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Question 1
Incorrect
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Which form of vitamin D is the most active in the human body?
Your Answer: 24,25 (OH) 2 vitamin D
Correct Answer: 1, 25 (OH) 2 vitamin D
Explanation:The Process of Vitamin D Production and Activation
Vitamin D comes in two forms, D2 and D3. D3 can be produced in the skin through a reaction that requires UV light, while D2 cannot. Both forms can also be obtained through diet, with some foods now being supplemented with Vitamin D. However, the production of Vitamin D3 in the skin can be affected by various factors such as seasons, latitude, clothing, sun block, and skin tone, making it difficult for individuals to get adequate levels of Vitamin D through sunlight alone, especially in the UK during winter.
Once absorbed into the lymph, Vitamin D2 and D3 circulate in the bloodstream and reach the liver. Here, the liver enzyme 25-hydroxylase adds an OH group to the Vitamin D molecule, resulting in 25(OH) Vitamin D. The compound then travels to the kidney, where the enzyme 1-alpha hydroxylase adds another OH group, creating the active form of Vitamin D, 1,25 (OH)2Vitamin D. When there is enough of this active form, an inactive metabolite called 24,25 (OH)2Vitamin D is produced instead. this process is important in ensuring adequate Vitamin D levels for overall health and well-being.
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This question is part of the following fields:
- Basic Sciences
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Question 2
Incorrect
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What is the primary reason for malnutrition?
Your Answer: Inadequate intake of dietary fat
Correct Answer: Inadequate intake of calories in any form
Explanation:Malnutrition
Malnutrition refers to a state where the dietary intake is insufficient to maintain a healthy state and stable weight. It can be caused by over- or under-nutrition, but it is commonly used to describe under-nutrition. Malnutrition can be defined as a state of nutrition where a deficiency, excess, or imbalance of energy, protein, and other nutrients causes measurable adverse effects on tissue, function, and clinical outcome. Protein malnutrition is the most severe form of malnutrition, causing significant mortality and clinical effects such as kwashiorkor. Carbohydrate malnutrition is less common as carbohydrate sources are widely grown and cheap. Fat malnutrition rarely results in problems if there is adequate dietary protein and carbohydrate. Deficiencies of fat-soluble vitamins can result in various clinical effects. Body size can give some indication of nutritional status, but many obese patients may have nutritional deficiencies due to their faddy diets.
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This question is part of the following fields:
- Basic Sciences
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Question 3
Incorrect
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A couple in their late 20s comes to your clinic seeking advice regarding the possibility of their children inheriting cystic fibrosis. The husband has a confirmed diagnosis of the condition, but the carrier status of the wife is unknown.
What is the likelihood of any of their offspring being affected by cystic fibrosis?Your Answer: 25%
Correct Answer: 2.50%
Explanation:Cystic Fibrosis Inheritance
Cystic fibrosis (CF) is a genetic disorder that affects the chloride ion channels, leading to the thickening of respiratory and other secretions. It is an autosomal recessive condition, which means that a person must inherit two copies of the defective gene, one from each parent, to develop the disease. The most common defective allele is carried by approximately 1 in 20 people.
If a man with CF has children with a woman who does not carry the recessive gene, then none of their children will be affected by the disease. However, they will all be carriers of the CF gene. On the other hand, if the woman is a carrier of the CF gene, there is a 50% chance that each child will inherit one copy of the defective gene from each parent and be affected by the disease. The remaining 50% of the children will inherit one copy of the defective gene and one normal gene, making them carriers of the CF gene but not affected by the disease.
In summary, the probability of any child being affected by CF is 2.5% if one parent has the defective gene and the other does not. It is important for individuals who are carriers of the CF gene to be aware of their status and seek genetic counseling before planning to have children.
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This question is part of the following fields:
- Basic Sciences
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Question 4
Correct
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What is the primary factor that increases the risk of thiamine (vitamin B1) deficiency?
Your Answer: Chronic alcohol excess
Explanation:Thiamine: Its Roles, Sources, Deficiency States, and Manifestations
Thiamine is a vital nutrient that plays several roles in the body. It acts as a cofactor to enzymes involved in energy production, metabolism of branched chain amino acids, and regulation of nerve and muscle action potentials. It is found in many foods, including wheat, oats, and yeast-containing products. However, deficiency states can occur in chronic alcohol dependence, renal dialysis, and cultures that mainly consume white rice. The deficiency can manifest as ‘dry’ beriberi, which causes peripheral neuropathy, muscle weakness, fatigue, and reduced concentration, or ‘wet’ beriberi, which also involves heart failure and edema. In severe cases, Wernicke-Korsakoff syndrome can develop, which is an emergency requiring urgent IV replacement of thiamine. If left untreated, it can lead to irreversible amnesia, confabulation, and dementia. Therefore, all patients with alcohol-related admissions should be considered for Pabrinex, a B vitamin infusion.
