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Question 1
Correct
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A 25-year-old man presents to the GP with a swelling in his scrotum. He is feeling well otherwise. Upon examination, there is a soft swelling on the right side of the scrotum that is painless and illuminates brightly with a pen torch. The swelling is localized to the scrotum, and the rest of the scrotum can be palpated above the mass. The testicle is palpable with no apparent mass. The patient is particularly concerned about the possibility of having testicular cancer.
What is the most probable diagnosis?Your Answer: Hydrocele
Explanation:Scrotal swelling caused by an accumulation of fluid in the tunica vaginalis is known as a hydrocele. This condition can be identified by its ability to transilluminate brightly with a pen torch and is confined to the scrotum. While epididymo-orchitis can also cause unilateral swelling, it is typically tender and accompanied by systemic symptoms. Testicular cancer may lead to a hydrocele, but if the testis is palpable and normal, it is less likely to be the cause of the swelling. In cases where the testis is not palpable, patients should be referred for a testicular ultrasound.
Common Scrotal Problems and Their Features
Epididymal cysts, hydroceles, and varicoceles are the most common scrotal problems seen in primary care. Epididymal cysts are usually found posterior to the testicle and are separate from the body of the testicle. They may be associated with conditions such as polycystic kidney disease, cystic fibrosis, and von Hippel-Lindau syndrome. Diagnosis is confirmed by ultrasound, and management is usually supportive, although surgical removal or sclerotherapy may be attempted for larger or symptomatic cysts.
Hydroceles, on the other hand, describe the accumulation of fluid within the tunica vaginalis. They may be communicating or non-communicating, and may develop secondary to conditions such as epididymo-orchitis, testicular torsion, or testicular tumors. Hydroceles are usually soft, non-tender swellings of the hemi-scrotum that transilluminate with a pen torch. Diagnosis may be clinical, but ultrasound is required if there is any doubt about the diagnosis or if the underlying testis cannot be palpated. Management depends on the severity of the presentation, with infantile hydroceles generally repaired if they do not resolve spontaneously by the age of 1-2 years.
Varicoceles, on the other hand, are abnormal enlargements of the testicular veins that are usually asymptomatic but may be associated with subfertility. They are much more common on the left side and are classically described as a bag of worms. Diagnosis is confirmed by ultrasound with Doppler studies, and management is usually conservative, although surgery may be required if the patient is troubled by pain. There is ongoing debate regarding the effectiveness of surgery to treat infertility.
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This question is part of the following fields:
- Renal Medicine/Urology
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Question 2
Incorrect
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A 35-year-old woman complains of rectal bleeding and discomfort during bowel movements for the past two weeks. She has a history of poor dietary habits and chronic constipation. Upon wiping, she notices fresh blood on the toilet paper. During examination, her abdomen is soft and nontender, and rectal examination is painful but reveals no masses.
What is the most probable diagnosis?Your Answer: Haemorrhoids
Correct Answer: Anal fissure
Explanation:Differential Diagnosis of Anal Pain: Understanding the Causes
Anal pain can be a distressing symptom that can have various underlying causes. One of the most common causes is an anal fissure, which is a painful tear in the anal canal. This condition is often caused by trauma from hard or painful bowel movements and is associated with low-fiber diets.
Patients with anal fissures typically experience severe pain during bowel movements, which can lead to constipation and worsening symptoms. However, medical therapy with stool-bulking agents and fiber supplementation can help resolve acute anal fissures in most cases.
Other potential causes of anal pain include distal colonic polyps, anal warts, hemorrhoids, and rectal carcinoma. Distal colonic polyps are slow-growing overgrowths of the colonic mucosa that carry a small risk of becoming malignant. Anal warts are caused by the human papillomavirus (HPV) and can present as painless bumps or eruptions in the anogenital area.
Hemorrhoids are swollen blood vessels in the lower rectum that can cause rectal bleeding, pain, pruritus, or prolapse. Rectal carcinoma is a rare but serious condition that can cause bleeding, change in bowel habits, abdominal pain, and malaise.
In summary, understanding the differential diagnosis of anal pain is crucial for accurate diagnosis and appropriate treatment. A thorough physical examination and medical history can help identify the underlying cause and guide management.
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This question is part of the following fields:
- Gastroenterology/Nutrition
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Question 3
Correct
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A 10-year-old boy is brought to surgery as his father is worried about his weight. This has been a concern for more than three years and dad believes it is affecting his son's performance in school. What is the best way to determine the extent of his obesity?
