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Question 1
Correct
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Which food is a rich source of vitamin D in the diet?
Your Answer: Oily fish
Explanation:Sources of Vitamin D
Vitamin D is a type of fat-soluble vitamin that can be found in certain foods such as cheese, butter, eggs, and oily fish. However, vegetable sources of vitamin D are limited, although some foods are fortified with this vitamin. For instance, 100 grams of sundried shiitake mushrooms contain 1600 IU of vitamin D, while one egg contains 20 IU. Wild salmon is also a good source of vitamin D, with 100 grams containing 800 IU, while farmed salmon contains 200 IU.
Aside from food sources, sunlight is also a good source of vitamin D. Exposure of arms and legs to sunlight for 10-15 minutes can provide 3000 IU of vitamin D. However, it is difficult to obtain the daily requirement of 25-50 IU of vitamin D through sunlight alone, especially for people living in temperate climates. As a result, many people may have insufficient vitamin D levels. It is important to ensure that we get enough vitamin D through a combination of food sources and sunlight exposure.
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This question is part of the following fields:
- Basic Sciences
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Question 2
Incorrect
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What are the potential clinical consequences of a lack of vitamin E?
Your Answer: Excessive bleeding
Correct Answer: Ataxia
Explanation:Vitamin E Deficiency
Vitamin E deficiency is a rare condition that is more likely to occur in individuals with problems affecting the absorption of dietary fats. This includes those with a history of bowel surgery, pancreatic insufficiency, and cystic fibrosis. Premature infants are also at a higher risk of developing this deficiency as vitamin E does not easily cross the placenta. However, supplementation with vitamin E can reverse the damage in some cases.
The effects of vitamin E deficiency can be severe and can cause spinocerebellar degeneration, which includes limb ataxia, loss of joint position sense, loss of sensation of vibration, and loss of deep tendon reflexes. Additionally, it can cause degeneration of retinal pigments, leading to blindness. In premature infants, it can cause haemolytic anaemia, thrombocytosis, and oedema.
Overall, vitamin E deficiency is crucial in preventing and treating its effects. It is important to identify individuals who are at a higher risk of developing this deficiency and provide them with appropriate supplementation to prevent any long-term damage.
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This question is part of the following fields:
- Basic Sciences
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Question 3
Incorrect
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What occurs in eukaryotic prometaphase?
Your Answer: The chromosomes align across a plane
Correct Answer: The nuclear membrane and the nucleoli disintegrate and kinetochores appear
Explanation:The Significance of Prometaphase in Cell Division
Prometaphase is a crucial phase in cell division that marks the transition from prophase to metaphase. Although it is often considered as a part of these two phases, it has distinct events that make it an individual phase. During prometaphase, the nuclear membrane disintegrates, and the nucleoli are no longer visible. Additionally, each chromosome forms two kinetochores near the centromere, which serve as attachment points for spindle fibers. These fibers connect to the opposite poles of the cell, forming travelling lines that will separate the sister chromatids during anaphase.
Prophase is characterized by chromatin condensation, while DNA and centrosome duplication occur during interphase. Chromosome alignment takes place during metaphase, and the sister chromatids separate during anaphase. Prometaphase, therefore, plays a crucial role in preparing the chromosomes for separation during anaphase. Its distinct events make it an essential phase in cell division, and its proper execution is necessary for successful cell division.
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This question is part of the following fields:
- Basic Sciences
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Question 4
Incorrect
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What is the primary means of transportation for vitamin D in the human body?
Your Answer: In blood, bound to albumin
Correct Answer: In blood, bound to the group specific component
Explanation:The Role of UV Light and Vitamin D in Calcium and Phosphate Regulation
In order for the body to produce Vitamin D3, UV light at a specific wavelength is required to convert cholesterol in the skin. Vitamin D2 and D3 are then transported in the bloodstream bound to the Vitamin-D Binding Protein and undergo further modifications in the liver and kidney to become the active form, 1,25 (OH)2Vitamin D. This active form plays a crucial role in regulating calcium and phosphate concentrations in the body.
1,25 (OH)2Vitamin D increases calcium absorption in the duodenum and inhibits the secretion and synthesis of PTH, which helps to maintain calcium concentrations. It also increases phosphate absorption in the jejunum and ileum, which is important for maintaining phosphate concentrations. Additionally, 1,25 (OH)2Vitamin D promotes bone turnover by stimulating both osteoblast and osteoclast activity.
