Differentiating between Acute EBV, CMV, and Toxoplasmosis

Acute EBV typically presents with symptoms such as fatigue, malaise, fever, pharyngitis, and bilateral lymphadenopathy. Heterophil antibody tests are usually positive. On the other hand, CMV mononucleosis has a lower incidence of pharyngitis and cervical adenopathy. The clinical presentation of CMV infectious mononucleosis may be similar to EBV, but it is usually not accompanied by posterior cervical adenopathy, and non-exudative pharyngitis is minimal or absent.

Primary toxoplasmosis is acquired through the ingestion of undercooked meat containing toxoplasma cysts or fresh food contaminated by toxoplasma excreted in cats’ faeces. The infection is asymptomatic in 80-90% of immunocompetent patients. Highly characteristic of toxoplasmosis is asymmetrical lymphadenopathy limited to an isolated lymph node group. Patients with toxoplasmosis have little or no fever, fatigue, or pharyngitis.

Mild transient thrombocytopenia is not uncommon in EBV infectious mononucleosis. In contrast, patients with toxoplasmosis have little or no fever, fatigue, or pharyngitis. The diagnosis of ALL and HD is made by a combination of blood film examination, bone marrow aspiration and biopsy, and lymph node biopsy.

In summary, while EBV and CMV mononucleosis may have similar clinical presentations, the absence of posterior cervical adenopathy and minimal or absent non-exudative pharyngitis may indicate CMV. Asymmetrical lymphadenopathy limited to an isolated lymph node group is highly characteristic of toxoplasmosis.

The NICE Feverish illness in children guidelines were introduced in 2007 and updated in 2013 to provide a ‘traffic light’ system for assessing the risk of febrile illness in children under 5 years old. The guidelines recommend recording the child’s temperature, heart rate, respiratory rate, and capillary refill time, as well as looking for signs of dehydration. Measuring temperature should be done with an electronic thermometer in the axilla for children under 4 weeks or with an electronic/chemical dot thermometer in the axilla or an infra-red tympanic thermometer. The risk stratification table categorizes children as green (low risk), amber (intermediate risk), or red (high risk) based on their symptoms. Management recommendations vary depending on the risk level, with green children managed at home, amber children provided with a safety net or referred to a specialist, and red children urgently referred to a specialist. The guidelines also advise against prescribing oral antibiotics without an apparent source of fever and note that a chest x-ray is not necessary if a child with suspected pneumonia is not being referred to the hospital.

The UK immunisation schedule recommends certain vaccines at different ages. At birth, the BCG vaccine is given if the baby is at risk of tuberculosis. At 2, 3, and 4 months, the ‘6-1 vaccine’ (diphtheria, tetanus, whooping cough, polio, Hib and hepatitis B) and oral rotavirus vaccine are given, along with Men B and PCV at specific intervals. At 12-13 months, the Hib/Men C, MMR, PCV, and Men B vaccines are given. At 3-4 years, the ‘4-in-1 Preschool booster’ (diphtheria, tetanus, whooping cough and polio) and MMR vaccines are given. At 12-13 years, the HPV vaccination is given, and at 13-18 years, the ‘3-in-1 teenage booster’ (tetanus, diphtheria and polio) and Men ACWY vaccines are given. Additionally, the flu vaccine is recommended annually for children aged 2-8 years.

It is important to note that the meningitis ACWY vaccine has replaced meningitis C for 13-18 year-olds due to an increased incidence of meningitis W disease in recent years. The ACWY vaccine is also offered to new students up to the age of 25 years at university. GP practices will automatically send letters inviting 17-and 18-year-olds in school year 13 to have the Men ACWY vaccine, while students going to university or college for the first time should contact their GP to have the vaccine before the start of the academic year.

The Men C vaccine used to be given at 3 months but has now been discontinued as there are almost no cases of Men C disease in babies or young children in the UK. All children will continue to be offered the Hib/Men C vaccine at one year of age, and the Men ACWY vaccine at 14 years of age to provide protection across all age groups.

Henoch-Schönlein Purpura (HSP) in Children

Henoch-Schönlein purpura (HSP) is a vasculitic condition that commonly affects children between the ages of 3 and 10. The core clinical features of HSP include a characteristic skin rash, joint pain, periarticular oedema, renal involvement, and abdominal pain. The skin rash, known as ‘palpable’ purpura, typically affects the buttocks and extensor surfaces of the legs and arms. Renal involvement can lead to hypertension, haematuria, and proteinuria, which can result in nephrotic and nephritic syndromes.

