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Question 1
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A mother brings her 5-month old baby daughter to your clinic for a birthmark on her arm. Upon examination, you identify a small vascular plaque that doesn't seem to be causing any discomfort to the baby. Your diagnosis is a strawberry naevus. What would be the most suitable initial course of action?
Your Answer: Watch and wait
Explanation:A congenital haemangioma known as a strawberry naevus affects approximately one in 20 infants. These haemangiomas grow quickly during the first few months of life and then gradually disappear over a few years without any intervention. Unless they are causing vision, hearing, breathing, or feeding problems, they typically do not require treatment. However, if they are located on the lower spine, they may indicate spina bifida and require further investigation. Additionally, if they are unusually large or atypical, medical attention may be necessary.
Strawberry naevi, also known as capillary haemangiomas, are not usually present at birth but can develop quickly within the first month of life. They appear as raised, red, and lobed tumours that commonly occur on the face, scalp, and back. These growths tend to increase in size until around 6-9 months before gradually disappearing over the next few years. However, in rare cases, they can obstruct the airway if they occur in the upper respiratory tract. Capillary haemangiomas are more common in white infants, particularly in females, premature infants, and those whose mothers have undergone chorionic villous sampling.
Complications of strawberry naevi include obstruction of vision or airway, bleeding, ulceration, and thrombocytopaenia. Treatment may be necessary if there is visual field obstruction, and propranolol is now the preferred choice over systemic steroids. Topical beta-blockers such as timolol may also be used. Cavernous haemangioma is a type of deep capillary haemangioma.
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This question is part of the following fields:
- Dermatology
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Question 2
Incorrect
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A 28-year-old woman presents with concerns regarding hair loss.
She has been noticing patches of hair loss over the past three months without any associated itching. Her medical history includes hypothyroidism, for which she takes 100 micrograms of thyroxine daily, and she takes the combined oral contraceptive for regular withdrawal bleeds.
During examination, she appears healthy with a BMI of 22 kg/m2 and a blood pressure of 122/72 mmHg. Upon examining her scalp, two distinct patches of hair loss, approximately 2-3 cm in diameter, are visible on the vertex of her head and the left temporo-occipital region.
What is the most probable cause of her hair loss?Your Answer: Alopecia areata
Correct Answer: Drug induced
Explanation:Hair Loss and Autoimmune Conditions
This young woman is experiencing hair loss and has been diagnosed with an autoimmune condition and hypothyroidism. Her symptoms are consistent with alopecia areata, a condition where hair loss occurs in discrete patches. While only 1% of cases of alopecia are associated with thyroid disease, it is a possibility in this case. However, scarring alopecia is more typical of systemic lupus erythematosus (SLE), which is not present in this patient. Androgenic alopecia, which causes thinning at the vertex and temporal areas, is also not consistent with this patient’s symptoms. Over-treatment with thyroxine or the use of oral contraceptives can cause generalised hair loss, but this is not the case for this patient. It is important to properly diagnose the underlying condition causing hair loss in order to provide appropriate treatment.
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This question is part of the following fields:
- Dermatology
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Question 3
Incorrect
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A 50-year-old man comes in with plaque psoriasis on his body, elbows, and knees. He has been using a potent corticosteroid ointment and a vitamin D preparation once daily for the past 8 weeks, but there has been no improvement in his skin. What should be the next course of action in managing his plaque psoriasis?
Your Answer: Step up the combination of corticosteroid and vitamin D preparation to twice daily
Correct Answer: Stop the corticosteroid and continue with topical vitamin D preparation twice daily for up to 12 weeks
Explanation:The best course of action would be to discontinue the corticosteroid and increase the frequency of vitamin D application to twice daily, as per NICE guidelines. It is necessary to take a 4-week break from the topical steroid, which has already been used for 8 weeks. Therefore, continuing or increasing the steroid usage to twice daily would be inappropriate. Dithranol and referral to Dermatology are not necessary at this point, as the treatment plan has not been finished.
