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Question 1
Correct
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A 35-year-old woman came to your GP clinic with a cold sore and left eye discomfort. She reported experiencing a red, painful eye with watering and sensitivity to light for the past 3 days. During fluorescein examination, you observed a dendritic ulcer on the cornea that was stained with fluorescein.
What is the primary treatment for this condition?Your Answer: Topical aciclovir drops
Explanation:The appropriate treatment for herpes simplex keratitis is the use of topical aciclovir. Antibiotics are ineffective against viral infections and should not be used. The use of steroids can worsen the condition and should be avoided. If the patient is already using topical steroids for another eye condition, the dosage should be decreased.
Understanding Herpes Simplex Keratitis
Herpes simplex keratitis is a condition that affects the cornea of the eye and is caused by the herpes simplex virus. The most common symptom of this condition is a dendritic corneal ulcer, which can cause a red, painful eye, photophobia, and epiphora. In some cases, visual acuity may also be decreased. Fluorescein staining may show an epithelial ulcer, which can help with diagnosis. One common treatment for this condition is topical aciclovir, which can help to reduce the severity of symptoms and prevent further damage to the cornea.
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This question is part of the following fields:
- Ophthalmology
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Question 2
Correct
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A 30-year-old woman is prescribed a 7-day course of erythromycin for cellulitis. She is in good health and uses the progesterone-only pill for birth control. She is concerned about the potential interaction between her antibiotic and contraceptive pill. What advice should she be given regarding her contraception?
Your Answer: Reassurance that no additional precautions are needed
Explanation:It was once believed that taking antibiotics while on any form of contraceptive pill could reduce the pill’s effectiveness. However, it is now known that broad-spectrum antibiotics do not interact with the progesterone-only pill, and therefore no extra precautions are necessary. The only exception is enzyme-inducing antibiotics like rifampicin, which may affect the pill’s efficacy. Additionally, if an antibiotic causes vomiting or diarrhea, it may also affect the pill’s effectiveness, but this is true for any form of vomiting or diarrhea. Therefore, the correct advice is to reassure patients that no additional precautions are needed. Advising the use of barrier contraceptives or ceasing the pill is incorrect, as there is no evidence to support these actions.
Counselling for Women Considering the Progestogen-Only Pill
Women who are considering taking the progestogen-only pill (POP) should receive counselling on various aspects of the medication. One of the most common potential adverse effects is irregular vaginal bleeding. When starting the POP, immediate protection is provided if it is commenced up to and including day 5 of the cycle. If it is started later, additional contraceptive methods such as condoms should be used for the first 2 days. If switching from a combined oral contraceptive (COC), immediate protection is provided if the POP is continued directly from the end of a pill packet.
It is important to take the POP at the same time every day, without a pill-free break, unlike the COC. If a pill is missed by less than 3 hours, it should be taken as normal. If it is missed by more than 3 hours, the missed pill should be taken as soon as possible, and extra precautions such as condoms should be used until pill taking has been re-established for 48 hours. Diarrhoea and vomiting do not affect the POP, but assuming pills have been missed and following the above guidelines is recommended. Antibiotics have no effect on the POP, unless they alter the P450 enzyme system, such as rifampicin. Liver enzyme inducers may reduce the effectiveness of the POP.
In addition to these specific guidelines, women should also have a discussion on sexually transmitted infections (STIs) when considering the POP. It is important for women to receive comprehensive counselling on the POP to ensure they are aware of its potential effects and how to use it effectively.
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This question is part of the following fields:
- Reproductive Medicine
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Question 3
Correct
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A 15-year-old Afro-Caribbean girl arrives at the emergency department with complaints of left hip pain. There is no history of recent trauma, but the patient has a medical history of sickle cell disease and has been admitted multiple times in the past with similar symptoms. What is the appropriate management plan for this patient?
Your Answer: Painkillers, oxygen and IV fluids
Explanation:To effectively manage sickle cell crisis, it is essential to administer analgesia, oxygen, and IV fluids. In addition, antibiotics may be necessary if an infection is suspected, and transfusion may be required if the patient’s Hb levels are low.
It is not advisable to simply monitor patients without providing any treatment, as this would result in significant pain and discomfort.
The most effective approach involves a combination of oxygen, fluids, and analgesia. Pain management is crucial, as the blockage of blood vessels by sickle-shaped red blood cells prevents the delivery of oxygen and blood to the tissues, resulting in pain. Oxygen supplementation is necessary to alleviate this pain, and IV fluids can help to slow or halt the sickling process. None of these components alone would be sufficient in managing pain, but together they form a comprehensive approach to pain management.
Managing Sickle-Cell Crises
Sickle-cell crises can be managed through various interventions. General management includes providing analgesia, rehydration, and oxygen. Antibiotics may also be considered if there is evidence of infection. Blood transfusion may be necessary for severe or symptomatic anemia, pregnancy, or pre-operative cases. However, it is important not to rapidly reduce the percentage of Hb S containing cells.