Overall, the production and activation of Vitamin D through UV light and dietary sources is essential for proper calcium and phosphate regulation in the body.
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This question is part of the following fields:
- Basic Sciences
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Question 5
Incorrect
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While taking a patient's medical history, you discover that their family has a strong history of a certain disease. Autosomal dominant diseases are often caused by defects in structural genes and typically present in early adulthood, affecting both males and females equally. Which of the following diseases does not follow an autosomal dominant pattern of inheritance?
Your Answer: Adult polycystic kidney disease
Correct Answer: Haemochromatosis
Explanation:Abnormal Binding Proteins and Iron Deposition: A Genetic Disorder
Abnormal binding proteins can lead to the deposition of iron in the body, resulting in various health complications. This genetic disorder is inherited in an autosomal recessive manner. The deposition of iron can cause cardiomyopathy, cirrhosis, pancreatic failure due to fibrosis, and skin pigmentation.
In general, disorders that affect metabolism or DNA replication on a cellular or genetic level tend to be autosomal recessive. On the other hand, genetic disorders that affect the structure of the body on a larger level are usually autosomal dominant. While there may be exceptions to these rules, they can serve as a helpful guide for exam preparation. Proper of this genetic disorder can aid in its diagnosis and management.
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This question is part of the following fields:
- Basic Sciences
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Question 6
Incorrect
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What controls the specific stages of the cell cycle?
Your Answer: The on/off activity of cyclases and cyclase-dependent kinases
Correct Answer: Cyclins and cyclin-dependent kinases
Explanation:Regulation of the Cell Cycle by Cyclins and Cyclin-Dependent Kinases
The cell cycle is controlled by the activity of proteins known as cyclins and phosphorylating enzymes called cyclin-dependent kinases (CDKs). Cyclins and CDKs combine to form an activated heterodimer, where cyclins act as the regulatory subunits and CDKs act as the catalytic subunits. Neither of these molecules is active on their own. When a cyclin binds to a CDK, the CDK phosphorylates other target proteins, either activating or deactivating them. This coordination leads to the entry into the next phase of the cell cycle. The specific proteins that are activated depend on the different combinations of cyclin-CDK. Additionally, CDKs are always present in cells, while cyclins are produced at specific points in the cell cycle in response to other signaling pathways.
In summary, the cell cycle is regulated by the interaction between cyclins and CDKs. This interaction leads to the phosphorylation of target proteins, which ultimately controls the progression of the cell cycle.
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This question is part of the following fields:
- Basic Sciences
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Question 7
Correct
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In which part of the cell are the electron transport chain carriers situated?
Your Answer: Mitochondrial cristae
Explanation:The Electron Transport Chain in Mitochondria
The electron transport chain (ETC) is a crucial process in cellular aerobic respiration that occurs in the mitochondrial cristae. These are folded membranes inside the organelle. During respiration, NADH and FADH produced from other parts of the process, such as glycolysis, transfer electrons from electron donors to electron acceptors through redox reactions. This electron transfer is coupled with proton transfer across the mitochondrial membrane, creating an electrochemical proton gradient. This gradient induces the production of ATP, which is used as an energy currency by the cell.
ATP is produced through a mechanism called chemiosmotic phosphorylation. The structure of the mitochondrion is essential for this process to occur. The cristae provide a large surface area for the ETC to take place, and the mitochondrial membrane is impermeable to protons, allowing for the creation of the proton gradient. The inner membrane also contains ATP synthase, the enzyme responsible for producing ATP through chemiosmotic phosphorylation.
In summary, the electron transport chain in mitochondria is a complex process that involves the transfer of electrons and protons across the mitochondrial membrane to create a proton gradient. This gradient is then used to produce ATP through chemiosmotic phosphorylation. The structure of the mitochondrion is crucial for this process to occur efficiently.
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This question is part of the following fields:
- Basic Sciences
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Question 8
Incorrect
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Which statement regarding microtubules is accurate in relation to Chédiak-Higashi syndrome?
Your Answer: They consist of beta tubulin subunits only
Correct Answer: They are arranged in a 9+2 formation in cilia
Explanation:Microtubules and Chédiak-Higashi Syndrome
Microtubules are made up of alpha and beta tubulin dimers that are arranged in a helix and can be added or removed to change the length. They are found in structures such as flagella, mitotic spindles, and cilia, where they have a 9+2 arrangement. These structures are important for cell movement and division. Chemotherapy agents, such as taxanes, target microtubules and are used in breast cancer treatment.
