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Question 1
Incorrect
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A 25-year-old patient presents with concerns about a recent alteration in her usual vaginal discharge. She is not sexually active at the moment and has no other systemic health issues. She does not report any itching symptoms but has observed a strong fishy odor and a greyish-white appearance in the discharge.
What is the most probable organism responsible for this change?Your Answer: Trichomonas vaginalis
Correct Answer: Gardnerella vaginalis
Explanation:Bacterial vaginosis (BV) is a common condition that affects up to a third of women during their childbearing years. It occurs when there is an overgrowth of bacteria, specifically Gardnerella vaginalis. This bacterium is anaerobic, meaning it thrives in environments without oxygen. As it multiplies, it disrupts the balance of bacteria in the vagina, leading to a rise in pH levels and a decrease in lactic acid-producing lactobacilli. It’s important to note that BV is not a sexually transmitted infection.
The main symptom of BV is a greyish discharge with a distinct fishy odor. However, it’s worth mentioning that around 50% of affected women may not experience any symptoms at all.
To diagnose BV, healthcare providers often use Amsel’s criteria. This involves looking for the presence of three out of four specific criteria: a vaginal pH greater than 4.5, a positive fishy smell test when potassium hydroxide is added, the presence of clue cells on microscopy, and a thin, white, homogeneous discharge.
The primary treatment for BV is oral metronidazole, typically taken for 5-7 days. This medication has an initial cure rate of about 75%. It’s crucial to provide special care to pregnant patients diagnosed with BV, as it has been linked to an increased risk of late miscarriage, early labor, and chorioamnionitis. Therefore, prompt treatment for these patients is of utmost importance.
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This question is part of the following fields:
- Sexual Health
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Question 2
Correct
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You are summoned to a cardiac arrest in the resuscitation area of your Emergency Department.
Which ONE statement about the utilization of amiodarone in cardiac arrest is accurate?Your Answer: It increases the duration of the action potential
Explanation:Amiodarone is a medication that is recommended to be administered after the third shock in a shockable cardiac arrest (Vf/pVT) while chest compressions are being performed. The prescribed dose is 300 mg, given as an intravenous bolus that is diluted in 5% dextrose to a volume of 20 mL. It is important to note that amiodarone is not suitable for treating PEA or asystole.
In cases where VF/pVT persists after five defibrillation attempts, an additional dose of 150 mg of amiodarone should be given. However, if amiodarone is not available, lidocaine can be used as an alternative. The recommended dose of lidocaine is 1 mg/kg. It is crucial to avoid administering lidocaine if amiodarone has already been given.
Amiodarone is classified as a membrane-stabilizing antiarrhythmic drug. It works by prolonging the duration of the action potential and the refractory period in both the atrial and ventricular myocardium. This medication also slows down atrioventricular conduction and has a similar effect on accessory pathways.
Additionally, amiodarone has a mild negative inotropic action, meaning it weakens the force of heart contractions. It also causes peripheral vasodilation through non-competitive alpha-blocking effects.
It is important to note that while there is no evidence of long-term benefits from using amiodarone, it may improve short-term survival rates, which justifies its continued use.
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This question is part of the following fields:
- Cardiology
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Question 3
Incorrect
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You review the blood results of a 65-year-old woman. Her full blood count is shown below:
Hb 11.9 g/dl (13-17 g/dl)
MCV 82 fl (80-100 fl)
WCC 18.4 x 109/l (4-11 x 109/l)
Neut 4.0 x 109/l (2.5-7.5 x 109/l)
Lymph 13.3 x 109/l (1.3-3.5 x 109/l)
Platelets 156 x 109/l (150-400 x 109/l)
What is the SINGLE most likely diagnosis?Your Answer: Chronic myeloid leukaemia
Correct Answer: Chronic lymphocytic leukaemia
Explanation:Chronic lymphocytic leukaemia (CLL) is the most common type of leukaemia in adults. It occurs when mature lymphocytes multiply uncontrollably. About 95% of cases are of B-cell lineage.
CLL is typically a slow-growing form of leukaemia and is often discovered incidentally during routine blood tests. As the disease progresses, patients may experience swollen lymph nodes, enlarged liver and spleen, anemia, and increased susceptibility to infections.
This condition primarily affects adult men, with over 75% of CLL patients being men over the age of 50.
A blood test for CLL usually reveals an increased number of lymphocytes (typically more than 5 x 109/l, but it can be higher). Advanced stages of the disease may also show normochromic, normocytic anemia. A peripheral blood smear can confirm the presence of lymphocytosis, and smudge cells are often observed.
The Binet system is used to stage CLL, categorizing it as follows:
– Stage A: Hemoglobin (Hb) levels above 10 g/dl, platelet count above 100 x 109/l, involvement of fewer than 3 lymph node areas.
– Stage B: Hb levels above 10 g/dl, platelet count above 100 x 109/l, involvement of more than 3 lymph node areas.
– Stage C: Hb levels below 10 g/dl, platelet count below 100 x 109/l, or both.Early stages of CLL (Binet stage A and B without active disease) do not require immediate treatment and can be monitored through regular follow-up and blood tests. Patients with more advanced disease have various treatment options available, including monoclonal antibodies (such as rituximab), purine analogues (like fludarabine), and alkylating agents (such as chlorambucil).
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This question is part of the following fields:
- Haematology
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Question 4
Correct
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A 22-year-old arrives at the emergency department after ingesting a combination of pills 45 minutes ago following a heated dispute with their partner. The patient reports consuming approximately 30 tablets in total, consisting of four or five different types. These tablets were sourced from their grandparents medication, although the patient is uncertain about their specific names. They mention the possibility of one tablet being called bisoprolol. What is the recommended antidote for beta-blocker toxicity?
Your Answer: Glucagon
Explanation:Glucagon is the preferred initial treatment for beta-blocker poisoning when there are symptoms of slow heart rate and low blood pressure.
Further Reading:
Poisoning in the emergency department is often caused by accidental or intentional overdose of prescribed drugs. Supportive treatment is the primary approach for managing most poisonings. This includes ensuring a clear airway, proper ventilation, maintaining normal fluid levels, temperature, and blood sugar levels, correcting any abnormal blood chemistry, controlling seizures, and assessing and treating any injuries.
In addition to supportive treatment, clinicians may need to consider strategies for decontamination, elimination, and administration of antidotes. Decontamination involves removing poisons from the skin or gastrointestinal tract. This can be done through rinsing the skin or using methods such as activated charcoal, gastric lavage, induced emesis, or whole bowel irrigation. However, induced emesis is no longer commonly used, while gastric lavage and whole bowel irrigation are rarely used.
Elimination methods include urinary alkalinization, hemodialysis, and hemoperfusion. These techniques help remove toxins from the body.
Activated charcoal is a commonly used method for decontamination. It works by binding toxins in the gastrointestinal tract, preventing their absorption. It is most effective if given within one hour of ingestion. However, it is contraindicated in patients with an insecure airway due to the risk of aspiration. Activated charcoal can be used for many drugs, but it is ineffective for certain poisonings, including pesticides (organophosphates), hydrocarbons, strong acids and alkalis, alcohols (ethanol, methanol, ethylene glycol), iron, lithium, and solvents.
Antidotes are specific treatments for poisoning caused by certain drugs or toxins. For example, cyanide poisoning can be treated with dicobalt edetate, hydroxocobalamin, or sodium nitrite and sodium thiosulphate. Benzodiazepine poisoning can be treated with flumazanil, while opiate poisoning can be treated with naloxone. Other examples include protamine for heparin poisoning, vitamin K or fresh frozen plasma for warfarin poisoning, fomepizole or ethanol for methanol poisoning, and methylene blue for methemoglobinemia caused by benzocaine or nitrates.
There are many other antidotes available for different types of poisoning, and resources such as TOXBASE and the National Poisons Information Service (NPIS) can provide valuable advice on managing poisonings.
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This question is part of the following fields:
- Pharmacology & Poisoning
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Question 5
Correct
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A 10-year-old girl presents with a history of a persistent cough that has been present for the past three weeks. The cough occurs in short bursts with an inspiration followed by a series of hacking coughs. She occasionally vomits after coughing. She mentions that the cough is worse at night and that she has fainted once during a coughing fit. She is otherwise healthy, and her vaccinations are up-to-date.
Upon examination, her chest is clear, but there are three small subconjunctival hemorrhages and some petechiae on her face. A complete blood count reveals a lymphocyte count of 22 x 109/l (1.3-3.5 x 109/l).
What is the SINGLE most likely diagnosis?Your Answer: Pertussis
Explanation:This presentation strongly indicates a diagnosis of whooping cough, also known as pertussis. Whooping cough is a respiratory infection caused by the bacteria Bordetella pertussis. It is transmitted through respiratory droplets and has an incubation period of about 7-21 days. The disease is highly contagious and can be transmitted to around 90% of close household contacts.
The clinical course of whooping cough can be divided into two stages. The first stage is called the catarrhal stage, which resembles a mild respiratory infection with low-grade fever and symptoms similar to a cold. A cough may be present, but it is usually mild and not as severe as in the second stage. The catarrhal stage typically lasts for about a week.
The second stage is known as the paroxysmal stage. During this stage, the characteristic paroxysmal cough develops as the symptoms from the catarrhal stage start to improve. The coughing occurs in spasms, often preceded by an inspiratory whoop sound, followed by a series of rapid coughs. Vomiting may occur, and patients may develop subconjunctival hemorrhages and petechiae. Patients generally feel well between coughing spasms, and there are usually no abnormal chest findings. This stage can last up to 3 months, with a gradual recovery over this period. The later stages of this stage are sometimes referred to as the convalescent stage.
Complications of whooping cough can include secondary pneumonia, rib fractures, pneumothorax, hernias, syncopal episodes, encephalopathy, and seizures. It is important to note that a history of vaccination does not guarantee immunity, as it only provides about 95% protection.
The presence of marked lymphocytosis in this case also supports a diagnosis of pertussis, as it is a common finding. A lymphocyte count greater than 20 x 109/l is highly suggestive of the disease.
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This question is part of the following fields:
- Respiratory
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Question 6
Correct
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A 52-year-old woman comes in with postmenopausal bleeding. Her medical records indicate that she recently underwent a transvaginal ultrasound, which revealed an endometrial thickness of 6.5 mm. What is the MOST suitable next step in investigating her condition?
Your Answer: Endometrial biopsy
Explanation:postmenopausal bleeding should always be treated as a potential malignancy until proven otherwise. The first-line investigation for this condition is transvaginal ultrasound (TVUS). This method effectively assesses the risk of endometrial cancer by measuring the thickness of the endometrium.
In postmenopausal women, the average endometrial thickness is much thinner compared to premenopausal women. The likelihood of endometrial cancer increases as the endometrium becomes thicker. Currently, in the UK, an endometrial thickness of 5 mm is considered the threshold.
If the endometrial thickness is greater than 5 mm, there is a 7.3% chance of endometrial cancer. However, if a woman with postmenopausal bleeding has a uniform endometrial thickness of less than 5 mm, the likelihood of endometrial cancer is less than 1%.
In cases where there is a high clinical risk, hysteroscopy and endometrial biopsy should also be performed. The definitive diagnosis is made through histological examination. If the endometrial thickness is greater than 5 mm, an endometrial biopsy is recommended.
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This question is part of the following fields:
- Obstetrics & Gynaecology
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Question 7
Incorrect
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A 45-year-old woman is brought into the emergency room by an ambulance with sirens blaring after being involved in a car accident. She was hit by a truck while crossing the street and is suspected to have a pelvic injury. Her condition is unstable, and the hospital has activated the massive transfusion protocol. You decide to also administer tranexamic acid and give an initial dose of 1 g intravenously over a period of 10 minutes.
What should be the subsequent dose of tranexamic acid and how long should it be administered for?Your Answer: 1 g IV over 1 hour
Correct Answer: 1 g IV over 8 hours
Explanation:ATLS guidelines now suggest administering only 1 liter of crystalloid fluid during the initial assessment. If patients do not respond to the crystalloid, it is recommended to quickly transition to blood products. Studies have shown that infusing more than 1.5 liters of crystalloid fluid is associated with higher mortality rates in trauma cases. Therefore, it is advised to prioritize the early use of blood products and avoid large volumes of crystalloid fluid in trauma patients. In cases where it is necessary, massive transfusion should be considered, defined as the transfusion of more than 10 units of blood in 24 hours or more than 4 units of blood in one hour. For patients with evidence of Class III and IV hemorrhage, early resuscitation with blood and blood products in low ratios is recommended.
Based on the findings of significant trials, such as the CRASH-2 study, the use of tranexamic acid is now recommended within 3 hours. This involves administering a loading dose of 1 gram intravenously over 10 minutes, followed by an infusion of 1 gram over eight hours. In some regions, tranexamic acid is also being utilized in the prehospital setting.
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This question is part of the following fields:
- Trauma
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Question 8
Incorrect
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A 42-year-old woman comes in with a painful, red left eye and sensitivity to light. She also reports seeing floaters and experiencing a dull, throbbing headache. She is currently being evaluated by the rheumatology team for persistent pain and stiffness in her upper back and discomfort in her buttocks and thighs. Her eye appears red, and a hypopyon is visible.
What is the SINGLE most probable diagnosis?Your Answer:
Correct Answer: Anterior uveitis
Explanation:The most probable diagnosis in this case is anterior uveitis, which refers to inflammation of the iris. It typically presents with symptoms such as a painful and red eye, sensitivity to light, excessive tearing, and decreased visual clarity. The photo above shows a possible indication of this condition, with the presence of pus in the front chamber of the eye, known as hypopyon.
Anterior uveitis can have various causes, including idiopathic cases where no specific cause is identified. Other potential triggers include trauma, chronic joint diseases like spondyloarthropathies and juvenile chronic arthritis, inflammatory bowel disease, psoriasis, sarcoidosis, and infections such as Lyme disease, tuberculosis, leptospirosis, herpes simplex virus (HSV), and varicella-zoster virus (VZV). Additionally, certain malignancies like non-Hodgkin lymphoma, ocular melanoma, and retinoblastoma can be associated with anterior uveitis.
It is worth noting that there is a strong link between the HLA-B27 genotype and anterior uveitis, with approximately 50% of patients having this genetic marker. In this particular case, the likely underlying diagnosis is ankylosing spondylitis, a condition characterized by chronic pain and stiffness in the mid-spine area and sacroiliitis. It is important to mention that around 30% of men with unilateral uveitis will be found to have ankylosing spondylitis.
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This question is part of the following fields:
- Ophthalmology
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Question 9
Incorrect
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A 25-year-old traveler comes back from a journey to South America with a fever, headache, and feeling nauseous. After a diagnosis, it is determined that she has contracted yellow fever.
Upon examination, it is observed that she has an uncommon combination of an extremely high body temperature (39.7°C) and a relative bradycardia (48 bpm).
What is the name of the clinical sign that she has developed, which is named after a person?Your Answer:
Correct Answer: Faget sign
Explanation:Faget sign is a unique occurrence where a fever and a relatively slow heart rate, known as bradycardia, are observed together. This phenomenon is sometimes called sphygmothermic dissociation. It can be observed in various infectious diseases, such as yellow fever, typhoid fever, tularaemia, brucellosis, Colorado tick fever, Legionella pneumonia, and Mycoplasma pneumonia. Normally, when a person has a fever, their heart rate increases, but in cases of Faget sign, the heart rate remains slow. Another term used to describe the combination of fever and increased heart rate is Leibermeister’s rule.
Auspitz’s sign is a characteristic feature seen in psoriasis. When the scales of psoriasis are scraped off, small bleeding spots, known as punctate bleeding spots, appear. This sign helps in the diagnosis of psoriasis.
Frank sign is a term used to describe a diagonal crease that appears on the earlobe. It has been hypothesized that this crease may be linked to cardiovascular disease and diabetes.
Levine’s sign refers to a specific response to chest pain caused by reduced blood flow to the heart, known as ischemic chest pain. In this sign, the person clenches their fist and holds it over their chest in an instinctive reaction to the pain.
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This question is part of the following fields:
- Infectious Diseases
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Question 10
Incorrect
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You are resuscitating a 38-year-old male patient with extensive burns. Your attending physician requests you to insert a femoral central venous line. How should the patient be positioned for this procedure?
Your Answer:
Correct Answer: Patient supine with slight abduction and external rotation of thigh/hip
Explanation:To insert a femoral line, the patient should be lying on their back with a pillow placed under their buttocks to elevate the groin area. The thigh should be slightly moved away from the body and rotated outward.
Further Reading:
A central venous catheter (CVC) is a type of catheter that is inserted into a large vein in the body, typically in the neck, chest, or groin. It has several important uses, including CVP monitoring, pulmonary artery pressure monitoring, repeated blood sampling, IV access for large volumes of fluids or drugs, TPN administration, dialysis, pacing, and other procedures such as placement of IVC filters or venous stents.
When inserting a central line, it is ideal to use ultrasound guidance to ensure accurate placement. However, there are certain contraindications to central line insertion, including infection or injury to the planned access site, coagulopathy, thrombosis or stenosis of the intended vein, a combative patient, or raised intracranial pressure for jugular venous lines.
The most common approaches for central line insertion are the internal jugular, subclavian, femoral, and PICC (peripherally inserted central catheter) veins. The internal jugular vein is often chosen due to its proximity to the carotid artery, but variations in anatomy can occur. Ultrasound can be used to identify the vessels and guide catheter placement, with the IJV typically lying superficial and lateral to the carotid artery. Compression and Valsalva maneuvers can help distinguish between arterial and venous structures, and doppler color flow can highlight the direction of flow.
In terms of choosing a side for central line insertion, the right side is usually preferred to avoid the risk of injury to the thoracic duct and potential chylothorax. However, the left side can also be used depending on the clinical situation.
Femoral central lines are another option for central venous access, with the catheter being inserted into the femoral vein in the groin. Local anesthesia is typically used to establish a field block, with lidocaine being the most commonly used agent. Lidocaine works by blocking sodium channels and preventing the propagation of action potentials.
In summary, central venous catheters have various important uses and should ideally be inserted using ultrasound guidance. There are contraindications to their insertion, and different approaches can be used depending on the clinical situation. Local anesthesia is commonly used for central line insertion, with lidocaine being the preferred agent.
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This question is part of the following fields:
- Resus
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Question 11
Incorrect
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A 25-year-old woman with a history of schizophrenia is brought to the Emergency Department. She is exhibiting signs of acute psychosis.
Which ONE of the following is acknowledged as a negative symptom of schizophrenia?Your Answer:
Correct Answer: Blunted affect
Explanation:The first-rank symptoms of schizophrenia, as described by Kurt Schneider, include auditory hallucinations such as hearing 3rd person voices discussing the patient, experiencing thought echo, and receiving commentary on one’s actions. Additionally, passivity phenomena may occur, such as thought insertion, thought withdrawal, thought broadcast, and feelings of thoughts and actions being under external control. Delusions, which can be primary or secondary, are also common in schizophrenia.
On the other hand, chronic schizophrenia is characterized by negative symptoms. These include poor motivation and self-care, social withdrawal, depression, flat and blunted affect, emotional incongruity, decreased activity, and poverty of thought and speech. These symptoms are often present in individuals with chronic schizophrenia.