In cases of acute vaso-occlusive crisis, such as stroke, acute chest syndrome, multiorgan failure, or splenic sequestration crisis, exchange transfusion may be necessary. This involves rapidly reducing the percentage of Hb S containing cells. It is important to note that the management of sickle-cell crises should be tailored to the individual patient’s needs and medical history. Proper management can help alleviate symptoms and prevent complications.
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This question is part of the following fields:
- Haematology/Oncology
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Question 4
Correct
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A 25-year-old woman presents with complaints of intermittent diarrhoea and constipation. She experiences bloating that is relieved by defecation and finds relief with hyoscine butylbromide (Buscopan). She denies any weight loss and has no relevant family history. Coeliac disease screening was negative and both full blood count and CRP were normal. Despite being diagnosed with irritable bowel syndrome and given dietary advice and antispasmodics, she disagrees with the diagnosis and requests further investigations. What is the most appropriate course of action?
Your Answer: Reassure that further tests are not required at this stage
Explanation:It is not recommended to use faecal occult blood testing for colorectal cancer screening in symptomatic patients who are under the age of 60. This woman is displaying symptoms of irritable bowel syndrome and has normal blood results, without any red flag symptoms. Repeating the full blood count is unlikely to provide any additional information. The use of steroids and azathioprine is not appropriate for treating irritable bowel syndrome, as they are typically used for ulcerative colitis, which is not likely in this case.
Colorectal Cancer Screening: Faecal Immunochemical Test (FIT)
Colorectal cancer is often developed from adenomatous polyps. Screening for this type of cancer has been proven to reduce mortality by 16%. The NHS offers a home-based screening programme called Faecal Immunochemical Test (FIT) to older adults. A one-off flexible sigmoidoscopy was trialled in England for people aged 55 years, but it was abandoned in 2021 due to the inability to recruit enough clinical endoscopists, which was exacerbated by the COVID-19 pandemic. The trial, partly funded by Cancer Research UK, showed promising early results, and it remains to be seen whether flexible sigmoidoscopy will be used as part of a future bowel screening programme.
Faecal Immunochemical Test (FIT) Screening:
The NHS now has a national screening programme that offers screening every two years to all men and women aged 60 to 74 years in England and 50 to 74 years in Scotland. Patients aged over 74 years may request screening. Eligible patients are sent FIT tests through the post. FIT is a type of faecal occult blood (FOB) test that uses antibodies that specifically recognise human haemoglobin (Hb). It is used to detect and quantify the amount of human blood in a single stool sample. FIT has advantages over conventional FOB tests because it only detects human haemoglobin, as opposed to animal haemoglobin ingested through diet. Only one faecal sample is needed compared to the 2-3 for conventional FOB tests. While a numerical value is generated, this is not reported to the patient or GP. Instead, they will be informed if the test is normal or abnormal. Patients with abnormal results are offered a colonoscopy. At colonoscopy, approximately 5 out of 10 patients will have a normal exam, 4 out of 10 patients will be found to have polyps that may be removed due to their premalignant potential, and 1 out of 10 patients will be found to have cancer. -
This question is part of the following fields:
- Gastroenterology/Nutrition
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Question 5
Correct
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A 45-year-old man is diagnosed with end-stage renal disease. What is the most frequent complication that may arise when considering long-term peritoneal dialysis for this patient?
Your Answer: Carpal tunnel syndrome
Explanation:Chronic dialysis patients may experience median nerve compression, which can be caused by oedema or vascular insufficiency related to a dialysis shunt or fistula. Amyloid disease, which can infiltrate the synovium within the carpal tunnel, may also contribute to nerve compression in patients with renal failure. Anaemia is a common complication of chronic kidney disease, resulting from decreased renal synthesis of erythropoietin. This type of anaemia is normochromic normocytic and can lead to the development of new-onset heart failure. However, the use of erythropoiesis-stimulating agents has reduced the incidence of congestive heart failure due to anaemia. Squamous cell skin cancer is a type of skin cancer that is strongly associated with high total exposure to ultraviolet radiation from the sun. Individuals who have received solid organ transplants and are taking chronic immunosuppressive medication are at a significantly increased risk of developing this type of cancer, particularly squamous cell carcinoma. There is no known increased risk of gastrointestinal malignancy in patients on long-term haemodialysis. Immunosuppression, such as in the case of kidney transplant recipients, is associated with an increased risk of non-Hodgkin’s lymphoma.
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This question is part of the following fields:
- Renal Medicine/Urology
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Question 6
Correct
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A patient with pyogenic meningitis has been admitted and the husband is worried about contracting the disease. What is the recommended prophylaxis in this situation? Choose ONE option from the list provided.
