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Question 1
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A 9-year-old patient is brought to General Practitioner by his parents because he has been disruptive at school. His teachers report that he does not pay attention in class, bullies other classmates and takes their food during lunchtime without their permission. One teacher also reported that the patient was seen hurting the class hamster.
Which of the following is the most likely diagnosis in this patient?Your Answer: Conduct disorder
Explanation:Understanding Different Types of Behavioral Disorders in Children and Adults
Conduct Disorder:
Conduct disorder is a behavioral disorder that affects individuals under the age of 18. It is characterized by repetitive behavior that violates the rights of others, including bullying and torture of animals.Major Depression:
Major depression is a mood disorder that is diagnosed when an individual experiences depressed mood along with at least five of the following symptoms: changes in sleep patterns, loss of interest in activities, feelings of guilt, decreased energy, difficulty concentrating, changes in appetite, sluggishness, and suicidal thoughts.Antisocial Disorder:
Individuals who exhibit signs of conduct disorder and are 18 years or older are diagnosed with antisocial personality disorder.Manic Episode:
Mania is a mood disorder characterized by elevated mood lasting for at least 7 days. Symptoms include increased energy, decreased need for sleep, risky sexual behavior, feelings of invincibility, distractibility, flight of ideas, agitation, and pressured speech.Oppositional Defiant Disorder:
Oppositional defiant disorder is a behavioral disorder characterized by oppositional behavior towards authority figures. However, there is no violation of the rights of others or extreme behavior such as bullying or animal cruelty. -
This question is part of the following fields:
- Psychiatry
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Question 2
Correct
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A 22-year-old woman presents to her GP for a follow-up appointment regarding her generalised anxiety disorder (GAD). During her previous visit, she was provided with information about GAD and referred for individual guided self-help. However, she continues to experience persistent worry throughout the day and has difficulty relaxing. Her family has also noticed that she is more irritable. The patient expresses interest in trying medication for her anxiety. What would be the most suitable medication to prescribe for her?
Your Answer: Sertraline
Explanation:Sertraline is the recommended first-line medication for treating generalised anxiety disorder (GAD). This patient exhibits typical symptoms of GAD and has already undergone step 1 and step 2 of treatment without improvement. Therefore, she requires step 3, which involves either high-intensity psychological intervention or drug treatment. As the patient prefers drug treatment, sertraline is the appropriate choice as it is the most cost-effective SSRI for GAD according to NICE guidelines. Citalopram and fluoxetine are also SSRIs that may be used as second-line treatments if sertraline is not effective or tolerated. Diazepam, a benzodiazepine, is not recommended for GAD due to the risk of dependence, except in short-term crisis situations.
Anxiety is a common disorder that can manifest in various ways. According to NICE, the primary feature is excessive worry about multiple events associated with heightened tension. It is crucial to consider potential physical causes when diagnosing anxiety disorders, such as hyperthyroidism, cardiac disease, and medication-induced anxiety. Medications that may trigger anxiety include salbutamol, theophylline, corticosteroids, antidepressants, and caffeine.
NICE recommends a step-wise approach for managing generalised anxiety disorder (GAD). This includes education about GAD and active monitoring, low-intensity psychological interventions, high-intensity psychological interventions or drug treatment, and highly specialist input. Sertraline is the first-line SSRI for drug treatment, and if it is ineffective, an alternative SSRI or a serotonin-noradrenaline reuptake inhibitor (SNRI) such as duloxetine or venlafaxine may be offered. If the patient cannot tolerate SSRIs or SNRIs, pregabalin may be considered. For patients under 30 years old, NICE recommends warning them of the increased risk of suicidal thinking and self-harm and weekly follow-up for the first month.
The management of panic disorder also follows a stepwise approach, including recognition and diagnosis, treatment in primary care, review and consideration of alternative treatments, review and referral to specialist mental health services, and care in specialist mental health services. NICE recommends either cognitive behavioural therapy or drug treatment in primary care. SSRIs are the first-line drug treatment, and if contraindicated or no response after 12 weeks, imipramine or clomipramine should be offered.
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This question is part of the following fields:
- Psychiatry
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Question 3
Incorrect
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A man of 45 years presents following the death of his wife.