Chédiak-Higashi syndrome is a rare inherited immunodeficiency disorder caused by mutations in the LYST gene. This condition is characterized by neutrophil inclusions, albinism, recurrent infections, and peripheral neuropathy. The neutrophil inclusions are thought to be caused by abnormal microtubule function, which affects the immune system’s ability to fight infections. While there is no cure for Chédiak-Higashi syndrome, treatment focuses on managing symptoms and preventing infections.
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This question is part of the following fields:
- Basic Sciences
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Question 9
Incorrect
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What is the statement of Henry's law?
Your Answer: Equal volumes of gases at standardised temperature and pressure each contain the same number of molecules
Correct Answer: The concentration of a gas when dissolved in liquid is proportional to its partial pressure
Explanation:Gas Laws
Gas laws are a set of scientific principles that describe the behavior of gases under different conditions. One of these laws is Avogadro’s law, which states that equal volumes of gases at a standardized temperature and pressure contain the same number of molecules. Another law is Boyle’s law, which explains that gases expand when the temperature is increased. Charles’ law, on the other hand, states that the pressure of a gas is inversely proportional to its volume at a standardized temperature. Lastly, Graham’s law explains that the rate of diffusion of a gas is in inverse proportion to its weight. The specific gas laws that you need to know may vary depending on your syllabus, but you should be able to recognize and apply them if given the formulae. It is unlikely that you will be expected to know the correct formula.
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This question is part of the following fields:
- Basic Sciences
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Question 10
Incorrect
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A couple in their early 30s come to your clinic seeking advice. The husband has a history of haemophilia B and they are worried about the possibility of passing it on to their children. Can you determine which of their offspring will be affected by the disease?
Your Answer: Half of the daughters and half of the sons will be affected
Correct Answer: All daughters will be carriers; no sons will be affected
Explanation:The inheritance of Haemophilia A and B is crucial in identifying individuals who are at risk of developing the condition. Haemophilia A and B are genetic disorders that are inherited in an X-linked recessive manner. Haemophilia A is caused by a deficiency in clotting factor VIII, while haemophilia B is caused by a deficiency in clotting factor IX.
On the other hand, haemophilia C, which is caused by a deficiency in clotting factor XI, is primarily inherited in an autosomal recessive manner. In X-linked recessive conditions like haemophilia B, males are more likely to be affected than females. This is because males only need one abnormal copy of the gene, which is carried on the X chromosome, to be affected.
Females, on the other hand, can be carriers of the condition if they carry one normal and one abnormal copy of the gene. While carriers can have clotting abnormalities, these are usually milder than those seen in affected individuals. Men cannot pass the condition to their sons, but they will pass on the abnormal X chromosome to all their daughters, who will be carriers.
Female carriers can pass on the condition to around half their sons, and half their daughters will be carriers. Females can only be affected if they are the offspring of an affected male and a carrier female. In summary, the inheritance of haemophilia A and B is crucial in identifying individuals who are at risk of developing the condition. It also helps in providing appropriate genetic counseling and management for affected individuals and their families.
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This question is part of the following fields:
- Basic Sciences
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Question 11
Incorrect
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You are evaluating a geriatric patient in the emergency department who has fallen and needs a venous cannula for fluid resuscitation. To ensure maximum flow into the vein, you plan to apply the Hagen-Poiseuille equation to select an appropriate cannula size. Which of the following statements is true according to this law?
Your Answer:
Correct Answer: Flow will be faster through a shorter cannula
Explanation:Poiseuille’s Equation and Fluid Flow in Cylinders
Poiseuille’s equation is used to describe the flow of non-pulsatile laminar fluids through a cylinder. The equation states that the flow rate is directly proportional to the pressure driving the fluid and the fourth power of the radius. Additionally, it is inversely proportional to the viscosity of the fluid and the length of the tube. This means that a short, wide cannula with pressure on the bag will deliver fluids more rapidly than a long, narrow one.
It is important to note that even small changes in the radius of a tube can greatly affect the flow rate. This is because the fourth power of the radius is used in the equation. Therefore, any changes in the radius will have a significant impact on the flow rate. Poiseuille’s equation is crucial in determining the optimal conditions for fluid delivery in medical settings.