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This question is part of the following fields:
- Mental Health
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Question 12
Incorrect
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A 10-year-old girl is brought into the Emergency Department with stomach pain and throwing up. Her mom tells you that she has been losing weight lately and seems to be drinking a lot and peeing a lot. During the examination, she appears tired and you notice that she is dehydrated. She is breathing deeply and quickly. Her blood sugar levels are found to be very high when her blood is tested.
Which of the following tests will be most useful in confirming the diagnosis?Your Answer:
Correct Answer: Urine dipstick
Explanation:The most probable diagnosis in this case is diabetic ketoacidosis (DKA). To confirm the diagnosis, it is important to establish that his blood glucose levels are high, he has significant ketonuria or ketonaemia, and that he is experiencing acidosis. Therefore, out of the options provided, a urine dipstick test will be the most useful.
DKA is a life-threatening condition that occurs when there is a lack of insulin, leading to an inability to metabolize glucose. This results in hyperglycemia and an osmotic diuresis, causing excessive thirst and increased urine production. If the urine output exceeds the patient’s ability to drink, dehydration becomes inevitable. Additionally, without insulin, fat becomes the primary energy source, leading to the production of large amounts of ketones and metabolic acidosis.
DKA is characterized by three main factors:
1. Hyperglycemia (blood glucose > 11 mmol/l)
2. Ketonaemia (> 3 mmol/l) or significant ketonuria (> 2+ on urine dipstick)
3. Acidosis (bicarbonate < 15 mmol/l and/or venous pH < 7.3) The clinical features of DKA include nausea, vomiting, excessive thirst, excessive urine production, abdominal pain, signs of dehydration, a smell of ketones on the breath (similar to pear drops), deep and rapid respiration (Kussmaul breathing), confusion or reduced consciousness, and tachycardia, hypotension, and shock. The following investigations should be performed:
– Blood glucose measurement
– Urine dipstick test (will show marked glycosuria and ketonuria)
– Blood ketone assay (more sensitive and specific than urine dipstick)
– Blood tests including full blood count (FBC) and urea and electrolytes (U&Es)
– Arterial or venous blood gas analysis (to assess for metabolic acidosis)The principles of managing DKA are as follows:
– Fluid boluses should only be given to reverse signs of shock and should be administered slowly in 10 ml/kg aliquots. If there are no signs of shock, fluid boluses should not be given, and specialist advice should be sought if a second bolus is required.
– Rehydration should be done with replacement therapy over 48 hours after signs of shock have been reversed.
– The first 20 ml/kg of fluid resuscitation should be given in addition -
This question is part of the following fields:
- Gastroenterology & Hepatology
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Question 13
Incorrect
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A one-week-old infant presents with eyelid swelling and a mucopurulent discharge from both eyes shortly after birth. The diagnosis of ophthalmia neonatorum is made. What is the most probable causative organism in this case?
Your Answer:
Correct Answer: Chlamydia trachomatis
Explanation:Ophthalmia neonatorum refers to any cause of conjunctivitis during the newborn period, regardless of the specific organism responsible.
Conjunctivitis is the most frequent occurrence of Chlamydia trachomatis infection in newborns. Chlamydia is now the leading cause, accounting for up to 40% of cases. Neisseria gonorrhoea, on the other hand, only accounts for less than 1% of reported cases. The remaining cases are caused by non-sexually transmitted bacteria like Staphylococcus, Streptococcus, Haemophilus species, and viruses.
Gonorrhoeal ophthalmia neonatorum typically presents within 1 to 5 days after birth. It is characterized by intense redness and swelling of the conjunctiva, eyelid swelling, and a severe discharge of pus. Corneal ulceration and perforation may also be present.
Chlamydial ophthalmia neonatorum, on the other hand, usually appears between 5 to 14 days after birth. It is characterized by a gradually increasing watery discharge that eventually becomes purulent. The inflammation in the eyes is usually less severe compared to gonococcal infection, and there is a lower risk of corneal ulceration and perforation.
The second most common manifestation of Chlamydia trachomatis infection in newborns is pneumonia. Approximately 5-30% of infected neonates will develop pneumonia. About half of these infants will also have a history of ophthalmia neonatorum.
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This question is part of the following fields:
- Ophthalmology
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Question 14
Incorrect
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A 28-year-old woman is diagnosed with tuberculosis during her pregnancy and given anti-tuberculous medication. The mother experiences liver damage, and the newborn experiences seizures and neuropathy.
Which of the following drugs is the most probable cause of these abnormalities?Your Answer:
Correct Answer: Isoniazid
Explanation:The standard drug regimen for tuberculosis is generally safe to use during pregnancy, with the exception of streptomycin which should be avoided. However, the use of isoniazid during pregnancy has been associated with potential risks such as liver damage in the mother and the possibility of neuropathy and seizures in the newborn.
Here is a list outlining some commonly encountered drugs that have adverse effects during pregnancy:
ACE inhibitors (e.g. ramipril): If taken during the second and third trimesters, these medications can lead to reduced blood flow, kidney failure, and a condition called oligohydramnios.
Aminoglycosides (e.g. gentamicin): These drugs can cause ototoxicity, resulting in hearing loss in the baby.
Aspirin: High doses of aspirin can increase the risk of first trimester abortions, delayed labor, premature closure of the fetal ductus arteriosus, and a condition called fetal kernicterus. However, low doses (e.g. 75 mg) do not pose significant risks.
Benzodiazepines (e.g. diazepam): When taken late in pregnancy, these medications can cause respiratory depression in the baby and lead to a withdrawal syndrome.
Calcium-channel blockers: If taken during the first trimester, these drugs can cause abnormalities in the fingers and toes. If taken during the second and third trimesters, they may result in fetal growth retardation.
Carbamazepine: This medication can increase the risk of hemorrhagic disease in the newborn and neural tube defects.
Chloramphenicol: Use of this drug in newborns can lead to a condition known as grey baby syndrome.
Corticosteroids: If taken during the first trimester, corticosteroids may increase the risk of orofacial clefts in the baby.
Danazol: When taken during the first trimester, this medication can cause masculinization of the female fetuses genitals.
Finasteride: Pregnant women should avoid handling crushed or broken tablets of finasteride as it can be absorbed through the skin and affect the development of male sex organs in the baby.
Haloperidol: If taken during the first trimester, this medication may increase the risk of limb malformations. If taken during the third trimester, it can lead to an increased risk of extrapyramidal symptoms in the newborn.
Heparin: Use of heparin during pregnancy is associated with an acceptable bleeding rate and a low rate of thrombotic recurrence in the mother.
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This question is part of the following fields:
- Pharmacology & Poisoning
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Question 15
Incorrect
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A 45-year-old man comes in with a high temperature, shivering, aching head, cough, and difficulty breathing. He also complains of a sore throat and occasional nosebleeds. He works at a nearby zoo in the birdhouse. During the examination, a red rash is noticed on his face, along with significant crackling sounds in both lower lobes of his lungs and an enlarged spleen.
What is the BEST antibiotic to prescribe for this patient?Your Answer:
Correct Answer: Doxycycline
Explanation:Psittacosis is a type of infection that can be transmitted from animals to humans, known as a zoonotic infection. It is caused by a bacterium called Chlamydia psittaci. This infection is most commonly seen in people who own domestic birds, but it can also affect those who work in pet shops or zoos.
The typical presentation of psittacosis includes symptoms similar to those of pneumonia that is acquired within the community. People may experience flu-like symptoms along with severe headaches and sensitivity to light. In about two-thirds of patients, an enlargement of the spleen, known as splenomegaly, can be observed.
Infected individuals often develop a reddish rash with flat spots on their face, known as Horder’s spots. Additionally, they may experience skin conditions such as erythema nodosum or erythema multiforme.
The recommended treatment for psittacosis is a course of tetracycline or doxycycline, which should be taken for a period of 2-3 weeks.
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This question is part of the following fields:
- Respiratory
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Question 16
Incorrect
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A 35-year-old woman comes in with a worsening of her asthma symptoms. She has been experiencing heart palpitations and decided to self-medicate with one of her sister's heart medications. Shortly after taking the medication, her asthma symptoms worsened.
Which of the following medications is most likely to have caused her asthma exacerbation?Your Answer:
Correct Answer: Propranolol
Explanation:Non-selective beta-blockers, like propranolol, can cause severe bronchospasm in individuals with asthma, particularly when taken in high doses. The current guidelines from the British Thoracic Society (BTS) recommend avoiding the use of beta-blockers in asthma patients. However, there is some evidence suggesting that the long-term use of cardioselective beta-blockers does not appear to trigger asthma attacks in individuals with mild or moderate asthma.
Beta-blockers play a crucial role in the treatment of patients who have a history of previous myocardial infarction or systolic dysfunction. In individuals with asthma and one of these diagnoses, it is unlikely that the potential benefits of beta-blockers outweigh the risks of worsening asthma symptoms.
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This question is part of the following fields:
- Pharmacology & Poisoning
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Question 17
Incorrect
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A 22-year-old arrives at the emergency department after ingesting a combination of pills following a heated dispute with their partner. The patient reports consuming approximately 30 tablets of various types, which were obtained from their partner's grandparents. However, the patient is unaware of the specific names of the tablets. You contemplate administering activated charcoal. What accurately describes the mechanism of action of activated charcoal?
Your Answer:
Correct Answer: Absorbs poisons onto its surface by weak electrostatic forces
Explanation:Activated charcoal prevents the absorption of poisons by absorbing them onto its surface through weak electrostatic forces.
Further Reading:
Poisoning in the emergency department is often caused by accidental or intentional overdose of prescribed drugs. Supportive treatment is the primary approach for managing most poisonings. This includes ensuring a clear airway, proper ventilation, maintaining normal fluid levels, temperature, and blood sugar levels, correcting any abnormal blood chemistry, controlling seizures, and assessing and treating any injuries.
In addition to supportive treatment, clinicians may need to consider strategies for decontamination, elimination, and administration of antidotes. Decontamination involves removing poisons from the skin or gastrointestinal tract. This can be done through rinsing the skin or using methods such as activated charcoal, gastric lavage, induced emesis, or whole bowel irrigation. However, induced emesis is no longer commonly used, while gastric lavage and whole bowel irrigation are rarely used.
Elimination methods include urinary alkalinization, hemodialysis, and hemoperfusion. These techniques help remove toxins from the body.
Activated charcoal is a commonly used method for decontamination. It works by binding toxins in the gastrointestinal tract, preventing their absorption. It is most effective if given within one hour of ingestion. However, it is contraindicated in patients with an insecure airway due to the risk of aspiration. Activated charcoal can be used for many drugs, but it is ineffective for certain poisonings, including pesticides (organophosphates), hydrocarbons, strong acids and alkalis, alcohols (ethanol, methanol, ethylene glycol), iron, lithium, and solvents.
Antidotes are specific treatments for poisoning caused by certain drugs or toxins. For example, cyanide poisoning can be treated with dicobalt edetate, hydroxocobalamin, or sodium nitrite and sodium thiosulphate. Benzodiazepine poisoning can be treated with flumazanil, while opiate poisoning can be treated with naloxone. Other examples include protamine for heparin poisoning, vitamin K or fresh frozen plasma for warfarin poisoning, fomepizole or ethanol for methanol poisoning, and methylene blue for methemoglobinemia caused by benzocaine or nitrates.
There are many other antidotes available for different types of poisoning, and resources such as TOXBASE and the National Poisons Information Service (NPIS) can provide valuable advice on managing poisonings.
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This question is part of the following fields:
- Pharmacology & Poisoning
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Question 18
Incorrect
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Your hospital’s neurology department is currently evaluating the utility of a triple marker test for use in diagnosing patients with suspected stroke. The test will use brain natriuretic peptide (BNP), neuron-specific enolase (NSE), and S100B protein.
How long after a stroke do levels of glial fibrillary acidic protein (GFAP) start to increase?Your Answer:
Correct Answer: 4-8 hours
Explanation:The timing of the initial rise, peak, and return to normality of various cardiac enzymes can serve as a helpful guide. Creatine kinase, the main cardiac isoenzyme, typically experiences an initial rise within 4-8 hours, reaches its peak at 18 hours, and returns to normal within 2-3 days. Myoglobin, which lacks specificity due to its association with skeletal muscle damage, shows an initial rise within 1-4 hours, peaks at 6-7 hours, and returns to normal within 24 hours. Troponin I, known for its sensitivity and specificity, exhibits an initial rise within 3-12 hours, reaches its peak at 24 hours, and returns to normal within 3-10 days. HFABP, or heart fatty acid binding protein, experiences an initial rise within 1.5 hours, peaks at 5-10 hours, and returns to normal within 24 hours. Lastly, LDH, predominantly found in cardiac muscle, shows an initial rise at 10 hours, peaks at 24-48 hours, and returns to normal within 14 days.
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This question is part of the following fields:
- Cardiology
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Question 19
Incorrect
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You are asked to participate in an ENT teaching session for the FY1's rotating to the emergency department and prepare slides on glandular fever.
What is the most frequent cause of glandular fever in adolescents?Your Answer:
Correct Answer: Epstein-Barr virus
Explanation:Infectious mononucleosis, also known as glandular fever, is a condition that is not clearly defined in medical literature. It is characterized by symptoms such as a sore throat, swollen tonsils with a whitish coating, enlarged lymph nodes in the neck, fatigue, and an enlarged liver and spleen. This condition is caused by a specific virus.
Further Reading:
Glandular fever, also known as infectious mononucleosis or mono, is a clinical syndrome characterized by symptoms such as sore throat, fever, and swollen lymph nodes. It is primarily caused by the Epstein-Barr virus (EBV), with other viruses and infections accounting for the remaining cases. Glandular fever is transmitted through infected saliva and primarily affects adolescents and young adults. The incubation period is 4-8 weeks.
The majority of EBV infections are asymptomatic, with over 95% of adults worldwide having evidence of prior infection. Clinical features of glandular fever include fever, sore throat, exudative tonsillitis, lymphadenopathy, and prodromal symptoms such as fatigue and headache. Splenomegaly (enlarged spleen) and hepatomegaly (enlarged liver) may also be present, and a non-pruritic macular rash can sometimes occur.
Glandular fever can lead to complications such as splenic rupture, which increases the risk of rupture in the spleen. Approximately 50% of splenic ruptures associated with glandular fever are spontaneous, while the other 50% follow trauma. Diagnosis of glandular fever involves various investigations, including viral serology for EBV, monospot test, and liver function tests. Additional serology tests may be conducted if EBV testing is negative.
Management of glandular fever involves supportive care and symptomatic relief with simple analgesia. Antiviral medication has not been shown to be beneficial. It is important to identify patients at risk of serious complications, such as airway obstruction, splenic rupture, and dehydration, and provide appropriate management. Patients can be advised to return to normal activities as soon as possible, avoiding heavy lifting and contact sports for the first month to reduce the risk of splenic rupture.
Rare but serious complications associated with glandular fever include hepatitis, upper airway obstruction, cardiac complications, renal complications, neurological complications, haematological complications, chronic fatigue, and an increased risk of lymphoproliferative cancers and multiple sclerosis.
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This question is part of the following fields:
- Infectious Diseases
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Question 20
Incorrect
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A 35-year-old presents to the emergency department complaining of palpitations. During the history-taking, the patient reveals a recent weight loss of approximately 10 kg over the past 6 months and the presence of hand tremors. Thyroid function tests are ordered and the results confirm hyperthyroidism. What is the predominant cause of thyrotoxicosis in the United Kingdom?
Your Answer:
Correct Answer: Graves' disease
Explanation:TSH-secreting pituitary adenoma is an uncommon cause of hyperthyroidism in the United Kingdom, accounting for only a small number of cases.
Further Reading:
The thyroid gland is an endocrine organ located in the anterior neck. It consists of two lobes connected by an isthmus. The gland produces hormones called thyroxine (T4) and triiodothyronine (T3), which regulate energy use, protein synthesis, and the body’s sensitivity to other hormones. The production of T4 and T3 is stimulated by thyroid-stimulating hormone (TSH) secreted by the pituitary gland, which is in turn stimulated by thyrotropin-releasing hormone (TRH) from the hypothalamus.
Thyroid disorders can occur when there is an imbalance in the production or regulation of thyroid hormones. Hypothyroidism is characterized by a deficiency of thyroid hormones, while hyperthyroidism is characterized by an excess. The most common cause of hypothyroidism is autoimmune thyroiditis, also known as Hashimoto’s thyroiditis. It is more common in women and is often associated with goiter. Other causes include subacute thyroiditis, atrophic thyroiditis, and iodine deficiency. On the other hand, the most common cause of hyperthyroidism is Graves’ disease, which is also an autoimmune disorder. Other causes include toxic multinodular goiter and subacute thyroiditis.
The symptoms and signs of thyroid disorders can vary depending on whether the thyroid gland is underactive or overactive. In hypothyroidism, common symptoms include weight gain, lethargy, cold intolerance, and dry skin. In hyperthyroidism, common symptoms include weight loss, restlessness, heat intolerance, and increased sweating. Both hypothyroidism and hyperthyroidism can also affect other systems in the body, such as the cardiovascular, gastrointestinal, and neurological systems.
Complications of thyroid disorders can include dyslipidemia, metabolic syndrome, coronary heart disease, heart failure, subfertility and infertility, impaired special senses, and myxedema coma in severe cases of hypothyroidism. In hyperthyroidism, complications can include Graves’ orbitopathy, compression of the esophagus or trachea by goiter, thyrotoxic periodic paralysis, arrhythmias, osteoporosis, mood disorders, and increased obstetric complications.
Myxedema coma is a rare and life-threatening complication of severe hypothyroidism. It can be triggered by factors such as infection or physiological insult and presents with lethargy, bradycardia, hypothermia, hypotension, hypoventilation, altered mental state, seizures and/or coma.
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This question is part of the following fields:
- Endocrinology
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Question 21
Incorrect
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A 65-year-old patient presents with nausea and vomiting and decreased urine output. He has only passed a small amount of urine in the last day, and he has noticeable swelling in his ankles. His blood tests show a sudden increase in his creatinine levels in the last 48 hours, leading to a diagnosis of acute kidney injury (AKI).
What is a potential cause of post-renal AKI?Your Answer:
Correct Answer: Papillary necrosis
Explanation:Acute kidney injury (AKI), previously known as acute renal failure, is a sudden decline in kidney function. This results in the accumulation of urea and other waste products in the body and disrupts the balance of fluids and electrolytes. AKI can occur in individuals with previously normal kidney function or those with pre-existing kidney disease, known as acute-on-chronic kidney disease. It is a relatively common condition, with approximately 15% of adults admitted to hospitals in the UK developing AKI.
The causes of AKI can be categorized into pre-renal, intrinsic renal, and post-renal factors. The majority of AKI cases that develop outside of healthcare settings are due to pre-renal causes, accounting for 90% of cases. These causes typically involve low blood pressure associated with conditions like sepsis and fluid depletion. Medications, particularly ACE inhibitors and NSAIDs, are also frequently implicated.