Which one of the following is going to heighten your suspicion of an abnormal grief reaction?
Your Answer: Searching for the deceased
Correct Answer: Delayed or absent grief
Explanation:Understanding Abnormal and Normal Grief Reactions
Grief is a highly individualized experience that can be influenced by personal, social, and cultural factors. There are three recognized types of abnormal grief reactions: delayed, inhibited, and prolonged. Delayed grief is characterized by a delay of more than two weeks before grieving begins, or sometimes not occurring at all until triggered by another subsequent bereavement. Inhibited grief occurs when the bereaved person appears minimally affected by the death, and prolonged grief lasts significantly longer than average.
On the other hand, normal grief reactions are characterized by features such as sadness, weeping, poor sleep, reduced appetite, motor restlessness, searching for the deceased, poor concentration and memory, low mood (but not frank depression), and the impression of seeing or hearing the deceased. Poor memory, brief episodes of seeing the dead person, poor concentration, and searching for the deceased are all common manifestations of a normal grief reaction.
It is important to note that there is a great degree of flexibility when assessing whether a grief reaction is normal or abnormal, as it is a highly personal experience. Understanding the different types of grief reactions can help individuals and their loved ones navigate the grieving process and seek appropriate support.
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This question is part of the following fields:
- Psychiatry
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Question 4
Incorrect
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You are on GP rotation and you assess a 22-year-old student who reports feeling consistently low for the past 6 months. You administer a PHQ-9 questionnaire which indicates persistent mild depression. What is the first line treatment for this patient?
Your Answer: Advise regards lifestyle and diet
Correct Answer: Psychological intervention
Explanation:The primary treatment for mild depression is psychological intervention, typically obtained through an IAPT referral. Although a patient may also be prescribed a Serotonin Specific Reuptake Inhibitor (SSRI) while waiting for their referral, it is important to note that the NICE guidelines prioritize the consideration of an IAPT referral as the first line of treatment. Therefore, an IAPT referral is the most appropriate answer in this scenario.
In 2022, NICE updated its guidelines on managing depression and now classifies it as either less severe or more severe based on a patient’s PHQ-9 score. For less severe depression, NICE recommends discussing treatment options with patients and considering the least intrusive and resource-intensive treatment first. Antidepressant medication should not be routinely offered as first-line treatment unless it is the patient’s preference. Treatment options for less severe depression include guided self-help, group cognitive behavioral therapy, group behavioral activation, individual CBT or BA, group exercise, group mindfulness and meditation, interpersonal psychotherapy, SSRIs, counseling, and short-term psychodynamic psychotherapy. For more severe depression, NICE recommends a shared decision-making approach and suggests a combination of individual CBT and an antidepressant as the preferred treatment option. Other treatment options for more severe depression include individual CBT or BA, antidepressant medication, individual problem-solving, counseling, short-term psychodynamic psychotherapy, interpersonal psychotherapy, guided self-help, and group exercise.
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This question is part of the following fields:
- Psychiatry
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Question 5
Correct
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A young woman tells you she has developed fears of getting lost in the crowd and has become very anxious about going to open public places. She also says that she had experienced panic attacks previously when she went to a crowded shopping mall. She is physically healthy and so far has no history of mental illness.
Which of the following is the most likely diagnosis?Your Answer: Agoraphobia
Explanation:Understanding Phobias and Dissociative Disorders
Phobias and dissociative disorders are two types of mental health conditions that can significantly impact a person’s daily life. Phobias are intense and irrational fears of specific objects or situations, while dissociative disorders involve a disconnection from reality as a coping mechanism.
Agoraphobia is a common and severe phobia that affects mostly women and involves a fear of open spaces and crowded places. Social phobia, on the other hand, is a fear of being scrutinized in public and tends to start in adolescence. Acrophobia is a specific phobia that involves a fear of heights.
Treatment for phobias often involves psychological interventions such as cognitive-behavioral therapy. Dissociative disorders, on the other hand, typically require more intensive therapy to address the underlying trauma that led to the dissociation.