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This question is part of the following fields:
- Basic Sciences
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Question 5
Correct
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The diabetes prevention program has been running for the last 5 years. At baseline, a well conducted study with a sample size of 500 showed that the prevalence of diabetes among adults aged 40 and above was 15%.
Five years later another survey (of 400 responders) showed that the prevalence of diabetes was 10%.
In the above example, which definition of prevalence is correct?Your Answer: Prevalence is the number of new and old smokers in a year
Explanation:Prevalence and Incidence in Smoking
Prevalence and incidence are two important concepts in the smoking habits of a population. Prevalence refers to the number of people who smoke at a particular time point, such as at the beginning or end of a study period. This is calculated by dividing the number of smokers by the total population.
On the other hand, incidence refers to the number of new cases of smoking at a particular time point. For example, this could be at the beginning of a study period for the whole year or at the 10th year. This is calculated by dividing the number of new smokers by the number of smoke-free individuals who are potentially at risk of taking up smoking.
prevalence and incidence is important in evaluating the effectiveness of smoking cessation programs and policies. By tracking changes in prevalence and incidence over time, researchers and policymakers can determine whether their efforts are making a difference in reducing smoking rates. Additionally, these concepts can help identify populations that are at higher risk of taking up smoking, allowing for targeted interventions to prevent smoking initiation.
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This question is part of the following fields:
- Basic Sciences
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Question 6
Incorrect
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A 65-year-old patient with suspected spinal cord compression has been admitted to the neurosurgical team for an urgent MRI of the spine. Which particle's magnetic properties does magnetic resonance imaging rely predominantly upon?
Your Answer: Injected radioactive isotopes, for example, technetium-99
Correct Answer: Hydrogen ion (proton)
Explanation:How MRI Scanners Use Hydrogen Ions to Create Images
MRI scanners use the magnetic properties of hydrogen ions, also known as protons, to create images of the human body. These protons have nuclear spin, which means they have magnetic vectors that can be aligned in an electromagnet. The scanner bombards the protons with radiofrequency radiation, causing them to release energy when they return to their resting state. This energy release is recorded and used to construct the MRI image.
While other nuclei, such as carbon 13, also have nuclear spin and could be used in MRI imaging, hydrogen ions are much more abundant in human tissues. This makes them the preferred choice for creating images of the body. The process of aligning the magnetic vectors of the protons and then recording their energy release is repeated many times to create a detailed image of the body’s internal structures.
Overall, MRI scanners use the magnetic properties of hydrogen ions to create detailed images of the human body. This non-invasive imaging technique has revolutionized medical diagnosis and treatment, allowing doctors to see inside the body without the need for surgery.
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This question is part of the following fields:
- Basic Sciences
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Question 7
Incorrect
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What is the end result of meiosis in a cell?
Your Answer: 4 diploid cells
Correct Answer: 4 haploid cells
Explanation:Meiosis
Meiosis is a crucial process that occurs in the genetic cells of eukaryotic organisms. Its primary purpose is to recombine genes, which results in genetic variation while also ensuring genetic preservation. Although meiosis shares some similarities with mitosis, it is restricted to genetic cells, also known as gametes, of eukaryotic organisms.
During meiosis, a gamete duplicates each of its chromosomes and divides into two diploid cells. These cells then divide into four haploid cells by the end of the second stage of meiosis (telophase II and cytokinesis). These haploid cells are either sperm cells (male) or eggs (female) in mammals. When these haploid cells fuse together, they produce a diploid zygote that contains two copies of parental genes.
In summary, meiosis is a crucial process that ensures genetic variation and preservation in eukaryotic organisms. It involves the duplication and division of genetic cells into haploid cells, which can then fuse together to produce a diploid zygote.
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This question is part of the following fields:
- Basic Sciences
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Question 8
Incorrect
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What are the vitamins that are soluble in fat?
