma. This is a genetic condition that causes high levels of triglycerides in the blood, and can lead to a range of health problems including cardiovascular disease. Uncontrolled diabetes mellitus, which is characterized by high blood sugar levels, can also be a risk factor for eruptive xanthoma.
It is important for individuals with hypertriglyceridaemia or diabetes mellitus to manage their condition through lifestyle changes and medication, in order to reduce the risk of complications such as eruptive xanthoma. Regular monitoring and treatment can help to prevent the development of this skin condition and other related health problems.
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This question is part of the following fields:
- Cardiology
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Question 13
Incorrect
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What is the most accurate statement regarding the electrocardiograph?
Your Answer:
Correct Answer: ST depression and tall R waves in leads V1 and V2 are consistent with a diagnosis of a posterior myocardial infarction
Explanation:Common ECG Findings and Their Significance
Electrocardiogram (ECG) is a valuable tool in diagnosing various cardiac conditions. Here are some common ECG findings and their significance:
1. ST depression and tall R waves in leads V1 and V2 are consistent with a diagnosis of a posterior myocardial infarction.
2. Pneumonia causes low-voltage QRS complexes. This can be caused by the dampening effect of extra layers of fat, fluid, or air between the heart and thoracic wall.
3. The corrected QT interval (QTc) is calculated by Bazett’s formula: QTc = QT interval ÷ square root of the RR interval (in seconds).
4. A 2-mm ST elevation in leads II, III, aVF, V4, and V5 is consistent with an anterior myocardial infarction. This suggests an inferior lateral infarction, as opposed to just an inferior myocardial infarction.
5. The S1Q3T3 pattern is seen in up to 20% of patients with a pulmonary embolism. Sinus tachycardia is the most common ECG abnormality seen in patients presenting with pulmonary emboli. Other potential findings include a right ventricular strain pattern, complete and incomplete right bundle branch block (RBBB), and P pulmonale indicating right atrial enlargement.
Understanding these common ECG findings can aid in the diagnosis and management of various cardiac conditions.
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This question is part of the following fields:
- Cardiology
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Question 14
Incorrect
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A 68-year-old man is being evaluated in the Cardiac Unit. He has developed a ventricular tachycardia of 160 bpm, appears ill, and has a blood pressure of 70/52 mmHg. What would be the most immediate treatment option?
Your Answer:
Correct Answer: DC cardioversion
Explanation:Treatment Options for Ventricular Arrhythmia: Evaluating the Choices
When faced with a patient experiencing ventricular arrhythmia, it is important to consider the appropriate treatment options. In the scenario of a broad complex tachycardia with low blood pressure, immediate DC cardioversion is the clear choice. Carotid sinus massage and IV adenosine are not appropriate options as they are used in the diagnosis and termination of SVT. Immediate heparinisation is not the immediate treatment for ventricular arrhythmia. Intravenous lidocaine may be considered if the VT is haemodynamically stable, but in this scenario, it cannot be the correct answer choice. It is important to carefully evaluate the available options and choose the most appropriate treatment for the patient’s specific condition.
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This question is part of the following fields:
- Cardiology
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Question 15
Incorrect
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A 55-year-old man presents to the clinic with complaints of chest pain and difficulty breathing. He had been hospitalized four weeks ago for acute coronary syndrome and was discharged on bisoprolol, simvastatin, aspirin, and ramipril. During the examination, a narrow complex tachycardia is observed. What is the absolute contraindication in this scenario?
Your Answer:
Correct Answer: Verapamil
Explanation:Verapamil and Beta Blockers: A Dangerous Combination
Verapamil is a type of medication that blocks calcium channels in the heart, leading to a decrease in cardiac output and a slower heart rate. However, it also has negative effects on the heart’s ability to contract, making it a highly negatively inotropic drug. Additionally, it may impair the conduction of electrical signals between the atria and ventricles of the heart.