Urine dipstick testing is essential in making a clinical diagnosis and guiding management and follow-up. Regular follow-up is necessary during the convalescent period as HSP can lead to chronic renal problems in some patients. Therefore, early detection and management of renal manifestations are crucial in preventing long-term complications. If left untreated, HSP can cause significant morbidity and mortality in children.

Individuals with Crouzon’s syndrome typically have a reduced cranial size.

Understanding Macrocephaly in Children

Macrocephaly is a condition characterized by an abnormally large head circumference in children. There are several possible causes of macrocephaly, including a normal variant, chronic hydrocephalus, chronic subdural effusion, neurofibromatosis, gigantism (such as Soto’s syndrome), metabolic storage diseases, and bone problems like thalassaemia.

In some cases, macrocephaly may be a normal variant and not a cause for concern. However, it is important to identify the underlying cause of macrocephaly in order to determine the appropriate treatment and management. Chronic hydrocephalus, for example, may require surgical intervention to relieve pressure on the brain. Neurofibromatosis may require ongoing monitoring and management to prevent complications.

Importance of Examining Adjacent Joints in Orthopaedic Cases

It is crucial to examine the joints above and below when an orthopaedic problem presents. This principle applies to all age groups, including paediatric cases. For instance, when a child presents with right knee pain, the clinician should also consider hip and ankle pathology.

In cases where the patient has a history of left slipped upper femoral epiphysis (SUFE) and no signs of knee pathology, the clinician should pay particular attention to adjacent joints, especially the hip. According to NICE CKS, urgent assessment is necessary if a child over nine years old experiences painful or restricted hip movements, especially internal rotation, to exclude slipped upper femoral epiphysis. This condition is more common in this age group and requires immediate investigation, including AP and lateral X-rays of the hips.

In summary, examining adjacent joints is crucial in orthopaedic cases, and clinicians should pay attention to any relevant history and symptoms to ensure prompt and accurate diagnosis and treatment.

If a child is experiencing a minor illness without fever or systemic illness, it is not necessary to postpone their vaccination. However, if the child is acutely unwell, it is recommended to delay the vaccination until they have fully recovered.

Guidelines for Safe Immunisation

Immunisation is an important aspect of public health, and the Department of Health has published guidelines to ensure its safe administration. The guidelines, titled ‘Immunisation against infectious disease’, outline general contraindications to immunisation, situations where vaccines should be delayed, and specific contraindications to live vaccines.

General contraindications include confirmed anaphylactic reactions to previous doses of a vaccine containing the same antigens or to another component in the relevant vaccine, such as egg protein. Vaccines should also be delayed in cases of febrile illness or intercurrent infection.

Live vaccines should not be administered to pregnant women or individuals with immunosuppression. In the case of the DTP vaccine, vaccination should be deferred in children with an evolving or unstable neurological condition.

However, there are several situations where immunisation is not contraindicated. These include asthma or eczema, a history of seizures (unless associated with fever), being breastfed, a previous history of natural infection with pertussis, measles, mumps, or rubella, a history of neonatal jaundice, a family history of autism, neurological conditions such as Down’s or cerebral palsy, low birth weight or prematurity, and patients on replacement steroids.

Overall, these guidelines aim to ensure the safe administration of vaccines and protect individuals from infectious diseases.

Calculation of Ranitidine Dose for a 5 kg Child

When administering medication to a child, it is important to calculate the correct dosage based on their weight. In this case, the child weighs 5 kg and the prescribed dose of ranitidine is 3 mg/kg TDS. To calculate the correct dose, we multiply the child’s weight by the prescribed dose: 5 x 3 = 15 mg TDS.

The oral solution of ranitidine is available in a concentration of 75 mg/5 ml. This means that there is 15 mg of ranitidine in 1 ml of the solution. Therefore, the correct dose for the child is 1 ml TDS.

It is important to ensure that the correct dosage is administered to avoid any potential adverse effects or ineffective treatment. By following the appropriate calculations and using the correct concentration of medication, healthcare professionals can ensure safe and effective treatment for their patients.

At the age of 12-13 months, the MMR vaccine is administered as a routine, followed by a Preschool booster at 3-4 years of age.

The UK immunisation schedule recommends certain vaccines at different ages. At birth, the BCG vaccine is given if the baby is at risk of tuberculosis. At 2, 3, and 4 months, the ‘6-1 vaccine’ (diphtheria, tetanus, whooping cough, polio, Hib and hepatitis B) and oral rotavirus vaccine are given, along with Men B and PCV at specific intervals. At 12-13 months, the Hib/Men C, MMR, PCV, and Men B vaccines are given. At 3-4 years, the ‘4-in-1 Preschool booster’ (diphtheria, tetanus, whooping cough and polio) and MMR vaccines are given. At 12-13 years, the HPV vaccination is given, and at 13-18 years, the ‘3-in-1 teenage booster’ (tetanus, diphtheria and polio) and Men ACWY vaccines are given. Additionally, the flu vaccine is recommended annually for children aged 2-8 years.

