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  • Question 1 - You are evaluating a patient with advanced breast cancer. The patient has asked...

    Incorrect

    • You are evaluating a patient with advanced breast cancer. The patient has asked you to fill out a DS1500 form. When is it appropriate to complete this form?

      Your Answer: When life expectancy is < 6 months

      Correct Answer:

      Explanation:

      When an individual’s life expectancy is less than 6 months, a DS1500 form is filled out to expedite the process of receiving benefit payments.

      Patients who suffer from chronic illnesses or cancer and require assistance with caring for themselves may be eligible for benefits. Those under the age of 65 can claim Personal Independence Payment (PIP), while those aged 65 and over can claim Attendance Allowance (AA). PIP is tax-free and divided into two components: daily living and mobility. Patients must have a long-term health condition or disability and have difficulties with activities related to daily living and/or mobility for at least 3 months, with an expectation that these difficulties will last for at least 9 months. AA is also tax-free and is for those who need help with personal care. Patients should have needed help for at least 6 months to claim AA.

      Patients who have a terminal illness and are not expected to live for more than 6 months can be fast-tracked through the system for claiming incapacity benefit (IB), employment support allowance (ESA), DLA or AA. A DS1500 form is completed by a hospital or hospice consultant, which contains questions about the diagnosis, clinical features, treatment, and whether the patient is aware of the condition/prognosis. The form is given directly to the patient and a fee is payable by the Department for Works and Pensions (DWP) for its completion. This ensures that the application is dealt with promptly and that the patient automatically receives the higher rate.

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  • Question 2 - You are seeing an elderly patient with advanced gastric cancer at home who...

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    • You are seeing an elderly patient with advanced gastric cancer at home who has called you due to persistent vomiting. The patient is receiving palliative care.

      The patient reports persistent large volume vomiting with little preceding nausea, frequent hiccups, early satiety, and acid reflux. The patient also reports that vomiting provides relief.

      Which antiemetic medication would be the most appropriate to prescribe?

      Your Answer:

      Correct Answer: Cyclizine

      Explanation:

      Treatment options for gastric stasis in palliative care

      Gastric stasis can cause distressing symptoms such as large volume vomiting, acid reflux, hiccoughs, and early satiety. In palliative care, the use of metoclopramide is advised despite restrictions issued by the European Medicines Agency. However, caution should be exercised when prescribing prokinetic drugs with antimuscarinic activity. Haloperidol is effective in treating nausea and vomiting caused by chemical imbalances, while cyclizine is indicated for patients with cerebral disease, motion sickness, and nausea due to mechanical bowel obstruction. Levopromazine is a broad-spectrum antiemetic that can be used when first-line treatments fail. Ondansetron, a 5-HT3 antagonist, is commonly used to treat emetogenic chemotherapy. By understanding the various treatment options available, healthcare professionals can provide effective symptom management for patients with gastric stasis in palliative care.

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  • Question 3 - A 50-year-old woman has a fungating metastatic breast cancer and is increasingly distressed...

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    • A 50-year-old woman has a fungating metastatic breast cancer and is increasingly distressed by the malodorous discharge from the affected breast, which is causing considerable social embarrassment.

      From the list below, choose the single treatment which would help alleviate this symptom.

      Your Answer:

      Correct Answer: Allevyn dressings

      Explanation:

      Managing Foul Odors in Palliative Care

      In palliative care, managing foul odors is an important aspect of providing comfort to patients. One approach is to use metronidazole, which can improve smells caused by anaerobic organisms that infect fungating tumors. Another option is to use charcoal dressings, which absorb malodorous substances. It is recommended to familiarize oneself with the British National Formulary (BNF) section on prescribing in palliative care, as it contains valuable information that is often tested in exams. By utilizing these strategies, healthcare providers can help alleviate unpleasant odors and improve the quality of life for their patients.

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  • Question 4 - A 75-year-old gentleman being treated palliatively for prostate cancer is reviewed.

    He has advanced...

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    • A 75-year-old gentleman being treated palliatively for prostate cancer is reviewed.

      He has advanced metastatic disease and is currently taking modified release morphine tablets at a dose of 60 mg BD for pain control. He tells you that since increasing his dose of morphine several weeks ago he is having a lot of problems with constipation.

      He weighs 70 kgs and has no known drug allergies or intolerances.

      What is the most appropriate regimen to prescribe alone as an initial treatment for his constipation?

      Your Answer:

      Correct Answer: Glycerol suppositories one PRN

      Explanation:

      Managing Constipation in Palliative Care

      Constipation is a common problem in palliative care, often caused by the use of opioid analgesics. To prevent constipation, laxatives should be co-prescribed with opioids. A combination of a faecal softener and a peristaltic stimulant, such as co-danthramer, is ideal. Alternatively, a stool softener like docusate sodium can be combined with a stimulant laxative like a senna preparation. PRN suppositories are not recommended for regular use. Lactulose can be used in combination with senna, but some sources advise against it due to its side effects. Methylnaltrexone bromide is indicated for opioid-induced constipation in terminally ill patients who do not respond to other laxatives. Prucalopride is not a palliative care medication and is only licensed for treating chronic constipation in women who have not found relief from other laxatives and lifestyle changes.