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This question is part of the following fields:
- Basic Sciences
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Question 12
Incorrect
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What is the primary function of riboflavin in the B vitamin group?
Your Answer:
Correct Answer: Mopping up free radicals
Explanation:The Role of Riboflavin in the Body
Riboflavin, also known as vitamin B2, is a B-vitamin that plays a crucial role in the body. One of its functions is to act as an antioxidant, mopping up free radicals that can cause damage to cells. However, if the metabolites formed during this process are not excreted promptly, the free radicals can be generated again. Riboflavin is also involved in the production of blue-light sensitive pigments in the eye, which help establish the circadian rhythm. This function is not related to visual acuity.
Riboflavin is found in a variety of foods, including milk and offal. Deficiency of this vitamin is rare, but when it does occur, it can cause non-specific effects on the skin and mucous membranes. There is no evidence of clear long-lasting damage from riboflavin deficiency. Overall, riboflavin is an important nutrient that plays a vital role in maintaining good health.
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This question is part of the following fields:
- Basic Sciences
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Question 13
Incorrect
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As part of your general practice placement, you have been tasked with conducting an audit on the duration of solid food introduction in the practice population. You review the data for the last six infants born within the practice:
6 months, 7 months, 8 months, 9 months, 10 months, 11 months.
What is the variance value for the duration of solid food introduction in the practice population?Your Answer:
Correct Answer: 74.9
Explanation:Variance and Standard Deviation in Breast Feeding Duration
Variance is a statistical measure that indicates how spread out a set of data is. In the case of breast feeding duration, variance can help us understand how much the duration varies from the mean. The formula for variance involves squaring the difference between each data point and the mean, then dividing the sum by n-1, where n is the total number of data points. In a sample population, n-1 is a better estimate of variance than n because it accounts for the variability within the sample.
For example, if the variance of breast feeding duration is 74.9 months, this indicates that the duration is widely distributed from the mean of 17.6 months. A smaller variance, such as 4.5 months, would indicate that the duration varies less and is closer to the mean. The standard deviation, which is the square root of the variance, is also important in the spread of data. In a normal distribution, 95% of observations will fall within two standard deviations of the mean.
In the case of breast feeding duration, the mean is 17.6 months, indicating that babies are breast fed for an average of 15 and a half months. The median, which is the middle number in the data set, is 15 months, meaning that half of the babies were breast fed for 15 months. variance and standard deviation can help us better understand the distribution of breast feeding duration and other medical measurements.
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This question is part of the following fields:
- Basic Sciences
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Question 14
Incorrect
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What are the vitamins that are soluble in fat?
Your Answer:
Correct Answer: Vitamins A, D, E and K
Explanation:Absorption of Fat-Soluble Vitamins
Fat-soluble vitamins, namely A, D, E, and K, have a different absorption process compared to water-soluble vitamins. In the gut, these vitamins are combined with other fat-soluble substances such as monoacylglycerols and cholesterol to form micelles. These micelles are then transported to the lymphatic system and eventually enter the bloodstream through the subclavian vein.
However, any issues that affect the absorption of fats will also impact the absorption of fat-soluble vitamins. This means that individuals with conditions that affect fat absorption, such as cystic fibrosis or celiac disease, may have difficulty absorbing these vitamins. It is important to ensure adequate intake of fat-soluble vitamins through a balanced diet or supplements to prevent deficiencies and associated health problems.
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This question is part of the following fields:
- Basic Sciences
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Question 15
Incorrect
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A man in his forties comes in with chest pain resembling a heart attack and is diagnosed with a myocardial infarction. During his hospitalization, it is discovered that he has familial hypercholesterolemia but his triglyceride levels are normal. What is the underlying biochemical abnormality?
Your Answer:
Correct Answer: Defective LDL receptors
Explanation:Lipid Metabolism and Transport in the Body
The breakdown of triglycerides in the small intestine is facilitated by pancreatic lipase. These triglycerides are then transported to the liver and other parts of the body through chylomicrons.
Very low-density lipoprotein (VLDL) is responsible for carrying triglycerides from the liver to peripheral tissues. When there is an overproduction of VLDL in the liver, it can lead to high levels of triglycerides in the body.