Your Answer: Ciprofloxacin
Explanation:Antibiotics for Meningitis: Recommended Drugs and Dosages
Meningitis is a serious infection that affects the membranes surrounding the brain and spinal cord. Antibiotics are the mainstay of treatment for meningitis, and prophylactic antibiotics are also recommended for close contacts of infected individuals. Here are the recommended drugs and dosages for meningitis treatment and prophylaxis:
Ciprofloxacin: This antibiotic is now the preferred choice for prophylaxis in all age groups and in pregnancy. It is a single dose and readily available in pharmacies, and does not interact with oral contraceptives. It should be given to all close contacts of probable or confirmed meningococcal meningitis, with dosages ranging from 250 mg to 500 mg depending on age.
Metronidazole: This drug has no role in the treatment of acute meningitis.
Ceftriaxone: This antibiotic has good penetration into inflamed meninges and can be given via intramuscular or oral route. It can be used in monotherapy in adults under 60 years old, or in dual therapy with amoxicillin in older adults.
Co-trimoxazole: This drug is an alternative to cefotaxime or ceftriaxone in older adults, and is also used in individuals with meningitis from Listeria monocytogenes infection.
Vancomycin: This antibiotic is recommended in cases of penicillin resistance or suspected penicillin-resistant pneumococci, but should never be used in monotherapy due to doubts about its penetration into adult CSF.
Chemoprophylaxis: Close contacts of infected individuals should receive prophylactic antibiotics to prevent nasopharyngeal carriage of the organism. Ciprofloxacin is the first-line choice, with dosages ranging from 10 mg/kg to 600 mg depending on age. Rifampicin can be given as an alternative for those unable to take ciprofloxacin.
It is important to seek microbiology and public health advice if in doubt about the appropriate antibiotics and dosages for meningitis treatment and prophylaxis.
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This question is part of the following fields:
- Infectious Diseases
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Question 7
Correct
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A 65-year-old woman comes to you with complaints of feeling low and having trouble sleeping. Upon further discussion and administering a validated symptom measure, you diagnose her with moderate depression. She has a medical history of ischemic heart disease and is currently on aspirin, ramipril, and simvastatin. What would be the best course of action in this situation?
Your Answer: Start sertraline + lansoprazole
Explanation:Selective serotonin reuptake inhibitors (SSRIs) are commonly used as the first-line treatment for depression. Citalopram and fluoxetine are the preferred SSRIs, while sertraline is recommended for patients who have had a myocardial infarction. However, caution should be exercised when prescribing SSRIs to children and adolescents. Gastrointestinal symptoms are the most common side-effect, and patients taking SSRIs are at an increased risk of gastrointestinal bleeding. Patients should also be aware of the possibility of increased anxiety and agitation after starting a SSRI. Fluoxetine and paroxetine have a higher propensity for drug interactions.
The Medicines and Healthcare products Regulatory Agency (MHRA) has issued a warning regarding the use of citalopram due to its association with dose-dependent QT interval prolongation. As a result, citalopram and escitalopram should not be used in patients with congenital long QT syndrome, known pre-existing QT interval prolongation, or in combination with other medicines that prolong the QT interval. The maximum daily dose of citalopram is now 40 mg for adults, 20 mg for patients older than 65 years, and 20 mg for those with hepatic impairment.
When initiating antidepressant therapy, patients should be reviewed by a doctor after 2 weeks. Patients under the age of 25 years or at an increased risk of suicide should be reviewed after 1 week. If a patient responds well to antidepressant therapy, they should continue treatment for at least 6 months after remission to reduce the risk of relapse. When stopping a SSRI, the dose should be gradually reduced over a 4 week period, except for fluoxetine. Paroxetine has a higher incidence of discontinuation symptoms, including mood changes, restlessness, difficulty sleeping, unsteadiness, sweating, gastrointestinal symptoms, and paraesthesia.
When considering the use of SSRIs during pregnancy, the benefits and risks should be weighed. Use during the first trimester may increase the risk of congenital heart defects, while use during the third trimester can result in persistent pulmonary hypertension of the newborn. Paroxetine has an increased risk of congenital malformations, particularly in the first trimester.
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This question is part of the following fields:
- Psychiatry
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Question 8
Incorrect
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Sarah is a 44-year-old hairdresser who contacts her GP due to a 2-day history of cough and fever. Her Covid-19 test is negative and she does not sound breathless on the phone. Sarah has been taking paracetamol regularly but despite this, she is still feeling feverish; she has recorded her temperature as 37.8ºC. She has a past medical history of eczema, gilbert's syndrome and adrenal insufficiency. She takes hydrocortisone 15 mg in the morning and 10mg at lunchtime, and also takes fludrocortisone 200 micrograms once a day.