Your Answer: Body mass index percentile adjusted to age and gender
Explanation:Understanding Obesity in Children
Childhood obesity is a complex issue that requires careful assessment and management. Unlike adults, defining obesity in children is more challenging as body mass index (BMI) varies with age. To accurately assess BMI, percentile charts are needed. According to recent guidelines by the National Institute for Health and Care Excellence (NICE), the UK 1990 BMI charts should be used to provide age- and gender-specific information.
NICE recommends tailored clinical intervention if BMI is at the 91st centile or above. If BMI is at the 98th centile or above, assessing for comorbidities is necessary. Lifestyle factors are the most common cause of obesity in childhood. However, other factors such as growth hormone deficiency, hypothyroidism, Down’s syndrome, Cushing’s syndrome, and Prader-Willi syndrome can also contribute to obesity in children.
Obesity in children can lead to various consequences, including orthopaedic problems such as slipped upper femoral epiphyses and Blount’s disease, musculoskeletal pains, psychological consequences like poor self-esteem and bullying, sleep apnoea, and benign intracranial hypertension. Moreover, obesity in childhood can increase the risk of developing type 2 diabetes mellitus, hypertension, and ischaemic heart disease in the long run. Therefore, it is crucial to identify and manage obesity in children to prevent these adverse outcomes.
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This question is part of the following fields:
- Paediatrics
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Question 4
Correct
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A 25-year-old football player comes to the GP clinic complaining of a loss of motor function in his left leg. He denies any specific injuries and has an important game next week that he's been anxious about. He enters the room using crutches. During the examination, it is found that he has 0/5 power in his left knee, ankle, and toes. The rest of the neurological and musculoskeletal examination is unremarkable. Blood tests and a lumbar MRI come back normal, making an organic cause for his symptoms unlikely. He is eager to know the reason behind his condition so that he can resume his training.
What is the most probable cause of his symptoms?Your Answer: Conversion disorder
Explanation:It is probable that the patient is experiencing conversion disorder, which is often triggered by stress and involves the loss of motor or sensory function. The potential grand final rugby game may have been the stressor in this case.
Somatisation disorder is unlikely as it requires the presence of multiple physical symptoms for at least two years, whereas this patient has only one acute onset symptom. Dissociative disorder is also improbable as there are no evident psychiatric symptoms such as amnesia, stupor, or fugue. The patient remembers clearly that he has a football game and has not sustained any recent injuries.
However, factitious disorder cannot be ruled out entirely. It is possible that the patient is feigning the symptom to avoid playing the game, but further investigation is necessary. The patient claims to be eager to return to playing, which does not support the notion of factitious disorder.
Psychiatric Terms for Unexplained Symptoms
There are various psychiatric terms used to describe patients who exhibit symptoms for which no organic cause can be found. One such disorder is somatisation disorder, which involves the presence of multiple physical symptoms for at least two years, and the patient’s refusal to accept reassurance or negative test results. Another disorder is illness anxiety disorder, which is characterized by a persistent belief in the presence of an underlying serious disease, such as cancer, despite negative test results.
Conversion disorder is another condition that involves the loss of motor or sensory function, and the patient does not consciously feign the symptoms or seek material gain. Patients with this disorder may be indifferent to their apparent disorder, a phenomenon known as la belle indifference. Dissociative disorder, on the other hand, involves the process of ‘separating off’ certain memories from normal consciousness, and may manifest as amnesia, fugue, or stupor. Dissociative identity disorder (DID) is the most severe form of dissociative disorder and was previously known as multiple personality disorder.
Factitious disorder, also known as Munchausen’s syndrome, involves the intentional production of physical or psychological symptoms. Finally, malingering is the fraudulent simulation or exaggeration of symptoms with the intention of financial or other gain. Understanding these psychiatric terms can help healthcare professionals better diagnose and treat patients with unexplained symptoms.
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This question is part of the following fields:
- Psychiatry
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Question 5
Correct
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A 50-year-old woman with a history of hypertension and hypercholesterolaemia presents with sudden shortness of breath one hour after undergoing primary percutaneous intervention for an anterior ST-elevation myocardial infarction. The procedure was successful and radial access was used. She initially appeared stable and a bedside echocardiogram showed normal left ventricular function. However, on examination, she appears unwell with diaphoresis, tachypnea, hypotension (80/42 mmHg), tachycardia (111/minute), and elevated JVP. There are no signs of peripheral oedema or deep venous thrombosis. What is the most urgent intervention that could save her life?