Pre-renal:
– Volume depletion (e.g., severe bleeding, excessive vomiting or diarrhea, burns)
– Oedematous states (e.g., heart failure, liver cirrhosis, nephrotic syndrome)
– Low blood pressure (e.g., cardiogenic shock, sepsis, anaphylaxis)
– Cardiovascular conditions (e.g., severe heart failure, arrhythmias)
– Renal hypoperfusion: NSAIDs, COX-2 inhibitors, ACE inhibitors or ARBs, abdominal aortic aneurysm
– Renal artery stenosis
– Hepatorenal syndromeIntrinsic renal:
– Glomerular diseases (e.g., glomerulonephritis, thrombosis, hemolytic-uremic syndrome)
– Tubular injury: acute tubular necrosis (ATN) following prolonged lack of blood supply
– Acute interstitial nephritis due to drugs (e.g., NSAIDs), infection, or autoimmune diseases
– Vascular diseases (e.g., vasculitis, polyarteritis nodosa, thrombotic microangiopathy, cholesterol emboli, renal vein thrombosis, malignant hypertension)
– EclampsiaPost-renal:
– Kidney stones
– Blood clot
– Papillary necrosis
– Urethral stricture
– Prostatic hypertrophy or malignancy
– Bladder tumor
– Radiation fibrosis
– Pelvic malignancy
– Retroperitoneal -
This question is part of the following fields:
- Nephrology
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Question 22
Incorrect
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A 65-year-old woman with a history of chronic alcohol abuse is diagnosed with Wernicke's encephalopathy. You have been requested to assess the patient.
Which of the following symptoms is MOST LIKELY to be observed?Your Answer:
Correct Answer: Ataxia
Explanation:Wernicke’s encephalopathy is a condition that is commonly associated with alcohol abuse and other causes of thiamine deficiency. It is characterized by a classic triad of symptoms, including acute confusion, ophthalmoplegia (paralysis or weakness of the eye muscles), and ataxia (loss of coordination). Additional possible features of this condition may include papilloedema (swelling of the optic disc), hearing loss, apathy, dysphagia (difficulty swallowing), memory impairment, and hypothermia. The majority of cases also experience peripheral neuropathy, which typically affects the legs.
The condition is marked by acute capillary haemorrhages, astrocytosis (increase in the number of astrocytes, a type of brain cell), and neuronal death in the upper brainstem and diencephalon. These abnormalities can be visualized using MRI scanning, while CT scanning is not very useful for diagnosis.
If left untreated, most patients with Wernicke’s encephalopathy will go on to develop a Korsakoff psychosis. This condition is characterized by retrograde amnesia (loss of memory for events that occurred before the onset of amnesia), an inability to form new memories, disordered time perception, and confabulation (fabrication of false memories).
When Wernicke’s encephalopathy is suspected, it is crucial to administer parenteral thiamine (such as Pabrinex) for at least 5 days. Following the parenteral therapy, oral thiamine should be continued.
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This question is part of the following fields:
- Neurology
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Question 23
Incorrect
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You are managing a patient in the resuscitation bay with suspected myxoedema coma. A member of the nursing team hands you the patient's ECG. What ECG findings would you anticipate in a patient with myxoedema coma?
Your Answer:
Correct Answer: Prolonged QT interval
Explanation:Patients with myxoedema coma often exhibit several common ECG abnormalities. These include bradycardia, a prolonged QT interval, and T wave flattening or inversion. Additionally, severe hypothyroidism (myxoedema) is associated with other ECG findings such as low QRS voltage, conduction blocks, and T wave inversions without ST deviation.
Further Reading:
The thyroid gland is an endocrine organ located in the anterior neck. It consists of two lobes connected by an isthmus. The gland produces hormones called thyroxine (T4) and triiodothyronine (T3), which regulate energy use, protein synthesis, and the body’s sensitivity to other hormones. The production of T4 and T3 is stimulated by thyroid-stimulating hormone (TSH) secreted by the pituitary gland, which is in turn stimulated by thyrotropin-releasing hormone (TRH) from the hypothalamus.
Thyroid disorders can occur when there is an imbalance in the production or regulation of thyroid hormones. Hypothyroidism is characterized by a deficiency of thyroid hormones, while hyperthyroidism is characterized by an excess. The most common cause of hypothyroidism is autoimmune thyroiditis, also known as Hashimoto’s thyroiditis. It is more common in women and is often associated with goiter. Other causes include subacute thyroiditis, atrophic thyroiditis, and iodine deficiency. On the other hand, the most common cause of hyperthyroidism is Graves’ disease, which is also an autoimmune disorder. Other causes include toxic multinodular goiter and subacute thyroiditis.
The symptoms and signs of thyroid disorders can vary depending on whether the thyroid gland is underactive or overactive. In hypothyroidism, common symptoms include weight gain, lethargy, cold intolerance, and dry skin. In hyperthyroidism, common symptoms include weight loss, restlessness, heat intolerance, and increased sweating. Both hypothyroidism and hyperthyroidism can also affect other systems in the body, such as the cardiovascular, gastrointestinal, and neurological systems.
Complications of thyroid disorders can include dyslipidemia, metabolic syndrome, coronary heart disease, heart failure, subfertility and infertility, impaired special senses, and myxedema coma in severe cases of hypothyroidism. In hyperthyroidism, complications can include Graves’ orbitopathy, compression of the esophagus or trachea by goiter, thyrotoxic periodic paralysis, arrhythmias, osteoporosis, mood disorders, and increased obstetric complications.
Myxedema coma is a rare and life-threatening complication of severe hypothyroidism. It can be triggered by factors such as infection or physiological insult and presents with lethargy, bradycardia, hypothermia, hypotension, hypoventilation, altered mental state, seizures and/or coma.
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This question is part of the following fields:
- Endocrinology
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Question 24
Incorrect
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A 35-year-old woman is involved in a car accident. Her observations are taken one hour after arriving in the Emergency Department. Her pulse rate is 145 bpm, BP is 72/38 mmHg, respiratory rate 45 breaths/minute, and her urine output over the past hour has been negligible. She is drowsy, lethargic, and confused. The patient weighs approximately 70 kg.
How would you classify her hemorrhage according to the ATLS hemorrhagic shock classification?Your Answer:
Correct Answer: Class IV
Explanation:This patient is showing significant signs of distress, including a highly elevated heart rate and respiratory rate, as well as very little urine output. Additionally, they are experiencing drowsiness, lethargy, and confusion. These symptoms indicate that the patient has suffered a class IV haemorrhage at this stage.
Recognizing the extent of blood loss based on vital signs and mental status abnormalities is a crucial skill. The Advanced Trauma Life Support (ATLS) classification for haemorrhagic shock correlates the amount of blood loss with expected physiological responses in a healthy 70 kg patient. In a 70 kg male patient, the total circulating blood volume is approximately five litres, accounting for around 7% of their total body weight.
The ATLS haemorrhagic shock classification is summarized as follows:
CLASS I
Blood loss (mL): Up to 750
Blood loss (% blood volume): Up to 15%
Pulse rate (bpm): <100
Systolic BP: Normal
Pulse pressure: Normal (or increased)
Respiratory rate: 14-20
Urine output (ml/hr): >30
CNS/mental status: Slightly anxiousCLASS II
Blood loss (mL): 750-1500
Blood loss (% blood volume): 15-30%
Pulse rate (bpm): 100-120
Systolic BP: Normal
Pulse pressure: Decreased
Respiratory rate: 20-30
Urine output (ml/hr): 20-30
CNS/mental status: Mildly anxiousCLASS III
Blood loss (mL): 1500-2000
Blood loss (% blood volume): 30-40%
Pulse rate (bpm): 120-140
Systolic BP: Decreased
Pulse pressure: Decreased
Respiratory rate: 30-40
Urine output (ml/hr): 5-15
CNS/mental status: Anxious, confusedCLASS IV
Blood loss (mL): >2000
Blood loss (% blood volume): >40%
Pulse rate (bpm): >140
Systolic BP: Decreased
Pulse pressure: Decreased
Respiratory rate: >40
Urine output (ml/hr): Negligible
CNS/mental status: Confused, lethargic -
This question is part of the following fields:
- Trauma
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Question 25
Incorrect
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You review a child with a history of attention deficit hyperactivity disorder (ADHD) who is currently experiencing hyperactive symptoms. During the evaluation, you observe that he is constantly repeating words. The repetitions do not appear to have any meaningful connection, but the words have similar sounds.
Which ONE of the following symptoms is he displaying?Your Answer:
Correct Answer: Clang association
Explanation:Clang associations refer to the grouping of words, typically rhyming words, that share similar sounds but lack any logical connection. These associations are commonly observed in individuals diagnosed with schizophrenia and bipolar disorder.
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This question is part of the following fields:
- Mental Health
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Question 26
Incorrect
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The right of capable individuals to make well-informed choices regarding their personal healthcare pertains to which of the subsequent principles?
Your Answer:
Correct Answer: Autonomy
Explanation:The principle of autonomy pertains to the right of capable individuals to make well-informed choices regarding their personal healthcare. Autonomy emphasizes the importance of respecting an individual’s ability to make decisions about their own health, based on their own values, beliefs, and preferences. It recognizes that individuals have the right to be informed about their healthcare options, to give informed consent, and to have their choices respected by healthcare providers. Autonomy is a fundamental principle in medical ethics that promotes patient-centered care and respects the individual’s right to self-determination.
Further Reading:
Principles of Medical Ethics:
1. Autonomy: Competent adults have the right to make informed decisions about their own medical care.
2. Beneficence: Healthcare professionals should take actions that serve the best interests of patients.
3. Non-maleficence: Healthcare professionals should not take actions that may injure or harm patients.
4. Justice: Healthcare professionals should take actions that are fair and equitable to both the individual and society as a whole.Confidentiality:
1. Use minimum necessary personal information and consider anonymizing information if possible.
2. Manage and protect personal information to prevent improper access, disclosure, or loss.
3. Understand and adhere to information governance appropriate to your role.
4. Comply with the law when handling personal information.
5. Share relevant information for direct care unless the patient objects.
6. Obtain explicit consent to disclose identifiable information for purposes other than care or local clinical audit, unless required by law or justified in the public interest.
7. Inform patients about disclosures of personal information they would not reasonably expect, unless not practicable or undermines the purpose of the disclosure.
8. Support patients in accessing their information and respecting their legal rights.Obtaining Patient’s Consent for Disclosure:
– Consent should be obtained for disclosing personal information for purposes other than direct care or local clinical audit, unless required by law or not appropriate or practicable.
Situations Where Patient Consent is Not Required for Disclosure:
– Adults at risk of or suffering abuse or neglect, as required by law.
– Adults lacking capacity, if neglect or harm is suspected, unless not overall beneficial to the patient.
– When required by law or approved through a statutory process.
– When justified in the public interest, such as for the prevention, detection, or prosecution of serious crime, patient’s fitness to drive, serious communicable disease, or posing a serious risk to others through being unfit for work.Confidentiality Following a Patient’s Death:
– Respect the patient’s confidentiality even after their death.
– If the patient previously requested not to share personal information with those close to them, abide by their wishes.
– Be considerate, sensitive, and responsive to those close to the patient, providing as much information as possible.The Law & Caldicott Guardians:
Data Protection Act:
– Sets rules and standards for the use and handling of personal data by organizations.
– Personal data must be used fairly, lawfully, transparently, and for specified purposes.
– Individuals have rights -
This question is part of the following fields:
- Safeguarding & Psychosocial Emergencies
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Question 27
Incorrect
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A 3-year-old boy has been brought into the Emergency Department having seizures that have lasted for 25 minutes prior to his arrival. On arrival, he is continuing to have a tonic-clonic seizure.
What dose of phenytoin is recommended in the treatment of the convulsing child that reaches that stage of the APLS algorithm?Your Answer:
Correct Answer: 20 mg/kg over 20 minutes
Explanation:If a child who is experiencing convulsions reaches step 3 of the APLS algorithm, it is recommended to prepare a phenytoin infusion. This infusion should be administered at a dosage of 20 mg/kg over a period of 20 minutes.
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This question is part of the following fields:
- Neurology
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Question 28
Incorrect
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A 30-year-old woman is brought in by ambulance following a car accident where her car was struck by a truck. She has suffered severe facial injuries and shows signs of airway obstruction. Her C-spine is triple immobilized. You perform a LEMON assessment for difficult intubation.
Which of the following factors indicates a difficult intubation?Your Answer:
Correct Answer: Mallampati score of 4
Explanation:Trauma patients who require a definitively secured airway include those who are apnoeic, have a Glasgow Coma Scale score of less than 9, experience sustained seizure activity, have unstable midface trauma or airway injuries, have a large flail segment or respiratory failure, have a high risk of aspiration, or are unable to maintain an airway or oxygenation through other means.
To predict difficult intubations, the LEMON assessment can be utilized. The LEMON mnemonic provides a systematic approach to assess potential challenges in intubation. It stands for the following:
– Look externally: Examine for any characteristics that are known to cause difficult intubation or ventilation.
– Evaluate the 3-3-2 rule: Measure the incisor distance, hyoid/mental distance, and thyroid-to-mouth distance. If any of these measurements are less than the specified number of fingerbreadths, it may indicate a difficult intubation.
– Mallampati: Assess the Mallampati score, which is a classification system based on the visibility of certain structures in the mouth and throat. A score of 3 or higher suggests a difficult intubation.
– Obstruction: Check for the presence of any conditions that could potentially obstruct the airway.
– Neck mobility: Evaluate the mobility of the patient’s neck, as limited mobility may make intubation more challenging.By utilizing the LEMON assessment, healthcare providers can identify potential difficulties in securing the airway and make appropriate interventions to ensure patient safety.
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This question is part of the following fields:
- Basic Anaesthetics
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Question 29
Incorrect
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A 45 year old male comes to the emergency department complaining of fatigue and a headache. The medical team records his vital signs and takes blood samples. The results are as follows:
Blood pressure: 192/98 mmHg
Pulse: 84 bpm
Respiration rate: 17 bpm
Temperature: 36.9ºC
Sodium (Na+): 149 mmol/l
Potassium (K+): 3.0 mmol/l
Urea: 3.8 mmol/l
Creatinine: 81 µmol/l
What is the most likely diagnosis?Your Answer:
Correct Answer: Primary hyperaldosteronism
Explanation:Primary hyperaldosteronism is the leading endocrine cause of secondary hypertension, commonly affecting individuals between the ages of 30 and 50. It is characterized by metabolic alkalosis and often presents with hypernatraemia, although normal sodium levels can also be observed. When compared to pheochromocytoma, primary hyperaldosteronism is more frequently encountered. The diagnostic test of choice is the plasma aldosterone-to-renin ratio.
Further Reading:
Hyperaldosteronism is a condition characterized by excessive production of aldosterone by the adrenal glands. It can be classified into primary and secondary hyperaldosteronism. Primary hyperaldosteronism, also known as Conn’s syndrome, is typically caused by adrenal hyperplasia or adrenal tumors. Secondary hyperaldosteronism, on the other hand, is a result of high renin levels in response to reduced blood flow across the juxtaglomerular apparatus.
Aldosterone is the main mineralocorticoid steroid hormone produced by the adrenal cortex. It acts on the distal renal tubule and collecting duct of the nephron, promoting the reabsorption of sodium ions and water while secreting potassium ions.
The causes of hyperaldosteronism vary depending on whether it is primary or secondary. Primary hyperaldosteronism can be caused by adrenal adenoma, adrenal hyperplasia, adrenal carcinoma, or familial hyperaldosteronism. Secondary hyperaldosteronism can be caused by renal artery stenosis, reninoma, renal tubular acidosis, nutcracker syndrome, ectopic tumors, massive ascites, left ventricular failure, or cor pulmonale.
Clinical features of hyperaldosteronism include hypertension, hypokalemia, metabolic alkalosis, hypernatremia, polyuria, polydipsia, headaches, lethargy, muscle weakness and spasms, and numbness. It is estimated that hyperaldosteronism is present in 5-10% of patients with hypertension, and hypertension in primary hyperaldosteronism is often resistant to drug treatment.
Diagnosis of hyperaldosteronism involves various investigations, including U&Es to assess electrolyte disturbances, aldosterone-to-renin plasma ratio (ARR) as the gold standard diagnostic test, ECG to detect arrhythmia, CT/MRI scans to locate adenoma, fludrocortisone suppression test or oral salt testing to confirm primary hyperaldosteronism, genetic testing to identify familial hyperaldosteronism, and adrenal venous sampling to determine lateralization prior to surgery.
Treatment of primary hyperaldosteronism typically involves surgical adrenalectomy for patients with unilateral primary aldosteronism. Diet modification with sodium restriction and potassium supplementation may also be recommended.
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This question is part of the following fields:
- Endocrinology
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Question 30
Incorrect
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A 35-year-old woman comes to the clinic with a red, warm, swollen left knee a few days after returning from a vacation in Thailand. She also reports feeling generally sick and has a rash on her trunk. The doctor decides to send a sample of the knee fluid to the lab for testing. What is the most likely finding on Gram-stain testing?
Your Answer:
Correct Answer: Gram-negative pairs of cocci
Explanation:Septic arthritis occurs when an infectious agent invades a joint, causing it to become purulent. The main symptoms of septic arthritis include pain in the affected joint, redness, warmth, and swelling of the joint, and difficulty moving the joint. Patients may also experience fever and systemic upset. The most common cause of septic arthritis is Staphylococcus aureus, but other bacteria such as Streptococcus spp., Haemophilus influenzae, Neisseria gonorrhoea, and Escherichia coli can also be responsible.
According to the current recommendations by NICE and the BNF, the initial treatment for septic arthritis is flucloxacillin. However, if a patient is allergic to penicillin, clindamycin can be used instead. If there is a suspicion of MRSA infection, vancomycin is the recommended choice. In cases where gonococcal arthritis or a Gram-negative infection is suspected, cefotaxime is the preferred treatment. The suggested duration of treatment is typically 4-6 weeks, although it may be longer if the infection is complicated.
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This question is part of the following fields:
- Musculoskeletal (non-traumatic)
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Question 31
Incorrect
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A 20-year-old woman presents with frequent urination, excessive thirst, and stomach pain. The results of her arterial blood gas (ABG) on air are as follows:
pH: 7.21
pO2: 11.4 kPa
PCO2: 3.1 kPa
HCO3-: 17 mmol/l
Na+: 149 mmol/l
Cl–: 100 mmol/l
Lactate: 6 IU/l
Which SINGLE statement about this patient is correct?Your Answer:
Correct Answer: She is likely to have a type B lactic acidosis
Explanation:Arterial blood gas (ABG) interpretation is essential for evaluating a patient’s respiratory gas exchange and acid-base balance. While the normal values on an ABG may slightly vary between analyzers, they generally fall within the following ranges:
pH: 7.35 – 7.45
pO2: 10 – 14 kPa
PCO2: 4.5 – 6 kPa
HCO3-: 22 – 26 mmol/l
Base excess: -2 – 2 mmol/lIn this particular case, the patient’s medical history raises concerns about a possible diagnosis of diabetic ketoacidosis (DKA). The relevant ABG findings are as follows:
Normal PO2
Low pH (acidaemia)
Low PCO2
Low bicarbonate
Raised lactateThe anion gap refers to the concentration of unmeasured anions in the plasma. It is calculated by subtracting the primary measured cations from the primary measured anions in the serum. The reference range for anion gap varies depending on the measurement methodology but typically falls between 8 to 16 mmol/L.
To calculate her anion gap, we can use the formula:
Anion gap = [Na+] – [Cl-] – [HCO3-]
Using the provided values, her anion gap can be calculated as:
Anion gap = [149] – [100] – [17]
Anion gap = 32Therefore, it is evident that she has a raised anion gap metabolic acidosis.