It is important to note that the meningitis ACWY vaccine has replaced meningitis C for 13-18 year-olds due to an increased incidence of meningitis W disease in recent years. The ACWY vaccine is also offered to new students up to the age of 25 years at university. GP practices will automatically send letters inviting 17-and 18-year-olds in school year 13 to have the Men ACWY vaccine, while students going to university or college for the first time should contact their GP to have the vaccine before the start of the academic year.

The Men C vaccine used to be given at 3 months but has now been discontinued as there are almost no cases of Men C disease in babies or young children in the UK. All children will continue to be offered the Hib/Men C vaccine at one year of age, and the Men ACWY vaccine at 14 years of age to provide protection across all age groups.

Bronchiolitis in Infants: When to Seek Hospital Admission

Bronchiolitis is a common respiratory illness in infants that can range from mild to severe. While most cases can be managed at home, severe cases may require hospital admission. It is important to be aware of the signs that indicate more severe disease and prompt immediate hospitalization. These signs include reduced feeding, lethargy, history of apnoea, respiratory rate over 60 breaths per minute, respiratory distress, cyanosis, and oxygen saturations of 95% or less.

It is especially important to seek medical attention for infants under 3 months of age and those born at less than 35 weeks gestation, as the threshold for admission should be lowered for these vulnerable populations.

The patient’s symptoms are consistent with Chickenpox, as evidenced by the presence of lesions at different stages of healing, fever, and itching. However, it should be noted that the use of NSAIDs can increase the risk of necrotising fasciitis in these patients.

While ibuprofen is an NSAID that can be used in patients of any age, it is not the best option for this patient.

Aspirin should be avoided in children with Chickenpox due to the risk of Reye’s syndrome. In this case, ibuprofen is a safer alternative.

When used for short periods during acute febrile illnesses, the risk of gastrointestinal side effects from this medication is minimal.

Chickenpox is a viral infection caused by the varicella zoster virus. It is highly contagious and can be spread through respiratory droplets. The virus can also reactivate later in life and cause shingles. Chickenpox is most infectious from four days before the rash appears until five days after. The incubation period is typically 10-21 days. Symptoms include fever and an itchy rash that starts on the head and trunk before spreading. The rash goes through stages of macular, papular, and vesicular. Management is supportive, with measures such as keeping cool and using calamine lotion. Immunocompromised patients and newborns with peripartum exposure should receive varicella zoster immunoglobulin. Complications can include secondary bacterial infection of the lesions, pneumonia, encephalitis, and rare complications such as disseminated haemorrhagic Chickenpox.

One common complication of Chickenpox is secondary bacterial infection of the lesions, which can be increased by the use of NSAIDs. This can manifest as a single infected lesion or small area of cellulitis. In rare cases, invasive group A streptococcal soft tissue infections may occur, resulting in necrotizing fasciitis. Other rare complications of Chickenpox include pneumonia, encephalitis (which may involve the cerebellum), disseminated haemorrhagic Chickenpox, and very rarely, arthritis, nephritis, and pancreatitis. It is important to note that school exclusion may be necessary, as Chickenpox is highly infectious and can be caught from someone with shingles. It is advised to avoid contact with others until all lesions have crusted over.

It is common for children with non-IgE-mediated cow’s milk protein allergy to become milk tolerant by the age of 3. This is typically achieved through exposure to increasing levels of milk protein via the milk ladder. Diagnosis of CMPA is based on clinical symptoms and withdrawal of cow’s milk protein-containing substances, followed by re-exposure. Lactose intolerance is rare in children under 3 years old. Milk tolerance is only uncommon in cases of IgE-mediated cow’s milk protein allergy.

Cow’s milk protein intolerance/allergy (CMPI/CMPA) is a condition that affects approximately 3-6% of children and typically presents in formula-fed infants within the first 3 months of life. However, it can also occur in exclusively breastfed infants, although this is rare. Both immediate (IgE mediated) and delayed (non-IgE mediated) reactions can occur, with CMPA usually used to describe immediate reactions and CMPI for mild-moderate delayed reactions. Symptoms of CMPI/CMPA include regurgitation and vomiting, diarrhea, urticaria, atopic eczema, colic symptoms such as irritability and crying, wheezing, chronic cough, and rarely, angioedema and anaphylaxis.