Your Answer: Pericardiocentesis
Explanation:Cardiac tamponade is suggested by the presence of Beck’s triad, which includes falling blood pressure, rising jugular venous pulse, and muffled heart sounds. Therefore, cardiogenic shock is unlikely as the patient underwent successful revascularization and had a normal echocardiogram post-procedure. While inotropes may provide temporary support for low blood pressure, they are not a curative option in this case. Sepsis is not the cause of hypotension as it is typically associated with a fever, bounding pulse, and warm extremities, and the jugular venous pulse would not be elevated. Intravenous antibiotics are therefore not the correct answer. Hypovolemia is also not associated with an elevated jugular venous pulse, so intravenous fluids are not the correct answer. Additionally, the use of radial access makes a retroperitoneal hematoma less likely. The correct answer is pericardiocentesis, as the clinical features suggest cardiac tamponade, which is a known complication of primary percutaneous intervention in myocardial infarction.
Cardiac tamponade is a condition where there is an accumulation of fluid in the pericardial sac, which puts pressure on the heart. This can lead to a range of symptoms, including hypotension, raised JVP, muffled heart sounds, dyspnoea, tachycardia, and pulsus paradoxus. One of the key features of cardiac tamponade is the absence of a Y descent on the JVP, which is due to limited right ventricular filling. Other diagnostic criteria include Kussmaul’s sign and electrical alternans on an ECG. Constrictive pericarditis is a similar condition, but it can be distinguished from cardiac tamponade by the presence of an X and Y descent on the JVP, the absence of pulsus paradoxus, and the presence of pericardial calcification on a chest X-ray. The management of cardiac tamponade involves urgent pericardiocentesis to relieve the pressure on the heart.
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This question is part of the following fields:
- Cardiovascular
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Question 6
Correct
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What is the recommended next step in managing the blood pressure of a 42 year old woman with a history of depression and a recent paracetamol overdose who has a manual blood pressure reading of 165/85 mmHg?
Your Answer: Offer ambulatory blood pressure monitoring
Explanation:The National Institute for Clinical Excellence updated its guideline for hypertension management in 2011, placing emphasis on the use of ambulatory blood pressure monitoring (ABPM) to confirm hypertension in individuals with elevated clinic readings. ABPM involves taking two measurements per hour during waking hours and using the average of at least 14 measurements to confirm a diagnosis of hypertension. Secondary causes of hypertension should be investigated in patients under 40 without traditional risk factors, those with other symptoms of secondary causes, and those with resistant hypertension. Hyperaldosteronism is the most common cause of secondary hypertension, and a trial of spironolactone may be used for both therapeutic and diagnostic purposes. Drug treatment for essential hypertension involves ACE inhibitors for those under 55 and calcium channel blockers for those over 55 or of black African or Caribbean origin. Step 2 involves using both ACE inhibitors and calcium channel blockers, while step 3 adds a thiazide-like diuretic. Further diuretics, beta-blockers, or alpha blockers may be considered in step 4, with expert advice sought. For a more detailed explanation, refer to the provided link.
NICE released updated guidelines in 2019 for the management of hypertension, building on previous guidelines from 2011. These guidelines aimed to classify hypertension into stages and recommend the use of ambulatory blood pressure monitoring (ABPM) and home blood pressure monitoring (HBPM) to accurately diagnose hypertension. This is important because some patients experience white coat hypertension, where their blood pressure rises in a clinical setting, leading to potential overdiagnosis of hypertension. ABPM and HBPM allow for a more accurate assessment of a patient’s overall blood pressure and can prevent overdiagnosis.
NICE recommends measuring blood pressure in both arms when considering a diagnosis of hypertension and repeating measurements if there is a difference of more than 20 mmHg between arms. If the blood pressure is >= 140/90 mmHg, NICE suggests offering ABPM or HBPM to confirm the diagnosis. If the blood pressure is >= 180/120 mmHg, referral for specialist assessment is recommended if there are signs of retinal haemorrhage or papilloedema or life-threatening symptoms. If target organ damage is identified, antihypertensive drug treatment may be started immediately.
ABPM involves taking at least 2 measurements per hour during the person’s usual waking hours and using the average value of at least 14 measurements. If ABPM is not tolerated, HBPM should be offered. HBPM involves taking two consecutive measurements at least 1 minute apart, twice daily for at least 4 days, and using the average value of all remaining measurements.
Interpreting the results of ABPM/HBPM is important for determining treatment. If the average blood pressure is >= 135/85 mmHg (stage 1 hypertension), treatment may be considered for patients under 80 years of age with target organ damage, established cardiovascular disease, renal disease, diabetes, or a 10-year cardiovascular risk equivalent to 10% or greater. In 2019, NICE also recommended considering antihypertensive drug treatment for adults under 60 with stage 1 hypertension and an estimated 10-year risk below 10%. If the average blood pressure is >= 150/95 mmHg (stage 2 hypertension), drug treatment should be offered regardless of age.