What is the most appropriate management plan for Sarah?Your Answer: Double the dose of both his hydrocortisone and fludrocortisone
Correct Answer: Double the dose of his hydrocortisone
Explanation:To manage an Addison’s patient with an intercurrent illness, it is recommended to double the dose of their glucocorticoids, specifically hydrocortisone, while keeping the fludrocortisone dose the same. This is because the patient’s fever >37.5 indicates a moderate intercurrent illness. Continuing paracetamol regularly is not the main priority in this situation. Advising the patient to call 999 for admission is unnecessary unless there are severe symptoms such as vomiting or persistent diarrhea. Doubling the dose of fludrocortisone is not recommended as it is a mineralocorticoid with weak glucocorticoid activity, and increasing the glucocorticoid is necessary to mimic a stress response.
Addison’s disease is a condition that requires patients to undergo both glucocorticoid and mineralocorticoid replacement therapy. This treatment usually involves taking a combination of hydrocortisone and fludrocortisone. Hydrocortisone is typically given in 2 or 3 divided doses, with patients requiring 20-30 mg per day, mostly in the first half of the day. Patient education is crucial, and it is essential to emphasize the importance of not missing glucocorticoid doses. Additionally, patients should consider wearing MedicAlert bracelets and steroid cards, and they should be provided with hydrocortisone for injection with needles and syringes to treat an adrenal crisis.
During an intercurrent illness, it is crucial to manage the glucocorticoid dose properly. In simple terms, the glucocorticoid dose should be doubled, while the fludrocortisone dose should remain the same. The Addison’s Clinical Advisory Panel has produced guidelines that detail specific scenarios, and patients should refer to these guidelines for more information. It is essential to discuss how to adjust the glucocorticoid dose during an intercurrent illness with a healthcare professional. Proper management of Addison’s disease is crucial to ensure that patients can lead healthy and fulfilling lives.
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This question is part of the following fields:
- Infectious Diseases
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Question 9
Correct
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A 25-year-old woman visits the GP clinic seeking emergency contraception after having unprotected sex last night, 14 days after giving birth. What is the most appropriate course of action?
Your Answer: Advice the patient that she does not require emergency contraception
Explanation:After giving birth, women need to use contraception only after 21 days.
As the woman in the question is only 14 days post-partum, she does not need emergency contraception. Therefore, the advice to her would be that emergency contraception is not necessary.
After giving birth, women need to use contraception after 21 days. The progestogen-only pill (POP) can be started at any time postpartum, according to the FSRH. Additional contraception should be used for the first two days after day 21. A small amount of progestogen enters breast milk, but it is not harmful to the infant. On the other hand, the combined oral contraceptive pill (COCP) is absolutely contraindicated (UKMEC 4) if breastfeeding is less than six weeks post-partum. If breastfeeding is between six weeks and six months postpartum, it is a UKMEC 2. The COCP may reduce breast milk production in lactating mothers. It should not be used in the first 21 days due to the increased venous thromboembolism risk post-partum. After day 21, additional contraception should be used for the first seven days. The intrauterine device or intrauterine system can be inserted within 48 hours of childbirth or after four weeks.
The lactational amenorrhoea method (LAM) is 98% effective if the woman is fully breastfeeding (no supplementary feeds), amenorrhoeic, and less than six months post-partum. It is important to note that an inter-pregnancy interval of less than 12 months between childbirth and conceiving again is associated with an increased risk of preterm birth, low birth weight, and small for gestational age babies.
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This question is part of the following fields:
- Reproductive Medicine
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Question 10
Correct
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What is the initial indication of puberty in young girls?
Your Answer: Breast development
Explanation:Puberty: Normal Changes in Males and Females
Puberty is a natural process that marks the transition from childhood to adulthood. In males, the first sign of puberty is testicular growth, which typically occurs around the age of 12. A testicular volume greater than 4 ml indicates the onset of puberty. The maximum height spurt for males occurs at the age of 14.
For females, the first sign of puberty is breast development, which typically occurs around the age of 11.5. The height spurt for females reaches its maximum early in puberty, at the age of 12, before menarche. Menarche, the onset of menstruation, typically occurs at the age of 13.
Following menarche, there is only a small increase of about 4% in height. It is important to note that normal changes in puberty may include gynaecomastia in boys, asymmetrical breast growth in girls, and diffuse enlargement of the thyroid gland. These changes are a natural part of the process and should not cause alarm. Understanding the normal changes that occur during puberty can help individuals navigate this important stage of development with confidence.
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This question is part of the following fields:
- Paediatrics
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Question 11
Correct
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A 28-year-old administrative assistant complains of pain on the thumb side of her left wrist, persisting for the past week. She also notices that her left wrist seems more swollen than her right. During the examination, she experiences discomfort over her radial styloid when her thumb is forcefully flexed.