      In summary, managing constipation in palliative care requires a combination of preventative measures and appropriate medication. Co-prescribing laxatives with opioids is essential, and a combination of a faecal softener and a peristaltic stimulant is ideal. Methylnaltrexone bromide can be used in terminally ill patients who do not respond to other laxatives. Prucalopride is not a palliative care medication and is only licensed for treating chronic constipation in women who have not found relief from other laxatives and lifestyle changes.

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  • Question 5 - You assess a hospice patient at their residence. They are presently taking 30...

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    • You assess a hospice patient at their residence. They are presently taking 30 mg MST twice a day, which is effectively managing their pain. However, due to their inability to swallow, you decide, after consulting with everyone involved, to transition them to morphine via a syringe driver. What would be the suitable initial dosage for the patient?

      Your Answer:

      Correct Answer: 30 mg over 24 hours

      Explanation:

      When switching from one strong opioid to another, the most common switch is from oral morphine sulphate to subcutaneous diamorphine or morphine. Diamorphine is more soluble and easier to administer in higher doses, but morphine is preferred in most cases. The potency ratio of parenteral diamorphine to oral morphine is 3:1, while the subcutaneous dose of morphine is one third to one half of the oral dose. Most centres divide the oral dose by two and re-titrate as necessary.

      Palliative care prescribing for pain is guided by NICE and SIGN guidelines. NICE recommends starting with regular oral modified-release or immediate-release morphine, with immediate-release morphine for breakthrough pain. Laxatives should be prescribed for all patients initiating strong opioids, and antiemetics should be offered if nausea persists. Drowsiness is usually transient, but if it persists, the dose should be adjusted. SIGN advises that the breakthrough dose of morphine is one-sixth the daily dose, and all patients receiving opioids should be prescribed a laxative. Opioids should be used with caution in patients with chronic kidney disease, and oxycodone is preferred to morphine in patients with mild-moderate renal impairment. Metastatic bone pain may respond to strong opioids, bisphosphonates, or radiotherapy, and all patients should be considered for referral to a clinical oncologist for further treatment. When increasing the dose of opioids, the next dose should be increased by 30-50%. Conversion factors between opioids are also provided. Opioid side-effects include nausea, drowsiness, and constipation, which are usually transient but may persist. Denosumab may be used to treat metastatic bone pain in addition to strong opioids, bisphosphonates, and radiotherapy.

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  • Question 6 - You are asked to prescribe diamorphine to go into a syringe driver for...

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    • You are asked to prescribe diamorphine to go into a syringe driver for a 85-year-old gentleman with terminal metastatic colorectal cancer. He is currently taking a total of 100 mg of oral morphine over 24 hours.

      Having calculated the correct dose of diamorphine for his syringe driver over 24 hours, what dose of subcutaneous diamorphine would you prescribe for breakthrough pain?

      Your Answer:

      Correct Answer: 5 mg

      Explanation:

      Drug Dose Calculations

      Calculating drug doses can be a challenging task, especially when it comes to converting between different medications and routes of administration. One common question in medical exams involves calculating the appropriate dose of a medication for a patient.

      To answer this question correctly, there are several steps to follow. Firstly, the total oral dose of morphine must be converted to diamorphine. Then, the breakthrough dose of subcutaneous diamorphine must be calculated, not the oral morphine dose.

      To calculate the 24-hour dose of diamorphine for a patient, the total daily dose of oral morphine should be divided by 3. For example, if a patient is taking 90 mg of oral morphine over 24 hours, this is equivalent to 30 mg of diamorphine over 24 hours by syringe driver.

      According to the BNF, the subcutaneous dose for breakthrough pain should be between one sixth and one tenth of the 24-hour dose. Therefore, for this patient, the correct breakthrough dose of subcutaneous diamorphine would be between 3 mg and 5 mg.

      It is important to note that drug dose calculations are a common area of weakness in medical exams. Examiners often include questions on this topic, and it is essential for healthcare professionals to have a good understanding of how to calculate drug doses accurately.

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  • Question 7 - A 50-year-old woman has metastatic breast cancer in her bones. Pain has been...

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    • A 50-year-old woman has metastatic breast cancer in her bones. Pain has been well controlled with modified-release morphine and she is still quite mobile. A palliative care nurse has given her a National Comprehensive Cancer Network (NCCN) Distress Thermometer for Patients. This is a visual analogue scale that records subjective distress on a scale of 0-10. She records 7-8 and most of this is recorded as being due to emotional issues (depression, nervousness, worry, loss of interest). She is assessed to have moderate depression with significant functional impairment. She declines psychological intervention, but would be happy to take medication.
      Which of the following is the most appropriate medication?