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This question is part of the following fields:
- Cardiovascular
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Question 7
Correct
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A 58-year-old man presents for follow-up. He has experienced two episodes of fainting in the past month. The first occurred while he was climbing stairs, and the second occurred last week as he was exiting a swimming pool. There were no warning signs before either episode. Witnesses to the most recent episode reported that he was unconscious for approximately 15 seconds. He reports feeling disoriented for only a few seconds after regaining consciousness. On physical examination, his pulse is 90 beats per minute, blood pressure is 110/86 mmHg, his lungs are clear, and there is a systolic murmur that radiates to the carotid area. Which of the following tests should be ordered first?
Your Answer: Echocardiogram
Explanation:The presence of a systolic murmur could indicate the possibility of aortic stenosis (AS). It is crucial to prioritize ruling out this condition as syncope, which is a late symptom, often occurs during physical activity in patients with AS.
Aortic Stenosis: Symptoms, Causes, and Management
Aortic stenosis is a condition characterized by the narrowing of the aortic valve, which can lead to various symptoms. These symptoms include chest pain, dyspnea, syncope, and a characteristic ejection systolic murmur that radiates to the carotids. Severe aortic stenosis can also cause a narrow pulse pressure, slow rising pulse, delayed ESM, soft/absent S2, S4, thrill, and left ventricular hypertrophy or failure. The most common causes of aortic stenosis are degenerative calcification in older patients and bicuspid aortic valve in younger patients.
If a patient is asymptomatic, observation is usually recommended. However, if the patient is symptomatic or has a valvular gradient greater than 40 mmHg with features such as left ventricular systolic dysfunction, valve replacement is necessary. Surgical AVR is the preferred treatment for young, low/medium operative risk patients, while TAVR is used for those with a high operative risk. Balloon valvuloplasty may be used in children without aortic valve calcification and in adults with critical aortic stenosis who are not fit for valve replacement.
In summary, aortic stenosis is a condition that can cause various symptoms and requires prompt management to prevent complications. The causes of aortic stenosis vary, and treatment options depend on the patient’s age, operative risk, and overall health.
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This question is part of the following fields:
- Cardiovascular
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Question 8
Incorrect
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A 54-year-old man with a history of hypertension comes in for a check-up. During his annual health assessment, he undergoes a U&E, HbA1c, and cholesterol test. The results are as follows:
His blood pressure today is 128/78 mmHg. He takes ramipril 5mg od as his only regular medication.
Na+ 142 mmol/l
K+ 4.6 mmol/l
Urea 5.2 mmol/l
Creatinine 88 µmol/l
Total cholesterol 5.2 mmol/l
HbA1c 45 mmol/mol (6.3%)
His 10-year QRISK2 score is 7%. What is the most appropriate course of action based on these findings?Your Answer: Start atorvastatin 20mg on
Correct Answer: Arrange a fasting glucose sample
Explanation:There is no need to take any action regarding his cholesterol as it is under control. Additionally, his blood pressure is also well managed. However, his HbA1c level is in the pre-diabetes range (42-47 mmol/mol) and requires further investigation. It is important to note that a HbA1c reading alone cannot rule out diabetes, and a fasting sample should be arranged for confirmation.
Type 2 diabetes mellitus can be diagnosed through a plasma glucose or HbA1c sample. The diagnostic criteria vary depending on whether the patient is experiencing symptoms or not. If the patient is symptomatic, a fasting glucose level of 7.0 mmol/l or higher or a random glucose level of 11.1 mmol/l or higher (or after a 75g oral glucose tolerance test) indicates diabetes. If the patient is asymptomatic, the same criteria apply but must be demonstrated on two separate occasions.
In 2011, the World Health Organization released supplementary guidance on the use of HbA1c for diagnosing diabetes. A HbA1c level of 48 mmol/mol (6.5%) or higher is diagnostic of diabetes mellitus. However, a HbA1c value of less than 48 mmol/mol (6.5%) does not exclude diabetes and may not be as sensitive as fasting samples for detecting diabetes. For patients without symptoms, the test must be repeated to confirm the diagnosis. It is important to note that increased red cell turnover can cause misleading HbA1c results.
There are certain conditions where HbA1c cannot be used for diagnosis, such as haemoglobinopathies, haemolytic anaemia, untreated iron deficiency anaemia, suspected gestational diabetes, children, HIV, chronic kidney disease, and people taking medication that may cause hyperglycaemia (such as corticosteroids).
Impaired fasting glucose (IFG) is defined as a fasting glucose level of 6.1 mmol/l or higher but less than 7.0 mmol/l. Impaired glucose tolerance (IGT) is defined as a fasting plasma glucose level less than 7.0 mmol/l and an OGTT 2-hour value of 7.8 mmol/l or higher but less than 11.1 mmol/l. People with IFG should be offered an oral glucose tolerance test to rule out a diagnosis of diabetes. A result below 11.1 mmol/l but above 7.8 mmol/l indicates that the person does not have diabetes but does have IGT.