What is the probable diagnosis?Your Answer: Tenosynovitis
Explanation:The patient is positive for Finkelstein test, indicating De Quervain’s tenosynovitis. This condition causes pain over the radial styloid when the thumb is forcefully abducted or flexed. Unlike De Quervain’s tenosynovitis, rheumatoid arthritis affects both sides of the body. Mallet thumb is an injury that causes the thumb to bend towards the palm. Carpal tunnel syndrome is caused by compression of the median nerve and results in numbness and tingling in the thumb, index, and middle fingers. Osteoarthritis is a degenerative condition that primarily affects the elderly due to mechanical wear and tear.
De Quervain’s Tenosynovitis: Symptoms, Diagnosis, and Treatment
De Quervain’s tenosynovitis is a condition that commonly affects women between the ages of 30 and 50. It occurs when the sheath containing the extensor pollicis brevis and abductor pollicis longus tendons becomes inflamed. The condition is characterized by pain on the radial side of the wrist, tenderness over the radial styloid process, and pain when the thumb is abducted against resistance. A positive Finkelstein’s test, in which the thumb is pulled in ulnar deviation and longitudinal traction, can also indicate the presence of tenosynovitis.
Treatment for De Quervain’s tenosynovitis typically involves analgesia, steroid injections, and immobilization with a thumb splint (spica). In some cases, surgical treatment may be necessary. With proper diagnosis and treatment, most patients are able to recover from this condition and resume their normal activities.
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This question is part of the following fields:
- Musculoskeletal
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Question 12
Correct
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An expectant mother visits the obstetrician's office with a complaint of a painful nipple and a white discharge from the nipple. It is suspected that she has a candidal infection. What advice and treatment should be provided?
Your Answer: Continue breast feeding treat both the mother and baby simultaneously
Explanation:It is essential to treat the candidal infection by administering miconazole cream to both the mother and child. The cream should be applied to the nipple after feeding and the infant’s oral mucosa. Breastfeeding should continue during the treatment period. Additionally, the mother should be educated on maintaining good hand hygiene after changing the baby’s nappy and sterilizing any objects that the baby puts in their mouth, such as dummies and teats. This information is provided by NICE CKS.
Breastfeeding Problems and Their Management
Breastfeeding is a natural process, but it can come with its own set of challenges. Some of the minor problems that breastfeeding mothers may encounter include frequent feeding, nipple pain, blocked ducts, and nipple candidiasis. These issues can be managed by seeking advice on proper positioning, trying breast massage, and using appropriate medication.
Mastitis is a more serious problem that affects around 1 in 10 breastfeeding women. It is characterized by symptoms such as fever, nipple fissure, and persistent pain. Treatment involves the use of antibiotics, such as flucloxacillin, for 10-14 days. Breastfeeding or expressing milk should continue during treatment to prevent complications such as breast abscess.
Breast engorgement is another common problem that causes breast pain in breastfeeding women. It occurs in the first few days after birth and affects both breasts. Hand expression of milk can help relieve the discomfort of engorgement. Raynaud’s disease of the nipple is a less common problem that causes nipple pain and blanching. Treatment involves minimizing exposure to cold, using heat packs, and avoiding caffeine and smoking.
If a breastfed baby loses more than 10% of their birth weight in the first week of life, it may be a sign of poor weight gain. This should prompt consideration of the above breastfeeding problems and an expert review of feeding. Monitoring of weight should continue until weight gain is satisfactory.
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This question is part of the following fields:
- Reproductive Medicine
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Question 13
Correct
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A 26-year-old man with a history of ulcerative colitis presents to the GP with symptoms of feeling unwell. He has been experiencing up to 8 bowel movements a day for the past 3 days, with blood present in his stool each time. He denies having a fever. Urgent blood tests reveal the following results:
Hb 110 g/L Male: (135-180) Female: (115 - 160)
Platelets 384 * 109/L (150 - 400)
WBC 16 * 109/L (4.0 - 11.0)
Na+ 138 mmol/L (135 - 145)
K+ 4.2 mmol/L (3.5 - 5.0)
Urea 2.4 mmol/L (2.0 - 7.0)
Creatinine 58 µmol/L (55 - 120)
CRP 109 mg/L (< 5)
What is the initial treatment plan for this patient, given the severity of his symptoms?Your Answer: Admit to hospital for IV steroids
Explanation:When dealing with a severe flare of ulcerative colitis, it is important to evaluate the severity of the condition. In this case, the patient is experiencing more than six bloody stools per day, as well as systemic upset indicated by raised inflammatory markers and anaemia. This places him in the severe category. The first line of treatment would be IV corticosteroids, with IV ciclosporin as a second-line option if the steroids do not induce remission. Hospital admission for IV steroids is the appropriate course of action to induce remission, after which maintenance treatment can be assessed. For moderate extensive disease, oral aminosalicylate and oral steroids can be used. It would be inappropriate to send this patient home without any treatment, as he is clearly unwell and experiencing a flare of UC.