Your Answer: Vitamins D, E and K
Correct Answer: Vitamins A, D, E and K
Explanation:Absorption of Fat-Soluble Vitamins
Fat-soluble vitamins, namely A, D, E, and K, have a different absorption process compared to water-soluble vitamins. In the gut, these vitamins are combined with other fat-soluble substances such as monoacylglycerols and cholesterol to form micelles. These micelles are then transported to the lymphatic system and eventually enter the bloodstream through the subclavian vein.
However, any issues that affect the absorption of fats will also impact the absorption of fat-soluble vitamins. This means that individuals with conditions that affect fat absorption, such as cystic fibrosis or celiac disease, may have difficulty absorbing these vitamins. It is important to ensure adequate intake of fat-soluble vitamins through a balanced diet or supplements to prevent deficiencies and associated health problems.
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This question is part of the following fields:
- Basic Sciences
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Question 9
Incorrect
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At what stage of meiosis does the process of homologous recombination occur?
Your Answer: Interphase I
Correct Answer: Prophase I
Explanation:Homologous Recombination: A Mechanism for DNA Repair and Genetic Variation
Homologous recombination is a process that allows for the exchange of nucleotide sequences between two similar or identical DNA molecules. This occurs during meiosis, specifically during the second phase of prophase I, where sister chromatids swap sequences. The primary purpose of homologous recombination is to accurately repair harmful double-strand DNA breaks. This process results in new combinations of DNA sequences that provide genetic variation in daughter cells and, ultimately, the organism’s offspring.
In prokaryotic organisms such as bacteria and viruses, homologous recombination occurs during horizontal gene transfer. This process involves the exchange of genetic material between different strains and species. Homologous recombination plays a crucial role in the evolution of these organisms by allowing for the acquisition of new traits and adaptations.
Overall, homologous recombination is a vital mechanism for DNA repair and genetic variation. It ensures the accuracy of DNA replication and contributes to the diversity of life on Earth.
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This question is part of the following fields:
- Basic Sciences
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Question 10
Incorrect
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While taking a patient's medical history, you discover that their family has a strong history of a certain disease. Autosomal dominant diseases are often caused by defects in structural genes and typically present in early adulthood, affecting both males and females equally. Which of the following diseases does not follow an autosomal dominant pattern of inheritance?
Your Answer: Marfan's syndrome
Correct Answer: Haemochromatosis
Explanation:Abnormal Binding Proteins and Iron Deposition: A Genetic Disorder
Abnormal binding proteins can lead to the deposition of iron in the body, resulting in various health complications. This genetic disorder is inherited in an autosomal recessive manner. The deposition of iron can cause cardiomyopathy, cirrhosis, pancreatic failure due to fibrosis, and skin pigmentation.
In general, disorders that affect metabolism or DNA replication on a cellular or genetic level tend to be autosomal recessive. On the other hand, genetic disorders that affect the structure of the body on a larger level are usually autosomal dominant. While there may be exceptions to these rules, they can serve as a helpful guide for exam preparation. Proper of this genetic disorder can aid in its diagnosis and management.
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This question is part of the following fields:
- Basic Sciences
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Question 11
Incorrect
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What are the typical clinical manifestations of a deficiency in vitamin B6 (pyridoxine)?
Your Answer: Bleeding tendency
Correct Answer: Sensory neuropathy
Explanation:The Importance of Pyridoxine in the Body
Pyridoxine is a group of B-vitamins that are crucial in various bodily functions. They act as essential cofactors in many reactions, particularly in the metabolism of amino acids and neurotransmitters. Pyridoxine also plays a role in regulating gene transcription and controlling steroid hormones.
The body can produce pyridoxine through bacterial flora in the gut, and it is also present in many dietary sources. However, overheating certain foods can destroy pyridoxine, and some medications can alter its metabolism. Pyridoxine is also used therapeutically to prevent neuropathy in the treatment of tuberculosis.
Deficiency in pyridoxine can lead to sensory neuropathy, skin changes, and damage to mucous membranes. On the other hand, deficiency in vitamin C can cause gingivitis and increased bleeding, while vitamin K deficiency can also lead to bleeding. Sleep disturbance is rarely attributed to vitamin B3 (niacin) deficiency.
In summary, pyridoxine is a vital nutrient that plays a crucial role in various bodily functions. Its deficiency can lead to various health problems, highlighting the importance of maintaining adequate levels of this vitamin in the body.