It is likely that she is experiencing a type B lactic acidosis secondary to diabetic ketoacidosis. Some potential causes of type A and type B lactic acidosis are listed below:
Type A lactic acidosis:
– Shock (including septic shock)
– Left ventricular failure
– Severe anemia
– Asphyxia
– Cardiac arrest
– Carbon monoxide poisoning
– Respiratory failure
– Severe asthma and COPD
– Regional hypoperfusionType B lactic acidosis:
– Renal failure
– Liver failure
– Sepsis (non-hypoxic sepsis)
– Thiamine deficiency
– Alcoholic ketoacidosis
– Diabetic ketoacidosis
– Cyanide poisoning
– Methanol poisoning
– Biguanide poisoning -
This question is part of the following fields:
- Endocrinology
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Question 32
Incorrect
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A 35-year-old woman of Asian descent comes to the Emergency Department with swelling of the face, lips, and tongue. Despite receiving IM adrenaline, her symptoms do not improve. She mentions that her doctor recently prescribed her a new medication.
Which of the following drugs is most likely causing her symptoms?Your Answer:
Correct Answer: Ramipril
Explanation:Angiotensin-converting enzyme (ACE) inhibitors are the primary cause of drug-induced angioedema in the UK and USA, mainly due to their widespread use. The incidence of angioedema caused by ACE inhibitors ranges from 0.1 to 0.7% among recipients, with evidence suggesting a consistent and persistent risk each year. Interestingly, individuals of African descent are approximately five times more likely to experience this adverse reaction.
The most common symptoms observed in patients with ACE inhibitor-induced angioedema include swelling of the lips, tongue, or face. However, another manifestation of this condition is episodic abdominal pain caused by intestinal angioedema. Notably, urticaria (hives) and itching are absent in these cases.
The underlying mechanism of ACE inhibitor-induced angioedema appears to involve the activation of the complement system or other pro-inflammatory cytokines, such as prostaglandins and histamine. These substances trigger rapid dilation of blood vessels and the accumulation of fluid, leading to edema.
Although less frequently associated with angioedema, other medications that may cause this condition include angiotensin-receptor blockers (ARBs), nonsteroidal anti-inflammatory drugs (NSAIDs), bupropion (e.g., Zyban and Wellbutrin), beta-lactam antibiotics, statins, and proton pump inhibitors.
Fortunately, most cases of drug-induced angioedema are mild and can be effectively managed by discontinuing the medication and prescribing oral antihistamines.
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This question is part of the following fields:
- Pharmacology & Poisoning
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Question 33
Incorrect
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You are requested to educate the foundation doctors and medical students assigned to the emergency department on evaluating the vomiting toddler. What is a potential risk factor for pyloric stenosis?
Your Answer:
Correct Answer: First born child
Explanation:Pyloric stenosis is a condition that primarily affects infants and is often seen in those with a positive family history. It is more commonly observed in first-born children and those who were bottle-fed or delivered by c-section. Additionally, it is more prevalent in white and hispanic children compared to other races and ethnicities. Smoking during pregnancy and premature birth are also associated with an increased risk of developing pyloric stenosis.
Further Reading:
Pyloric stenosis is a condition that primarily affects infants, characterized by the thickening of the muscles in the pylorus, leading to obstruction of the gastric outlet. It typically presents between the 3rd and 12th weeks of life, with recurrent projectile vomiting being the main symptom. The condition is more common in males, with a positive family history and being first-born being additional risk factors. Bottle-fed children and those delivered by c-section are also more likely to develop pyloric stenosis.
Clinical features of pyloric stenosis include projectile vomiting, usually occurring about 30 minutes after a feed, as well as constipation and dehydration. A palpable mass in the upper abdomen, often described as like an olive, may also be present. The persistent vomiting can lead to electrolyte disturbances, such as hypochloremia, alkalosis, and mild hypokalemia.
Ultrasound is the preferred diagnostic tool for confirming pyloric stenosis. It can reveal specific criteria, including a pyloric muscle thickness greater than 3 mm, a pylorus longitudinal length greater than 15-17 mm, a pyloric volume greater than 1.5 cm3, and a pyloric transverse diameter greater than 13 mm.
The definitive treatment for pyloric stenosis is pyloromyotomy, a surgical procedure that involves making an incision in the thickened pyloric muscle to relieve the obstruction. Before surgery, it is important to correct any hypovolemia and electrolyte disturbances with intravenous fluids. Overall, pyloric stenosis is a relatively common condition in infants, but with prompt diagnosis and appropriate management, it can be effectively treated.
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This question is part of the following fields:
- Paediatric Emergencies
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Question 34
Incorrect
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A 21 year old female is brought to the emergency department by her parents and admits to ingesting 36 paracetamol tablets. You determine that the patient fulfills the requirements for receiving activated charcoal. What would be the appropriate dosage to administer?
Your Answer:
Correct Answer: 50 g
Explanation:The recommended dose of activated charcoal for adults and children aged 12 or over to prevent the absorption of poisons in the gastrointestinal tract is 50g.
Further Reading:
Paracetamol poisoning occurs when the liver is unable to metabolize paracetamol properly, leading to the production of a toxic metabolite called N-acetyl-p-benzoquinone imine (NAPQI). Normally, NAPQI is conjugated by glutathione into a non-toxic form. However, during an overdose, the liver’s conjugation systems become overwhelmed, resulting in increased production of NAPQI and depletion of glutathione stores. This leads to the formation of covalent bonds between NAPQI and cell proteins, causing cell death in the liver and kidneys.
Symptoms of paracetamol poisoning may not appear for the first 24 hours or may include abdominal symptoms such as nausea and vomiting. After 24 hours, hepatic necrosis may develop, leading to elevated liver enzymes, right upper quadrant pain, and jaundice. Other complications can include encephalopathy, oliguria, hypoglycemia, renal failure, and lactic acidosis.
The management of paracetamol overdose depends on the timing and amount of ingestion. Activated charcoal may be given if the patient presents within 1 hour of ingesting a significant amount of paracetamol. N-acetylcysteine (NAC) is used to increase hepatic glutathione production and is given to patients who meet specific criteria. Blood tests are taken to assess paracetamol levels, liver function, and other parameters. Referral to a medical or liver unit may be necessary, and psychiatric follow-up should be considered for deliberate overdoses.
In cases of staggered ingestion, all patients should be treated with NAC without delay. Blood tests are also taken, and if certain criteria are met, NAC can be discontinued. Adverse reactions to NAC are common and may include anaphylactoid reactions, rash, hypotension, and nausea. Treatment for adverse reactions involves medications such as chlorpheniramine and salbutamol, and the infusion may be stopped if necessary.
The prognosis for paracetamol poisoning can be poor, especially in cases of severe liver injury. Fulminant liver failure may occur, and liver transplant may be necessary. Poor prognostic indicators include low arterial pH, prolonged prothrombin time, high plasma creatinine, and hepatic encephalopathy.
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This question is part of the following fields:
- Pharmacology & Poisoning
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Question 35
Incorrect
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You are summoned to a cardiac arrest in the resuscitation area of your Emergency Department.
Which ONE statement about the utilization of amiodarone in cardiac arrest is NOT true?Your Answer:
Correct Answer: It should be administered as an infusion of 300 mg over 20-60 minutes
Explanation:Amiodarone is a medication that is recommended to be administered after the third shock in a shockable cardiac arrest (Vf/pVT) while chest compressions are being performed. The prescribed dose is 300 mg, given as an intravenous bolus that is diluted in 5% dextrose to a volume of 20 mL. It is important to note that amiodarone is not suitable for treating PEA or asystole.
In cases where VF/pVT persists after five defibrillation attempts, an additional dose of 150 mg of amiodarone should be given. However, if amiodarone is not available, lidocaine can be used as an alternative. The recommended dose of lidocaine is 1 mg/kg. It is crucial to avoid administering lidocaine if amiodarone has already been given.
Amiodarone is classified as a membrane-stabilizing antiarrhythmic drug. It works by prolonging the duration of the action potential and the refractory period in both the atrial and ventricular myocardium. This medication also slows down atrioventricular conduction and has a similar effect on accessory pathways.
Additionally, amiodarone has a mild negative inotropic action, meaning it weakens the force of heart contractions. It also causes peripheral vasodilation through non-competitive alpha-blocking effects.
It is important to note that while there is no evidence of long-term benefits from using amiodarone, it may improve short-term survival rates, which justifies its continued use.
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This question is part of the following fields:
- Cardiology
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Question 36
Incorrect
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A fourth-year medical student is studying subarachnoid hemorrhage (SAH) and has some questions about the topic. What is the ONE accurate statement about SAH?
Your Answer:
Correct Answer: SAH is associated with polycystic kidneys
Explanation:A subarachnoid haemorrhage (SAH) occurs when there is spontaneous bleeding into the subarachnoid space and is often a catastrophic event. The incidence of SAH is 9 cases per 100,000 people per year, and it typically affects individuals between the ages of 35 and 65.
Approximately 80% of SAH cases are caused by the rupture of berry (saccular) aneurysms, while 15% are caused by arteriovenous malformations (AVM). In less than 5% of cases, no specific cause can be identified. Berry aneurysms are commonly associated with polycystic kidneys, Ehlers-Danlos Syndrome, and coarctation of the aorta.
There are several risk factors for SAH, including smoking, hypertension, bleeding disorders, alcohol misuse, and mycotic aneurysm. Additionally, a family history of SAH can increase the likelihood of developing the condition.
Patients with SAH typically experience a sudden and severe occipital headache, often described as the worst headache of my life. This may be accompanied by symptoms such as vomiting, collapse, seizures, and coma. Clinical signs of SAH include neck stiffness, a positive Kernig’s sign, and focal neurological abnormalities. Fundoscopy may reveal subhyaloid retinal haemorrhages in approximately 25% of patients.
Re-bleeding occurs in 30-40% of patients who survive the initial episode, with the highest risk occurring between 7 and 14 days after the initial bleed. If left untreated, SAH has a mortality rate of nearly 50% within the first eight weeks following presentation. Prolonged coma is associated with a 100% mortality rate.
The first-line investigation for SAH is a CT head scan, which can detect over 95% of cases if performed within the first 24 hours. The sensitivity of the CT scan increases to nearly 100% if performed within 6 hours of symptom onset. If the CT scan is negative, a lumbar puncture (LP) should be performed to diagnose SAH. The LP should be conducted at least 12 hours after the onset of headache, unless there are contraindications. Approximately 3% of patients with a negative CT scan will be confirmed to have had a SAH following an LP.
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This question is part of the following fields:
- Neurology
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Question 37
Incorrect
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A 42 year old man is brought into the emergency department after a car accident. He has significant bruising on the right side of his chest. You suspect he may have a hemothorax. When would thoracotomy be considered as a treatment option?
Your Answer:
Correct Answer: Prompt drainage of ≥1500 ml of blood following chest drain insertion
Explanation:Thoracotomy is recommended when there is a need for prompt drainage of at least 1500 ml of blood following the insertion of a chest drain. Additionally, it is indicated when there is a continuous blood loss of more than 200 ml per hour for a period of 2-4 hours or when there is a persistent requirement for blood transfusion.
Further Reading:
Haemothorax is the accumulation of blood in the pleural cavity of the chest, usually resulting from chest trauma. It can be difficult to differentiate from other causes of pleural effusion on a chest X-ray. Massive haemothorax refers to a large volume of blood in the pleural space, which can impair physiological function by causing blood loss, reducing lung volume for gas exchange, and compressing thoracic structures such as the heart and IVC.
The management of haemothorax involves replacing lost blood volume and decompressing the chest. This is done through supplemental oxygen, IV access and cross-matching blood, IV fluid therapy, and the insertion of a chest tube. The chest tube is connected to an underwater seal and helps drain the fluid, pus, air, or blood from the pleural space. In cases where there is prompt drainage of a large amount of blood, ongoing significant blood loss, or the need for blood transfusion, thoracotomy and ligation of bleeding thoracic vessels may be necessary. It is important to have two IV accesses prior to inserting the chest drain to prevent a drop in blood pressure.
In summary, haemothorax is the accumulation of blood in the pleural cavity due to chest trauma. Managing haemothorax involves replacing lost blood volume and decompressing the chest through various interventions, including the insertion of a chest tube. Prompt intervention may be required in cases of significant blood loss or ongoing need for blood transfusion.
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This question is part of the following fields:
- Trauma
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Question 38
Incorrect
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A 40-year-old man is brought to the Emergency Department by his wife following taking an overdose of one of his prescribed medications. Upon further questioning, you discover that he has taken an overdose of quetiapine. You discuss the case with your consultant, and she explains that the clinical features of this type of poisoning are due to central and peripheral acetylcholine receptor blockade.
Which of the following clinical effects occurs as a result of peripheral acetylcholine receptor blockade?Your Answer:
Correct Answer: Mydriasis
Explanation:Anticholinergic drugs work by blocking the effects of acetylcholine, a neurotransmitter, in both the central and peripheral nervous systems. These drugs are commonly used in clinical practice and include antihistamines, typical and atypical antipsychotics, anticonvulsants, antidepressants, antispasmodics, antiemetics, antiparkinsonian agents, antimuscarinics, and certain plants. When someone ingests an anticholinergic drug, they may experience a toxidrome, which is characterized by an agitated delirium and various signs of acetylcholine receptor blockade in the central and peripheral systems.
The central effects of anticholinergic drugs result in an agitated delirium, which is marked by fluctuating mental status, confusion, restlessness, visual hallucinations, picking at objects in the air, mumbling, slurred speech, disruptive behavior, tremor, myoclonus, and in rare cases, coma or seizures. On the other hand, the peripheral effects can vary and may include dilated pupils, sinus tachycardia, dry mouth, hot and flushed skin, increased body temperature, urinary retention, and ileus.
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This question is part of the following fields:
- Pharmacology & Poisoning
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Question 39
Incorrect
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Large numbers of casualties are observed after a suspected CBRN (chemical, biological, radiological, and nuclear) incident. It is believed that sarin gas is the responsible agent. Which combination of clinical features is most likely to be present?
Your Answer:
Correct Answer: Miosis, bronchorrhoea, salivation and muscle weakness
Explanation:The nerve agents, also known as nerve gases, are a group of highly toxic chemical warfare agents that were initially developed just before and during World War II.
The first compounds to be created are called the G agents (G stands for German, as they were discovered and synthesized by German scientists). These include Tabun (GA), Sarin (GB), and Soman (GD).
In the 1950s, the V agents (V stands for venomous) were synthesized and are approximately 10 times more poisonous than sarin. These include Venomous agent X (VX), Venomous agent E (VE), Venomous agent G (VG), and Venomous agent M (VM).
One of the most well-known incidents involving the use of a nerve agent was the March 1995 Tokyo subway sarin attack. During this attack, Sarin was released into the Tokyo subway system during rush hour. As a result, over 5,000 people sought medical attention. Among them, 984 were moderately poisoned, 54 were severely poisoned, and 12 died.
Nerve agents are organophosphorus esters that are chemically related to organophosphorus insecticides. They work by inhibiting acetylcholinesterase (AChE), an enzyme that breaks down the neurotransmitter acetylcholine (ACh). This leads to an accumulation of ACh at both muscarinic and nicotinic cholinergic receptors.
Nerve agents can be absorbed through any body surface. When dispersed as a spray or aerosol, they can be absorbed through the skin, eyes, and respiratory tract. When dispersed as a vapor, they are primarily absorbed through the respiratory tract and eyes. If a sufficient amount of agent is absorbed, local effects are followed by generalized systemic effects.
The clinical features observed after exposure are a result of a combination of muscarinic, nicotinic, and central nervous system effects.
Muscarinic effects (DUMBBELS):
– Diarrhea
– Urination
– Miosis
– Bronchorrhea
– Bronchospasm
– Emesis
– Lacrimation
– Salivation
Plus bradycardia and hypotension.Nicotinic effects:
– Sweating
– Tremor
– Fasciculations
– Muscle weakness
– Flaccid paralysisCentral nervous system effects:
– Agitation and irritability
– Amnesia
– Ataxia
– Respiratory -
This question is part of the following fields:
- Major Incident Management & PHEM
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Question 40
Incorrect
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A 45-year-old woman comes in with a temporary vision loss in her right eye half an hour after a yoga session. She had observed flickering lights in the eye before the incident and also experienced a headache that persisted for a few hours. Her visual symptoms disappeared after 45 minutes, but she still experiences slight nausea.
What is the SINGLE most probable diagnosis?Your Answer:
Correct Answer: Migraine
Explanation:The presentation, in this instance, is consistent with retinal (ocular) migraine. As per the International Headache Society, the primary clinical features of retinal migraine include an expanding blind-spot in the center of vision, flickering or flashing lights, temporary loss of vision in one eye lasting less than an hour, headache lasting anywhere from 4 to 72 hours (often affecting only one side of the head), nausea and vomiting, sensitivity to light and sound, and a prodrome present in 50-60% of cases. Retinal migraine is relatively uncommon, affecting only 1 in 200 individuals with migraines, and is believed to occur due to the narrowing of blood vessels in the choroidal or retinal arteries. Factors that can trigger retinal migraine include recent intense exercise, changes in posture, and the use of oral contraceptives.
Acute optic neuritis typically presents with unilateral vision loss that worsens over a couple of weeks and then spontaneously improves within three weeks. This condition is more commonly seen in individuals under the age of 45 and is often accompanied by pain around the eyes that worsens with eye movement. A relative afferent pupillary defect and pallor of the optic disc, visible 4-6 weeks after the onset, are frequently observed. The most common cause of optic neuritis in this age group is acute demyelination.
Retinal hemorrhage leads to painless vision loss, while acute glaucoma and amaurosis fugax are unlikely to occur in individuals of this age group.
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This question is part of the following fields:
- Ophthalmology
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Question 41
Incorrect
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A 45-year-old man presents with palpitations and is found to have atrial fibrillation. You are requested to evaluate his ECG.
Which of the following statements is correct regarding the ECG findings in atrial fibrillation?Your Answer:
Correct Answer: Some impulses are filtered out by the AV node
Explanation:The classic ECG features of atrial fibrillation include an irregularly irregular rhythm, the absence of p-waves, an irregular ventricular rate, and the presence of fibrillation waves. This irregular rhythm occurs because the atrial impulses are filtered out by the AV node.
In addition, Ashman beats may be observed in atrial fibrillation. These beats are characterized by wide complex QRS complexes, often with a morphology resembling right bundle branch block. They occur after a short R-R interval that is preceded by a prolonged R-R interval. Fortunately, Ashman beats are generally considered harmless.
The disorganized electrical activity in atrial fibrillation typically originates at the root of the pulmonary veins.
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This question is part of the following fields:
- Cardiology
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Question 42
Incorrect
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A child presents with a headache, high temperature, and a very itchy rash on their face and body. The doctor diagnoses the child with chickenpox. When would it be necessary to administer acyclovir through injection in this patient?
Your Answer:
Correct Answer: Chronic skin disorder
Explanation:Chickenpox is a highly contagious illness caused by the varicella-zoster virus, a DNA virus from the Herpesviridae family. Most cases are mild to moderate, and the infection usually resolves on its own. Severe complications are rare but can occur, especially in individuals with weakened immune systems or underlying health conditions.
The incubation period for chickenpox is typically between 14 to 21 days. It is contagious from a few days before the rash appears until about a week after the first lesions show up.