Ulcerative colitis can be managed through inducing and maintaining remission. The severity of the condition is classified as mild, moderate, or severe based on the number of stools and presence of systemic upset. Treatment for mild-to-moderate cases of proctitis involves using topical aminosalicylate, while proctosigmoiditis and left-sided ulcerative colitis may require a combination of oral and topical medications. Extensive disease may require a high-dose oral aminosalicylate and topical treatment. Severe colitis should be treated in a hospital with intravenous steroids or ciclosporin. Maintaining remission can involve using a low maintenance dose of an oral aminosalicylate or oral azathioprine/mercaptopurine. Methotrexate is not recommended, but probiotics may prevent relapse in mild to moderate cases.
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This question is part of the following fields:
- Gastroenterology/Nutrition
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Question 14
Correct
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A 3-year-old girl is referred to the paediatric clinic for failure to thrive. She has failed to maintain her weight and suffers from frequent vomiting and respiratory tract infections. A sweat test is performed and the chloride content of the sweat is 72 mmol/l (normal level <60 mmol/l).
Which of the following modes of inheritance fits best with this condition?Your Answer: Autosomal recessive
Explanation:Understanding Cystic Fibrosis: Inheritance and Characteristics
Cystic fibrosis is a genetic disorder that affects the chloride transport and secretion viscosity in the body due to a mutation in the CFTR gene. This disorder follows an autosomal recessive pattern of inheritance, meaning that an individual must inherit two copies of the mutated gene (one from each parent) to develop the disease. The most common mutation involved is the Δ508 mutation.
Cystic fibrosis is prevalent in northern European populations, with a frequency of approximately 1 in 3200. Males with the disease are often infertile due to congenital absence of the vas deferens.
It is important to note that cystic fibrosis is not an autosomal dominant or sex-linked disorder. Chromosomal non-disjunction and translocation can cause other genetic conditions, but they are not associated with cystic fibrosis. Understanding the inheritance and characteristics of cystic fibrosis can aid in diagnosis and management of the disease.
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This question is part of the following fields:
- Genetics
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Question 15
Incorrect
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A 56-year-old man with type 2 diabetes mellitus is being seen in the clinic. He is on a medication regimen that includes metformin, aspirin, simvastatin, and pioglitazone. What is the most probable issue that can be caused by pioglitazone?
Your Answer: Myalgia
Correct Answer: Peripheral oedema
Explanation:Fluid retention may be caused by pioglitazone.
Thiazolidinediones: A Class of Diabetes Medications
Thiazolidinediones are a type of medication used to treat type 2 diabetes. They work by activating the PPAR-gamma receptor, which reduces insulin resistance in the body. However, one medication in this class, rosiglitazone, was withdrawn in 2010 due to concerns about its cardiovascular side effects.
The PPAR-gamma receptor is a nuclear receptor found inside cells. It is naturally activated by free fatty acids and is involved in regulating the differentiation and function of adipocytes (fat cells).
While thiazolidinediones can be effective in treating diabetes, they can also have adverse effects. Patients may experience weight gain, liver impairment (which requires monitoring of liver function tests), and fluid retention. Thiazolidinediones are contraindicated in patients with heart failure due to the increased risk of fluid retention, especially if the patient is also taking insulin. Recent studies have also shown an increased risk of fractures and bladder cancer in patients taking pioglitazone, another medication in this class.
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This question is part of the following fields:
- Endocrinology/Metabolic Disease
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Question 16
Incorrect
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A 31-year-old female patient visits her doctor with complaints of feeling unwell for the past week. She reports experiencing headaches and mild abdominal discomfort. She denies having any diarrhea but mentions severe constipation. Recently, she returned from a 3-week trip to India. During the examination, her temperature is recorded as 38.5ºC, and she appears bloated. Additionally, a sparse macular rash is observed on her chest. What is the probable causative agent for this presentation?
Your Answer: Campylobacter jejuni
Correct Answer: Salmonella typhi
Explanation:While salmonella can cause diarrhoea, typhoid fever is more likely to result in constipation. This is a typical symptom of typhoid fever, along with the appearance of rose spots. It’s important to note that constipation can be a significant indicator of this illness. In contrast, Campylobacter jejuni infection usually causes bloody diarrhoea and abdominal pain. E. coli is a common cause of watery diarrhoea, but certain strains like E. coli O157:H7 can lead to severe abdominal cramping, vomiting, and bloody diarrhoea. Giardiasis can cause similar symptoms such as bloating and abdominal pain, but it usually results in chronic diarrhoea. Shigellosis typically causes abdominal pain and diarrhoea, which may or may not be bloody.