Pure hypercholesterolaemia is a condition that arises due to a defect in the process of cholesterol uptake into cells. This process relies on apolipoprotein B-100 binding to LDL receptors and facilitating endocytosis. When this process is disrupted, it can lead to high levels of cholesterol in the body.
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This question is part of the following fields:
- Basic Sciences
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Question 16
Incorrect
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What are the clinical consequences of a lack of vitamin A?
Your Answer:
Correct Answer: Dry conjunctiva
Explanation:The Devastating Effects of Vitamin A Deficiency
Vitamin A deficiency is a serious health concern that can lead to a range of devastating effects. One of the most common consequences is blindness, particularly in children. Poor night vision is often an early sign of this deficiency, which can progress to complete blindness if left untreated.
In addition to blindness, vitamin A deficiency can also cause dry conjunctiva, a condition known as conjunctival xerosis. This occurs when the normally moist and fine conjunctiva becomes thickened and dysfunctional, leading to the formation of white plaques known as Bitot’s spots. Corneal ulceration can also occur as a result of this condition.
The respiratory and gastrointestinal epithelia can also be affected by vitamin A deficiency, leading to reduced resistance to infection. This deficiency is a major public health issue in some parts of the world and is the single most common preventable cause of blindness. It is crucial to address this issue through education and access to vitamin A-rich foods and supplements.
Overall, the devastating effects of vitamin A deficiency highlight the importance of proper nutrition and access to essential vitamins and minerals. By addressing this issue, we can help prevent blindness and improve overall health outcomes for individuals and communities around the world.
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This question is part of the following fields:
- Basic Sciences
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Question 17
Incorrect
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A couple in their late 30s come to the clinic seeking information about the risk of their three children inheriting Huntington's disease. The husband has recently been diagnosed with the disease, while the wife is not affected. What is the likelihood, expressed as a percentage, that their children will inherit the disease?
Your Answer:
Correct Answer: 50%
Explanation:Huntington’s Disease
Huntington’s disease is a genetic disorder that typically appears later in life and is characterized by symptoms such as chorea, cognitive decline, and personality changes. It is an autosomal dominant disease, meaning that there is a 50% chance of passing it on to offspring. If the gene is inherited from an unaffected parent, the child will not be affected. This is different from autosomal recessive inheritance, where both parents must pass on the gene for it to affect their children.
The disease is caused by an increase in the length of a repeating trinucleotide sequence (CAG) in the Huntington protein. This sequence can change in length through generations, and longer sequences are associated with earlier onset of symptoms (genetic anticipation). Since Huntington’s disease usually presents itself after people have already started their families, there are many issues associated with genetic testing.
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This question is part of the following fields:
- Basic Sciences
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Question 18
Incorrect
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The arrangement of amphipathic phospholipids in the mammalian cell membrane, what is it like?
Your Answer:
Correct Answer: A lipid bilayer with hydrophilic heads facing out and hydrophobic tails facing in
Explanation:The Function and Structure of the Mammalian Cell Membrane
The mammalian cell membrane serves as a protective barrier that separates the cytoplasm from the extracellular environment. It also acts as a filter for molecules that move across it. Unlike plant and prokaryotic cells, mammalian cells do not have a cell wall. The main component of the cell membrane is a bilayer of amphipathic lipids, which have a hydrophilic head and a hydrophobic tail. The phospholipids in the bilayer are oriented with their hydrophilic heads facing outward and their hydrophobic tails facing inward. This arrangement allows for the separation of the watery extracellular environment from the watery intracellular compartment.
It is important to note that the cell membrane is not a monolayer and the phospholipids are not linked head-to-tail. This is in contrast to DNA, which has a helical chain formation. Overall, the structure and function of the mammalian cell membrane are crucial for maintaining the integrity and proper functioning of the cell.
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This question is part of the following fields:
- Basic Sciences
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Question 19
Incorrect
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The Krebs or TCA cycle is a series of metabolic processes beginning with the synthesis of citrate from acetyl-CoA which results in a number of important metabolic products. Where in the cell does this cycle occur?
Your Answer:
Correct Answer: Mitochondria
Explanation:Cellular Processes and Organelles
Metabolic processes in the cell occur in specific locations. Acetyl-CoA production and the Krebs cycle take place in the mitochondrium, while glycolysis occurs in the cytoplasm. The nucleus is the central structure of the cell that contains DNA and is double membrane-bound. The rough endoplasmic reticulum is responsible for packaging and transporting proteins, while the smooth endoplasmic reticulum performs a similar function but lacks ribosomes.