The common clinical features of chickenpox include:
– Fever, which lasts for approximately 3-5 days.
– The initial rash starts as flat red spots and progresses into raised bumps.
– These bumps then turn into fluid-filled blisters and eventually form pustules surrounded by redness.
– The lesions are extremely itchy.
– The rash reaches its peak around 48 hours in individuals with a healthy immune system.
– The rash tends to be more concentrated on the face and trunk, with fewer lesions on the limbs.
– The blisters eventually dry up and form crusts, which can lead to scarring if scratched.
– Headache, fatigue, and abdominal pain may also occur.Chickenpox tends to be more severe in teenagers and adults compared to children. Antiviral treatment should be considered for these individuals if they seek medical attention within 24 hours of rash onset. The recommended oral dose of aciclovir is 800 mg taken five times a day for seven days.
Immunocompromised patients and those at higher risk, such as individuals with severe cardiovascular or respiratory disease or chronic skin disorders, should receive antiviral treatment for ten days, with at least seven days of intravenous administration.
Although most cases are relatively mild, if serious complications like pneumonia, encephalitis, or dehydration are suspected, it is important to refer the patient for hospital admission.
For more information, you can refer to the NICE Clinical Knowledge Summary on Chickenpox.
https://cks.nice.org.uk/topics/chickenpox/ -
This question is part of the following fields:
- Dermatology
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Question 43
Incorrect
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A 40-year-old man has a confirmed diagnosis of von Willebrand disease.
Which of the following abnormalities is MOST likely to appear on his clotting profile?Your Answer:
Correct Answer: Prolonged APTT
Explanation:Von Willebrand disease (vWD) is a common hereditary coagulation disorder that affects approximately 1 in 100 individuals. It occurs due to a deficiency in Von Willebrand factor (vWF), which plays a crucial role in blood clotting. vWF not only binds to factor VIII to protect it from rapid breakdown, but it is also necessary for proper platelet adhesion. When vWF is lacking, both factor VIII levels and platelet function are affected, leading to prolonged APTT and bleeding time. However, the platelet count and thrombin time remain unaffected.
While some individuals with vWD may not experience any symptoms and are diagnosed incidentally during a clotting profile check, others may present with easy bruising, nosebleeds (epistaxis), and heavy menstrual bleeding (menorrhagia). In severe cases, more significant bleeding and joint bleeding (haemarthrosis) can occur.
For mild cases of von Willebrand disease, bleeding can be managed with desmopressin. This medication works by stimulating the release of vWF stored in the Weibel-Palade bodies, which are storage granules found in the endothelial cells lining the blood vessels and heart. By increasing the patient’s own levels of vWF, desmopressin helps improve clotting. In more severe cases, replacement therapy is necessary. This involves infusing cryoprecipitate or Factor VIII concentrate to provide the missing vWF. Replacement therapy is particularly recommended for patients with severe von Willebrand’s disease who are undergoing moderate or major surgical procedures.
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This question is part of the following fields:
- Haematology
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Question 44
Incorrect
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A 28 year old male is brought to the emergency department by his partner due to increasing drowsiness. The patient's partner informs you that the patient was involved in a physical altercation approximately 40 minutes ago. The patient was struck in the temple and experienced a brief loss of consciousness for about 20 seconds. Initially, the patient appeared to be fine, but after approximately 20 minutes, he started to become progressively more drowsy. A CT scan reveals the presence of an extradural hematoma.
Which vascular structure is typically injured as the underlying cause of an extradural hematoma?Your Answer:
Correct Answer: Middle meningeal artery
Explanation:Extradural hematoma is most frequently caused by injury to the middle meningeal artery. This artery is particularly susceptible to damage as it passes behind the pterion.
Further Reading:
Extradural haematoma (EDH) is a collection of blood that forms between the inner surface of the skull and the outer layer of the dura, the dura mater. It is typically caused by head trauma and is often associated with a skull fracture, with the pterion being the most common site of injury. The middle meningeal artery is the most common source of bleeding in EDH.
Clinical features of EDH include a history of head injury with transient loss of consciousness, followed by a lucid interval and gradual loss of consciousness. Other symptoms may include severe headache, sixth cranial nerve palsies, nausea and vomiting, seizures, signs of raised intracranial pressure, and focal neurological deficits.
Imaging of EDH typically shows a biconvex shape and may cause mass effect with brain herniation. It can be differentiated from subdural haematoma by its appearance on imaging.
Management of EDH involves prompt referral to neurosurgery for evacuation of the haematoma. In some cases with a small EDH, conservative management may be considered. With prompt evacuation, the prognosis for EDH is generally good.
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This question is part of the following fields:
- Neurology
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Question 45
Incorrect
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A 70-year-old woman presents with a 4-day history of feeling generally unwell and having experienced fevers at home. She has a history of breast cancer for which she is currently undergoing radiation therapy. Her vital signs are as follows: HR 100 bpm, BP 120/80, SaO2 95% on room air, temperature 38.5°C.
The results of her complete blood count are as follows:
Hemoglobin (Hb) 9.2 g/dl
Mean Corpuscular Volume (MCV) 80 fl
Platelets 60 x 109/l
White Cell Count (WCC) 1.2 x 109/l
Lymphocytes 0.4 x 109/l
Neutrophils 0.6 x 109/l
Monocytes 0.1 x 109/l
Which of the following antibiotics would be most appropriate for the initial empiric treatment of this patient?Your Answer:
Correct Answer: Tazocin alone
Explanation:The patient is showing signs of pancytopenia along with a fever, indicating a likely case of neutropenic sepsis. Their blood test results reveal microcytic anemia, leucopenia (with significant neutropenia), and thrombocytopenia. Neutropenic sepsis is a serious condition that can be life-threatening, characterized by a low neutrophil count. There are several potential causes of neutropenia, including cytotoxic chemotherapy, immunosuppressive drugs, stem cell transplantation, infections, bone marrow disorders like aplastic anemia and myelodysplastic syndromes, and nutritional deficiencies.
To diagnose neutropenic sepsis in patients undergoing anticancer treatment, their neutrophil count should be 0.5 x 109 per liter or lower, and they should have either a temperature above 38°C or other signs and symptoms indicative of clinically significant sepsis. According to the current NICE guidelines, initial empiric antibiotic therapy for suspected neutropenic sepsis should involve monotherapy with piperacillin with tazobactam (Tazocin 4.5 g IV). It is not recommended to use an aminoglycoside, either alone or in combination therapy, unless there are specific patient-related or local microbiological reasons to do so.
Reference:
NICE guidance: ‘Neutropenic sepsis: prevention and management of neutropenic sepsis in cancer patients’ -
This question is part of the following fields:
- Oncological Emergencies
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Question 46
Incorrect
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A 68-year-old diabetic man presents with a gradual decrease in consciousness and confusion over the past week. He normally controls his diabetes with metformin 500 mg twice a day. He recently received treatment for a urinary tract infection from his doctor, and his family reports that he has been excessively thirsty. He has vomited multiple times today. A urine dipstick test shows a small amount of white blood cells and moderate ketones. The results of his arterial blood gas test are as follows:
pH: 7.29
pO2: 11.1 kPa
pCO2: 4.6 kPa
HCO3-: 22 mmol/l
Na+: 154 mmol/l
K+: 3.2 mmol/l
Cl-: 100 mmol/l
Urea: 17.6 mmol/l
Glucose: 32 mmol/l
What is his serum osmolality?Your Answer:
Correct Answer: 364 mmol/l
Explanation:In an elderly patient with a history of gradual decline accompanied by high blood sugar levels, excessive thirst, and recent infection, the most likely diagnosis is hyperosmolar hyperglycemic state (HHS). This condition can be life-threatening, with a mortality rate of approximately 50%. Common symptoms include dehydration, elevated blood sugar levels, altered mental status, and electrolyte imbalances. About half of the patients with HHS also experience hypernatremia.
To calculate the serum osmolality, the formula is 2(K+ + Na+) + urea + glucose. In this case, the serum osmolality is 364 mmol/l, indicating a high level. It is important to discontinue the use of metformin in this patient due to the risk of metformin-associated lactic acidosis (MALA). Additionally, an intravenous infusion of insulin should be initiated.
The treatment goals for HHS are to address the underlying cause and gradually and safely:
– Normalize the osmolality
– Replace fluid and electrolyte losses
– Normalize blood glucose levelsIf significant ketonaemia is present (3β-hydroxybutyrate is more than 1 mmol/L), it indicates a relative lack of insulin, and insulin should be administered immediately. However, if significant ketonaemia is not present, insulin should not be started.
Patients with HHS are at a high risk of thromboembolism, and it is recommended to routinely administer low molecular weight heparin. In cases where the serum osmolality exceeds 350 mmol/l, full heparinization should be considered.
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This question is part of the following fields:
- Endocrinology
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Question 47
Incorrect
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A 65-year-old man comes in with a chief complaint of sudden vision loss in his right eye over the past couple of hours. During fundoscopic examination, you observe engorgement of the retinal veins and notice multiple flame-shaped hemorrhages and cotton wool spots scattered throughout the entire retina.
What is the SINGLE most probable diagnosis?Your Answer:
Correct Answer: Central retinal vein occlusion
Explanation:Central retinal vein occlusion (CRVO) is a condition that usually leads to painless, one-sided vision loss. When examining the retina, it may appear similar to a ‘pizza thrown against a wall’, with swollen retinal veins, swelling of the optic disc, numerous flame-shaped hemorrhages, and cotton wool spots. Hypertension is present in about 65% of CRVO cases and is more common in individuals aged 65 and above.
On the other hand, branch retinal vein occlusion (BRVO) typically affects only one section of the retina, resulting in visual field deficits in that specific quadrant rather than complete vision loss.
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This question is part of the following fields:
- Ophthalmology
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Question 48
Incorrect
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You evaluate a 45-year-old woman who presents with lower abdominal and pelvic pain. During a bimanual vaginal examination, you detect a significant pelvic mass. She has no significant medical history or gynecological issues, such as uterine fibroids.
What would be the MOST suitable next step in managing this patient?Your Answer:
Correct Answer: Urgent referral to gynaecology service (for an appointment within 2 weeks)
Explanation:Women who are 18 years or older and have a pelvic mass that is not clearly uterine fibroids should be promptly referred for assessment. In this case, an abdominal X-ray would not provide much useful information, and it is not advisable to take no action at this point. For more information, please refer to the NICE referral guidelines for suspected cancer.
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This question is part of the following fields:
- Obstetrics & Gynaecology
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Question 49
Incorrect
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A 60-year-old woman has recently been diagnosed with Hodgkin’s lymphoma.
Which characteristic is considered to be a ‘B’ symptom of Hodgkin’s lymphoma?Your Answer:
Correct Answer: Night sweats
Explanation:The ‘B’ symptoms associated with Hodgkin’s lymphoma include fever, night sweats, and weight loss. Fever is defined as a body temperature exceeding 38 degrees Celsius. Night sweats refer to excessive sweating during sleep. Weight loss is considered significant if it amounts to more than 10% of a person’s body weight over a period of six months. It is important to note that pain after consuming alcohol is a distinctive sign of Hodgkin’s lymphoma, but it is not classified as a ‘B’ symptom. This symptom is relatively rare, occurring in only 2-3% of individuals diagnosed with Hodgkin’s lymphoma.
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This question is part of the following fields:
- Haematology
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Question 50
Incorrect
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A 45-year-old man presents with palpitations and is found to have atrial fibrillation. You are requested to evaluate his ECG.
Which of the following statements is NOT true regarding the ECG in atrial fibrillation?Your Answer:
Correct Answer: Ashman beats have a poor prognosis
Explanation:The classic ECG features of atrial fibrillation include an irregularly irregular rhythm, the absence of p-waves, an irregular ventricular rate, and the presence of fibrillation waves. This irregular rhythm occurs because the atrial impulses are filtered out by the AV node.
In addition, Ashman beats may be observed in atrial fibrillation. These beats are characterized by wide complex QRS complexes, often with a morphology resembling right bundle branch block. They occur after a short R-R interval that is preceded by a prolonged R-R interval. Fortunately, Ashman beats are generally considered harmless.
The disorganized electrical activity in atrial fibrillation typically originates at the root of the pulmonary veins.
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This question is part of the following fields:
- Cardiology
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Question 51
Incorrect
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You evaluate a 40-year-old man with a sudden onset entrapment neuropathy involving the ulnar nerve in his left arm.
Which of the following muscles is MOST unlikely to be impacted in this individual?Your Answer:
Correct Answer: Lateral two lumbricals
Explanation:The ulnar nerve provides innervation to several muscles in the hand. These include the palmar interossei, dorsal interossei, medial two lumbricals, and the abductor digiti minimi. It is important to note that the lateral two lumbricals are not affected by an ulnar nerve lesion as they are innervated by the median nerve.
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This question is part of the following fields:
- Neurology
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Question 52
Incorrect
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You assess a 62-year-old woman who is currently receiving treatment with a DMARD for severe psoriatic arthropathy. She has been experiencing increasing difficulty breathing during physical activity for the past few months. During the examination, you detect fine bibasal crepitations. You order a chest X-ray, which reveals signs of pulmonary fibrosis.
What is the SINGLE medication she is most likely taking?Your Answer:
Correct Answer: Methotrexate
Explanation:There is a significant link between methotrexate and the development of pulmonary fibrosis. While there have been instances of pulmonary fibrosis occurring as a result of infliximab, this particular side effect is more commonly associated with methotrexate use.
Methotrexate can also cause other side effects such as nausea and vomiting, abdominal pain, gastrointestinal bleeding, dizziness, stomatitis, hepatotoxicity, neutropenia, and pneumonitis.
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This question is part of the following fields:
- Pharmacology & Poisoning
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Question 53
Incorrect
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A 28-year-old woman comes in with a severe skin rash. After a consultation with the on-call dermatology consultant, the woman is diagnosed with Stevens-Johnson syndrome.
Which of the following statements about Stevens-Johnson syndrome is NOT true?Your Answer:
Correct Answer: Epidermal detachment is seen in greater than 30% of the body surface area
Explanation:Stevens-Johnson syndrome is a severe and potentially deadly form of erythema multiforme. It can be triggered by anything that causes erythema multiforme, but it is most commonly seen as a reaction to medication within 1-3 weeks of starting treatment. Initially, there may be symptoms like fever, fatigue, joint pain, and digestive issues, followed by the development of severe mucocutaneous lesions that are blistering and ulcerating.
Stevens-Johnson syndrome and toxic epidermal necrolysis are considered to be different stages of the same mucocutaneous disease, with toxic epidermal necrolysis being more severe. The extent of epidermal detachment is used to differentiate between the two. In Stevens-Johnson syndrome, less than 10% of the body surface area is affected by epidermal detachment, while in toxic epidermal necrolysis, it is greater than 30%. An overlap syndrome occurs when detachment affects between 10-30% of the body surface area.
Several drugs can potentially cause Stevens-Johnson syndrome and toxic epidermal necrolysis, including tetracyclines, penicillins, vancomycin, sulphonamides, NSAIDs, and barbiturates.
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This question is part of the following fields:
- Dermatology
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Question 54
Incorrect
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A 2 year old girl is brought to the emergency department by her father. The child developed a high fever and a sore throat yesterday but today her condition has worsened. You observe that the patient is from a nomadic community and has not received any immunizations. During the examination, you notice that the patient is sitting upright, drooling, and has audible stridor with visible moderate chest retractions. What is the most suitable initial approach to managing this patient?
Your Answer:
Correct Answer: Call and await senior ENT and anaesthetic support
Explanation:The top priority when dealing with suspected epiglottitis is to assess and secure the airway. This is especially important in patients who have not been vaccinated against Haemophilus influenzae type b (HiB), as they are at risk for complications from this infection. Classic signs of epiglottitis include tripod positioning, drooling, stridor, and a muffled voice. It is crucial to avoid agitating patients, particularly children, during examination or procedures, as this can trigger laryngospasm and potentially lead to airway obstruction. In such cases, it is recommended to call in senior ENT and anaesthetic support to perform laryngoscopy and be prepared for intubation or tracheostomy if necessary to address any airway compromise. If the patient is in a critical condition, securing the airway through intubation becomes the top priority.
Further Reading:
Epiglottitis is a rare but serious condition characterized by inflammation and swelling of the epiglottis, which can lead to a complete blockage of the airway. It is more commonly seen in children between the ages of 2-6, but can also occur in adults, particularly those in their 40s and 50s. Streptococcus infections are now the most common cause of epiglottitis in the UK, although other bacterial agents, viruses, fungi, and iatrogenic causes can also be responsible.
The clinical features of epiglottitis include a rapid onset of symptoms, high fever, sore throat, painful swallowing, muffled voice, stridor and difficulty breathing, drooling of saliva, irritability, and a characteristic tripod positioning with the arms forming the front two legs of the tripod. It is important for healthcare professionals to avoid examining the throat or performing any potentially upsetting procedures until the airway has been assessed and secured.
Diagnosis of epiglottitis is typically made through fibre-optic laryngoscopy, which is considered the gold standard investigation. Lateral neck X-rays may also show a characteristic thumb sign, indicating an enlarged and swollen epiglottis. Throat swabs and blood cultures may be taken once the airway is secured to identify the causative organism.
Management of epiglottitis involves assessing and securing the airway as the top priority. Intravenous or oral antibiotics are typically prescribed, and supplemental oxygen may be given if intubation or tracheostomy is planned. In severe cases where the airway is significantly compromised, intubation or tracheostomy may be necessary. Steroids may also be used, although the evidence for their benefit is limited.
Overall, epiglottitis is a potentially life-threatening condition that requires urgent medical attention. Prompt diagnosis, appropriate management, and securing the airway are crucial in ensuring a positive outcome for patients with this condition.
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This question is part of the following fields:
- Ear, Nose & Throat
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Question 55
Incorrect
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A 21 year old male presents to the emergency department with a 3 day history of a sore throat and fever. The patient denies having a cough. On examination, the patient's temperature is 37.9°C, blood pressure is 120/80 mmHg, and pulse rate is 90 bpm. There is visible white exudate on both tonsils, which are severely inflamed, and tenderness on palpation of the lymph nodes around the sternocleidomastoid muscles bilaterally.
What is this patient's FeverPAIN score?Your Answer:
Correct Answer: 4
Explanation:The FeverPAIN score is a clinical scoring system that helps determine the likelihood of a streptococcal infection and whether antibiotic treatment is necessary. It consists of several criteria that are assessed to assign a score.
Firstly, if the patient has a fever higher than 38°C, they score 0 or 1 depending on the presence or absence of this symptom.
Secondly, the presence of purulence, such as pharyngeal or tonsillar exudate, results in a score of 1.
Thirdly, if the patient sought medical attention within 3 days or less, they score 1.
Fourthly, if the patient has severely inflamed tonsils, they score 1.
Lastly, if the patient does not have a cough or coryza (nasal congestion), they score 1.
By adding up the scores from each criterion, the FeverPAIN score can help healthcare professionals determine the likelihood of a streptococcal infection and guide the decision on whether antibiotic treatment is necessary. In this particular case, the patient has a score of 4.