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This question is part of the following fields:
- Endocrinology/Metabolic Disease
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Question 9
Incorrect
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A 32-year-old woman who is 8 weeks pregnant is curious about the anomaly scan after hearing about a friend's experience. She wants to know the earliest possible time she can have the scan.
When can the anomaly scan be done at the earliest?Your Answer: 20 weeks
Correct Answer: 18 weeks
Explanation:The earliest possible time for an anomaly scan is at 18 weeks, with the latest being at 20 weeks and 6 days. For a dating scan, the earliest possible time is at 8 weeks. As for a nuchal scan, it can be done at the earliest at 11 weeks.
NICE guidelines recommend 10 antenatal visits for first pregnancies and 7 for subsequent pregnancies if uncomplicated. The purpose of each visit is outlined, including booking visits, scans, screening for Down’s syndrome, routine care for blood pressure and urine, and discussions about labour and birth plans. Rhesus negative women are offered anti-D prophylaxis at 28 and 34 weeks. The guidelines also recommend discussing options for prolonged pregnancy at 41 weeks.
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This question is part of the following fields:
- Reproductive Medicine
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Question 10
Incorrect
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A 42-year-old man has been receiving weekly intramuscular injections for rheumatoid arthritis for the past 8 weeks. Routine urinalysis shows that he has a proteinuria.
Which of the following is he most likely to have been prescribed?Your Answer: Celecoxib
Correct Answer: Gold
Explanation:Rheumatoid arthritis can be treated with various drugs, including gold, infliximab, d-penicillamine, leflunomide, and celecoxib. Gold is given by injection and can cause side effects such as glomerulonephritis. Infliximab is administered intravenously and can lead to infections and autoimmune syndromes. D-penicillamine can cause proteinuria and is taken orally. Leflunomide blocks T cell expansion and can cause diarrhea, nausea, and abnormal blood test results. Celecoxib is an NSAID taken orally and can increase the risk of vascular events and gastrointestinal issues. Understanding the different drug categories and their side effects is important for effective treatment of rheumatoid arthritis. Monitoring for side effects is necessary for all disease-modifying drugs.
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This question is part of the following fields:
- Musculoskeletal
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Question 11
Incorrect
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A 27-year-old man complains of back pain. What symptom may indicate a possible diagnosis of ankylosing spondylitis?
Your Answer: Bone tenderness
Correct Answer: Pain at night
Explanation:Ankylosing spondylitis is a type of spondyloarthropathy that is associated with HLA-B27. It is more commonly seen in young males, with a sex ratio of 3:1, and typically presents with lower back pain and stiffness that develops gradually. The stiffness is usually worse in the morning and improves with exercise, while pain at night may improve upon getting up. Clinical examination may reveal reduced lateral and forward flexion, as well as reduced chest expansion. Other features associated with ankylosing spondylitis include apical fibrosis, anterior uveitis, aortic regurgitation, Achilles tendonitis, AV node block, amyloidosis, cauda equina syndrome, and peripheral arthritis (more common in females).
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This question is part of the following fields:
- Musculoskeletal
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Question 12
Correct
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A 26 year-old woman, who is 36 weeks pregnant, presents to her GP with a blood pressure reading of 170/110 mmHg. She is feeling well otherwise and is currently taking 250 mg labetalol. Urinalysis shows 3+ proteinuria. Fetal monitoring is normal. Her blood tests reveal a hemoglobin level of 135 g/l, platelet count of 280 * 109/l, white blood cell count of 6.0 * 109/l, sodium level of 142 mmol/l, potassium level of 4.0 mmol/l, urea level of 2.8 mmol/l, and creatinine level of 24 µmol/l. What is the most appropriate course of action for her management?
Your Answer: Admit the patient to hospital as an emergency
Explanation:Despite the absence of symptoms, the patient’s blood pressure remains elevated at a level exceeding 160/100 mmHg, and there is also significant proteinuria, despite receiving labetalol treatment. As a result, emergency admission is necessary to monitor and manage the hypertension in a controlled setting. If there is no improvement, delivery may be considered as an option.
Hypertension during pregnancy is a common occurrence that requires careful management. In normal pregnancies, blood pressure tends to decrease in the first trimester and then gradually increase to pre-pregnancy levels by term. However, in cases of hypertension during pregnancy, the systolic blood pressure is usually above 140 mmHg or the diastolic blood pressure is above 90 mmHg. Additionally, an increase of more than 30 mmHg systolic or 15 mmHg diastolic from the initial readings may also indicate hypertension.