Psoriasis is a chronic skin condition that can also affect the joints. The National Institute for Health and Care Excellence (NICE) has released guidelines for managing psoriasis and psoriatic arthropathy. For chronic plaque psoriasis, NICE recommends a stepwise approach starting with regular use of emollients to reduce scale loss and itching. First-line treatment involves applying a potent corticosteroid and vitamin D analogue separately, once daily in the morning and evening, for up to 4 weeks. If there is no improvement after 8 weeks, a vitamin D analogue twice daily can be used as second-line treatment. Third-line options include a potent corticosteroid applied twice daily for up to 4 weeks or a coal tar preparation applied once or twice daily. Phototherapy and systemic therapy are also options for managing psoriasis.
For scalp psoriasis, NICE recommends using a potent topical corticosteroid once daily for 4 weeks. If there is no improvement, a different formulation of the corticosteroid or a topical agent to remove adherent scale can be used before applying the corticosteroid. For face, flexural, and genital psoriasis, a mild or moderate potency corticosteroid applied once or twice daily for a maximum of 2 weeks is recommended.
When using topical steroids, it is important to be aware of potential side effects such as skin atrophy, striae, and rebound symptoms. The scalp, face, and flexures are particularly prone to steroid atrophy, so topical steroids should not be used for more than 1-2 weeks per month. Systemic side effects may occur when potent corticosteroids are used on large areas of the body. NICE recommends a 4-week break before starting another course of topical corticosteroids and using potent corticosteroids for no longer than 8 weeks at a time and very potent corticosteroids for no longer than 4 weeks at a time. Vitamin D analogues, such as calcipotriol, can be used long-term and tend to reduce the scale and thickness of plaques but not the redness. Dithranol and coal tar are other treatment options with their own unique mechanisms of action and potential adverse effects.
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This question is part of the following fields:
- Dermatology
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Question 4
Incorrect
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A 23-year-old man visits your clinic with a concern about spots on his face, neck, and trunk that have been present for a few months. Despite using an over-the-counter facial wash, the spots have not improved. The patient is becoming increasingly self-conscious about them and seeks treatment. Upon examination, you observe comedones and inflamed lesions on his face, as well as nodules, pustules, and scarring. The patient is in good health, with normal vital signs.
What is the most appropriate initial approach to managing this patient?Your Answer: Trial of topical antibiotics
Correct Answer: Refer to dermatology
Explanation:A patient with severe acne, including scarring, hyperpigmentation, and widespread pustules, should be referred to a dermatologist for specialized treatment. In this case, the patient has nodules, pustules, and scarring, indicating the need for consideration of oral isotretinoin. A trial of low-strength topical benzoyl peroxide would not be appropriate for severe and widespread acne, but may be suitable for mild to moderate cases. Same-day hospital admission is unnecessary for a patient with normal observations and no other health concerns. A review in 2 months is not appropriate for severe acne, which should be managed with topical therapies, oral antibiotics, or referral to a dermatologist. Topical antibiotics are also not recommended for severe and widespread acne, and a dermatology referral is necessary for this patient with lesions on the face, neck, and trunk.
Acne vulgaris is a common skin condition that usually affects teenagers and is characterized by the obstruction of hair follicles with keratin plugs, resulting in comedones, inflammation, and pustules. The severity of acne can be classified as mild, moderate, or severe, depending on the number and type of lesions present. Treatment for acne typically involves a step-up approach, starting with single topical therapy and progressing to combination therapy or oral antibiotics if necessary. Tetracyclines are commonly used but should be avoided in certain populations, and a topical retinoid or benzoyl peroxide should always be co-prescribed to reduce the risk of antibiotic resistance. Combined oral contraceptives can also be used in women, and oral isotretinoin is reserved for severe cases under specialist supervision. Dietary modification has no role in the management of acne.
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This question is part of the following fields:
- Dermatology
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Question 5
Correct
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A 49-year-old woman visits her General Practitioner with a complaint of itching, fatigue and malaise for the past six months. She has had no major medical history and is not on any regular medications. There are no visible signs of a skin rash.
What is the most suitable investigation that is likely to result in a diagnosis?Your Answer: Liver function tests (LFTs)
Explanation:Diagnosis of Pruritis without a Rash: Primary Biliary Cholangitis
Pruritis without a rash can be a challenging diagnosis. In this case, the symptoms suggest the possibility of primary biliary cholangitis, an autoimmune disease of the liver that leads to cholestasis and can progress to fibrosis and cirrhosis. To diagnose this condition, a full blood count, serum ferritin, erythrocyte sedimentation rate, urea and electrolytes, thyroid function tests, and liver function tests are necessary. A chest X-ray may be useful to rule out malignancy, but skin biopsy and skin scraping for microscopy are unlikely to be helpful in the absence of a rash. Low serum B12 is not relevant to pruritis. Overall, a thorough evaluation is necessary to diagnose pruritis without a rash, and primary biliary cholangitis should be considered as a potential cause.