Further Reading:
Pharyngitis and tonsillitis are common conditions that cause inflammation in the throat. Pharyngitis refers to inflammation of the oropharynx, which is located behind the soft palate, while tonsillitis refers to inflammation of the tonsils. These conditions can be caused by a variety of pathogens, including viruses and bacteria. The most common viral causes include rhinovirus, coronavirus, parainfluenza virus, influenza types A and B, adenovirus, herpes simplex virus type 1, and Epstein Barr virus. The most common bacterial cause is Streptococcus pyogenes, also known as Group A beta-hemolytic streptococcus (GABHS). Other bacterial causes include Group C and G beta-hemolytic streptococci and Fusobacterium necrophorum.
Group A beta-hemolytic streptococcus is the most concerning pathogen as it can lead to serious complications such as rheumatic fever and glomerulonephritis. These complications can occur due to an autoimmune reaction triggered by antigen/antibody complex formation or from cell damage caused by bacterial exotoxins.
When assessing a patient with a sore throat, the clinician should inquire about the duration and severity of the illness, as well as associated symptoms such as fever, malaise, headache, and joint pain. It is important to identify any red flags and determine if the patient is immunocompromised. Previous non-suppurative complications of Group A beta-hemolytic streptococcus infection should also be considered, as there is an increased risk of further complications with subsequent infections.
Red flags that may indicate a more serious condition include severe pain, neck stiffness, or difficulty swallowing. These symptoms may suggest epiglottitis or a retropharyngeal abscess, which require immediate attention.
To determine the likelihood of a streptococcal infection and the need for antibiotic treatment, two scoring systems can be used: CENTOR and FeverPAIN. The CENTOR criteria include tonsillar exudate, tender anterior cervical lymphadenopathy or lymphadenitis, history of fever, and absence of cough. The FeverPAIN criteria include fever, purulence, rapid onset of symptoms, severely inflamed tonsils, and absence of cough or coryza. Based on the scores from these criteria, the likelihood of a streptococcal infection can be estimated, and appropriate management can be undertaken. can
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This question is part of the following fields:
- Ear, Nose & Throat
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Question 56
Incorrect
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A child with a known history of latex allergy arrives at the Emergency Department with a severe allergic reaction caused by accidental exposure.
Which of the following fruits is this child MOST likely to have an allergy to as well?Your Answer:
Correct Answer: Banana
Explanation:The connection between latex sensitivity and food allergy is commonly known as the latex-fruit syndrome. Foods that have been found to be allergenic in relation to latex are categorized into high, moderate, or low risk groups.
High risk foods include banana, avocado, chestnut, and kiwi fruit.
Moderate risk foods include apple, carrot, celery, melon, papaya, potato, and tomato.
Citrus fruits and pears are considered to have a low risk of causing allergic reactions in individuals with latex sensitivity.
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This question is part of the following fields:
- Allergy
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Question 57
Incorrect
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A 25-year-old male presents to the emergency department with notable facial swelling following an assault. A facial fracture is suspected due to the patient losing consciousness during the incident. As a precaution, the decision is made to send him for CT scans of the brain and facial views. The CT results confirm a zygomaticomaxillary complex (ZMC) fracture, but no mandible fracture is observed. Upon examination, it is observed that the patient is experiencing difficulty fully opening or closing their mouth. What is the probable cause of this issue?
Your Answer:
Correct Answer: Temporalis muscle entrapment
Explanation:Injuries to the zygomatic arch that result in limited mouth opening or closing can occur when the temporalis muscle or mandibular condyle becomes trapped. If this happens, it is important to seek immediate medical attention. It is worth noting that the muscles responsible for chewing (masseter, temporalis, medial pterygoid, and lateral pterygoid) are innervated by the mandibular nerve (V3).
Further Reading:
Zygomatic injuries, also known as zygomatic complex fractures, involve fractures of the zygoma bone and often affect surrounding bones such as the maxilla and temporal bones. These fractures can be classified into four positions: the lateral and inferior orbital rim, the zygomaticomaxillary buttress, and the zygomatic arch. The full extent of these injuries may not be visible on plain X-rays and may require a CT scan for accurate diagnosis.
Zygomatic fractures can pose risks to various structures in the face. The temporalis muscle and coronoid process of the mandible may become trapped in depressed fractures of the zygomatic arch. The infraorbital nerve, which passes through the infraorbital foramen, can be injured in zygomaticomaxillary complex fractures. In orbital floor fractures, the inferior rectus muscle may herniate into the maxillary sinus.
Clinical assessment of zygomatic injuries involves observing facial asymmetry, depressed facial bones, contusion, and signs of eye injury. Visual acuity must be assessed, and any persistent bleeding from the nose or mouth should be noted. Nasal injuries, including septal hematoma, and intra-oral abnormalities should also be evaluated. Tenderness of facial bones and the temporomandibular joint should be assessed, along with any step deformities or crepitus. Eye and jaw movements must also be evaluated.
Imaging for zygomatic injuries typically includes facial X-rays, such as occipitomental views, and CT scans for a more detailed assessment. It is important to consider the possibility of intracranial hemorrhage and cervical spine injury in patients with facial fractures.
Management of most zygomatic fractures can be done on an outpatient basis with maxillofacial follow-up, assuming the patient is stable and there is no evidence of eye injury. However, orbital floor fractures should be referred immediately to ophthalmologists or maxillofacial surgeons. Zygomatic arch injuries that restrict mouth opening or closing due to entrapment of the temporalis muscle or mandibular condyle also require urgent referral. Nasal fractures, often seen in conjunction with other facial fractures, can be managed by outpatient ENT follow-up but should be referred urgently if there is uncontrolled epistaxis, CSF rhinorrhea, or septal hematoma.
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This question is part of the following fields:
- Maxillofacial & Dental
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Question 58
Incorrect
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A 21 year old female is brought to the emergency department by her boyfriend as he is concerned the patient has become drowsy after intermittent vomiting throughout the day. The boyfriend informs you that the patient is a type 1 diabetic. After evaluation, the patient is diagnosed with diabetic ketoacidosis and started on fluids and an insulin infusion. Due to a lack of available beds, the patient is transferred to the A&E observation ward. Several hours later, you are asked about discontinuing the insulin infusion. What criteria must be met before stopping the insulin infusion?
Your Answer:
Correct Answer: Ketones less than 0.3 mmol/l and venous pH over 7.3
Explanation:In the treatment of diabetic ketoacidosis (DKA), it is important to continue the infusion of insulin until certain criteria are met. These criteria include ketone levels being less than 0.3 mmol/L and the pH of the blood being above 7.3 or the bicarbonate levels being above 18 mmol/L. Additionally, the patient should feel comfortable enough to eat at this point. It is crucial not to stop the intravenous insulin infusion until at least 30 minutes after administering subcutaneous short-acting insulin.
Further Reading:
Diabetic ketoacidosis (DKA) is a serious complication of diabetes that occurs due to a lack of insulin in the body. It is most commonly seen in individuals with type 1 diabetes but can also occur in type 2 diabetes. DKA is characterized by hyperglycemia, acidosis, and ketonaemia.
The pathophysiology of DKA involves insulin deficiency, which leads to increased glucose production and decreased glucose uptake by cells. This results in hyperglycemia and osmotic diuresis, leading to dehydration. Insulin deficiency also leads to increased lipolysis and the production of ketone bodies, which are acidic. The body attempts to buffer the pH change through metabolic and respiratory compensation, resulting in metabolic acidosis.
DKA can be precipitated by factors such as infection, physiological stress, non-compliance with insulin therapy, acute medical conditions, and certain medications. The clinical features of DKA include polydipsia, polyuria, signs of dehydration, ketotic breath smell, tachypnea, confusion, headache, nausea, vomiting, lethargy, and abdominal pain.
The diagnosis of DKA is based on the presence of ketonaemia or ketonuria, blood glucose levels above 11 mmol/L or known diabetes mellitus, and a blood pH below 7.3 or bicarbonate levels below 15 mmol/L. Initial investigations include blood gas analysis, urine dipstick for glucose and ketones, blood glucose measurement, and electrolyte levels.
Management of DKA involves fluid replacement, electrolyte correction, insulin therapy, and treatment of any underlying cause. Fluid replacement is typically done with isotonic saline, and potassium may need to be added depending on the patient’s levels. Insulin therapy is initiated with an intravenous infusion, and the rate is adjusted based on blood glucose levels. Monitoring of blood glucose, ketones, bicarbonate, and electrolytes is essential, and the insulin infusion is discontinued once ketones are below 0.3 mmol/L, pH is above 7.3, and bicarbonate is above 18 mmol/L.
Complications of DKA and its treatment include gastric stasis, thromboembolism, electrolyte disturbances, cerebral edema, hypoglycemia, acute respiratory distress syndrome, and acute kidney injury. Prompt medical intervention is crucial in managing DKA to prevent potentially fatal outcomes.
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This question is part of the following fields:
- Endocrinology
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Question 59
Incorrect
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A 62-year-old man presents with depressive symptoms, mood swings, difficulty writing, memory impairment, and difficulty generating ideas.
Which of the following is the SINGLE MOST likely diagnosis?Your Answer:
Correct Answer: Alzheimer’s Disease
Explanation:Alzheimer’s disease is characterized by various clinical features. These include memory loss, mood swings, apathy, and the presence of depressive or paranoid symptoms. Additionally, individuals with Alzheimer’s may experience Parkinsonism, a condition that affects movement, as well as a syndrome associated with the parietal lobe. Other symptoms may include difficulties with tasks such as copying 2D drawings, dressing properly, and carrying out a sequence of actions. Furthermore, individuals may struggle with copying gestures and may exhibit denial of their disorder, known as anosognosia. Topographical agnosia, or getting lost in familiar surroundings, may also be present, along with sensory inattention and astereognosis, which is the inability to identify objects when placed in the hand. Ultimately, Alzheimer’s disease is characterized by a relentless progression of personality and intellectual deterioration.
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This question is part of the following fields:
- Elderly Care / Frailty
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Question 60
Incorrect
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A 2-year-old girl presents with a barking cough. You suspect croup as the diagnosis.
Which SINGLE statement regarding croup is true?Your Answer:
Correct Answer: There is often a prodromal illness for 1-2 days before stridor begins
Explanation:Croup, also known as laryngo-tracheo-bronchitis, is typically caused by the parainfluenza virus. Other viruses such as rhinovirus, influenza, and respiratory syncytial viruses can also be responsible. Before the onset of stridor, there is often a mild cold-like illness that lasts for 1-2 days. Symptoms usually reach their peak within 1-3 days, with the cough often being more troublesome at night. A milder cough may persist for another 7-10 days.
Since croup is caused by a viral infection, antibiotics are not effective unless there is a suspicion of a secondary bacterial infection. It is important to note that sedation should not be used in a child experiencing respiratory distress. To reduce airway swelling, dexamethasone and prednisolone are commonly prescribed, although they do not shorten the duration of the illness. In severe cases, nebulized adrenaline can be administered.
A barking cough is a characteristic symptom of croup, but it does not necessarily indicate the severity of the condition. Hospitalization for croup is rare and typically reserved for children who show worsening respiratory distress or signs of drowsiness/agitation.
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This question is part of the following fields:
- Ear, Nose & Throat
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Question 61
Incorrect
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A 35-year-old weightlifter who acknowledges frequent use of anabolic steroids presents with extremely severe acne. He has numerous disfiguring, ulcerated, nodular lesions covering his face, back, and chest. Many of the lesions have bleeding crusts, and he has significant scarring present. Several have also connected and formed sinuses. He is also experiencing overall discomfort with joint pains and a sensation of fever. You measure his temperature, and it is currently 39°C.
What is the MOST LIKELY single diagnosis?Your Answer:
Correct Answer: Acne fulminans
Explanation:Acne conglobata is an extremely severe form of acne where acne nodules come together and create sinuses. Acne fulminans, on the other hand, is a rare and severe complication of acne conglobata that is accompanied by systemic symptoms. It is linked to elevated levels of androgenic hormones, specific autoimmune conditions, and a genetic predisposition.
The typical clinical characteristics of acne fulminans are as follows:
– Sudden and abrupt onset
– Inflammatory and ulcerated nodular acne primarily found on the chest and back
– Often painful lesions
– Ulcers on the upper trunk covered with bleeding crusts
– Severe acne scarring
– Fluctuating fever
– Painful joints and arthropathy
– General feeling of illness (malaise)
– Loss of appetite and weight loss
– Enlarged liver and spleen (hepatosplenomegaly)It is crucial to refer patients immediately for a specialist evaluation and hospital admission. Treatment options for acne fulminans include systemic corticosteroids, dapsone, ciclosporin, and high-dose intravenous antibiotics.
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This question is part of the following fields:
- Dermatology
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Question 62
Incorrect
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A 45-year-old man has developed drug-induced lupus after starting a new medication.
What is the PRIMARY cause of this?Your Answer:
Correct Answer: Hydralazine
Explanation:The drugs that have the highest association with the development of drug-induced lupus are procainamide and hydralazine. While some of the other medications mentioned in this question have also been reported to cause drug-induced lupus, the strength of their association is much weaker.
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This question is part of the following fields:
- Pharmacology & Poisoning
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Question 63
Incorrect
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A 60-year-old woman originally from South Sudan has developed a chronic skin condition. She has widespread areas of both hyper- and hypopigmented skin along with areas of skin atrophy and lichenification. The hypopigmented areas are mostly confined to her forearms. Over the past few years, her vision has gradually deteriorated, and she has now been registered blind.
What is the SINGLE most likely causative organism?Your Answer:
Correct Answer: Onchocerca volvulus
Explanation:Onchocerciasis is a parasitic disease caused by the filarial nematode Onchocerca volvulus. It is transmitted through the bites of infected blackflies of Simulium species, which carry immature larval forms of the parasite from human to human.
In the human body, the larvae form nodules in the subcutaneous tissue, where they mature to adult worms. After mating, the female adult worm can release up to 1000 microfilariae a day.
Onchocerciasis is currently endemic in 30 African countries, Yemen, and a few isolated regions of South America. Approximately 37 million people worldwide are currently infected.
Symptoms start to occur around a year after the patient is infected. The earliest symptom is usually an intensely itchy rash. Various skin manifestations occur, including scattered, red, pruritic papules (acute papular onchodermatitis), larger, chronic, hyperpigmented papules (chronic papular onchodermatitis), lichenified, oedematous, hyperpigmented papules and plaques (lichenified onchodermatitis), areas of skin atrophy with loss of elasticity (‘Lizard skin’), and depigmented areas with a ‘leopard skin appearance, usually on shins.
Ocular involvement provides the common name associated with onchocerciasis, river blindness, and it can involve any part of the eye. Almost a million people worldwide have at least a partial degree of vision loss caused by onchocerciasis. Initially, there may be intense watering, foreign body sensation, and photophobia. This can progress to conjunctivitis, iridocyclitis, and chorioretinitis. Secondary glaucoma and optic atrophy may also occur.
In a number of countries, onchocerciasis has been controlled through spraying of blackfly breeding sites with insecticide. The drug ivermectin is the preferred treatment for onchocerciasis.
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This question is part of the following fields:
- Dermatology
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Question 64
Incorrect
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A 70-year-old female smoker presents with intense chest discomfort. Her ECG indicates an acute myocardial infarction and she is immediately taken to the cath lab. Angiography reveals a blockage in the left anterior descending artery.
Which area of the heart is most likely affected in this scenario?Your Answer:
Correct Answer: Right ventricle
Explanation:A summary of the vessels involved in different types of myocardial infarction, along with the corresponding ECG leads and the location of the infarction.
For instance, an anteroseptal infarction involving the left anterior descending artery is indicated by ECG leads V1-V3. Similarly, an anterior infarction involving the left anterior descending artery is indicated by leads V3-V4.
In cases of anterolateral infarctions, both the left anterior descending artery and the left circumflex artery are involved, and this is reflected in ECG leads V5-V6. An extensive anterior infarction involving the left anterior descending artery is indicated by leads V1-V6.
Lateral infarcts involving the left circumflex artery are indicated by leads I, II, aVL, and V6. Inferior infarctions, on the other hand, involve either the right coronary artery (in 80% of cases) or the left circumflex artery (in 20% of cases), and this is shown by leads II, III, and aVF.
In the case of a right ventricular infarction, the right coronary artery is involved, and this is indicated by leads V1 and V4R. Lastly, a posterior infarction involving the right coronary artery is shown by leads V7-V9.
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This question is part of the following fields:
- Cardiology
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Question 65
Incorrect
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A 2 year old is brought to the emergency department by his father due to a 24 hour history of worsening left sided otalgia and high temperature. During examination, a bulging red tympanic membrane is observed and acute otitis media is diagnosed.
What is the most probable causative organism in this case?Your Answer:
Correct Answer: Streptococcus pneumoniae
Explanation:The most probable causative organism in this case is Streptococcus pneumoniae. This bacterium is a common cause of acute otitis media, especially in young children. It is known to cause infection in the middle ear, leading to symptoms such as ear pain (otalgia), fever, and a red, bulging tympanic membrane. Other organisms such as Escherichia coli, Candida albicans, Pseudomonas aeruginosa, and Staphylococcus aureus can also cause ear infections, but Streptococcus pneumoniae is the most likely culprit in this particular case.
Further Reading:
Acute otitis media (AOM) is an inflammation in the middle ear accompanied by symptoms and signs of an ear infection. It is commonly seen in young children below 4 years of age, with the highest incidence occurring between 9 to 15 months of age. AOM can be caused by viral or bacterial pathogens, and co-infection with both is common. The most common viral pathogens include respiratory syncytial virus (RSV), rhinovirus, adenovirus, influenza virus, and parainfluenza virus. The most common bacterial pathogens include Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pyogenes.
Clinical features of AOM include ear pain (otalgia), fever, a red or cloudy tympanic membrane, and a bulging tympanic membrane with loss of anatomical landmarks. In young children, symptoms may also include crying, grabbing or rubbing the affected ear, restlessness, and poor feeding.
Most children with AOM will recover within 3 days without treatment. Serious complications are rare but can include persistent otitis media with effusion, recurrence of infection, temporary hearing loss, tympanic membrane perforation, labyrinthitis, mastoiditis, meningitis, intracranial abscess, sinus thrombosis, and facial nerve paralysis.
Management of AOM involves determining whether admission to the hospital is necessary based on the severity of systemic infection or suspected acute complications. For patients who do not require admission, regular pain relief with paracetamol or ibuprofen is advised. Decongestants or antihistamines are not recommended. Antibiotics may be offered immediately for patients who are systemically unwell, have symptoms and signs of a more serious illness or condition, or have a high risk of complications. For other patients, a decision needs to be made on the antibiotic strategy, considering the rarity of acute complications and the possible adverse effects of antibiotics. Options include no antibiotic prescription with advice to seek medical help if symptoms worsen rapidly or significantly, a back-up antibiotic prescription to be used if symptoms do not improve within 3 days, or an immediate antibiotic prescription with advice to seek medical advice if symptoms worsen rapidly or significantly.
The first-line antibiotic choice for AOM is a 5-7 day course of amoxicillin. For individuals allergic to or intolerant of penicillin, clarithromycin or erythromycin a 5–7 day course of clarithromycin or erythromycin (erythromycin is preferred in pregnant women).
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This question is part of the following fields:
- Ear, Nose & Throat
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Question 66
Incorrect
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A 3-week-old girl presents with vomiting, poor weight gain, and decreased muscle tone. She is hypotensive and has a fast heart rate. During the examination, you notice that she has enlarged labia and increased pigmentation. Blood tests show high potassium, low sodium, and elevated levels of 17-hydroxyprogesterone. A venous blood gas reveals the presence of metabolic acidosis, and her blood glucose level is slightly low. Intravenous fluids have already been started.