According to the British National Formulary (BNF), verapamil should not be given to patients who are already taking beta blockers. This is because the combination of these two drugs can lead to dangerously low blood pressure and even asystole, a condition where the heart stops beating altogether.
Therefore, it is important for healthcare professionals to carefully consider a patient’s medication history before prescribing verapamil. If a patient is already taking beta blockers, alternative treatments should be considered to avoid the potentially life-threatening consequences of combining these two drugs.
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This question is part of the following fields:
- Cardiology
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Question 16
Incorrect
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A 55-year-old woman visits her GP and mentions her diagnosis of heart failure. She expresses interest in learning about medications that can potentially decrease mortality in heart failure. Which drug has been proven to have this effect?
Your Answer:
Correct Answer: Spironolactone
Explanation:Common Medications for Heart Failure: Benefits and Limitations
Heart failure is a chronic condition that affects millions of people worldwide. While there is no cure for heart failure, medications can help manage symptoms and improve quality of life. Here are some common medications used in the treatment of heart failure, along with their benefits and limitations.
Spironolactone: Recent trials have shown that spironolactone can reduce mortality in severe heart failure. This drug works by antagonizing the deleterious effects of aldosterone on cardiac remodeling, rather than its diuretic effect.
Simvastatin: While statins are effective in reducing morbidity and mortality in patients with coronary artery disease, their beneficial effects in heart failure remain inconclusive.
Atenolol: Atenolol has not been shown to be effective in reducing mortality in heart failure and is not used as part of the condition’s management. However, certain beta-blockers like carvedilol, metoprolol, or bisoprolol are recommended in patients who have been stabilized on diuretic and angiotensin-converting enzyme (ACE-I) therapy.
Furosemide: Furosemide is a mainstay in the treatment of both acute and long-term heart failure, particularly for relieving symptoms of fluid overload. However, there is little data to prove that it improves long-term mortality in patients with chronic congestive cardiac failure (CCF).
Digoxin: Digoxin does not decrease mortality in heart failure. Its use is reserved for patients in atrial fibrillation and those who cannot be controlled on an ACE-I, beta-blocker, and loop diuretic. Some studies suggest a decreased rate in CHF-related hospital admissions.
In conclusion, while these medications can help manage symptoms and improve quality of life in heart failure patients, their limitations should also be considered. It is important to work closely with a healthcare provider to determine the best treatment plan for each individual.
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This question is part of the following fields:
- Cardiology
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Question 17
Incorrect
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A 70-year-old obese woman is admitted with episodic retrosternal chest pain not relieved by rest, for the past 3 weeks. The pain is described as squeezing in nature, and is not affected by meals or breathing. The episodic pain is of fixed pattern and is of same intensity. She has a background of diabetes mellitus, hyperlipidaemia and hypertension. Her family history is remarkable for a paternal myocardial infarction at the age of 63. She is currently haemodynamically stable.
What is the most likely diagnosis in this patient?Your Answer:
Correct Answer: Acute coronary syndrome
Explanation:Differentiating Acute Coronary Syndrome from Other Cardiac Conditions
The patient in question presents with retrosternal chest pain that is squeezing in nature and unrelated to meals or breathing. This highly suggests a cardiac origin for the pain. However, the episodic nature of the pain and its duration of onset over three weeks point towards unstable angina, a type of acute coronary syndrome.
It is important to differentiate this condition from other cardiac conditions such as aortic dissection, which presents with sudden-onset tearing chest pain that radiates to the back. Stable angina pectoris, on the other hand, manifests with episodic cardiac chest pain that has a fixed pattern of precipitation, duration, and termination, lasting at least one month.
Myocarditis is associated with a constant stabbing chest pain and recent flu-like symptoms or upper respiratory infection. Aortic stenosis may also cause unstable angina, but the most common cause of this condition is critical coronary artery occlusion.
In summary, careful consideration of the pattern, duration, and characteristics of chest pain can help differentiate acute coronary syndrome from other cardiac conditions.