There are three categories of hypertension during pregnancy: pre-existing hypertension, pregnancy-induced hypertension (PIH), and pre-eclampsia. Pre-existing hypertension refers to a history of hypertension before pregnancy or elevated blood pressure before 20 weeks gestation. PIH occurs in the second half of pregnancy and resolves after birth. Pre-eclampsia is characterized by hypertension and proteinuria, and may also involve edema.
The management of hypertension during pregnancy involves the use of antihypertensive medications such as labetalol, nifedipine, and hydralazine. In cases of pre-existing hypertension, ACE inhibitors and angiotensin II receptor blockers should be stopped immediately and alternative medications should be prescribed. Women who are at high risk of developing pre-eclampsia should take aspirin from 12 weeks until the birth of the baby. It is important to carefully monitor blood pressure and proteinuria levels during pregnancy to ensure the health of both the mother and the baby.
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This question is part of the following fields:
- Reproductive Medicine
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Question 13
Incorrect
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A 31-year-old female patient visits her doctor with complaints of feeling unwell for the past week. She reports experiencing headaches and mild abdominal discomfort. She denies having any diarrhea but mentions severe constipation. Recently, she returned from a 3-week trip to India. During the examination, her temperature is recorded as 38.5ºC, and she appears bloated. Additionally, a sparse macular rash is observed on her chest. What is the probable causative agent for this presentation?
Your Answer: Campylobacter jejuni
Correct Answer: Salmonella typhi
Explanation:While salmonella can cause diarrhoea, typhoid fever is more likely to result in constipation. This is a typical symptom of typhoid fever, along with the appearance of rose spots. It’s important to note that constipation can be a significant indicator of this illness. In contrast, Campylobacter jejuni infection usually causes bloody diarrhoea and abdominal pain. E. coli is a common cause of watery diarrhoea, but certain strains like E. coli O157:H7 can lead to severe abdominal cramping, vomiting, and bloody diarrhoea. Giardiasis can cause similar symptoms such as bloating and abdominal pain, but it usually results in chronic diarrhoea. Shigellosis typically causes abdominal pain and diarrhoea, which may or may not be bloody.
Enteric fever, also known as typhoid or paratyphoid, is caused by Salmonella typhi and Salmonella paratyphi respectively. These bacteria are not normally found in the gut and are transmitted through contaminated food and water or the faecal-oral route. The symptoms of enteric fever include headache, fever, and joint pain, as well as abdominal pain and distension. Constipation is more common in typhoid than diarrhoea, and rose spots may appear on the trunk in some patients. Complications can include osteomyelitis, gastrointestinal bleeding or perforation, meningitis, cholecystitis, and chronic carriage. Chronic carriage is more likely in adult females and occurs in approximately 1% of cases.
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This question is part of the following fields:
- Infectious Diseases
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Question 14
Incorrect
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A 32-year-old man presents to his General Practitioner with a 3-day history of flu-like symptoms and jaundice. He is a prison doctor. He sustained a needlestick injury six weeks ago from a high-risk patient after performing venepuncture. He immediately presented to the Emergency Department (ED) and was given a booster vaccination and post-exposure prophylaxis (PPE) treatment for human immunodeficiency virus (HIV). He is awaiting blood-borne virus (BBV) screening.
What is the most likely diagnosis?
Select ONE option only.Your Answer: Hepatitis A
Correct Answer: Hepatitis C
Explanation:Overview of Viral Hepatitis: Types, Transmission, and Risk Factors
Viral hepatitis is a group of infectious diseases that affect the liver and can cause serious health complications. There are five main types of viral hepatitis: A, B, C, D, and E. Each type has its own unique characteristics, transmission routes, and risk factors.
Hepatitis A is transmitted via the faecal-oral route and is most common in developing countries. It can cause symptoms similar to other types of viral hepatitis, but is less severe. Hepatitis B is transmitted via blood-to-blood and bloody fluid contact, and is most prevalent in migrant populations from certain regions. Hepatitis C is highly infectious and is commonly transmitted through shared needles or other injecting paraphernalia used for illicit drugs. Hepatitis D is a rare type of viral hepatitis that can only occur in patients with existing hepatitis B infection. Hepatitis E is also transmitted via the faecal-oral route, but is less common and usually only causes mild illness.
If a healthcare professional sustains a needlestick injury or other high-risk exposure to hepatitis C, they should have blood tests taken at specific intervals to confirm active infection. Hepatitis B vaccination is recommended for individuals working in high-risk clinical areas, and can also prevent hepatitis D infection. Chronic infection is rare for hepatitis E, unless the affected person is immunocompromised.