What is the SINGLE most appropriate next step in management?Your Answer:
Correct Answer: IV hydrocortisone and IV dextrose
Explanation:Congenital adrenal hyperplasia (CAH) is a group of inherited disorders that are caused by autosomal recessive genes. The majority of affected patients, over 90%, have a deficiency of the enzyme 21-hydroxylase. This enzyme is encoded by the 21-hydroxylase gene, which is located on chromosome 6p21 within the HLA histocompatibility complex. The second most common cause of CAH is a deficiency of the enzyme 11-beta-hydroxylase. The condition is rare, with an incidence of approximately 1 in 500 births in the UK. It is more prevalent in the offspring of consanguineous marriages.
The deficiency of 21-hydroxylase leads to a deficiency of cortisol and/or aldosterone, as well as an excess of precursor steroids. As a result, there is an increased secretion of ACTH from the anterior pituitary, leading to adrenocortical hyperplasia.
The severity of CAH varies depending on the degree of 21-hydroxylase deficiency. Female infants often exhibit ambiguous genitalia, such as clitoral hypertrophy and labial fusion. Male infants may have an enlarged scrotum and/or scrotal pigmentation. Hirsutism, or excessive hair growth, occurs in 10% of cases.
Boys with CAH often experience a salt-losing adrenal crisis at around 1-3 weeks of age. This crisis is characterized by symptoms such as vomiting, weight loss, floppiness, and circulatory collapse.
The diagnosis of CAH can be made by detecting markedly elevated levels of the metabolic precursor 17-hydroxyprogesterone. Neonatal screening is possible, primarily through the identification of persistently elevated 17-hydroxyprogesterone levels.
In infants presenting with a salt-losing crisis, the following biochemical abnormalities are observed: hyponatremia (low sodium levels), hyperkalemia (high potassium levels), metabolic acidosis, and hypoglycemia.
Boys experiencing a salt-losing crisis will require fluid resuscitation, intravenous dextrose, and intravenous hydrocortisone.
Affected females will require corrective surgery for their external genitalia. However, they have an intact uterus and ovaries and are capable of having children.
The long-term management of both sexes involves lifelong replacement of hydrocortisone (to suppress ACTH levels).
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This question is part of the following fields:
- Endocrinology
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Question 67
Incorrect
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A 32-year-old individual comes in with a recent onset of low back pain that has been getting worse over the past few days. They have been experiencing chills today and their temperature is elevated at 38°C.
Which of the following is a warning sign that suggests an infectious origin for their back pain?Your Answer:
Correct Answer: Use of immunosuppressant drugs
Explanation:Infectious factors that can lead to back pain consist of discitis, vertebral osteomyelitis, and spinal epidural abscess. There are certain warning signs, known as red flags, that indicate the presence of an infectious cause for back pain. These red flags include experiencing a fever, having tuberculosis, being diabetic, having recently had a bacterial infection such as a urinary tract infection, engaging in intravenous drug use, and having a weakened immune system due to conditions like HIV or the use of immunosuppressant drugs.
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This question is part of the following fields:
- Musculoskeletal (non-traumatic)
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Question 68
Incorrect
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A 32-year-old woman with a known history of HIV presents with multiple new small lumps around her anus and genitalia. During examination, two clusters of small lumps are observed. The lumps range in size from 1 to 5 mm, with two being pedunculated. They have a firm texture and exhibit colors ranging from grey to brown.
What is the SINGLE most probable diagnosis?Your Answer:
Correct Answer: Verruca acuminata
Explanation:Verruca acuminata, also known as Condylomata acuminata, are genital warts. These warts are typically transmitted through sexual activity and are primarily caused by different subtypes of the human papillomavirus (HPV). They usually appear in clusters, can be pedunculated, and vary in size between 1-5 mm. Immunosuppression increases the risk, and some studies suggest that 25% of affected patients will acquire a second sexually transmitted infection.
Condylomata lata, on the other hand, are warty-plaque like lesions found on the genitals and perianal area during secondary syphilis.
Verruca vulgaris, commonly known as common warts, present as raised warts with a roughened surface. They are most frequently observed on the hands.
Verruca planae, which are smooth and flattened flesh-colored warts, can occur in large numbers. They are commonly seen on the face, hands, neck, wrists, and knees.
Lastly, Verruca plantaris, also known as plantar warts or verrucas, manifest as hard and painful lumps, often with black specks in the center. These warts are typically found only on pressure points on the soles of the feet.
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This question is part of the following fields:
- Sexual Health
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Question 69
Incorrect
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A 32-year-old traveler returns from a visit to West Africa with frequent headaches and occasional fevers. Laboratory tests reveal the presence of malaria. The patient is promptly initiated on treatment, but his condition worsens, leading to the development of jaundice, renal failure, and haemoglobinuria.
What is the MOST LIKELY organism responsible for this illness?Your Answer:
Correct Answer: Plasmodium falciparum
Explanation:Malaria is a contagious illness that is spread by female mosquitoes of the Anopheles genus. It is a parasitic infection caused by the Plasmodium genus. There are five species of Plasmodium that are known to cause disease in humans: Plasmodium falciparum, Plasmodium ovale, Plasmodium vivax, Plasmodium malariae, and Plasmodium knowlesi.
The main symptom of malaria is the malarial paroxysm, which is a recurring pattern of symptoms. It begins with a cold phase, during which the patient experiences intense chills. This is followed by a hot stage, where the patient feels extremely hot. Finally, there is a sweating stage, during which the fever subsides and the patient sweats profusely. Upon examination, the patient may exhibit signs of anemia, jaundice, and have an enlarged liver and spleen, but there is no evidence of swollen lymph nodes.
If a patient develops haemoglobinuria (the presence of hemoglobin in the urine) and renal failure after treatment, it may indicate a condition called blackwater fever, which is caused by Plasmodium falciparum. In this condition, an autoimmune reaction occurs between the parasite and quinine, leading to the destruction of red blood cells, hemoglobinuria, jaundice, and renal failure. Blackwater fever can be life-threatening.
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This question is part of the following fields:
- Infectious Diseases
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Question 70
Incorrect
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A 65 year old is brought into the emergency department by two members of the public after collapsing in a nearby park. The patient appears confused, looking around the room but not responding to questions or commands. Verbal output is limited to grunting and coughing. Observations are taken and are shown below:
Blood pressure 148/76 mmHg
Pulse 90 bpm
Respirations 18 bpm
Temperature 36.8ºC
Oxygen Saturations 98% on air
Capillary glucose 1.2 mmol/l
What is the most appropriate next step in this patient's management?Your Answer:
Correct Answer: Give glucagon 1 mg via intramuscular injection
Explanation:The use of glucose infusion is not recommended due to its hypertonic nature, which can potentially increase the risk of extravasation injury.
Further Reading:
Diabetes Mellitus:
– Definition: a group of metabolic disorders characterized by persistent hyperglycemia caused by deficient insulin secretion, resistance to insulin, or both.
– Types: Type 1 diabetes (absolute insulin deficiency), Type 2 diabetes (insulin resistance and relative insulin deficiency), Gestational diabetes (develops during pregnancy), Other specific types (monogenic diabetes, diabetes secondary to pancreatic or endocrine disorders, diabetes secondary to drug treatment).
– Diagnosis: Type 1 diabetes diagnosed based on clinical grounds in adults presenting with hyperglycemia. Type 2 diabetes diagnosed in patients with persistent hyperglycemia and presence of symptoms or signs of diabetes.
– Risk factors for type 2 diabetes: obesity, inactivity, family history, ethnicity, history of gestational diabetes, certain drugs, polycystic ovary syndrome, metabolic syndrome, low birth weight.Hypoglycemia:
– Definition: lower than normal blood glucose concentration.
– Diagnosis: defined by Whipple’s triad (signs and symptoms of low blood glucose, low blood plasma glucose concentration, relief of symptoms after correcting low blood glucose).
– Blood glucose level for hypoglycemia: NICE defines it as <3.5 mmol/L, but there is inconsistency across the literature.
– Signs and symptoms: adrenergic or autonomic symptoms (sweating, hunger, tremor), neuroglycopenic symptoms (confusion, coma, convulsions), non-specific symptoms (headache, nausea).
– Treatment options: oral carbohydrate, buccal glucose gel, glucagon, dextrose. Treatment should be followed by re-checking glucose levels.Treatment of neonatal hypoglycemia:
– Treat with glucose IV infusion 10% given at a rate of 5 mL/kg/hour.
– Initial stat dose of 2 mL/kg over five minutes may be required for severe hypoglycemia.
– Mild asymptomatic persistent hypoglycemia may respond to a single dose of glucagon.
– If hypoglycemia is caused by an oral anti-diabetic drug, the patient should be admitted and ongoing glucose infusion or other therapies may be required.Note: Patients who have a hypoglycemic episode with a loss of warning symptoms should not drive and should inform the DVLA.
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This question is part of the following fields:
- Endocrinology
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Question 71
Incorrect
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You are participating in a mountain expedition and have been airlifted to camp at an elevation of 2750m. As part of your responsibilities, you need to identify individuals displaying indications of acute mountain sickness (AMS). At what point would you anticipate the emergence of signs and symptoms of AMS?
Your Answer:
Correct Answer: After 6-12 hours of being at altitude
Explanation:The symptoms of acute mountain sickness (AMS) typically appear within 6-12 hours of reaching an altitude above 2500 meters. On the other hand, the onset of high altitude cerebral edema (HACE) and high altitude pulmonary edema (HAPE) usually occurs after 2-4 days of being at high altitude.
Further Reading:
High Altitude Illnesses
Altitude & Hypoxia:
– As altitude increases, atmospheric pressure decreases and inspired oxygen pressure falls.
– Hypoxia occurs at altitude due to decreased inspired oxygen.
– At 5500m, inspired oxygen is approximately half that at sea level, and at 8900m, it is less than a third.Acute Mountain Sickness (AMS):
– AMS is a clinical syndrome caused by hypoxia at altitude.
– Symptoms include headache, anorexia, sleep disturbance, nausea, dizziness, fatigue, malaise, and shortness of breath.
– Symptoms usually occur after 6-12 hours above 2500m.
– Risk factors for AMS include previous AMS, fast ascent, sleeping at altitude, and age <50 years old.
– The Lake Louise AMS score is used to assess the severity of AMS.
– Treatment involves stopping ascent, maintaining hydration, and using medication for symptom relief.
– Medications for moderate to severe symptoms include dexamethasone and acetazolamide.
– Gradual ascent, hydration, and avoiding alcohol can help prevent AMS.High Altitude Pulmonary Edema (HAPE):
– HAPE is a progression of AMS but can occur without AMS symptoms.
– It is the leading cause of death related to altitude illness.
– Risk factors for HAPE include rate of ascent, intensity of exercise, absolute altitude, and individual susceptibility.
– Symptoms include dyspnea, cough, chest tightness, poor exercise tolerance, cyanosis, low oxygen saturations, tachycardia, tachypnea, crepitations, and orthopnea.
– Management involves immediate descent, supplemental oxygen, keeping warm, and medication such as nifedipine.High Altitude Cerebral Edema (HACE):
– HACE is thought to result from vasogenic edema and increased vascular pressure.
– It occurs 2-4 days after ascent and is associated with moderate to severe AMS symptoms.
– Symptoms include headache, hallucinations, disorientation, confusion, ataxia, drowsiness, seizures, and manifestations of raised intracranial pressure.
– Immediate descent is crucial for management, and portable hyperbaric therapy may be used if descent is not possible.
– Medication for treatment includes dexamethasone and supplemental oxygen. Acetazolamide is typically used for prophylaxis. -
This question is part of the following fields:
- Environmental Emergencies
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Question 72
Incorrect
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A 65-year-old diabetic man presents with a gradual decrease in consciousness and confusion over the past week. His diabetes is typically controlled with metformin 500 mg twice daily. He recently received treatment for a urinary tract infection from his primary care physician, and his family reports that he has been experiencing excessive thirst. He has vomited multiple times today. A urine dipstick test shows a small amount of white blood cells and 1+ ketones. The results of his arterial blood gas analysis are as follows:
pH: 7.29
pO2: 11.1 kPa
pCO2: 4.6 kPa
HCO3-: 22 mmol/l
Na+: 154 mmol/l
K+: 3.2 mmol/l
Cl-: 100 mmol/l
Urea: 17.6 mmol/l
Glucose: 32 mmol/l
Which SINGLE statement is true regarding this case?Your Answer:
Correct Answer: Anticoagulation should be given
Explanation:In an elderly patient with a history of gradual decline accompanied by high blood sugar levels, excessive thirst, and recent infection, the most likely diagnosis is hyperosmolar hyperglycemic state (HHS). This condition can be life-threatening, with a mortality rate of approximately 50%. Common symptoms include dehydration, elevated blood sugar levels, altered mental status, and electrolyte imbalances. About half of the patients with HHS also experience hypernatremia.
To calculate the serum osmolality, the formula is 2(K+ + Na+) + urea + glucose. In this case, the serum osmolality is 364 mmol/l, indicating a high level. It is important to discontinue the use of metformin in this patient due to the risk of metformin-associated lactic acidosis (MALA). Additionally, an intravenous infusion of insulin should be initiated.
The treatment goals for HHS are to address the underlying cause and gradually and safely:
– Normalize the osmolality
– Replace fluid and electrolyte losses
– Normalize blood glucose levelsIf significant ketonaemia is present (3β-hydroxybutyrate is more than 1 mmol/L), it indicates a relative lack of insulin, and insulin should be administered immediately. However, if significant ketonaemia is not present, insulin should not be started.
Patients with HHS are at a high risk of thromboembolism, and it is recommended to routinely administer low molecular weight heparin. In cases where the serum osmolality exceeds 350 mmol/l, full heparinization should be considered.
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This question is part of the following fields:
- Endocrinology
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Question 73
Incorrect
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A 32-year-old woman comes in with a history of worsening wheezing for the past three days. She has a history of seasonal allergies during the spring months, which have been more severe than usual in recent weeks. Upon listening to her chest, you can hear scattered polyphonic wheezes. Her peak flow at the time of presentation is 280 L/min, and her personal best peak flow is 550 L/min.
What classification would you assign to this asthma exacerbation?Your Answer:
Correct Answer: Acute severe asthma
Explanation:This man is experiencing an acute episode of asthma. His initial peak flow measurement is 46% of his best, indicating a severe exacerbation. According to the BTS guidelines, acute asthma can be classified as moderate, acute severe, life-threatening, or near-fatal.
Moderate asthma is characterized by increasing symptoms and a peak expiratory flow rate (PEFR) between 50-75% of the individual’s best or predicted value. There are no signs of acute severe asthma in this case.
Acute severe asthma is identified by any one of the following criteria: a PEFR between 33-50% of the best or predicted value, a respiratory rate exceeding 25 breaths per minute, a heart rate over 110 beats per minute, or the inability to complete sentences in one breath.
Life-threatening asthma is indicated by any one of the following: a PEFR below 33% of the best or predicted value, oxygen saturation (SpO2) below 92%, arterial oxygen pressure (PaO2) below 8 kPa, normal arterial carbon dioxide pressure (PaCO2) between 4.6-6.0 kPa, a silent chest, cyanosis, poor respiratory effort, arrhythmia, exhaustion, altered conscious level, or hypotension.
Near-fatal asthma is characterized by elevated PaCO2 levels and/or the need for mechanical ventilation with increased inflation pressures.
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This question is part of the following fields:
- Respiratory
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Question 74
Incorrect
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A 25-year-old female patient arrives at the Emergency Department displaying clinical signs of a sexually transmitted infection.
Which of the following organisms is frequently transmitted through sexual contact?Your Answer:
Correct Answer: Human papillomavirus
Explanation:The human papillomavirus (HPV) is a viral infection that is primarily responsible for the development of genital warts. This virus is predominantly transmitted through sexual contact.
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This question is part of the following fields:
- Sexual Health
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Question 75
Incorrect
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An 8-year-old boy is brought to the emergency department by concerned parents. The parents inform you that the patient has had a fever with temperatures ranging between 37.5 and 38.1ºC and a runny nose for a few days before developing a barking cough. During examination, you observe stridor at rest and moderate sternal recession (retractions). The child appears lethargic and does not consistently respond to verbal stimuli. Oxygen saturation levels are 94% on air, and there is marked bilateral decreased air entry upon auscultation of the chest. The child's mother inquires if this could be croup.
Your consultant requests you to calculate the Westley score for this child. What is the correct score?Your Answer:
Correct Answer: 11
Explanation:Croup, also known as laryngotracheobronchitis, is a respiratory infection that primarily affects infants and toddlers. It is characterized by a barking cough and can cause stridor (a high-pitched sound during breathing) and respiratory distress due to swelling of the larynx and excessive secretions. The majority of cases are caused by parainfluenza viruses 1 and 3. Croup is most common in children between 6 months and 3 years of age and tends to occur more frequently in the autumn.
The clinical features of croup include a barking cough that is worse at night, preceded by symptoms of an upper respiratory tract infection such as cough, runny nose, and congestion. Stridor, respiratory distress, and fever may also be present. The severity of croup can be graded using the NICE system, which categorizes it as mild, moderate, severe, or impending respiratory failure based on the presence of symptoms such as cough, stridor, sternal/intercostal recession, agitation, lethargy, and decreased level of consciousness. The Westley croup score is another commonly used tool to assess the severity of croup based on the presence of stridor, retractions, air entry, oxygen saturation levels, and level of consciousness.
In cases of severe croup with significant airway obstruction and impending respiratory failure, symptoms may include a minimal barking cough, harder-to-hear stridor, chest wall recession, fatigue, pallor or cyanosis, decreased level of consciousness, and tachycardia. A respiratory rate over 70 breaths per minute is also indicative of severe respiratory distress.
Children with moderate or severe croup, as well as those with certain risk factors such as chronic lung disease, congenital heart disease, neuromuscular disorders, immunodeficiency, age under 3 months, inadequate fluid intake, concerns about care at home, or high fever or a toxic appearance, should be admitted to the hospital. The mainstay of treatment for croup is corticosteroids, which are typically given orally. If the child is too unwell to take oral medication, inhaled budesonide or intramuscular dexamethasone may be used as alternatives. Severe cases may require high-flow oxygen and nebulized adrenaline.
When considering the differential diagnosis for acute stridor and breathing difficulty, non-infective causes such as inhaled foreign bodies
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This question is part of the following fields:
- Paediatric Emergencies
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Question 76
Incorrect
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A young woman is referred to the GUM clinic for investigation of symptoms that can be associated with sexually transmitted infection. Following her assessment, she is diagnosed with gonorrhoea.
Which of the following is the most common presenting clinical feature of gonorrhoea in women?Your Answer:
Correct Answer: Urethritis
Explanation:Neisseria gonorrhoeae is a type of bacteria that is shaped like two spheres and stains pink when tested. It is responsible for causing the sexually transmitted infection known as gonorrhoea. This infection is most commonly seen in individuals between the ages of 15 and 35, and it is primarily transmitted through sexual contact. One important thing to note is that the gonococcal pili, which are hair-like structures on the bacteria, can change their appearance. This means that even if someone has recovered from a previous infection, they can still be reinfected due to the bacteria’s ability to change.