      Your Answer:

      Correct Answer: Sertraline

      Explanation:

      Chlorine salicylate gel

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  • Question 8 - A 75-year-old man has been recently diagnosed with terminal pancreatic cancer. His son...

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    • A 75-year-old man has been recently diagnosed with terminal pancreatic cancer. His son attends with the patient and requests more support at home. When would it be appropriate to complete a DS1500 form?

      Your Answer:

      Correct Answer: Death expected within 6 months

      Explanation:

      If a patient or their representative believes that the patient may have a terminal illness, they can request a form DS1500 to be issued. According to Social Security legislation, a terminal illness is a disease that is advancing and is expected to result in death within six months.

      Patients who suffer from chronic illnesses or cancer and require assistance with caring for themselves may be eligible for benefits. Those under the age of 65 can claim Personal Independence Payment (PIP), while those aged 65 and over can claim Attendance Allowance (AA). PIP is tax-free and divided into two components: daily living and mobility. Patients must have a long-term health condition or disability and have difficulties with activities related to daily living and/or mobility for at least 3 months, with an expectation that these difficulties will last for at least 9 months. AA is also tax-free and is for those who need help with personal care. Patients should have needed help for at least 6 months to claim AA.

      Patients who have a terminal illness and are not expected to live for more than 6 months can be fast-tracked through the system for claiming incapacity benefit (IB), employment support allowance (ESA), DLA or AA. A DS1500 form is completed by a hospital or hospice consultant, which contains questions about the diagnosis, clinical features, treatment, and whether the patient is aware of the condition/prognosis. The form is given directly to the patient and a fee is payable by the Department for Works and Pensions (DWP) for its completion. This ensures that the application is dealt with promptly and that the patient automatically receives the higher rate.

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  • Question 9 - A 27-year-old man was diagnosed with a melanoma six weeks after being referred...

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    • A 27-year-old man was diagnosed with a melanoma six weeks after being referred to the Dermatology Department by his General Practitioner (GP). His friends call his GP, concerned that he has withdrawn to his room over the last four weeks, has stopped playing basketball, has appeared to lose weight, and has missed his hospital appointments. There is a letter in his medical records informing the practice that he has missed two surgery appointments.
      He later attends the surgery with a friend. He is dressed scruffily and doesn't make eye contact during your conversation. His Patient Health Questionnaire-9 score is 15.
      What is the most likely diagnosis?

      Your Answer:

      Correct Answer: Major depression

      Explanation:

      Mental Health Issues in Young Cancer Patients: Understanding the Symptoms

      Young cancer patients often experience mental health issues that can affect their treatment, survival, and quality of life. Depression and anxiety are common, affecting up to 20% and 10% of patients, respectively. In diagnosing major depression, symptoms such as depressed mood, diminished interest in activities, and significant weight changes are present. Brain metastases typically present with symptoms such as headaches, seizures, or neurological disease, which this patient doesn’t have. Acute psychotic reactions involve symptoms of delusions, hallucinations, or thought disorders, which are not present in this case. Phobic anxiety disorder involves anxiety out of proportion with the threat posed, which is not present in this patient. PTSD involves recurrent intrusive thoughts about a traumatic event, which this patient doesn’t exhibit. Understanding these symptoms can help healthcare professionals provide appropriate support and treatment for young cancer patients with mental health issues.

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  • Question 10 - A 72-year-old man has prostate cancer with bony metastases. He is being treated...

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    • A 72-year-old man has prostate cancer with bony metastases. He is being treated with gonadorelin analogue injections and he feels reasonably well. He complains of excessive sweating, particularly at night, that often requires him to change clothes and bedding. This is a chronic problem.
      Which of the following is the most likely cause of the patient's presentation?

      Your Answer:

      Correct Answer: Gonadorelin analogue therapy

      Explanation:

      Causes and Treatment of Excessive Sweating in Advanced Cancer Patients

      Excessive sweating is a common issue among patients with advanced cancer, and it can be caused by various factors. One of the main causes is sex hormone suppression, which is a common treatment for cancer. However, other factors such as infection, lymphoma, widespread cancer, and medication (such as SSRI antidepressants, hormone therapies, and opioids) can also contribute to excessive sweating.

      Endocrine issues such as oestrogen deficiency, androgen deficiency, hypoglycaemia, and hyperthyroidism can also cause excessive sweating. Autonomic neuropathy is another potential cause.

      To alleviate excessive sweating, patients can try reducing the room temperature, removing excess bedding and clothing, increasing ventilation, and using a fan. If necessary, patients can seek advice from their oncologist about hormone replacement therapy using diethylstilboestrol.

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