Understanding the different types of viral hepatitis, their transmission routes, and risk factors is important for preventing and managing these infections.
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This question is part of the following fields:
- Immunology/Allergy
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Question 15
Correct
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A mother brings in her 2-day-old baby girl to the GP surgery. She expresses concern about some white discharge from the baby's vagina. Upon examination, a small amount of mucoid white discharge is observed at the entrance of the vagina. The external appearance of the genitalia is otherwise normal. What is the recommended next step in management?
Your Answer: Reassure the mother that it is normal at this age
Explanation:It is common for newborn girls to experience a mucoid white vaginal discharge, which typically resolves by the age of 3 months. Reassurance is the most suitable course of action, and there is no need to refer to paediatrics or suspect sexual abuse. Arranging a transvaginal ultrasound for these symptoms is not necessary.
Gynaecological Problems in Children
In children, gynaecological problems are not uncommon. However, it is important to note that vaginal examinations and vaginal swabs should not be performed. Instead, referral to a paediatric gynaecologist is appropriate for persistent problems. One of the most common gynaecological disorders in girls is vulvovaginitis. This condition can be caused by bacterial or fungal organisms and is often associated with poor hygiene, tight clothing, lack of labial fat pads protecting the vaginal orifice, and lack of protective acid secretion found in the reproductive years. In some cases, vulvovaginitis may be a result of sexual abuse, which can present as bloody discharge.
It is important to manage vulvovaginitis appropriately. Advising children about hygiene is crucial, and soothing creams may be useful. Topical antibiotics or antifungals may also be prescribed. In resistant cases, oestrogen cream may be recommended. It is important to note that most newborn girls have some mucoid white vaginal discharge, which usually disappears by three months of age.
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This question is part of the following fields:
- Paediatrics
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Question 16
Correct
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You are asked to evaluate a 19-year-old student who has recently returned from a gap-year trip to India. He complains of extreme fatigue and loss of appetite during the last week of his journey and noticed that he had jaundice just before his return home. He denies being an intravenous drug user and having unprotected sexual intercourse. Additionally, he did not receive any blood transfusions or tattoos during his trip. He reports having a fever, but it subsided once his jaundice appeared. After conducting liver function tests (LFTs), you find that his alanine aminotransferase (ALT) level is 950 iu/l (reference range 20–60 iu/l), total bilirubin level is 240 μmol/l (reference range <20 μmol/l), and his alkaline phosphatase (ALP) level is slightly above the upper limit of normal. His white blood cell count, albumin level, and prothrombin times are all normal. What is the most probable diagnosis based on this clinical presentation?
Your Answer: Hepatitis A
Explanation:Overview of Viral Infections and Their Clinical Manifestations
Hepatitis A, B, and C, leptospirosis, and cytomegalovirus (CMV) are all viral infections that can cause a range of clinical manifestations. Hepatitis A is typically transmitted through ingestion of contaminated food and is most common in resource-poor regions. Leptospirosis is associated with exposure to rodents and contaminated water or soil. Hepatitis B is transmitted through blood and sexual contact, while hepatitis C is most commonly spread through injection drug use. CMV is typically asymptomatic but can cause severe disease in immunocompromised individuals. Understanding the transmission and clinical manifestations of these viral infections is important for accurate diagnosis and appropriate treatment.
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This question is part of the following fields:
- Infectious Diseases
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Question 17
Incorrect
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A 45-year-old otherwise healthy man presents to his General Practitioner (GP) with complaints of chest pain and shortness of breath on minimal exertion that have been worsening over the past few months. Investigations reveal normal angiogram and chest x-ray results, but an echocardiogram shows severe aortic stenosis. What is the most suitable management option?
Your Answer: Annual echocardiography monitoring
Correct Answer: Surgical aortic valve replacement
Explanation:Treatment Options for Aortic Stenosis
Aortic stenosis (AS) is a serious condition that requires prompt treatment. The gold standard treatment for symptomatic AS is surgical aortic valve replacement, which involves open-heart surgery and the use of mechanical or biological valves. However, for patients who are deemed too high risk for open-heart surgery, aortic balloon valvuloplasty or transcatheter aortic valve implantation (TAVI) may be considered as less invasive options.
Annual echocardiography monitoring is necessary to ensure the effectiveness of the treatment. It is important to note that oral nitrates are contraindicated in patients with AS as they can cause profound hypotension. Direct oral anticoagulants are also not licensed or indicated for the treatment of valvular heart disease. Overall, the choice of treatment depends on the patient’s individual risk factors and overall health status.
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This question is part of the following fields:
- Cardiovascular
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Question 18
Incorrect
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Crohn's disease is characterized by which of the following features? Please select the ONE most characteristic feature from the list provided.