Diagnosis of CMPI/CMPA is often based on clinical presentation, such as improvement with cow’s milk protein elimination. However, investigations such as skin prick/patch testing and total IgE and specific IgE (RAST) for cow’s milk protein may also be performed. If symptoms are severe, such as failure to thrive, referral to a pediatrician is necessary.

Management of CMPI/CMPA depends on whether the child is formula-fed or breastfed. For formula-fed infants with mild-moderate symptoms, extensive hydrolyzed formula (eHF) milk is the first-line replacement formula, while amino acid-based formula (AAF) is used for infants with severe CMPA or if there is no response to eHF. Around 10% of infants with CMPI/CMPA are also intolerant to soy milk. For breastfed infants, mothers should continue breastfeeding while eliminating cow’s milk protein from their diet. Calcium supplements may be prescribed to prevent deficiency while excluding dairy from the diet. When breastfeeding stops, eHF milk should be used until the child is at least 12 months old and for at least 6 months.

The prognosis for CMPI/CMPA is generally good, with most children eventually becoming milk tolerant. In children with IgE-mediated intolerance, around 55% will be milk tolerant by the age of 5 years, while in children with non-IgE mediated intolerance, most will be milk tolerant by the age of 3 years. However, a challenge is often performed in a hospital setting as anaphylaxis can occur.

Sudden infant death syndrome (SIDS) is more likely to occur in infants who sleep on their stomachs, have parents who smoke, share a bed with their parents, experience overheating or have their heads covered, and are born prematurely. Additionally, male infants are at a higher risk for SIDS than female infants.

Sudden infant death syndrome (SIDS) is the leading cause of death in infants during their first year of life, with the highest incidence occurring at three months of age. There are several major risk factors associated with SIDS, including placing the baby to sleep on their stomach, parental smoking, prematurity, bed sharing, and hyperthermia or head covering. These risk factors are additive, meaning that the more risk factors present, the higher the likelihood of SIDS. Other risk factors include male sex, multiple births, lower social classes, and maternal drug use. SIDS incidence also tends to increase during the winter months. However, there are protective factors that can reduce the risk of SIDS, such as breastfeeding, room sharing (but not bed sharing), and the use of pacifiers. In the event of a SIDS case, it is important to screen siblings for potential sepsis and inborn errors of metabolism.

Appropriate Management of Suspected Diabetes Mellitus in a Paediatric Patient

When a paediatric patient presents with symptoms of polyuria, polydipsia, and weight loss, along with a raised capillary blood glucose, diabetes mellitus is a likely diagnosis. This insidious onset over several weeks can make it difficult to detect, and children may appear well despite being in diabetic ketoacidosis. Therefore, it is crucial to confirm the diagnosis and initiate appropriate treatment on the same day to prevent any life-threatening complications.

While urine culture may be appropriate for suspected urinary tract infections, elevated blood glucose makes diabetes mellitus a more likely diagnosis. Therefore, arranging for fasting blood sugar, haemoglobin A1c, and paediatric outpatient review within two weeks is necessary.

Initiating insulin therapy in primary care is essential, but the patient will also need urgent secondary care investigation, such as blood gas analysis, to rule out ketoacidosis. The patient may require fluid resuscitation and extensive education regarding diabetes, which can be best accessed in secondary care.

Although measuring C-peptide may distinguish between different types of diabetes, it is usually unnecessary in patients with features suggestive of type I diabetes, as seen in this patient. Therefore, appropriate management of suspected diabetes mellitus in a paediatric patient involves prompt diagnosis, initiation of insulin therapy, and urgent secondary care investigation to prevent any life-threatening complications.

To treat umbilical granulomas, salt or silver nitrate cautery can be applied. These granulomas are a common occurrence in babies and appear as a painless lump in the umbilicus, often accompanied by discharge. The umbilical stump typically falls off within ten days of birth, but granulomas can form as the area heals. To speed up the healing process, table salt can be applied for thirty minutes, followed by rinsing the area. This treatment should be repeated twice daily for five days and usually results in resolution within three weeks. If salt treatment is ineffective, silver nitrate cautery can be used, but it’s important to protect the surrounding skin with petroleum jelly.