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This question is part of the following fields:
- Dermatology
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Question 6
Incorrect
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A father brings his 4-year-old daughter to your GP surgery. He has noticed that she has been scratching her face, particularly around her mouth and that she has developed some 'spots and scabs' in the area. The patient doesn't appear systemically unwell or distressed. The child has a history of atopic eczema and viral-induced wheeze.
On examination of the child's face you note the presence of pustules and vesicles surrounding the mouth and nose area along with some honey-coloured plaques. You diagnose impetigo and prescribe topical fusidic acid as well as advising good hygiene measures.
The father is concerned about sending the child to preschool. What do you advise?Your Answer: The patient can return to daycare immediately because he feels well
Correct Answer: The patient must have been on treatment for 48h before returning to daycare
Explanation:Patients with impetigo can go back to school or work once they are no longer contagious, which is either when all lesions have crusted over or after 48 hours of starting treatment. For measles or rubella, it is recommended to wait for at least 4 days after the rash appears before returning to work or school.
Understanding Impetigo: Causes, Symptoms, and Management
Impetigo is a common bacterial skin infection that is caused by either Staphylococcus aureus or Streptococcus pyogenes. It can occur as a primary infection or as a complication of an existing skin condition such as eczema. Impetigo is most common in children, especially during warm weather. The infection can develop anywhere on the body, but it tends to occur on the face, flexures, and limbs not covered by clothing.
The infection spreads through direct contact with discharges from the scabs of an infected person. The bacteria invade the skin through minor abrasions and then spread to other sites by scratching. Infection is spread mainly by the hands, but indirect spread via toys, clothing, equipment, and the environment may occur. The incubation period is between 4 to 10 days.
Symptoms of impetigo include ‘golden’, crusted skin lesions typically found around the mouth. It is highly contagious, and children should be excluded from school until the lesions are crusted and healed or 48 hours after commencing antibiotic treatment.
Management of impetigo depends on the extent of the disease. Limited, localized disease can be treated with hydrogen peroxide 1% cream or topical antibiotic creams such as fusidic acid or mupirocin. MRSA is not susceptible to either fusidic acid or retapamulin, so topical mupirocin should be used in this situation. Extensive disease may require oral flucloxacillin or oral erythromycin if penicillin-allergic. The use of hydrogen peroxide 1% cream was recommended by NICE and Public Health England in 2020 to cut antibiotic resistance. The evidence base shows it is just as effective at treating non-bullous impetigo as a topical antibiotic.
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This question is part of the following fields:
- Dermatology
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Question 7
Correct
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A 40-year-old man is concerned about the appearance of both his great toe nails. He has noticed separation of the nail plate from the nail bed distally. The other toenails appear normal.
What is the most probable diagnosis?Your Answer: Trauma
Explanation:Differential diagnosis of onycholysis
Onycholysis is a condition where the nail separates from the nail bed, often starting at the distal edge and progressing proximally. It can have various causes, including infections, skin diseases, and mechanical trauma. Here we consider some possible diagnoses for a patient with onycholysis of the great toenails without other significant findings.
Trauma: Onycholysis can result from repeated or acute trauma to the nail, which is common in sports or due to ill-fitting shoes. This is a likely cause in this case, given the location and absence of other features.
Psoriasis: Psoriasis is a chronic autoimmune disease that can affect the skin and nails, causing red, scaly patches and pitting of the nails. However, the patient would typically have other skin lesions and a history of psoriasis, which is not evident here.
Chronic paronychia: Paronychia is an infection of the skin around the nail, which can cause pain, swelling, and pus. However, this doesn’t involve the nail itself and is not consistent with the presentation.
Eczema: Eczema is a common skin condition that can cause itching, redness, and scaling of the skin. If it affects the nail matrix, it can lead to transverse ridging of the nail, but not onycholysis.