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This question is part of the following fields:
- Basic Sciences
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Question 12
Incorrect
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As part of your general practice placement, you have been tasked with conducting an audit on the duration of solid food introduction in the practice population. You review the data for the last six infants born within the practice:
6 months, 7 months, 8 months, 9 months, 10 months, 11 months.
What is the variance value for the duration of solid food introduction in the practice population?Your Answer: 17.6
Correct Answer: 74.9
Explanation:Variance and Standard Deviation in Breast Feeding Duration
Variance is a statistical measure that indicates how spread out a set of data is. In the case of breast feeding duration, variance can help us understand how much the duration varies from the mean. The formula for variance involves squaring the difference between each data point and the mean, then dividing the sum by n-1, where n is the total number of data points. In a sample population, n-1 is a better estimate of variance than n because it accounts for the variability within the sample.
For example, if the variance of breast feeding duration is 74.9 months, this indicates that the duration is widely distributed from the mean of 17.6 months. A smaller variance, such as 4.5 months, would indicate that the duration varies less and is closer to the mean. The standard deviation, which is the square root of the variance, is also important in the spread of data. In a normal distribution, 95% of observations will fall within two standard deviations of the mean.
In the case of breast feeding duration, the mean is 17.6 months, indicating that babies are breast fed for an average of 15 and a half months. The median, which is the middle number in the data set, is 15 months, meaning that half of the babies were breast fed for 15 months. variance and standard deviation can help us better understand the distribution of breast feeding duration and other medical measurements.
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This question is part of the following fields:
- Basic Sciences
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Question 13
Incorrect
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A premature baby is born and the anaesthetists are struggling to ventilate the lungs because of insufficient surfactant. How does Laplace's law explain the force pushing inwards on the walls of the alveolus caused by surface tension between two static fluids, such as air and water in the alveolus?
Your Answer: Proportional to the square of the radius of the alveolus
Correct Answer: Inversely proportional to the radius of the alveolus
Explanation:The Relationship between Alveolar Size and Surface Tension in Respiratory Physiology
In respiratory physiology, the alveolus is often represented as a perfect sphere to apply Laplace’s law. According to this law, there is an inverse relationship between the size of the alveolus and the surface tension. This means that smaller alveoli experience greater force than larger alveoli for a given surface tension, and they will collapse first. This phenomenon explains why, when two balloons are attached together by their ends, the smaller balloon will empty into the bigger balloon.
In the lungs, this same principle applies to lung units, causing atelectasis and collapse when surfactant is not present. Surfactant is a substance that reduces surface tension, making it easier to expand the alveoli and preventing smaller alveoli from collapsing. Therefore, surfactant plays a crucial role in maintaining the proper functioning of the lungs and preventing respiratory distress. the relationship between alveolar size and surface tension is essential in respiratory physiology and can help in the development of treatments for lung diseases.
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This question is part of the following fields:
- Basic Sciences
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Question 14
Incorrect
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What is a good dietary source of vitamin A?
Your Answer:
Correct Answer: Liver
Explanation:The Importance of Vitamin A in Our Body
Vitamin A is an essential nutrient that can be found in various sources such as liver, fish liver oils, dark green leafy vegetables, carrots, and mangoes. It can also be added to certain foods like cereals and margarines. This nutrient plays a crucial role in our body as it is required for vision, growth and development of tissues, regulation of gene transcription, and synthesis of hydrophobic glycoproteins and parts of the protein kinase enzyme pathways.
One of the primary functions of vitamin A is to support our vision. It is a component of rhodopsin, a pigment that is necessary for the rod cells of the retina. Without vitamin A, our eyesight can be compromised, leading to various eye problems. Additionally, vitamin A is also essential for the growth and development of many types of tissues in our body. It helps in maintaining healthy skin, teeth, and bones.
Moreover, vitamin A is involved in regulating gene transcription, which is the process of converting DNA into RNA. This nutrient also plays a role in the synthesis of hydrophobic glycoproteins and parts of the protein kinase enzyme pathways. These processes are essential for the proper functioning of our body.
In conclusion, vitamin A is a vital nutrient that our body needs to function correctly. It is essential for our vision, growth and development of tissues, regulation of gene transcription, and synthesis of hydrophobic glycoproteins and parts of the protein kinase enzyme pathways. Therefore, it is crucial to include vitamin A-rich foods in our diet or take supplements if necessary.