It is important to understand where these processes occur in the cell to better understand their functions and how they contribute to the overall functioning of the cell. The mitochondrium is responsible for producing energy in the form of ATP, while the cytoplasm is where glucose is broken down during glycolysis. The nucleus is where genetic information is stored and replicated, and the endoplasmic reticulum is involved in protein synthesis and transport.
In summary, the cell is a complex system with various organelles that perform specific functions. where these processes occur in the cell is crucial to how they contribute to the overall functioning of the cell.
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This question is part of the following fields:
- Basic Sciences
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Question 20
Incorrect
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What type of molecule does haemoglobin belong to?
Your Answer:
Correct Answer: Quaternary protein structure
Explanation:The Structure and Functions of Proteins
Proteins are complex molecules that can vary in structure from single amino acids to large, folded molecules. Amino acids are joined together by peptide bonds to form dipeptides and polypeptides. More complex molecules can also have disulphide bonds and ionic bonds. The primary structure of a protein is a simple amino acid chain, while the secondary structure is a specific shape such as a helix or pleated sheet. The tertiary structure is a more globular shape, arranged by ionic, hydrogen, and disulphide bonds, and hydrophobic interactions. The quaternary structure is a complex protein containing several polypeptide chains held together by interactions.
Proteins have multiple roles within the human body, including as hormones, food substrates, enzymes, receptor molecules, muscles, cell membrane constituents, carrier molecules in blood, and determinants of oncotic/osmotic pressures. However, proteins can be easily damaged by denaturation, which is the loss of the specific three-dimensional shape of a molecule. Denaturation can be caused by heat, salts, heavy metals, solvents, detergents, and extremes of pH.
In summary, proteins are essential molecules with a diverse range of structures and functions within the human body. their structure and potential for denaturation is crucial for maintaining their proper function.
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This question is part of the following fields:
- Basic Sciences
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Question 21
Incorrect
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What significance do linoleic and alpha-linolenic acids hold?
Your Answer:
Correct Answer: They are essential fatty acids
Explanation:The Importance of Essential Fatty Acids in the Diet
Essential fatty acids, such as linoleic and alpha-linolenic acids, are crucial components of a healthy diet. Although they are only required in small amounts, they play several important roles in the body. These fatty acids are necessary for the synthesis of phospholipids, which are essential components of cell membranes. They also help regulate cholesterol transport and synthesis, and serve as precursors for omega-3 fatty acids and arachidonic acid. Additionally, essential fatty acids are important for the synthesis of prostaglandins, leukotrienes, and thromboxanes.
A lack of adequate essential fatty acids in the diet can have negative consequences, particularly for brain growth in infancy. It can also lead to alopecia, dermatitis, and fatty liver. Therefore, it is important to ensure that the diet includes sources of these essential fatty acids, such as certain types of fish, nuts, and seeds. By doing so, individuals can support their overall health and well-being.
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This question is part of the following fields:
- Basic Sciences
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Question 22
Incorrect
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At what stage of eukaryotic mitosis do the centromeres of chromosomes separate?
Your Answer:
Correct Answer: Anaphase
Explanation:Chromosome Division during Anaphase
Chromosomes are joined together in an X shape at the centromere. During anaphase, the centromeres break down and the chromosomes divide into two identical pairs called sister chromatids. These sister chromatids then move to opposite sides of the cell along a network of spindle fibres. When the cell divides during telophase, each daughter cell receives one sister chromatid from the parent cell. This ensures the accurate copying and propagation of genes. The process of chromosome division during anaphase is crucial for the proper distribution of genetic material in cells.
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This question is part of the following fields:
- Basic Sciences
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Question 23
Incorrect
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Of which cellular structure is the fibrillar centre a component?
Your Answer:
Correct Answer: The nucleolus
Explanation:The Fibrillar Centre in the Nucleolus
The fibrillar centre is a crucial component of the nucleolus, which is found in most metazoan nucleoli, particularly in higher eukaryotes. Along with the dense fibrillar components and the granular component, it forms the three major components of the nucleolus. During the end of mitosis, the fibrillar centre serves as a storage point for nucleolar ribosomal chromatin and associated ribonucleoprotein transcripts. As the nucleolus becomes active, the ribosomal chromatin and ribonucleoprotein transcripts begin to form the dense fibrillar components, which are more peripherally located and surround the fibrillar centres. The transcription zone for multiple copies of the pre-rRNA genes is the border between these two structures. It is important to note that the fibrillar centre is not a component of any of the cell structures mentioned in the incorrect answer options.