Paediatric Umbilical Disorders

Embryology plays a significant role in the development of umbilical disorders in children. The umbilicus has two umbilical arteries and one umbilical vein during development. After birth, the cord separates, and the umbilical ring closes. Umbilical hernia is a common disorder in neonates, with up to 20% of infants affected. It is more prevalent in premature infants and usually resolves spontaneously within three years. Strangulation is rare. Paraumbilical hernia is another disorder caused by defects in the linea alba near the umbilicus. It is less likely to resolve spontaneously than an umbilical hernia. Omphalitis is a severe condition caused by an infection of the umbilicus, usually by Staphylococcus aureus. It can spread rapidly through the umbilical vessels, leading to portal pyaemia and portal vein thrombosis. Treatment involves a combination of topical and systemic antibiotics. Umbilical granuloma is characterised by cherry red lesions surrounding the umbilicus, which may bleed on contact and discharge seropurulent fluid. Chemical cautery with silver nitrate is an effective treatment. Persistent urachus is characterised by urinary discharge from the umbilicus and is caused by the persistence of the urachus, which attaches to the bladder. It is associated with other urogenital abnormalities. Persistent vitello-intestinal duct presents as an umbilical discharge that discharges small bowel content. It is best imaged using a contrast study to delineate the anatomy and is managed by laparotomy and surgical closure.

• Infected burns are rarely a sign of abuse:
  • Incorrect: Infected burns can indeed be a sign of abuse. Neglect in treating burns can lead to infection, which may indicate a lack of proper care and potentially abusive behavior.
• Burns from hot water where there are no splash marks are rarely a sign of abuse:
  • Incorrect: Burns from hot water without splash marks are often a sign of abuse. These burns may indicate forced immersion, where the child is held in hot water intentionally, resulting in clear demarcation lines instead of splashes.
• Burns on the back are rarely a sign of abuse:
  • Incorrect: Burns on the back can be indicative of abuse, as accidental burns typically occur on accessible areas like the front of the body, arms, and legs. Unusual burn locations, such as the back, should raise suspicion for abuse.
• There is no pathognomonic pattern of burns in child abuse:
  • Correct: There is no single pathognomonic pattern of burns that definitively indicates child abuse. However, certain patterns, such as immersion burns, cigarette burns, and patterned burns (e.g., from an iron), are highly suspicious for abuse but not exclusively diagnostic. The absence of a single definitive pattern underscores the need for careful assessment and consideration of the context in which the burns occurred.
• Burns with discrete edges are rarely a sign of abuse:
  • Incorrect: Burns with discrete edges can be a sign of abuse, especially when they are from forced immersion in hot water or contact with a hot object. These burns typically show clear boundaries, unlike accidental burns, which often have irregular edges.

Giardia Lamblia: Causes, Symptoms, and Treatment

Giardia lamblia is a parasite that can cause malabsorption and non-bloody diarrhea. The condition can be acquired locally, and stool microscopy may not always detect it. However, the good news is that it can be treated with metronidazole. Once treated, malabsorption typically resolves. If you experience symptoms of giardia lamblia, it is important to seek medical attention promptly to receive an accurate diagnosis and appropriate treatment.

There is no need to exclude children with head lice from school, so the answer to the question is no. The mother should be comforted that her daughter can still attend school, and there is no reason for the patient to stay home. Therefore, the other answer options for this question are incorrect.

The Health Protection Agency has provided guidance on when children should be excluded from school due to infectious conditions. Some conditions, such as conjunctivitis, fifth disease, roseola, infectious mononucleosis, head lice, threadworms, and hand, foot and mouth, do not require exclusion. Scarlet fever requires exclusion for 24 hours after commencing antibiotics, while whooping cough requires exclusion for 2 days after commencing antibiotics or 21 days from onset of symptoms if no antibiotics are taken. Measles requires exclusion for 4 days from onset of rash, rubella for 5 days from onset of rash, and Chickenpox until all lesions are crusted over. Mumps requires exclusion for 5 days from onset of swollen glands, while diarrhoea and vomiting require exclusion until symptoms have settled for 48 hours. Impetigo requires exclusion until lesions are crusted and healed, or for 48 hours after commencing antibiotic treatment, and scabies requires exclusion until treated. influenza requires exclusion until the child has recovered for 48 hours.

Regarding Chickenpox, Public Health England recommends that children should be excluded until all lesions are crusted over, while Clinical Knowledge Summaries suggest that infectivity continues until all lesions are dry and have crusted over, usually about 5 days after the onset of the rash. It is important to follow official guidance and consult with healthcare professionals if unsure about exclusion periods for infectious conditions.

Managing Asthma in Children: NICE Guidelines

The National Institute for Health and Care Excellence (NICE) released guidelines in 2017 for the management of asthma in children aged 5-16. These guidelines follow a stepwise approach, with treatment options based on the severity of the child’s symptoms. For newly-diagnosed asthma, short-acting beta agonists (SABA) are recommended. If symptoms persist or worsen, a combination of SABA and paediatric low-dose inhaled corticosteroids (ICS) may be used. Leukotriene receptor antagonists (LTRA) and long-acting beta agonists (LABA) may also be added to the treatment plan.