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This question is part of the following fields:
- Cardiology
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Question 18
Incorrect
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Which of the options below is not a cause of mid-diastolic murmur?
Your Answer:
Correct Answer: Aortic stenosis
Explanation:Causes of Heart Murmurs
Heart murmurs are abnormal sounds heard during a heartbeat. Aortic stenosis, a condition where the aortic valve narrows, causes an ejection systolic murmur. On the other hand, left atrial myxomas and right atrial myxomas, which are rare tumors, can cause a mid-diastolic murmur by blocking the valve orifice during diastole. Mitral stenosis, which is often the result of rheumatic fever or a congenital defect, causes mid-diastolic murmurs. Lastly, tricuspid stenosis, which is also commonly caused by rheumatic fever, can cause a mid-diastolic murmur. the causes of heart murmurs is important in diagnosing and treating heart conditions.
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This question is part of the following fields:
- Cardiology
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Question 19
Incorrect
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A 65-year-old man visited the dermatology clinic in the summer with a rash on his forearms, shins, and face. Which medication is most likely to be linked with this photosensitive rash?
Your Answer:
Correct Answer: Bendroflumethiazide
Explanation:Adverse Effects of Cardiology Drugs
Photosensitivity is a frequently observed negative reaction to certain cardiology drugs, such as amiodarone and thiazide diuretics. This means that patients taking these medications may experience an increased sensitivity to sunlight, resulting in skin rashes or other skin-related issues. Additionally, ACE inhibitors and A2RBs, which are commonly prescribed for cardiovascular conditions, have been known to cause rashes that may also be photosensitive. It is important for patients to be aware of these potential side effects and to take necessary precautions, such as wearing protective clothing and using sunscreen, when exposed to sunlight.
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This question is part of the following fields:
- Cardiology
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Question 20
Incorrect
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A 28-year-old man comes to the clinic complaining of intermittent sharp central chest pains over the past 48 hours. The pain worsens with exertion and when he lies down. He reports no difficulty breathing. The ECG reveals widespread ST elevation.
What is the most probable diagnosis?Your Answer:
Correct Answer: Pericarditis
Explanation:Distinguishing Pericarditis from Other Cardiac Conditions: A Clinical Overview
Pericarditis is a common cause of widespread ST elevation, characterized by chest pain that is often pleuritic and relieved by sitting forwards. Other symptoms include dry cough, dyspnoea, and flu-like symptoms, with the most important sign being pericardial rub. It can be caused by viral infections, post-MI, tuberculosis, or uraemia.
While pulmonary embolism may cause similar pleuritic pain, it would not result in the same ECG changes as pericarditis. Acute MI causes ST elevation in the affected coronary artery territory, with reciprocal ST depression. Hypertrophic cardiomyopathy presents with syncope or pre-syncope, and ECG changes consistent with left ventricular and septal hypertrophy. Ventricular aneurysm is another cause of ST elevation, but the clinical scenario and patient age align with a diagnosis of acute pericarditis.
In summary, recognizing the unique clinical presentation and ECG changes of pericarditis is crucial in distinguishing it from other cardiac conditions.
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This question is part of the following fields:
- Cardiology
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Question 21
Incorrect
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A 32-year-old woman presents with dyspnoea on exertion and palpitations. She has an irregularly irregular and tachycardic pulse, and a systolic murmur is heard on auscultation. An ECG reveals atrial fibrillation and right axis deviation, while an echocardiogram shows an atrial septal defect.
What is the process of atrial septum formation?Your Answer:
Correct Answer: The septum secundum grows down to the right of the septum primum
Explanation:During embryonic development, the septum primum grows down from the roof of the primitive atrium and fuses with the endocardial cushions. It initially has a hole called the ostium primum, which closes as the septum grows downwards. However, a second hole called the ostium secundum develops in the septum primum before fusion can occur. The septum secundum then grows downwards and to the right of the septum primum and ostium secundum. The foramen ovale is a passage through the septum secundum that allows blood to shunt from the right to the left atrium in the fetus, bypassing the pulmonary circulation. This defect closes at birth due to a drop in pressure within the pulmonary circulation after the infant takes a breath. If there is overlap between the foramen ovale and ostium secundum or if the ostium primum fails to close, an atrial septal defect results. This defect does not cause cyanosis because oxygenated blood flows from left to right through the defect.