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This question is part of the following fields:
- Basic Sciences
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Question 24
Incorrect
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What is the most common method of assessing nutritional status in adults?
Your Answer:
Correct Answer: Body mass index
Explanation:The Body Mass Index as a Measure of Nutritional Status
The measurement and assessment of nutritional status can be challenging, and there is no single test that can provide a complete picture. However, the body mass index (BMI) is a commonly used measurement in clinical practice. The BMI is calculated by dividing a person’s weight in kilograms by their height in meters squared. This measure is used to assess adiposity and nutritional status, and it is simple and quick to calculate and interpret.
Although the BMI is a convenient measure, it has limitations for assessing obesity in individual patients. It is best used to track trends in an individual patient’s BMI over time. In some cases, the BMI may overestimate fat mass in patients who are very tall or have a high proportion of lean tissue due to an active lifestyle. Additionally, the BMI may not be accurate for athletes and children.
Other measurements, such as skin fold thickness and weight, can also be useful, but the BMI is generally considered the better option. The ponderal index is used specifically for children. It is important to note that albumin is not a reliable marker of nutritional status, as it can also be affected by inflammation.
Overall, the BMI is a widely used measure of nutritional status and is recommended by the World Health Organization. However, it is important to consider its limitations and use it in conjunction with other measurements to obtain a more complete picture of a patient’s nutritional status.
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This question is part of the following fields:
- Basic Sciences
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Question 25
Incorrect
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The diabetes prevention program has been running for the last 5 years. At baseline, a well conducted study with a sample size of 500 showed that the prevalence of diabetes among adults aged 40 and above was 15%.
Five years later another survey (of 400 responders) showed that the prevalence of diabetes was 10%.
In the above example, which definition of prevalence is correct?Your Answer:
Correct Answer: Prevalence is the number of new and old smokers in a year
Explanation:Prevalence and Incidence in Smoking
Prevalence and incidence are two important concepts in the smoking habits of a population. Prevalence refers to the number of people who smoke at a particular time point, such as at the beginning or end of a study period. This is calculated by dividing the number of smokers by the total population.
On the other hand, incidence refers to the number of new cases of smoking at a particular time point. For example, this could be at the beginning of a study period for the whole year or at the 10th year. This is calculated by dividing the number of new smokers by the number of smoke-free individuals who are potentially at risk of taking up smoking.
prevalence and incidence is important in evaluating the effectiveness of smoking cessation programs and policies. By tracking changes in prevalence and incidence over time, researchers and policymakers can determine whether their efforts are making a difference in reducing smoking rates. Additionally, these concepts can help identify populations that are at higher risk of taking up smoking, allowing for targeted interventions to prevent smoking initiation.
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This question is part of the following fields:
- Basic Sciences
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Question 26
Incorrect
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What is the primary factor that increases the risk of thiamine (vitamin B1) deficiency?
Your Answer:
Correct Answer: Chronic alcohol excess
Explanation:Thiamine: Its Roles, Sources, Deficiency States, and Manifestations
Thiamine is a vital nutrient that plays several roles in the body. It acts as a cofactor to enzymes involved in energy production, metabolism of branched chain amino acids, and regulation of nerve and muscle action potentials. It is found in many foods, including wheat, oats, and yeast-containing products. However, deficiency states can occur in chronic alcohol dependence, renal dialysis, and cultures that mainly consume white rice. The deficiency can manifest as ‘dry’ beriberi, which causes peripheral neuropathy, muscle weakness, fatigue, and reduced concentration, or ‘wet’ beriberi, which also involves heart failure and edema. In severe cases, Wernicke-Korsakoff syndrome can develop, which is an emergency requiring urgent IV replacement of thiamine. If left untreated, it can lead to irreversible amnesia, confabulation, and dementia. Therefore, all patients with alcohol-related admissions should be considered for Pabrinex, a B vitamin infusion.
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This question is part of the following fields:
- Basic Sciences
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Question 27
Incorrect
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What stage of cellular respiration is responsible for the production of pyruvic acid?