Enteric fever, also known as typhoid or paratyphoid, is caused by Salmonella typhi and Salmonella paratyphi respectively. These bacteria are not normally found in the gut and are transmitted through contaminated food and water or the faecal-oral route. The symptoms of enteric fever include headache, fever, and joint pain, as well as abdominal pain and distension. Constipation is more common in typhoid than diarrhoea, and rose spots may appear on the trunk in some patients. Complications can include osteomyelitis, gastrointestinal bleeding or perforation, meningitis, cholecystitis, and chronic carriage. Chronic carriage is more likely in adult females and occurs in approximately 1% of cases.
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This question is part of the following fields:
- Infectious Diseases
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Question 17
Correct
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A 68-year-old man came to your GP clinic complaining of stiffness and pain in his knee joints, painful urination, and a red eye with circumcorneal redness, hypopyon, and photophobia. What is the most probable reason for his red eye?
Your Answer: Iritis
Explanation:When dealing with reactive arthritis, it is important to keep in mind that anterior uveitis may also be present in addition to conjunctivitis.
Since reactive arthritis is linked to HLA-B27, it is important to consider the possibility of iritis or anterior uveitis, even though conjunctivitis is more commonly seen as part of the triad of symptoms. The specific description of a red eye with circumcorneal redness and hypopyon suggests iritis rather than conjunctivitis. Conjunctivitis typically causes a more generalized redness of the eye and hypopyon is not commonly observed. Corneal ulceration is unlikely in this case as there is no mention of increased fluorescein uptake on the cornea or a visible ulcer. Scleritis can be ruled out as it does not present with circumcorneal redness or hypopyon. While scleritis is associated with systemic conditions such as rheumatoid arthritis and other collagen/vascular disorders like Wegener’s granulomatosis, polyarteritis nodosa, and systemic lupus erythematosus, it is not associated with reactive arthritis. Blepharitis is also an incorrect diagnosis as there were no eyelid symptoms and blepharitis does not typically cause a red eye with photophobic symptoms.
Anterior uveitis, also known as iritis, is a type of inflammation that affects the iris and ciliary body in the front part of the uvea. It is a common cause of red eye and is associated with HLA-B27, which may also be linked to other conditions. Symptoms of anterior uveitis include sudden onset of eye discomfort and pain, small or irregular pupils, intense sensitivity to light, blurred vision, redness, tearing, and the presence of pus and inflammatory cells in the front part of the eye. This condition may be associated with ankylosing spondylitis, reactive arthritis, ulcerative colitis, Crohn’s disease, Behcet’s disease, and sarcoidosis. Urgent review by an ophthalmologist is necessary, and treatment may involve the use of cycloplegics and steroid eye drops.
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This question is part of the following fields:
- Ophthalmology
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Question 18
Correct
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A 59-year-old woman comes in for a routine check-up with her primary care physician. She has a history of type 2 diabetes mellitus and is currently taking metformin and sitagliptin. During her last visit, her blood pressure was measured at 161/88 mmHg and she was advised to undergo 7 days of ambulatory blood pressure monitoring.
During this visit, her average ambulatory blood pressure is recorded as 158/74 mmHg. All other observations are stable and her cardiorespiratory examination is unremarkable. Her blood sugar level is 6.2 mmol/L.
What medication would be recommended to manage this patient's blood pressure?Your Answer: Lisinopril
Explanation:Regardless of age, ACE inhibitors/A2RBs are the first-line treatment for hypertension in diabetics.
Blood Pressure Management in Diabetes Mellitus
Patients with diabetes mellitus have traditionally been managed with lower blood pressure targets to reduce their overall cardiovascular risk. However, a 2013 Cochrane review found that there was little difference in outcomes between patients who had tight blood pressure control (targets < 130/85 mmHg) and those with more relaxed control (< 140-160/90-100 mmHg), except for a slightly reduced rate of stroke in the former group. As a result, NICE recommends a blood pressure target of < 140/90 mmHg for type 2 diabetics, the same as for patients without diabetes. For patients with type 1 diabetes, NICE recommends a blood pressure target of 135/85 mmHg unless they have albuminuria or two or more features of metabolic syndrome, in which case the target should be 130/80 mmHg. ACE inhibitors or angiotensin-II receptor antagonists (A2RBs) are the first-line antihypertensive regardless of age, as they have a renoprotective effect in diabetes. A2RBs are preferred for black African or African-Caribbean diabetic patients. Further management then follows that of non-diabetic patients. It is important to note that autonomic neuropathy may result in more postural symptoms in patients taking antihypertensive therapy. Therefore, the routine use of beta-blockers in uncomplicated hypertension should be avoided, particularly when given in combination with thiazides, as they may cause insulin resistance, impair insulin secretion, and alter the autonomic response to hypoglycemia.