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This question is part of the following fields:
- Basic Sciences
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Question 15
Incorrect
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Over the last five years, the total number of patients admitted and deaths in the East and North Hertfordshire NHS Trust have been recorded. In the year 2010/2011, there were 95,071 patients admitted and 1,912 deaths. What is the crude mortality ratio for this group in that year (per 100 admissions)?
Your Answer:
Correct Answer: 2
Explanation:In this scenario, the crude mortality ratio is established by comparing the number of deaths occurring within the hospital in a given year to the total number of admissions, disregarding age or gender-specific mortality rates. For instance, with 1,912 deaths out of 95,071 admissions, the ratio computes to 0.02, or 2.0% when calculated per 100 admissions (1,912/95,071 = 0.02/100= 2.0%. When recalculated per 1,000 admissions, the crude admission rate would be 20 per 1,000.
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This question is part of the following fields:
- Basic Sciences
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Question 16
Incorrect
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A 65-year-old patient with suspected spinal cord compression has been admitted to the neurosurgical team for an urgent MRI of the spine. The MRI technique primarily relies on the magnetic properties of which particle?
Your Answer:
Correct Answer: Hydrogen ion (proton)
Explanation:How MRI Scanners Use Hydrogen Ions to Create Images
MRI scanners use the magnetic properties of hydrogen ions, also known as protons, to create images of the human body. These protons have nuclear spin, which means they have magnetic vectors that can be aligned in an electromagnet. The scanner bombards the protons with radiofrequency radiation, causing them to release energy when they return to their resting state. This energy release is recorded and used to construct the MRI image.
While other nuclei, such as carbon 13, also have net nuclear spin and could be used in MRI imaging, hydrogen ions are much more abundant in human tissues. This makes them the preferred choice for creating images of the body. By using the magnetic properties of hydrogen ions, MRI scanners can create detailed images of internal structures without the use of harmful radiation.
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This question is part of the following fields:
- Basic Sciences
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Question 17
Incorrect
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At what stage of eukaryotic mitosis do the centromeres of chromosomes separate?
Your Answer:
Correct Answer: Anaphase
Explanation:Chromosome Division during Anaphase
Chromosomes are joined together in an X shape at the centromere. During anaphase, the centromeres break down and the chromosomes divide into two identical pairs called sister chromatids. These sister chromatids then move to opposite sides of the cell along a network of spindle fibres. When the cell divides during telophase, each daughter cell receives one sister chromatid from the parent cell. This ensures the accurate copying and propagation of genes. The process of chromosome division during anaphase is crucial for the proper distribution of genetic material in cells.
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This question is part of the following fields:
- Basic Sciences
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Question 18
Incorrect
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What is the conversion of pyruvate before it enters the Krebs cycle?
Your Answer:
Correct Answer: Acetyl-CoA
Explanation:The Krebs cycle occurs in the mitochondrion and involves the conversion of acetyl-CoA to oxaloacetate. This cycle produces six NADH, two FADH, and two ATP for each molecule of glucose. Pyruvate is converted to acetyl-CoA before entering the Krebs cycle, and water and carbon dioxide are end products. Acetic acid itself has no role in the cycle, but its acetyl group is used to form acetyl-CoA. Some anaerobic bacteria can convert sugars to acetic acid directly.
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This question is part of the following fields:
- Basic Sciences
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Question 19
Incorrect
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What are the clinical consequences of a lack of vitamin A?
Your Answer:
Correct Answer: Dry conjunctiva
Explanation:The Devastating Effects of Vitamin A Deficiency
Vitamin A deficiency is a serious health concern that can lead to a range of devastating effects. One of the most common consequences is blindness, particularly in children. Poor night vision is often an early sign of this deficiency, which can progress to complete blindness if left untreated.
In addition to blindness, vitamin A deficiency can also cause dry conjunctiva, a condition known as conjunctival xerosis. This occurs when the normally moist and fine conjunctiva becomes thickened and dysfunctional, leading to the formation of white plaques known as Bitot’s spots. Corneal ulceration can also occur as a result of this condition.
The respiratory and gastrointestinal epithelia can also be affected by vitamin A deficiency, leading to reduced resistance to infection. This deficiency is a major public health issue in some parts of the world and is the single most common preventable cause of blindness. It is crucial to address this issue through education and access to vitamin A-rich foods and supplements.
Overall, the devastating effects of vitamin A deficiency highlight the importance of proper nutrition and access to essential vitamins and minerals. By addressing this issue, we can help prevent blindness and improve overall health outcomes for individuals and communities around the world.