It’s important to seek professional help if you or someone you know is struggling with a phobia or dissociative disorder. With the right treatment and support, it is possible to manage these conditions and improve overall quality of life.
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This question is part of the following fields:
- Psychiatry
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Question 6
Incorrect
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Sarah is a 25-year-old woman with schizophrenia who has had multiple admissions under the Mental Health Act (1983).
Her consultant has utilized a Section of the Mental Health Act that permits Sarah to be brought back to the hospital for treatment if certain conditions are not met, such as if she declines to take her depot antipsychotic.
What is the name of this Section?Your Answer: Section 2
Correct Answer: Section 17a (Community Treatment Order)
Explanation:Sectioning under the Mental Health Act is a legal process used for individuals who refuse voluntary admission. This process excludes patients who are under the influence of drugs or alcohol. There are several sections under the Mental Health Act that allow for different types of admission and treatment.
Section 2 allows for admission for assessment for up to 28 days, which is not renewable. An Approved Mental Health Professional (AMHP) or the nearest relative (NR) can make the application on the recommendation of two doctors, one of whom should be an approved consultant psychiatrist. Treatment can be given against the patient’s wishes.
Section 3 allows for admission for treatment for up to 6 months, which can be renewed. An AMHP and two doctors, both of whom must have seen the patient within the past 24 hours, can make the application. Treatment can also be given against the patient’s wishes.
Section 4 is used as an emergency 72-hour assessment order when a section 2 would involve an unacceptable delay. A GP and an AMHP or NR can make the application, which is often changed to a section 2 upon arrival at the hospital.
Section 5(2) allows a doctor to legally detain a voluntary patient in hospital for 72 hours, while section 5(4) allows a nurse to detain a voluntary patient for 6 hours.
Section 17a allows for Supervised Community Treatment (Community Treatment Order) and can be used to recall a patient to the hospital for treatment if they do not comply with the conditions of the order in the community, such as taking medication.
Section 135 allows for a court order to be obtained to allow the police to break into a property to remove a person to a Place of Safety. Section 136 allows for someone found in a public place who appears to have a mental disorder to be taken by the police to a Place of Safety. This section can only be used for up to 24 hours while a Mental Health Act assessment is arranged.
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This question is part of the following fields:
- Psychiatry
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Question 7
Incorrect
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Which of the following is linked to a favorable prognosis in individuals with schizophrenia?
Your Answer: Premorbid history of social withdrawal
Correct Answer: Acute onset
Explanation:A poor prognosis is often linked to a gradual onset rather than an acute one.
Schizophrenia is a mental disorder that can have varying prognoses depending on certain factors. Some indicators associated with a poor prognosis include a strong family history of the disorder, a gradual onset of symptoms, a low IQ, a prodromal phase of social withdrawal, and a lack of an obvious precipitant. These factors can contribute to a more severe and chronic course of the illness, making it more difficult to manage and treat. It is important for individuals with schizophrenia and their loved ones to be aware of these indicators and seek appropriate treatment and support.
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This question is part of the following fields:
- Psychiatry
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Question 8
Correct
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A 30-year-old man with a history of schizophrenia presents to the Emergency Department with drowsiness. Upon examination, he appears rigid. The medical team suspects neuroleptic malignant syndrome. Which of the following is not a feature of this condition?
Your Answer: Usually occurs after prolonged treatment
Explanation:Patients who have recently started treatment are commonly affected by neuroleptic malignant syndrome, which can lead to renal failure due to rhabdomyolysis.
Understanding Neuroleptic Malignant Syndrome
Neuroleptic malignant syndrome is a rare but serious condition that can occur in patients taking antipsychotic medication. It can also happen with dopaminergic drugs used for Parkinson’s disease. The exact cause of this condition is unknown, but it is believed that dopamine blockade induced by antipsychotics triggers massive glutamate release, leading to neurotoxicity and muscle damage. Symptoms of neuroleptic malignant syndrome typically appear within hours to days of starting an antipsychotic and include fever, muscle rigidity, autonomic lability, and agitated delirium with confusion.