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This question is part of the following fields:
- Cardiology
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Question 22
Incorrect
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A 42-year-old man presents with central chest pain which is worse unless sitting forward. He says that the pain gets worse when he takes a deep breath in. There is no previous cardiac history and he is a non-smoker. Over the past few days, he has had a fever with cold and flu type symptoms.
On examination, his blood pressure is 130/80 mmHg, and he has an audible pericardial rub.
Investigations:
Investigation Result Normal value
Haemoglobin 135 g/l 135–175 g/l
Erythrocyte sedimentation rate (ESR) 40 mm/h 0–10mm in the 1st hour
White cell count (WCC) 8.5 × 109/l 4–11 × 109/l
Platelets 320 × 109/l 150–400 × 109/l
Creatine kinase (CK) 190 IU/l 23–175 IU/l
Total cholesterol 4.9 mmol/l < 5.2 mmol/l
Electrocardiogram – saddle-shaped ST elevation across all leads.
Which of the following diagnoses fits best with this clinical picture?Your Answer:
Correct Answer: Acute pericarditis
Explanation:Differential Diagnosis of Chest Pain: Acute Pericarditis, Cardiac Tamponade, Myocarditis, Acute Myocardial Infarction, and Unstable Angina
Chest pain can have various causes, and it is important to differentiate between them to provide appropriate treatment. In this case, the clinical history suggests acute pericarditis, which can be caused by viral infections or other factors. Management involves rest and analgesia, with non-steroidals being particularly effective. If there is no improvement, a tapering course of oral prednisolone may be helpful.
Cardiac tamponade is another possible cause of chest pain, which is caused by fluid accumulation in the pericardial space. Patients may present with shortness of breath, hypotension, and muffled heart sounds. Beck’s triad includes a falling blood pressure, a rising JVP, and a small, quiet heart.
Myocarditis can present with signs of heart failure but does not typically cause pain unless there is concurrent pericarditis. Acute myocardial infarction, on the other hand, typically presents with central chest pain that is not affected by inspiration. Unstable angina also causes central chest pain or discomfort at rest, which worsens over time if untreated. However, in this case, the patient has no risk factors for ischaemic heart disease, making it unlikely to be the cause of their symptoms.
In summary, chest pain can have various causes, and it is important to consider the patient’s clinical history and risk factors to make an accurate diagnosis and provide appropriate treatment.
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This question is part of the following fields:
- Cardiology
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Question 23
Incorrect
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A 29-year-old man with valvular heart disease is urgently admitted with fever, worsening shortness of breath and a letter from his GP confirming the presence of a new murmur. During examination, a harsh pansystolic murmur and early diastolic murmur are detected, along with a temperature of 38.3 °C and bilateral fine basal crepitations. Initial blood cultures have been collected.
What is the most pressing concern that needs to be addressed immediately?Your Answer:
Correct Answer: Administration of intravenous antibiotics
Explanation:Prioritizing Interventions in Suspected Infective Endocarditis
When dealing with suspected infective endocarditis, time is of the essence. The following interventions should be prioritized in order to limit valve destruction and improve patient outcomes.