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This question is part of the following fields:
- Basic Sciences
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Question 20
Incorrect
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The arrangement of amphipathic phospholipids in the mammalian cell membrane, what is it like?
Your Answer:
Correct Answer: A lipid bilayer with hydrophilic heads facing out and hydrophobic tails facing in
Explanation:The Function and Structure of the Mammalian Cell Membrane
The mammalian cell membrane serves as a protective barrier that separates the cytoplasm from the extracellular environment. It also acts as a filter for molecules that move across it. Unlike plant and prokaryotic cells, mammalian cells do not have a cell wall. The main component of the cell membrane is a bilayer of amphipathic lipids, which have a hydrophilic head and a hydrophobic tail. The phospholipids in the bilayer are oriented with their hydrophilic heads facing outward and their hydrophobic tails facing inward. This arrangement allows for the separation of the watery extracellular environment from the watery intracellular compartment.
It is important to note that the cell membrane is not a monolayer and the phospholipids are not linked head-to-tail. This is in contrast to DNA, which has a helical chain formation. Overall, the structure and function of the mammalian cell membrane are crucial for maintaining the integrity and proper functioning of the cell.
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This question is part of the following fields:
- Basic Sciences
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Question 21
Incorrect
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What is the cause of the symptoms of weakness, dermatitis, diarrhoea and dementia in pellagra?
Your Answer:
Correct Answer: Deficiency of the vitamin niacin
Explanation:Niacin Deficiency and Other Genetic Diseases
Niacin, a vitamin present in two forms – nicotinamide and nicotinic acid, is found in a variety of plant and animal foodstuffs. However, in some cases, the form of the vitamin is not easily absorbed by the human body, leading to deficiency. This deficiency is common in areas where maize is the primary dietary carbohydrate. Additionally, niacin can be produced by the body from the amino acid tryptophan. Diseases that affect the availability of tryptophan, such as Hartnup disease and carcinoid syndrome, can also result in niacin deficiency.
Pellagra is a condition that arises from niacin deficiency. It initially presents with non-specific symptoms such as nausea, fatigue, and reduced appetite, followed by pigmented dermatitis in sun-exposed areas, gastrointestinal disturbance, mood disturbance, and dementia in severe cases.
Apart from niacin deficiency, genetic diseases affecting collagen synthesis, such as Ehlers Danlos, present with symptoms of fragile stretchy skin and joint hypermobility. Genetic diseases affecting haemoglobin, such as sickle cell anaemia, present with symptoms of pain, hepatosplenomegaly, shortness of breath, and anaemia. Deficiencies in B12 and folate can also lead to macrocytic anaemia, paresthesia, and lethargy.
In conclusion, the causes and symptoms of niacin deficiency and other genetic diseases is crucial for early diagnosis and effective treatment. A balanced diet and regular medical check-ups can help prevent and manage these conditions.
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This question is part of the following fields:
- Basic Sciences
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Question 22
Incorrect
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What is the term for the process described below in laboratory testing?
Enzymes are immobilised on a solid surface, such as a bead or well, and allowed to come into contact with the sample. After washing, another enzyme is added with a label allowing quantitation of the analyte.Your Answer:
Correct Answer: Enzyme-linked immunosorbent assay
Explanation:ELISA: A Common Immunoassay in Medical Diagnostic Testing
An enzyme-linked immunosorbent assay (ELISA) is a type of immunoassay that is widely used in medical diagnostic testing. This method uses antibodies to identify and/or quantify the analyte being tested. The ELISA process involves several steps, including coating a plate with the antigen, adding the patient’s sample, washing the plate to remove any unbound material, adding an enzyme-linked antibody, washing the plate again, and adding a substrate to produce a measurable signal.
Over time, many modifications have been made to the ELISA, making it a versatile tool in the laboratory for measuring various analytes. Some of the substances that can be measured using immunoassays include thyroid hormone, testosterone, oestrogen, troponin, and vitamin D. The ELISA has been around for a long time and is still widely used today due to its accuracy, sensitivity, and specificity.
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This question is part of the following fields:
- Basic Sciences
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Question 23
Incorrect
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What are the primary constituents of the cytoskeleton in eukaryotic cells?