For children under 5 years old, clinical judgement plays a greater role in diagnosis and treatment. The stepwise approach for this age group includes an 8-week trial of paediatric moderate-dose ICS for newly-diagnosed asthma or uncontrolled symptoms. If symptoms persist, a combination of SABA and paediatric low-dose ICS with LTRA may be used. If symptoms still persist, referral to a paediatric asthma specialist is recommended.

It is important to note that NICE doesn’t recommend changing treatment for patients with well-controlled asthma simply to adhere to the latest guidelines. Additionally, maintenance and reliever therapy (MART) may be used for combined ICS and LABA treatment, but only for LABAs with a fast-acting component. The definitions for low, moderate, and high-dose ICS have also changed, with different definitions for children and adults.

Young women presenting with midfoot pain on walking should consider Freiberg’s disease as a possible cause. This condition occurs when the blood supply to the metatarsal head is interrupted, leading to infarction and flattening of the affected area. It is most commonly seen in adolescents, particularly tall, athletic females, whose bones may grow faster than blood vessels can keep up with. Symptoms include pain, swelling, and stiffness, which can be managed with conservative measures, although improvement may take up to a year. Other conditions that may cause similar symptoms include Morton’s neuroma, complex regional pain syndrome, and sesamoiditis, but each has its own unique presentation and risk factors.

Understanding Freiberg Disease

Freiberg disease, also known as metatarsal avascular necrosis, is a condition that occurs when the blood supply to the metatarsal head is disrupted, leading to infarction and flattening of the affected area. This condition is most commonly observed in adolescents, particularly tall, athletic females, as their bones may grow faster than blood vessels can keep up with. The second metatarsal is the most commonly affected area.

The symptoms of Freiberg’s disease include pain, swelling, and stiffness, which can be managed through conservative measures such as activity limitation, analgesia, and orthotic devices like walking casts or boots. While operative management is rarely necessary, it is important to inform patients that improvement can be gradual and may take up to a year.

Overall, understanding Freiberg disease is crucial for individuals who may be at risk, as early detection and management can help prevent further complications and improve overall outcomes.

Soya milk may not be a suitable alternative for infants with cow’s milk protein allergy as many of them are also intolerant to it. Amino acid-based formula is the recommended management for severe cases or when extensive hydrolysed formula milk is ineffective.

Breastfeeding is encouraged if the mother eliminates cows milk proteins from her diet, but it may not be practical if she cannot produce enough milk for the child. For infants with mild to moderate cows milk protein allergy who are formula-fed, extensive hydrolysed milk formula is the first-line management.

Gastro-oesophageal reflux (GORD) may be managed with omeprazole or ranitidine, but only after a 1-2 week trial of alginate therapy. However, if the infant presents with persistent diarrhoea, cow’s milk protein allergy is a more likely diagnosis than GORD.

Cow’s milk protein intolerance/allergy (CMPI/CMPA) is a condition that affects approximately 3-6% of children and typically presents in formula-fed infants within the first 3 months of life. However, it can also occur in exclusively breastfed infants, although this is rare. Both immediate (IgE mediated) and delayed (non-IgE mediated) reactions can occur, with CMPA usually used to describe immediate reactions and CMPI for mild-moderate delayed reactions. Symptoms of CMPI/CMPA include regurgitation and vomiting, diarrhea, urticaria, atopic eczema, colic symptoms such as irritability and crying, wheezing, chronic cough, and rarely, angioedema and anaphylaxis.

Diagnosis of CMPI/CMPA is often based on clinical presentation, such as improvement with cow’s milk protein elimination. However, investigations such as skin prick/patch testing and total IgE and specific IgE (RAST) for cow’s milk protein may also be performed. If symptoms are severe, such as failure to thrive, referral to a pediatrician is necessary.

Management of CMPI/CMPA depends on whether the child is formula-fed or breastfed. For formula-fed infants with mild-moderate symptoms, extensive hydrolyzed formula (eHF) milk is the first-line replacement formula, while amino acid-based formula (AAF) is used for infants with severe CMPA or if there is no response to eHF. Around 10% of infants with CMPI/CMPA are also intolerant to soy milk. For breastfed infants, mothers should continue breastfeeding while eliminating cow’s milk protein from their diet. Calcium supplements may be prescribed to prevent deficiency while excluding dairy from the diet. When breastfeeding stops, eHF milk should be used until the child is at least 12 months old and for at least 6 months.

The prognosis for CMPI/CMPA is generally good, with most children eventually becoming milk tolerant. In children with IgE-mediated intolerance, around 55% will be milk tolerant by the age of 5 years, while in children with non-IgE mediated intolerance, most will be milk tolerant by the age of 3 years. However, a challenge is often performed in a hospital setting as anaphylaxis can occur.