Your Answer:
Correct Answer: Glycolysis
Explanation:The Versatility of Pyruvic Acid in Cellular Metabolism
Pyruvic acid is a simple alpha-keto acid that plays a crucial role in several metabolic pathways within the cell. It serves as a central intersection where different pathways converge and diverge. One of the primary ways pyruvic acid is produced is through glycolysis, where glucose is broken down into pyruvic acid. Depending on the cell’s needs, pyruvic acid can be converted back into glucose through gluconeogenesis or used to synthesize fatty acids through the acetyl-CoA pathway. Additionally, pyruvic acid can be used to produce the amino acid alanine.
Pyruvic acid is also involved in respiration, where it enters the Krebs cycle under aerobic conditions. This cycle produces energy in the form of ATP, which is used by the cell for various functions. Under anaerobic conditions, pyruvic acid can ferment into lactic acid, which is used by some organisms as a source of energy.
In summary, pyruvic acid is a versatile molecule that plays a critical role in cellular metabolism. Its ability to be converted into different molecules depending on the cell’s needs makes it an essential component of many metabolic pathways.
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This question is part of the following fields:
- Basic Sciences
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Question 28
Incorrect
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What function does vitamin E serve in the body?
Your Answer:
Correct Answer: Antioxidant
Explanation:Vitamin E and its Functions
Several substances are classified as vitamin E, with alpha-tocopherol being the most common, accounting for 90% of human vitamin E. Alpha-tocopherol is composed of two carbon rings and a long saturated hydrocarbon chain, making it hydrophobic. It has an aromatic ring with an OH- group attached to it. Other substances with vitamin E activity include other tocopherols and tocotrienols, all of which act as antioxidants. Alpha-tocopherol is particularly important in cell membranes, preventing the peroxidation of unsaturated fatty acids by free radicals. It also has other functions, such as regulating gene transcription, inhibiting clotting formation, reducing proliferation of vascular smooth muscle, and playing a role in immunity.
Despite claims that taking vitamin E can reduce the risk of heart disease, cancer, and enhance sexual performance, there is currently no strong evidence to support these claims.
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This question is part of the following fields:
- Basic Sciences
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Question 29
Incorrect
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A 50-year-old female patient with varicose veins presents to the vascular clinic for evaluation.
During the assessment, a test is conducted to determine the location of incompetence. The patient is instructed to lie down, and the veins are emptied by elevating her legs off the couch. The examiner then identifies the site of the sapheno-femoral junction and applies pressure with their fingers. The patient is then asked to stand up to evaluate vein filling.
What is the name of this test?Your Answer:
Correct Answer: Trendelenburg's test
Explanation:Assessing Varicose Vein Site of Incompetence
The Trendelenburg and tourniquet tests are both used to evaluate the site of incompetence in varicose veins at the sapheno-femoral junction. During the Trendelenburg test, the examiner applies pressure with their fingers over the junction site, while in the tourniquet test, a tourniquet is placed just below the junction level.
If the veins fill quickly upon standing, it indicates that the sapheno-femoral junction is not the source of the incompetence. These tests are essential in determining the location of the varicose vein site of incompetence, which is crucial in planning the appropriate treatment. By identifying the site of incompetence, physicians can perform targeted interventions to improve venous function and alleviate symptoms. Therefore, the Trendelenburg and tourniquet tests are valuable tools in the diagnosis and management of varicose veins.
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This question is part of the following fields:
- Basic Sciences
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Question 30
Incorrect
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Which of the following would not increase the rate of diffusion of a substance across a lipid membrane such as the cell wall?
Your Answer:
Correct Answer: Thickness of the membrane
Explanation:Diffusion and Fick’s Law
Diffusion is a natural process that occurs when molecules move from an area of high concentration to an area of low concentration. This process is passive and random, meaning that it does not require any external energy input. Fick’s Law states that diffusion occurs more quickly across a large, permeable, and thin membrane. For example, in lung disease, the thickening of the alveolar epithelial barrier can lead to a poor carbon monoxide transfer coefficient because the thicker membrane slows down the diffusion process. the principles of diffusion and Fick’s Law can help us better understand how molecules move and interact in various biological and chemical processes. By optimizing the conditions for diffusion, we can improve the efficiency of many natural and artificial systems.
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This question is part of the following fields:
- Basic Sciences
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