Your Answer:
Correct Answer: Microfilaments, intermediate filaments and microtubules
Explanation:The Eukaryotic Cytoskeleton: A Structural Support System
The eukaryotic cytoskeleton is a network of structures that provide structural support to the cell. It helps the cell maintain its shape, protects it from external pressure, and performs intracellular transport. The cytoskeleton is made up of three major structures: microfilaments, intermediate filaments, and microtubules. Microfilaments are thin double helices made up of actin and are involved in pressure resistance and cell motility. Intermediate filaments have a more complex structure and maintain cell shape while bearing tension. Microtubules are hollow cylinders made up of alpha and beta tubulin proteins and are involved in intracellular transport, cell movement, and form the mitotic spindle during cytokinesis.
Cilia, flagella, and lamellipodia are structures that are not part of the cell’s cytoskeleton but are made up of components of it and perform unique functions such as cell movement and extracellular sensing. Kinesin and dynein are motor proteins that support microtubule function. Microfilaments and alpha/beta microtubules are incorrect because they leave out intermediate filaments. Tubulin and actin are proteins of microtubules and microfilaments, respectively, but myosin is a motility protein involved in muscle contraction. The eukaryotic cytoskeleton is an essential component of the cell that provides structural support and enables various cellular functions.
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This question is part of the following fields:
- Basic Sciences
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Question 24
Incorrect
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Which food is a rich source of vitamin D in the diet?
Your Answer:
Correct Answer: Oily fish
Explanation:Sources of Vitamin D
Vitamin D is a type of fat-soluble vitamin that can be found in certain foods such as cheese, butter, eggs, and oily fish. However, vegetable sources of vitamin D are limited, although some foods are fortified with this vitamin. For instance, 100 grams of sundried shiitake mushrooms contain 1600 IU of vitamin D, while one egg contains 20 IU. Wild salmon is also a good source of vitamin D, with 100 grams containing 800 IU, while farmed salmon contains 200 IU.
Aside from food sources, sunlight is also a good source of vitamin D. Exposure of arms and legs to sunlight for 10-15 minutes can provide 3000 IU of vitamin D. However, it is difficult to obtain the daily requirement of 25-50 IU of vitamin D through sunlight alone, especially for people living in temperate climates. As a result, many people may have insufficient vitamin D levels. It is important to ensure that we get enough vitamin D through a combination of food sources and sunlight exposure.
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This question is part of the following fields:
- Basic Sciences
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Question 25
Incorrect
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Which process occurs mainly in the smooth endoplasmic reticulum?
Your Answer:
Correct Answer: Steroid synthesis
Explanation:The Functions of Endoplasmic Reticulum and Lysosomes
The endoplasmic reticulum (ER) is a complex network of membranes that is divided into two types: rough and smooth. The rough ER is characterized by the presence of ribosomes on its cytosolic side, which makes it an important site for protein production, modification, and transport. On the other hand, the smooth ER is involved in cholesterol and steroid handling, as well as calcium storage in some cells. This type of ER is particularly prominent in cells that produce large amounts of steroid hormones, such as those found in the adrenal cortex.
Lysosomes, on the other hand, are organelles that are responsible for breaking down and recycling cellular waste. They are formed by the Golgi apparatus, which is another complex network of membranes found in eukaryotic cells. Lysosomes contain a variety of enzymes that are capable of breaking down different types of molecules, including proteins, lipids, and carbohydrates.
In summary, the ER and lysosomes are two important organelles in eukaryotic cells that play different roles in cellular metabolism. While the ER is involved in protein production, modification, and transport, the lysosomes are responsible for breaking down and recycling cellular waste.
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This question is part of the following fields:
- Basic Sciences
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Question 26
Incorrect
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A 50-year-old female patient with varicose veins presents to the vascular clinic for evaluation.
During the assessment, a test is conducted to determine the location of incompetence. The patient is instructed to lie down, and the veins are emptied by elevating her legs off the couch. The examiner then identifies the site of the sapheno-femoral junction and applies pressure with their fingers. The patient is then asked to stand up to evaluate vein filling.
What is the name of this test?Your Answer:
Correct Answer: Trendelenburg's test
Explanation:Assessing Varicose Vein Site of Incompetence
The Trendelenburg and tourniquet tests are both used to evaluate the site of incompetence in varicose veins at the sapheno-femoral junction. During the Trendelenburg test, the examiner applies pressure with their fingers over the junction site, while in the tourniquet test, a tourniquet is placed just below the junction level.