Tinea unguium: Tinea unguium, also known as onychomycosis, is a fungal infection of the nail that can cause thickening, discoloration, and onycholysis. However, the nail would typically be yellow or white and show other signs of fungal infection.
In summary, trauma is the most likely cause of onycholysis in this case, but other possibilities should be considered based on the clinical context and additional findings.
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This question is part of the following fields:
- Dermatology
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Question 8
Correct
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A 55-year-old man has well demarcated itchy erythematous round scaly patches between 1 cm and 3 cm in diameter on his both shins. The scaling is not accentuated by scratching the patches. He has no nail changes.
Select from the list the single most suitable management option.Your Answer: Betamethasone valerate 0.1% cream
Explanation:Understanding Discoid Eczema: Symptoms, Diagnosis, and Treatment
Discoid eczema, also known as nummular eczema, is a skin condition characterized by coin-shaped patches of itchy, red, and scaly skin. Unlike psoriasis, these patches are flat and not raised. The condition can occur anywhere on the body, but it tends to affect the extensor aspects of the limbs.
In some cases, the lesions may be vesicular and weep. Skin scrapings may be sent for mycology to exclude dermatophyte fungus infection, especially if the condition is more prominent on one side of the body. However, the absence of nail changes makes psoriasis and fungal infection less likely.
To treat discoid eczema, a potent topical corticosteroid is usually needed and should be used until the inflammation is suppressed, which typically takes 2-4 weeks. Emollients, such as emulsifying ointment, can also be beneficial if the skin is dry and can be applied indefinitely as a soap substitute.
It’s important to note that 1% hydrocortisone cream is much less effective in treating discoid eczema. Instead, calcipotriol ointment is used for psoriasis, and terbinafine cream is used for dermatophyte fungal infections. If you suspect you have discoid eczema, it’s best to consult with a dermatologist for proper diagnosis and treatment.
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This question is part of the following fields:
- Dermatology
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Question 9
Correct
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A 31-year-old woman comes to the clinic complaining of a painful rash on her shins. Upon examination, there are multiple tender nodules that appear purple in color. She has no significant medical history. What is the most probable diagnosis?
Your Answer: Erythema nodosum
Explanation:Skin Conditions: Erythema Nodosum, Insect Bites, Discoid Eczema, Erysipelas, and Post-Traumatic Ecchymoses
Erythema nodosum is a painful skin condition characterized by tender, red nodules caused by inflammation of subcutaneous fat. It is more common in women aged 25-40 and can be associated with underlying conditions or occur in isolation.
Insect bites from non-venomous insects like mosquitoes, fleas, lice, and bed bugs can result in itchy papules or blisters grouped in the exposed body site. Bites often appear in clusters.
Discoid eczema is a type of eczema with unknown causes. It is characterized by round-to-oval, itchy, red, scaly plaques that may contain vesicles with serous exudate.
Erysipelas is a tender, red, indurated plaque with a well-defined border caused by group A beta-hemolytic streptococci.
Post-traumatic ecchymosis or bruises are large blood extravasations under the skin that may be caused by coagulation or vascular disorders. However, there is no history of trauma to support this diagnosis.
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This question is part of the following fields:
- Dermatology
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Question 10
Incorrect
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A 25-year-old male comes to the surgery with a chronic issue of excessive sweating in his armpits. Apart from this, he is healthy, but the problem is impacting his self-esteem and social activities. What would be the best course of action for managing this condition?
Your Answer: Refer to dermatology
Correct Answer: Topical aluminium chloride
Explanation:Hyperhidrosis is typically treated with topical preparations containing aluminium chloride as the first-line option.
Managing Hyperhidrosis
Hyperhidrosis is a condition characterized by excessive sweating. To manage this condition, there are several options available. The first-line treatment is the use of topical aluminium chloride preparations, which can cause skin irritation as a side effect. Another option is iontophoresis, which is particularly useful for patients with palmar, plantar, and axillary hyperhidrosis. Botulinum toxin is also licensed for axillary symptoms. Surgery, such as endoscopic transthoracic sympathectomy, is another option, but patients should be informed of the risk of compensatory sweating. Overall, there are several management options available for hyperhidrosis, and patients should work with their healthcare provider to determine the best course of treatment for their individual needs.
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This question is part of the following fields:
- Dermatology
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