Administration of Intravenous Antibiotics
Prompt initiation of intravenous antibiotics is crucial. An empirical regime of gentamicin and benzylpenicillin may be used until microbiological advice suggests any alternative.Electrocardiogram (ECG)
An ECG provides important diagnostic information and should be performed as part of the initial work-up. However, it does not take priority over antibiotic administration.Echocardiogram (ECHO)
An ECHO should be performed in all patients with suspected infective endocarditis, but it does not take priority over administration of antibiotics. A transoesophageal ECHO is more sensitive and should be considered if necessary.Throat Swab
While a throat swab may be useful in identifying the causative organism of infective endocarditis, it should not take precedence over commencing antibiotics. Careful examination of a patient’s dentition is also crucial to evaluate for a possible infectious source.Administration of Paracetamol
Symptomatic relief is important, but administration of paracetamol should not take priority over antibiotic delivery. Both interventions should be given as soon as possible to improve patient outcomes. -
This question is part of the following fields:
- Cardiology
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Question 24
Incorrect
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A final-year medical student is taking a history from a 63-year-old patient as a part of their general practice attachment. The patient informs her that she has a longstanding heart condition, the name of which she cannot remember. The student decides to review an old electrocardiogram (ECG) in her notes, and from it she is able to see that the patient has atrial fibrillation (AF).
Which of the following ECG findings is typically found in AF?Your Answer:
Correct Answer: Absent P waves
Explanation:Common ECG Findings and Their Significance
Electrocardiogram (ECG) is a diagnostic tool used to evaluate the electrical activity of the heart. It records the heart’s rhythm and detects any abnormalities. Here are some common ECG findings and their significance:
1. Absent P waves: Atrial fibrillation causes an irregular pulse and palpitations. ECG findings include absent P waves and irregular QRS complexes.
2. Long PR interval: A long PR interval indicates heart block. First-degree heart block is a fixed prolonged PR interval.
3. T wave inversion: T wave inversion can occur in fast atrial fibrillation, indicating cardiac ischaemia.
4. Bifid P wave (p mitrale): Bifid P waves are caused by left atrial hypertrophy.
5. ST segment elevation: ST segment elevation typically occurs in myocardial infarction. However, it may also occur in pericarditis and subarachnoid haemorrhage.
Understanding these ECG findings can help healthcare professionals diagnose and treat various cardiac conditions.
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This question is part of the following fields:
- Cardiology
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Question 25
Incorrect
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A 27-year-old intravenous drug user presents with a systolic murmur that is most audible at the fifth costal cartilage on the left sternal edge. What is the most probable anatomical site of the disease causing the murmur?
Your Answer:
Correct Answer: Tricuspid valve
Explanation:Auscultation of Heart Murmurs and Associated Cardiac Structures
When listening to heart sounds, the location of the murmur can provide clues about the underlying cardiac structure involved. A pansystolic murmur heard at the left sternal margin at the fifth costal cartilage suggests tricuspid regurgitation, likely caused by infective endocarditis in an intravenous drug user. A ventricular septal defect can be auscultated as a pansystolic murmur, while an atrial septal defect is associated with an ejection systolic murmur and split second heart sound over the pulmonary area. Abnormalities of the mitral valve are heard in the fifth intercostal space at the mid-clavicular line, and the aortic valve can be auscultated at the second intercostal space in the right sternal edge. Understanding the relationship between heart murmurs and associated cardiac structures can aid in diagnosis and management of cardiac conditions.
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This question is part of the following fields:
- Cardiology
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Question 26
Incorrect
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A 68-year-old man presents with severe epigastric pain and nausea. He reports not having a bowel movement in 3 days, despite normal bowel habits prior to this. The patient has a history of coronary stents placed after a heart attack 10 years ago. He has been asymptomatic since then and takes aspirin for his cardiac condition and NSAIDs for knee arthritis. He has not consumed alcohol in the past 5 years due to a previous episode of acute gastritis.
On examination, there is mild tenderness over the epigastrium but no guarding. Bowel sounds are normal. An erect CXR and abdominal X-ray are unremarkable. Blood gases and routine blood tests (FBC, U&E, LFTs) are normal, with a normal amylase. Upper GI endoscopy reveals gastric erosions.