If the veins fill quickly upon standing, it indicates that the sapheno-femoral junction is not the source of the incompetence. These tests are essential in determining the location of the varicose vein site of incompetence, which is crucial in planning the appropriate treatment. By identifying the site of incompetence, physicians can perform targeted interventions to improve venous function and alleviate symptoms. Therefore, the Trendelenburg and tourniquet tests are valuable tools in the diagnosis and management of varicose veins.
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This question is part of the following fields:
- Basic Sciences
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Question 27
Incorrect
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A 32-year-old snowboarder presents to the Emergency department complaining of pain and swelling around the first metacarpophalangeal joint (MCP joint) following a fall during practice.
Upon examination, there is significant swelling and bruising on the ulnar side of the joint.
What is the most probable injury that the patient has sustained?Your Answer:
Correct Answer: Ulnar collateral ligament
Explanation:Skier’s Thumb: A Common Injury in Winter Sports
Skier’s thumb, also known as gamekeeper’s thumb, is a common injury that occurs in winter sports. It is caused by damage or rupture of the ulnar collateral ligament, which is located at the base of the thumb. This injury can result in acute swelling and gross instability of the thumb. In severe cases where a complete tear of the ligament is suspected, an MRI may be necessary to confirm the diagnosis, and surgical repair may be required.
Once the acute swelling has subsided, treatment for skier’s thumb typically involves immobilization in a thumb spica. This is the standard therapy for cases of partial rupture.
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This question is part of the following fields:
- Basic Sciences
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Question 28
Incorrect
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What is the estimated percentage of oxygen in the blood that is attached to haemoglobin?
Your Answer:
Correct Answer: 100%
Explanation:Calculation of Oxygen in Blood
The majority of oxygen in the blood is bound to haemoglobin, with the exact amount varying based on the oxygen saturation and haemoglobin level. To calculate the amount of oxygen per litre of blood, the formula (13.9 × Hb × sats/100) + (PaO2 × 0.03) can be used. For example, an average man with an Hb of 14, saturations of 98% on room air, and a PaO2 of 12 would have 191 ml of oxygen per litre of blood. It is important to note that only 0.36 ml of this oxygen is dissolved in the blood.
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This question is part of the following fields:
- Basic Sciences
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Question 29
Incorrect
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What factor causes a shift of the oxygen dissociation curve to the left?
Your Answer:
Correct Answer: Increased pH
Explanation:The Oxygen Dissociation Curve and its Effects on Oxygen Saturation
The oxygen dissociation curve is a graph that compares the oxygen saturation of hemoglobin (Hb) at different partial pressures of oxygen. When more oxygen is needed by the tissues, the curve shifts to the right. This means that at the same partial pressure of oxygen, less oxygen is bound to Hb, allowing it to be released to the tissues. This effect is caused by increased levels of CO2 and temperature, which assist in the transfer of oxygen to more metabolically active tissues. Additionally, increased levels of 2,3-DPG also aid in this process.
On the other hand, a left shift in the curve reflects conditions where there is less need for oxygen in the tissues, such as in the lungs. This allows for increased binding of oxygen to Hb, allowing it to be taken up before transport to the tissues that require it. Overall, the oxygen dissociation curve plays a crucial role in regulating oxygen saturation in the body and ensuring that oxygen is delivered to the tissues that need it most.
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This question is part of the following fields:
- Basic Sciences
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Question 30
Incorrect
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What is the fundamental meaning of carbohydrate?
Your Answer:
Correct Answer: A compound following the formula Cx(H2O)y
Explanation:Carbohydrates: Building Blocks of Energy and Storage
Carbohydrates are organic compounds made up of carbon, hydrogen, and oxygen, with a general formula of Cx(H2O)y. They can be classified as either aldehydes or ketones and contain multiple hydroxyl groups. Monosaccharides are the simplest form of carbohydrates, consisting of a single unit. They are categorized based on the number of carbon atoms they contain, with trioses having three, pentoses having five, and hexoses having six carbon atoms. These monosaccharides are essential for energy production and building larger carbohydrate structures.
Disaccharides are formed when two monosaccharides are joined together through a condensation reaction, releasing a water molecule. The most common disaccharides are lactose, maltose, and sucrose. Polysaccharides, on the other hand, are long, branched polymers made up of multiple single units. They serve as convenient storage molecules for energy reserves, such as glycogen in humans and starch in plants.
In summary, carbohydrates are vital building blocks for energy production and storage in living organisms. Monosaccharides, disaccharides, and polysaccharides all play important roles in maintaining the body’s energy balance and overall health.
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This question is part of the following fields:
- Basic Sciences
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