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This question is part of the following fields:
- Cardiovascular
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Question 19
Correct
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A 25-year-old man is brought to the Emergency Department by his friends. Around 2 hours ago he was allegedly assaulted outside of a bar. He was repeatedly punched in the head and has sustained some bruising around his eyes. His friends report that he is 'concussed' and say that he is confused. On examination his GCS is 14 (M6 V4 E4) and he has trouble explaining where he is. There are no focal neurological features. There is no past medical history of note. Tonight he has drunk around four pints of lager. What is the most appropriate management with regards to a possible head injury?
Your Answer: CT head scan within 1 hour
Explanation:According to the latest NICE guidelines, a CT head scan is necessary for this patient as their GCS remains below 15 after 2 hours.
NICE Guidelines for Investigating Head Injuries in Adults
Head injuries can be serious and require prompt medical attention. The National Institute for Health and Care Excellence (NICE) has provided clear guidelines for healthcare professionals to determine which adult patients need further investigation with a CT head scan. Patients who require immediate CT head scans include those with a Glasgow Coma Scale (GCS) score of less than 13 on initial assessment, suspected open or depressed skull fractures, signs of basal skull fractures, post-traumatic seizures, focal neurological deficits, and more than one episode of vomiting.
For patients with any loss of consciousness or amnesia since the injury, a CT head scan within 8 hours is recommended for those who are 65 years or older, have a history of bleeding or clotting disorders, experienced a dangerous mechanism of injury, or have more than 30 minutes of retrograde amnesia of events immediately before the head injury. Additionally, patients on warfarin who have sustained a head injury with no other indications for a CT head scan should also receive a scan within 8 hours of the injury.
It is important for healthcare professionals to follow these guidelines to ensure that patients receive appropriate and timely care for their head injuries. By identifying those who require further investigation, healthcare professionals can provide the necessary treatment and support to prevent further complications and improve patient outcomes.
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This question is part of the following fields:
- Neurology
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Question 20
Correct
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Liam is a 30-year-old software engineer who has been admitted to the hospital due to a relapse of his schizophrenia. He has been detained under section 3 of the Mental Health Act for 2 weeks after refusing to take his medication.
The consultant psychiatrist suggests starting Liam on risperidone, but during the team meeting, Liam was informed of the potential risks and benefits of the medication and decided he does not want to take it. The team believes that Liam has the capacity to make this decision, but they also feel that he needs treatment with an antipsychotic to reduce the risk to himself and others.
What is the most appropriate course of action in this situation?Your Answer: Rosie can be treated against her will under section 3, even if she has capacity
Explanation:If a patient is under section 2 or 3, treatment can be administered even if they refuse it. Patients who are detained under section 3 can be treated against their will, regardless of their capacity. However, after three months, if the patient still refuses treatment, an impartial psychiatrist must review the proposed medication and agree with the treating team’s plan. The Mental Health Act takes precedence over the Mental Capacity Act, so a best interests meeting is not necessary. The treating team must consider the patient’s best interests, and in this case, they believe that medication is necessary for Rosie’s mental health. While benzodiazepines can alleviate agitation and distress, they are unlikely to improve her psychotic symptoms, so they are not a suitable option. If Rosie continues to refuse treatment after three months under section 3, a second opinion will be required.
Sectioning under the Mental Health Act is a legal process used for individuals who refuse voluntary admission. This process excludes patients who are under the influence of drugs or alcohol. There are several sections under the Mental Health Act that allow for different types of admission and treatment.
Section 2 allows for admission for assessment for up to 28 days, which is not renewable. An Approved Mental Health Professional (AMHP) or the nearest relative (NR) can make the application on the recommendation of two doctors, one of whom should be an approved consultant psychiatrist. Treatment can be given against the patient’s wishes.
Section 3 allows for admission for treatment for up to 6 months, which can be renewed. An AMHP and two doctors, both of whom must have seen the patient within the past 24 hours, can make the application. Treatment can also be given against the patient’s wishes.
Section 4 is used as an emergency 72-hour assessment order when a section 2 would involve an unacceptable delay. A GP and an AMHP or NR can make the application, which is often changed to a section 2 upon arrival at the hospital.
Section 5(2) allows a doctor to legally detain a voluntary patient in hospital for 72 hours, while section 5(4) allows a nurse to detain a voluntary patient for 6 hours.
Section 17a allows for Supervised Community Treatment (Community Treatment Order) and can be used to recall a patient to the hospital for treatment if they do not comply with the conditions of the order in the community, such as taking medication.
Section 135 allows for a court order to be obtained to allow the police to break into a property to remove a person to a Place of Safety. Section 136 allows for someone found in a public place who appears to have a mental disorder to be taken by the police to a Place of Safety. This section can only be used for up to 24 hours while a Mental Health Act assessment is arranged.
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This question is part of the following fields:
- Psychiatry
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