What is the most important differential diagnosis to consider for this patient?Your Answer:
Correct Answer: Myocardial infarction
Explanation:Possible Diagnoses for a Patient with Epigastric Pain and History of Cardiac Stents
Introduction:
A patient with a history of cardiac stents presents with epigastric pain. The following are possible diagnoses that should be considered.Myocardial Infarction:
Due to the patient’s history of cardiac stents, ruling out a myocardial infarction (MI) is crucial. An electrocardiogram (ECG) should be performed early to treat any existing cardiac condition without delay.Duodenal Ulcer:
A duodenal ulcer would have likely been visualized on an oesophagogastroduodenoscopy (OGD). However, a normal erect CXR and absence of peritonitis exclude a perforated duodenal ulcer.Acute Gastritis:
Given the patient’s history of aspirin and NSAID use, as well as the gastric erosions visualized on endoscopy, acute gastritis is the most likely diagnosis. However, it is important to first exclude MI as a cause of the patient’s symptoms due to their history of MI and presentation of epigastric pain.Pancreatitis:
Pancreatitis is unlikely, given the normal amylase. However, on occasion, this can be normal in cases depending on the timing of the blood test or whether the pancreas has had previous chronic inflammation.Ischaemic Bowel:
Ischaemic bowel would present with more generalized abdominal pain and metabolic lactic acidosis on blood gas. Therefore, it is less likely to be the cause of the patient’s symptoms. -
This question is part of the following fields:
- Cardiology
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Question 27
Incorrect
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A 50-year-old man with atrial fibrillation visited the Cardiology Clinic for electrophysiological ablation. What is the least frequent pathological alteration observed in atrial fibrillation?
Your Answer:
Correct Answer: Fourth heart sound
Explanation:Effects of Atrial Fibrillation on the Heart
Atrial fibrillation is a condition characterized by irregular and rapid heartbeats. This condition can have several effects on the heart, including the following:
Fourth Heart Sound: In conditions such as hypertensive heart disease, active atrial contraction can cause active filling of a stiff left ventricle, leading to the fourth heart sound. However, this sound cannot be heard in atrial fibrillation.
Apical-Radial Pulse Deficit: Ineffective left ventricular filling can lead to cardiac ejections that cannot be detected by radial pulse palpation, resulting in the apical-radial pulse deficit.
Left Atrial Thrombus: Stasis of blood in the left atrial appendage due to ineffective contraction in atrial fibrillation is the main cause of systemic embolisation.
Reduction of Cardiac Output by 20%: Ineffective atrial contraction reduces left ventricular filling volumes, leading to a reduction in stroke volume and cardiac output by up to 20%.
Symptomatic Palpitations: Palpitations are the most common symptom reported by patients in atrial fibrillation.
Overall, atrial fibrillation can have significant effects on the heart and may require medical intervention to manage symptoms and prevent complications.
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This question is part of the following fields:
- Cardiology
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Question 28
Incorrect
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A 68-year-old woman presents to the hospital with complaints of shortness of breath, extreme weakness, and epigastric pain that started 30 minutes ago while she was using the restroom. She is still experiencing these symptoms and is sweating profusely. Her heart rate is 150 bpm, and her blood pressure is 180/110 mmHg. An ECG is ordered, which shows elevated ST segments in consecutive leads and Q waves. What is the most probable cause of this woman's condition?
Your Answer:
Correct Answer: Completely occlusive thrombus
Explanation:Causes of Chest Pain: Understanding Myocardial Infarction and Other Conditions
Chest pain can be a symptom of various conditions, including myocardial infarction, coronary artery stenosis, coronary vasospasm, partially occlusive thrombus, and pulmonary embolism. Understanding the differences between these conditions is crucial for accurate diagnosis and treatment.
Myocardial Infarction
Myocardial infarction, or heart attack, is a serious condition that occurs when a completely occlusive thrombus blocks blood flow to the heart. Women are more likely to experience atypical symptoms such as shortness of breath, weakness, and fatigue, rather than the typical substernal chest pain. However, heart rate, blood pressure, and ECG changes indicate a myocardial infarction.