A raised creatine kinase is present in most cases, and acute kidney injury may develop in severe cases. Management of neuroleptic malignant syndrome involves stopping the antipsychotic medication and transferring the patient to a medical ward or intensive care unit. Intravenous fluids may be given to prevent renal failure, and dantrolene or bromocriptine may be used in selected cases. It is important to differentiate neuroleptic malignant syndrome from serotonin syndrome, which has similar symptoms but is caused by excessive serotonin activity.
In summary, neuroleptic malignant syndrome is a rare but potentially life-threatening condition that can occur in patients taking antipsychotic medication or dopaminergic drugs. Early recognition and management are crucial to prevent complications and improve outcomes.
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This question is part of the following fields:
- Psychiatry
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Question 9
Incorrect
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You are a junior doctor working in the Emergency Department. A 54-year-old man is brought in by his wife. He looks unwell and is sweating profusely. He tells you he has abruptly stopped drinking alcohol and used to drink heavily. What is the neurotransmitter mechanism responsible for alcohol withdrawal?
Your Answer: Increased inhibitory GABA and decreased excitatory glutamate
Correct Answer: Decreased inhibitory GABA and increased excitatory glutamate
Explanation:Alcohol withdrawal occurs due to a decrease in the inhibitory neurotransmitter GABA and an increase in the excitatory neurotransmitter NMDA glutamate. GABA typically reduces brain activity and induces a calming effect when levels are high, which is heightened during alcohol consumption. On the other hand, glutamate increases brain activity and acts as a natural stimulant, which is reduced during alcohol consumption, leading to a physiological slowdown.
When a person drinks alcohol, the brain assumes that there is an excess of GABA and a shortage of glutamate. However, if the person continues to drink excessively, the brain produces less GABA and more glutamate to restore normal brain chemistry. If the person then stops drinking, the brain experiences a rebound effect, where it still produces less GABA and more glutamate than required without alcohol. As a result, the brain acts as if there is a deficiency of GABA and an excess of glutamate, leading to withdrawal symptoms.
Alcohol withdrawal occurs when an individual who has been consuming alcohol chronically suddenly stops or reduces their intake. Chronic alcohol consumption enhances the inhibitory effects of GABA in the central nervous system, similar to benzodiazepines, and inhibits NMDA-type glutamate receptors. However, alcohol withdrawal leads to the opposite effect, resulting in decreased inhibitory GABA and increased NMDA glutamate transmission. Symptoms of alcohol withdrawal typically start at 6-12 hours and include tremors, sweating, tachycardia, and anxiety. Seizures are most likely to occur at 36 hours, while delirium tremens, which includes coarse tremors, confusion, delusions, auditory and visual hallucinations, fever, and tachycardia, peak at 48-72 hours.
Patients with a history of complex withdrawals from alcohol, such as delirium tremens, seizures, or blackouts, should be admitted to the hospital for monitoring until their withdrawals stabilize. The first-line treatment for alcohol withdrawal is long-acting benzodiazepines, such as chlordiazepoxide or diazepam, which are typically given as part of a reducing dose protocol. Lorazepam may be preferable in patients with hepatic failure. Carbamazepine is also effective in treating alcohol withdrawal, while phenytoin is said to be less effective in treating alcohol withdrawal seizures.
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This question is part of the following fields:
- Psychiatry
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Question 10
Incorrect
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Which of the following is a side-effect of lithium therapy?
Your Answer: Leucopenia
Correct Answer: Hypothyroidism
Explanation:Understanding the Side-Effects of Lithium Maintenance Therapy
Lithium maintenance therapy is a common treatment for bipolar disorder, but it can also cause a range of side-effects. One of the most common is hypothyroidism, which affects up to 5% of patients on lithium and requires regular thyroid function tests. Weight gain, acne, tremors, and polydipsia are also common, as well as ankle edema and a metallic taste in the mouth. Lithium can also cause renal toxicity, so regular urea and electrolyte tests are necessary. However, lithium does not cause abnormal liver function or fever, and actually causes leukocytosis rather than leucopenia. Cystitis is also not a typical side-effect of lithium. Overall, understanding the potential side-effects of lithium maintenance therapy is crucial for managing bipolar disorder effectively.
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This question is part of the following fields:
- Psychiatry
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