Your Answer: Crypt abscess formation
Correct Answer: Skip lesions
Explanation:Comparison of Crohn’s Disease and Ulcerative Colitis
Crohn’s disease and ulcerative colitis are two types of inflammatory bowel disease that affect the gastrointestinal tract. Crohn’s disease can occur anywhere along the GI tract, while ulcerative colitis typically only affects the large intestine.
One characteristic of Crohn’s disease is the presence of skip lesions, or areas of inflammation discontinuity. The colon wall may also appear thickened and have a cobblestone appearance. In contrast, ulcerative colitis shows continuous inflammation in affected areas, with a thinner colon wall and ulcers limited to the mucous lining of the large intestine.
Both diseases can cause rectal bleeding, but it is more common in ulcerative colitis. Other symptoms of ulcerative colitis include frequent stools and mucus discharge from the rectum, while Crohn’s disease often presents with prolonged diarrhea and abdominal pain.
Pseudopolyps, or benign lesions originating from the mucosa, can occur in both diseases but are more prevalent in ulcerative colitis. Crypt abscess formation, characterized by intense infiltration of the mucosa and submucosa with neutrophils and crypt abscesses, is a hallmark of ulcerative colitis.
Management of these diseases includes medical therapy, endoscopy, and surgery for complications such as bleeding or obstruction. Understanding the differences between Crohn’s disease and ulcerative colitis is crucial for proper diagnosis and treatment.
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This question is part of the following fields:
- Gastroenterology/Nutrition
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Question 19
Correct
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A 35-year-old man presents to his General Practitioner (GP) with concerns about a mole on his leg. He has noticed over the past few months that it has increased in size. On examination, the mole is 7 mm in diameter and has an irregular border but is a consistent colour.
What is the most appropriate management option for this patient?
Your Answer: 2-week wait referral to dermatology
Explanation:Understanding Referral Guidelines for Suspicious Pigmented Lesions
When assessing pigmented lesions, the National Institute of Health and Care Excellence (NICE) recommends using the 7-point scoring system.
The 7-point checklist includes:
Major features (2 points each):
change in size
irregular shape or border
irregular colour.
Minor features (1 point each):
> 7 mm at greatest diameter
inflammation
oozing or crusting
change in sensation including itch.Lesions scoring 3 or more or with other suspicious features of melanoma should be referred urgently via the cancer fast-track pathway to dermatology.
For lesions with a low suspicion of melanoma, a photo should be taken with a ruler and the patient advised to return in eight weeks for review. However, lesions scoring 5 on the checklist, like those with a change in size, irregular shape or border, and irregular color, should be referred urgently to a dermatologist to avoid any delay in diagnosis and subsequent treatment.
Excision of lesions suspicious of melanoma should be avoided in primary care as this can delay treatment, and incomplete excision is more common. Routine referral to dermatology would be suitable for a pigmented lesion which scores less than 3 on the 7-point checklist if there are no other features to suggest melanoma. Referral to genetics is recommended if three or more family members have been diagnosed with melanoma.
It is important to understand these referral guidelines to ensure timely and appropriate management of suspicious pigmented lesions.
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This question is part of the following fields:
- Dermatology
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Question 20
Incorrect
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A 55-year-old woman presents with urgency and frequency. Three weeks ago she consulted with a colleague as she felt 'dry' during intercourse. She has been treated for urinary tract infections on multiple occasions in the past but urine culture is always negative. Her only medication is continuous hormone replacement therapy. A vaginal examination is performed which shows no evidence of vaginal atrophy and no masses are felt. An ultrasound is requested:
Both kidneys, spleen and liver are normal size. Outline of the bladder normal. 6 cm complex ovarian cyst noted on left ovary. Right ovary and uterus normal
What is the most appropriate next step?Your Answer: Trial topical oestrogen
Correct Answer: Urgent referral to gynaecology
Explanation:Investigation is necessary for any ovarian mass found in a woman who has undergone menopause.
Ovarian enlargement is typically diagnosed through ultrasound imaging, which can determine whether the cyst is simple or complex. Simple cysts are unilocular and more likely to be benign, while complex cysts are multilocular and more likely to be malignant. Management of ovarian enlargement depends on the patient’s age and symptoms. Younger women may be treated conservatively if the cyst is small and simple, with a repeat ultrasound scheduled in 8-12 weeks. Postmenopausal women, however, should always be referred to a gynecologist for assessment, as physiological cysts are unlikely in this population. It’s important to note that ovarian cancer can present with vague symptoms, leading to delayed diagnosis.
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This question is part of the following fields:
- Reproductive Medicine
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