Coronary Artery Stenosis
Coronary artery stenosis causes stable angina, which subsides with rest. It is characterized by a narrowing of the coronary arteries that supply blood to the heart.
Coronary Vasospasm
Coronary vasospasm is the cause of Prinzmetal’s angina, which presents as intermittent chest pain at rest. It is caused by the sudden constriction of the coronary arteries.
Partially Occlusive Thrombus
A partially occlusive thrombus may present similarly to a completely occlusive thrombus, but it does not usually cause an elevation in the ST segment.
Pulmonary Embolism
A pulmonary embolism is an occlusion of circulation in the lungs and presents as severe shortness of breath. However, it does not typically cause the specific ECG changes seen in myocardial infarction.
Understanding the differences between these conditions can help healthcare professionals accurately diagnose and treat chest pain.
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This question is part of the following fields:
- Cardiology
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Question 29
Incorrect
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A 65-year-old man arrives at the Emergency Department complaining of central crushing chest pain that spreads to his arm and jaw. Upon examination, his ECG reveals ST elevation in leads II, III, and aVF, with reciprocal changes in I and aVL. Based on this information, which of the following vessels is most likely obstructed?
Your Answer:
Correct Answer: Right coronary artery
Explanation:Differentiating Myocardial Infarctions Based on ECG Changes
Myocardial infarction (MI) is a serious condition that requires prompt diagnosis and treatment. Electrocardiogram (ECG) changes can help differentiate the location of the MI and guide appropriate management. Here are the ECG changes expected in different types of MI:
Right Coronary Artery (RCA) Infarction: An inferior MI affects the RCA in 80% of cases, with ST elevation in leads II, III, and aVF, and reciprocal changes in leads I and aVL.
Left Circumflex Artery (LCX) Infarction: LCX infarction presents with ST elevation in leads I, aVL, V5, and V6 (lateral leads), and reciprocal changes in the inferior leads II, III, and aVF.
Left Coronary Artery (LCA) Infarction: If the clot is in the LCA before bifurcation, ST changes are expected in leads I, aVL, and V1–V6 (anterolateral leads).
Posterior Descending Artery (PDA) Infarction: PDA infarction gives ECG changes in keeping with a posterior MI, such as ST depression in the anterior leads.
Left Anterior Descending Artery (LAD) Infarction: LAD runs in the anterior of the heart, almost parallel to the septum, and then lateralizes. Therefore, in an LAD infarction, ST changes are expected in leads V1–V6 (anteroseptal leads).
In conclusion, recognizing the ECG changes in different types of MI can help clinicians make an accurate diagnosis and provide appropriate treatment.
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This question is part of the following fields:
- Cardiology
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Question 30
Incorrect
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A 63-year-old man experiences a myocardial infarction (MI) that results in necrosis of the anterior papillary muscle of the right ventricle, leading to valve prolapse. Which structure is most likely responsible for the prolapse?
Your Answer:
Correct Answer: Anterior and posterior cusps of the tricuspid valve
Explanation:Cusps and Papillary Muscles of the Heart Valves
The heart valves play a crucial role in regulating blood flow through the heart. The tricuspid and mitral valves are located between the atria and ventricles of the heart. These valves have cusps, which are flaps of tissue that open and close to allow blood to flow in one direction. The papillary muscles, located in the ventricles, attach to the cusps of the valves and help to control their movement.
Tricuspid Valve:
The tricuspid valve has three cusps: anterior, posterior, and septal. The anterior and posterior cusps are attached to the anterior and posterior papillary muscles, respectively. The septal cusp is attached to the septal papillary muscle.Mitral Valve:
The mitral valve has two cusps: anterior and posterior. These cusps are not attached to papillary muscles directly, but rather to chordae tendineae, which are thin tendons that connect the cusps to the papillary muscles.Understanding the anatomy of the heart valves and their associated papillary muscles is important for diagnosing and treating heart conditions such as valve prolapse or regurgitation.
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This question is part of the following fields:
- Cardiology
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