Croup is a respiratory infection that affects young children, typically those between 6 months and 3 years old. It is most common in the autumn and is caused by parainfluenza viruses. The main symptom is stridor, which is caused by swelling and secretions in the larynx. Other symptoms include a barking cough, fever, and cold-like symptoms. The severity of croup can be graded based on the child’s symptoms, with mild cases having occasional coughing and no audible stridor at rest, and severe cases having frequent coughing, prominent stridor, and significant distress or lethargy. Children with moderate or severe croup should be admitted to the hospital, especially if they are under 6 months old or have other airway abnormalities. Diagnosis is usually made based on clinical symptoms, but a chest x-ray can show subglottic narrowing. Treatment typically involves a single dose of oral dexamethasone or prednisolone, and emergency treatment may include high-flow oxygen or nebulized adrenaline. While dexamethasone is the preferred and commonly used treatment for croup, prednisolone is not typically recommended as a first-line treatment for croup in clinical guidelines. Dexamethasone is the standard corticosteroid used due to its efficacy and safety profile in managing croup symptoms.

NICE Guidance on Depression in Children and Young People

NICE has released guidance on how to manage depression in children and young people. For those presenting with mild depression, a ‘watchful waiting’ approach should be taken, with a further assessment arranged two weeks later. If the depression persists after up to four weeks of watchful waiting, psychological therapies such as individual non-directive supportive therapy, group cognitive behavioural therapy, or guided self-help can be offered for a limited period of around two to three months. Antidepressant medication should not be used at this stage. If the mild depression remains unresponsive to psychological therapies after two to three months, referral to tier 2-3 CAMHS can be made for further assessment and management. This guidance aims to provide a structured approach to managing depression in children and young people, ensuring that appropriate interventions are offered at the right time.

To confirm the suspected IgE mediated allergy diagnosis, an atopy patch test is utilized.

Cow’s milk protein intolerance/allergy (CMPI/CMPA) is a condition that affects approximately 3-6% of children and typically presents in formula-fed infants within the first 3 months of life. However, it can also occur in exclusively breastfed infants, although this is rare. Both immediate (IgE mediated) and delayed (non-IgE mediated) reactions can occur, with CMPA usually used to describe immediate reactions and CMPI for mild-moderate delayed reactions. Symptoms of CMPI/CMPA include regurgitation and vomiting, diarrhea, urticaria, atopic eczema, colic symptoms such as irritability and crying, wheezing, chronic cough, and rarely, angioedema and anaphylaxis.

Diagnosis of CMPI/CMPA is often based on clinical presentation, such as improvement with cow’s milk protein elimination. However, investigations such as skin prick/patch testing and total IgE and specific IgE (RAST) for cow’s milk protein may also be performed. If symptoms are severe, such as failure to thrive, referral to a pediatrician is necessary.

Management of CMPI/CMPA depends on whether the child is formula-fed or breastfed. For formula-fed infants with mild-moderate symptoms, extensive hydrolyzed formula (eHF) milk is the first-line replacement formula, while amino acid-based formula (AAF) is used for infants with severe CMPA or if there is no response to eHF. Around 10% of infants with CMPI/CMPA are also intolerant to soy milk. For breastfed infants, mothers should continue breastfeeding while eliminating cow’s milk protein from their diet. Calcium supplements may be prescribed to prevent deficiency while excluding dairy from the diet. When breastfeeding stops, eHF milk should be used until the child is at least 12 months old and for at least 6 months.

The prognosis for CMPI/CMPA is generally good, with most children eventually becoming milk tolerant. In children with IgE-mediated intolerance, around 55% will be milk tolerant by the age of 5 years, while in children with non-IgE mediated intolerance, most will be milk tolerant by the age of 3 years. However, a challenge is often performed in a hospital setting as anaphylaxis can occur.

Breath Holding Attacks and Reflex Anoxic Seizures in Toddlers

Breath holding attacks and reflex anoxic seizures are two types of episodes that can occur in toddlers. Breath holding attacks are triggered by upset and can start as early as six months of age, with a peak incidence at two years and typically stopping by five years of age. During a breath holding attack, the child cries, holds their breath, and becomes cyanosed, which can sometimes lead to loss of consciousness and stiffening. However, rapid recovery is common, and no treatment is required.

On the other hand, reflex anoxic seizures are triggered by pain or discomfort, such as minor head trauma, cold food, or fright. After the trigger, the child becomes pale and falls to the floor, which can induce a seizure due to hypoxia resulting from cardiac asystole from vagal inhibition. These episodes are characterized by the pallor typically seen in reflex anoxic seizures.

It is important to note that breath holding attacks can be confused with other options, especially when the child stiffens or progresses to a seizure. However, understanding the differences between these two types of episodes can help parents and caregivers provide appropriate care and reassurance to the child.

The baby is displaying signs that suggest infantile colic, which typically begins in the first few weeks of life and resolves by 3-4 months of age. The crying usually occurs in the late afternoon or evening, and the baby may arch their back or draw their knees up to their abdomen while crying. The symptoms appear to be ongoing but occasional, as the baby is happy during the day.

Although antimuscarinics have been shown to be effective, they come with serious adverse effects and are not recommended. Simeticone (Infacol) is commonly used, but there is no evidence to support its use and it is not recommended by CKS. Gaviscon is not necessary as there is no indication of gastro-oesophageal reflux. Low-lactose formula and paracetamol are also not recommended.

Since the baby is happy during the day, it is unlikely that they have cow’s milk protein allergy, which is rare in breastfed infants. Therefore, there is no need for the mother to exclude dairy from her diet.

Understanding Infantile Colic

Infantile colic is a common condition that affects infants under three months old. It is characterized by excessive crying and pulling up of the legs, usually worse in the evening. This condition affects up to 20% of infants, and its cause is unknown.

Despite its prevalence, the use of simeticone and lactase drops is not recommended by NICE Clinical Knowledge Summaries. These drops are commonly used to alleviate the symptoms of infantile colic, but their effectiveness is not supported by evidence. Therefore, it is important to seek medical advice before using any medication to treat infantile colic.

Understanding Infantile Colic

Infantile colic is a common condition that affects infants under three months old. It is characterized by excessive crying and pulling up of the legs, usually worse in the evening. This condition affects up to 20% of infants, and its cause is unknown.

Despite its prevalence, the use of simeticone and lactase drops is not recommended by NICE Clinical Knowledge Summaries. These drops are commonly used to alleviate the symptoms of infantile colic, but their effectiveness is not supported by evidence. Therefore, it is important to seek medical advice before using any medication to treat infantile colic.

Developmental Milestones for Infants

As infants grow and develop, they acquire new skills at different rates. However, there are certain milestones that most children will have achieved by a certain age. For instance, naming a simple picture in a book is a skill that is typically mastered by the age of 23 months. By 25-26 months, most children can name several body parts. Removing socks and shoes without assistance is a skill that is usually achieved by 27-28 months. By 31-32 months, throwing a ball overarm is a skill that most children will have mastered. Finally, using four or five words in a sentence is a milestone that is typically achieved by the age of 35-36 months. It’s important to remember that there is variation in the rate of development among infants, but these milestones can serve as a general guide for parents and caregivers.

NICE Guidelines for UTI in Children

According to the National Institute for Health and Care Excellence (NICE), children between 3 months to 3 years old with suspected urinary tract infection (UTI) can start antibiotic treatment if their urine sample shows either leucocyte or nitrite positive, or both. However, it is still recommended to send off the sample for culture to confirm the diagnosis and ensure appropriate treatment. These guidelines aim to provide a standardized approach in managing UTI in children and prevent complications associated with untreated infections.

If lifestyle measures and a reward chart have not helped with nocturnal enuresis in a child over the age of 5, the next step would be to consider an enuresis alarm or desmopressin. As the child in this scenario is 6 years-old, the first-line treatment would be to try an enuresis alarm before considering other options. Desmopressin may be used first-line for children over the age of 7 who do not wish to use an enuresis alarm or if a short term solution is needed.

Managing Nocturnal Enuresis in Children

Nocturnal enuresis, also known as bedwetting, is a common condition in children. It is defined as the involuntary discharge of urine during sleep in children aged 5 years or older who have not yet achieved continence. There are two types of nocturnal enuresis: primary and secondary. Primary enuresis occurs when a child has never achieved continence, while secondary enuresis occurs when a child has been dry for at least 6 months before.

When managing nocturnal enuresis, it is important to look for possible underlying causes or triggers such as constipation, diabetes mellitus, or recent onset urinary tract infections. General advice includes monitoring fluid intake and encouraging regular toileting patterns, such as emptying the bladder before sleep. Lifting and waking techniques and reward systems, such as star charts, can also be effective.

The first-line treatment for nocturnal enuresis is an enuresis alarm, which has a high success rate. These alarms have sensor pads that detect wetness and wake the child up when they start to wet the bed. If an enuresis alarm is not effective or not acceptable to the family, desmopressin can be used for short-term control, such as for sleepovers. It is important to note that reward systems should be given for agreed behavior rather than dry nights, such as using the toilet to pass urine before sleep. By following these management strategies, children with nocturnal enuresis can achieve continence and improve their quality of life.