In men, the clinical signs of gonorrhoea include inflammation of the urethra, which is seen in approximately 80% of cases. Around 50% of men experience pain or discomfort during urination, and a mucopurulent discharge may also be present. Rectal infection is possible, although it is usually asymptomatic. In some cases, it can cause anal discharge. Pharyngitis, or inflammation of the throat, is also possible but typically does not cause any noticeable symptoms.
Women with gonorrhoea may experience a vaginal discharge, which is seen in about 50% of cases. Lower abdominal pain is reported in approximately 25% of women, and dysuria, or painful urination, is seen in 10-15% of cases. Pelvic or lower abdominal tenderness is less common, occurring in less than 5% of women. Additionally, women may have an endocervical discharge and/or bleeding. Similar to men, rectal infection is usually asymptomatic but can cause anal discharge. Pharyngitis is also possible in women, but it is typically asymptomatic.
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This question is part of the following fields:
- Sexual Health
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Question 77
Incorrect
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A 4-year-old girl presents with stridor and a barking cough. Her mother reports that she has had a slight cold for a few days and her voice had been hoarse. Her vital signs are as follows: temperature 38.1°C, heart rate 135, respiratory rate 30, oxygen saturation 97% on room air. Her chest examination is unremarkable, but you observe the presence of stridor at rest.
What is the SINGLE most probable causative organism?Your Answer:
Correct Answer: Parainfluenza virus
Explanation:Croup, also known as laryngo-tracheo-bronchitis, is typically caused by the parainfluenza virus. Other viruses such as rhinovirus, influenza, and respiratory syncytial viruses can also be responsible. Before the onset of stridor, there is often a mild cold-like illness that lasts for 1-2 days. Symptoms usually reach their peak within 1-3 days, with the cough often being more troublesome at night. A milder cough may persist for another 7-10 days.
A distinctive feature of croup is a barking cough, but it does not indicate the severity of the condition. To reduce airway swelling, dexamethasone and prednisolone are commonly prescribed. If a child is experiencing vomiting, nebulized budesonide can be used as an alternative. However, it is important to note that steroids do not shorten the duration of the illness. In severe cases, nebulized adrenaline can be administered.
Hospitalization for croup is uncommon and typically reserved for children who are experiencing worsening respiratory distress or showing signs of drowsiness or agitation.
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This question is part of the following fields:
- Respiratory
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Question 78
Incorrect
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A 35-year-old man comes to the clinic complaining of increasing numbness and weakness in his legs over the past 4 days. The symptoms seem to be spreading upwards towards his thighs, and he has also noticed some weakness in his hands. He mentions that he had a bad bout of diarrhea about three weeks ago, but otherwise, he has been healthy. What is the most likely organism responsible for his symptoms?
Your Answer:
Correct Answer: Campylobacter jejuni
Explanation:This patient’s medical history suggests a diagnosis of Guillain-Barré syndrome (GBS). GBS typically presents with initial symptoms of sensory changes or pain, accompanied by muscle weakness in the hands and/or feet. This weakness often spreads to the arms and upper body, affecting both sides. During the acute phase, GBS can be life-threatening, with around 15% of patients experiencing respiratory muscle weakness and requiring mechanical ventilation.
The exact cause of GBS is unknown, but it is believed to involve an autoimmune response where the body’s immune system attacks the myelin sheath surrounding the peripheral nerves. In about 75% of cases, there is a preceding infection, commonly affecting the gastrointestinal or respiratory tracts.
In this particular case, the most likely underlying cause is Campylobacter jejuni, a gastrointestinal pathogen. This is supported by the recent history of a severe diarrheal illness.
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This question is part of the following fields:
- Neurology
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Question 79
Incorrect
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A 25-year-old woman with a known history of generalized anxiety disorder presents hyperventilating. You suspect that she is experiencing a panic attack. She was seen by a resident physician shortly before your assessment, and an arterial blood gas was taken.
What type of acid-base disorder would you anticipate being caused by hyperventilation secondary to anxiety?Your Answer:
Correct Answer: Respiratory alkalosis
Explanation:Respiratory alkalosis can be caused by hyperventilation, such as during periods of anxiety. It can also be a result of conditions like pulmonary embolism, CNS disorders (such as stroke or encephalitis), altitude, pregnancy, or the early stages of aspirin overdose.
Respiratory acidosis is often associated with chronic obstructive pulmonary disease (COPD) or life-threatening asthma. Other causes include pulmonary edema, sedative drug overdose (such as opiates or benzodiazepines), neuromuscular disease, obesity, or certain medications.
Metabolic alkalosis can occur due to vomiting, potassium depletion (often caused by diuretic usage), Cushing’s syndrome, or Conn’s syndrome.
Metabolic acidosis with a raised anion gap can be caused by conditions like lactic acidosis (which can result from hypoxemia, shock, sepsis, or infarction) or ketoacidosis (commonly seen in diabetes, starvation, or alcohol excess). Other causes include renal failure or poisoning (such as late stages of aspirin overdose, methanol, or ethylene glycol).
Metabolic acidosis with a normal anion gap can be attributed to conditions like renal tubular acidosis, diarrhea, ammonium chloride ingestion, or adrenal insufficiency.
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This question is part of the following fields:
- Mental Health
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Question 80
Incorrect
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A 35-year-old woman is injured in a car crash and sustains severe facial trauma. Imaging tests show that she has a Le Fort III fracture.
What is the most accurate description of the injury pattern seen in a Le Fort III fracture?Your Answer:
Correct Answer: Transverse fracture of the midface
Explanation:Le Fort fractures are complex fractures of the midface that involve the maxillary bone and surrounding structures. These fractures can occur in a horizontal, pyramidal, or transverse direction. The distinguishing feature of Le Fort fractures is the traumatic separation of the pterygomaxillary region. They make up approximately 10% to 20% of all facial fractures and can have severe consequences, both in terms of potential life-threatening injuries and disfigurement.
The Le Fort classification system categorizes midface fractures into three groups based on the plane of injury. As the classification level increases, the location of the maxillary fracture moves from inferior to superior within the maxilla.
Le Fort I fractures are horizontal fractures that occur across the lower aspect of the maxilla. These fractures cause the teeth to separate from the upper face and extend through the lower nasal septum, the lateral wall of the maxillary sinus, and into the palatine bones and pterygoid plates. They are sometimes referred to as a floating palate because they often result in the mobility of the hard palate from the midface. Common accompanying symptoms include facial swelling, loose teeth, dental fractures, and misalignment of the teeth.
Le Fort II fractures are pyramidal-shaped fractures, with the base of the pyramid located at the level of the teeth and the apex at the nasofrontal suture. The fracture line extends from the nasal bridge and passes through the superior wall of the maxilla, the lacrimal bones, the inferior orbital floor and rim, and the anterior wall of the maxillary sinus. These fractures are sometimes called a floating maxilla because they typically result in the mobility of the maxilla from the midface. Common symptoms include facial swelling, nosebleeds, subconjunctival hemorrhage, cerebrospinal fluid leakage from the nose, and widening and flattening of the nasal bridge.
Le Fort III fractures are transverse fractures of the midface. The fracture line passes through the nasofrontal suture, the maxillo frontal suture, the orbital wall, and the zygomatic arch and zygomaticofrontal suture. These fractures cause separation of all facial bones from the cranial base, earning them the nickname craniofacial disjunction or floating face fractures. They are the rarest and most severe type of Le Fort fracture. Common symptoms include significant facial swelling, bruising around the eyes, facial flattening, and the entire face can be shifted.
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This question is part of the following fields:
- Maxillofacial & Dental
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Question 81
Incorrect
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A 65 year old female is brought into the emergency department by her husband following a fall. The patient seems unsure about how the fall occurred. The patient's husband takes you aside to express his growing concern about the patient's memory and overall functioning in the past year. He has previously suggested visiting the doctor about it, but the patient has consistently refused, claiming to be perfectly fine. The patient's husband is worried that the patient might be suffering from dementia. What is the leading cause of dementia?
Your Answer:
Correct Answer: Alzheimer's disease
Explanation:Dementia is a condition characterized by a decline in cognitive abilities, such as memory, thinking, and reasoning, that is severe enough to interfere with daily functioning. There are several different causes of dementia, but the leading cause is Alzheimer’s disease. Alzheimer’s disease is a progressive brain disorder that affects memory, thinking, and behavior. It is the most common cause of dementia, accounting for approximately 60-80% of cases.
Further Reading:
Dementia is a progressive and irreversible clinical syndrome characterized by cognitive and behavioral symptoms. These symptoms include memory loss, impaired reasoning and communication, personality changes, and reduced ability to carry out daily activities. The decline in cognition affects multiple domains of intellectual functioning and is not solely due to normal aging.
To diagnose dementia, a person must have impairment in at least two cognitive domains that significantly impact their daily activities. This impairment cannot be explained by delirium or other major psychiatric disorders. Early-onset dementia refers to dementia that develops before the age of 65.
The most common cause of dementia is Alzheimer’s disease, accounting for 50-75% of cases. Other causes include vascular dementia, dementia with Lewy bodies, and frontotemporal dementia. Less common causes include Parkinson’s disease dementia, Huntington’s disease, prion disease, and metabolic and endocrine disorders.
There are several risk factors for dementia, including age, mild cognitive impairment, genetic predisposition, excess alcohol intake, head injury, depression, learning difficulties, diabetes, obesity, hypertension, smoking, Parkinson’s disease, low social engagement, low physical activity, low educational attainment, hearing impairment, and air pollution.
Assessment of dementia involves taking a history from the patient and ideally a family member or close friend. The person’s current level of cognition and functional capabilities should be compared to their baseline level. Physical examination, blood tests, and cognitive assessment tools can also aid in the diagnosis.
Differential diagnosis for dementia includes normal age-related memory changes, mild cognitive impairment, depression, delirium, vitamin deficiencies, hypothyroidism, adverse drug effects, normal pressure hydrocephalus, and sensory deficits.
Management of dementia involves a multi-disciplinary approach that includes non-pharmacological and pharmacological measures. Non-pharmacological interventions may include driving assessment, modifiable risk factor management, and non-pharmacological therapies to promote cognition and independence. Drug treatments for dementia should be initiated by specialists and may include acetylcholinesterase inhibitors, memantine, and antipsychotics in certain cases.
In summary, dementia is a progressive and irreversible syndrome characterized by cognitive and behavioral symptoms. It has various causes and risk factors, and its management involves a multi-disciplinary approach.
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This question is part of the following fields:
- Neurology
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Question 82
Incorrect
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You are evaluating a 7-year-old girl who recently immigrated from South East Asia. Her parents have expressed concerns about her lack of energy and pale appearance. A complete blood count was conducted, and the results are as follows:
- Hemoglobin (Hb): 4.4 g/dl (normal range: 11.5-14 g/dl)
- Red blood cells (RBC): 2.6 x 1012/l (normal range: 4-5 x 1012/l)
- Mean corpuscular volume (MCV): 59 fl (normal range: 80-100 fl)
- Mean corpuscular hemoglobin (MCH): 21 pg (normal range: 25-35 pg)
- Mean corpuscular hemoglobin concentration (MCHC): 27 g/dl (normal range: 30-37 g/dl)
- Platelets: 466 x 109/l (normal range: 150-400 x 109/l)
- White blood cell count (WCC): 7.4 x 109/l (normal range: 4-11 x 109/l)
The peripheral blood smear reveals evidence of anisocytosis and pencil cells. Based on these findings, what is the most likely diagnosis for this patient?Your Answer:
Correct Answer: Iron deficiency anaemia
Explanation:The complete blood count findings indicate a severe case of iron deficiency anemia. The patient’s red blood cells are significantly reduced in number, and there is a noticeable hypochromic microcytic anemia. When examining the peripheral blood smear, variations in shape (poikilocytosis) and size (anisocytosis) can be observed, which are typical of iron deficiency anemia. Pencil cells are commonly seen in this condition. Additionally, it is common for iron deficiency anemia to be accompanied by thrombocytosis, an increase in platelet count.
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This question is part of the following fields:
- Haematology
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Question 83
Incorrect
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A 3-year-old girl is brought to the Emergency Department by her father after she accidentally spilled a cup of hot tea on her legs and feet. Her upper body is unaffected, but she is crying in agony. Her pain is evaluated using a numerical rating scale, and the triage nurse informs you that she has 'intense pain'.
Which pain relief method is most suitable to be used as a temporary measure until more effective pain relief can be given?Your Answer:
Correct Answer: Inhaled entonox
Explanation:A recent audit conducted by the Royal College of Emergency Medicine (RCEM) in 2018 revealed a concerning decline in the standards of pain management for children with fractured limbs in Emergency Departments (EDs). The audit found that the majority of patients experienced longer waiting times for pain relief compared to previous years. Shockingly, more than 1 in 10 children who presented with significant pain due to a limb fracture did not receive any pain relief at all.
To address this issue, the Agency for Health Care Policy and Research (AHCPR) in the USA recommends following the ABCs of pain management for all patients, including children. This approach involves regularly asking about pain, systematically assessing it, believing the patient and their family in their reports of pain and what relieves it, choosing appropriate pain control options, delivering interventions in a timely and coordinated manner, and empowering patients and their families to have control over their pain management.
The RCEM has established standards that require a child’s pain to be assessed within 15 minutes of their arrival at the ED. This is considered a fundamental standard. Various rating scales are available for assessing pain in children, with the choice depending on the child’s age and ability to use the scale. These scales include the Wong-Baker Faces Pain Rating Scale, Numeric rating scale, and Behavioural scale.
To ensure timely administration of analgesia to children in acute pain, the RCEM has set specific standards. These standards state that 100% of patients in severe pain should receive appropriate analgesia within 60 minutes of their arrival or triage, whichever comes first. Additionally, 75% should receive analgesia within 30 minutes, and 50% within 20 minutes.
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This question is part of the following fields:
- Pain & Sedation
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Question 84
Incorrect
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A 68-year-old individual reports feeling unwell after having their dislocated shoulder reduced while under sedation. You decide to prescribe ondansetron. What is the mechanism of action of ondansetron?
Your Answer:
Correct Answer: 5-HT3 receptor antagonist
Explanation:Ondansetron is a medication that works by blocking serotonin receptors in the body. It is commonly used as a first-line treatment for postoperative nausea and vomiting (PONV), which can occur after procedures done under sedation or anesthesia.
Further Reading:
postoperative nausea and vomiting (PONV) is a common occurrence following procedures performed under sedation or anesthesia. It can be highly distressing for patients. Several risk factors have been identified for PONV, including female gender, a history of PONV or motion sickness, non-smoking status, patient age, use of volatile anesthetics, longer duration of anesthesia, perioperative opioid use, use of nitrous oxide, and certain types of surgery such as abdominal and gynecological procedures.
To manage PONV, antiemetics are commonly used. These medications work by targeting different receptors in the body. Cyclizine and promethazine are histamine H1-receptor antagonists, which block the action of histamine and help reduce nausea and vomiting. Ondansetron is a serotonin 5-HT3 receptor antagonist, which blocks the action of serotonin and is effective in preventing and treating PONV. Prochlorperazine is a dopamine D2 receptor antagonist, which blocks the action of dopamine and helps alleviate symptoms of nausea and vomiting. Metoclopramide is also a dopamine D2 receptor antagonist and a 5-HT3 receptor antagonist, providing dual action against PONV. It is also a 5-HT4 receptor agonist, which helps improve gastric emptying and reduces the risk of PONV.
Assessment and management of PONV involves a comprehensive approach. Healthcare professionals need to assess the patient’s risk factors for PONV and take appropriate measures to prevent its occurrence. This may include selecting the appropriate anesthesia technique, using antiemetics prophylactically, and providing adequate pain control. In cases where PONV does occur, prompt treatment with antiemetics should be initiated to alleviate symptoms and provide relief to the patient. Close monitoring of the patient’s condition and response to treatment is essential to ensure effective management of PONV.
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This question is part of the following fields:
- Basic Anaesthetics
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Question 85
Incorrect
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A 7-year-old girl is brought to the Emergency Department by her father with a high temperature and pain in her ear. During the examination, you observe that the mastoid area is red and there is a soft, painful lump in the same spot. You diagnose her with acute mastoiditis, start her on intravenous antibiotics, and refer her to the ENT team on duty.
Which section of the temporal bone is affected in this situation?Your Answer:
Correct Answer: Petrous part
Explanation:Mastoiditis occurs when a suppurative infection spreads from otitis media, affecting the middle ear, to the mastoid antrum. This infection causes inflammation in the mastoid and surrounding tissues, potentially leading to damage to the bone.
The mastoid antrum, also known as the tympanic antrum, is an air space located in the petrous part of the temporal bone. It connects to the mastoid cells at the back and the epitympanic recess through the aditus to the mastoid antrum.
The mastoid cells come in different types, varying in number and size. There are cellular cells with thin septa, diploeic cells that are marrow spaces with few air cells, and acellular cells that are neither cells nor marrow spaces.
These air spaces serve various functions, including acting as sound receptors, providing voice resonance, offering acoustic insulation and dissipation, protecting against physical damage, and reducing the weight of the cranium.
Overall, mastoiditis occurs when an infection from otitis media spreads to the mastoid antrum, causing inflammation and potential damage to the surrounding tissues and bone. The mastoid antrum and mastoid air cells within the temporal bone play important roles in sound reception, voice resonance, protection, and reducing cranial mass.
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This question is part of the following fields:
- Ear, Nose & Throat
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Question 86
Incorrect
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A 28 year old female comes to the emergency department complaining of a sore throat that has been bothering her for the past 4 days. She denies having any cough or runny nose. During the examination, her temperature is measured at 37.7°C, blood pressure at 120/68 mmHg, and pulse rate at 88 bpm. Erythema is observed in the oropharynx and tonsils. The neck is nontender and no palpable masses are found.
What would be the most appropriate course of action for managing this patient?Your Answer:
Correct Answer: Discharge with self care advice
Explanation:Patients who have a CENTOR score of 0, 1, or 2 should be given advice on self-care and safety measures. In this case, the patient has a CENTOR score of 1/4 and a FeverPAIN score of 1, indicating that antibiotics are not necessary. The patient should be advised to drink enough fluids, use over-the-counter pain relievers like ibuprofen or paracetamol, try salt water gargling or medicated lozenges, and avoid hot drinks as they can worsen the pain. It is important to inform the patient that if they experience difficulty swallowing, develop a fever above 38ºC, or if their symptoms do not improve after 3 days, they should seek reassessment.
Further Reading:
Pharyngitis and tonsillitis are common conditions that cause inflammation in the throat. Pharyngitis refers to inflammation of the oropharynx, which is located behind the soft palate, while tonsillitis refers to inflammation of the tonsils. These conditions can be caused by a variety of pathogens, including viruses and bacteria. The most common viral causes include rhinovirus, coronavirus, parainfluenza virus, influenza types A and B, adenovirus, herpes simplex virus type 1, and Epstein Barr virus. The most common bacterial cause is Streptococcus pyogenes, also known as Group A beta-hemolytic streptococcus (GABHS). Other bacterial causes include Group C and G beta-hemolytic streptococci and Fusobacterium necrophorum.
Group A beta-hemolytic streptococcus is the most concerning pathogen as it can lead to serious complications such as rheumatic fever and glomerulonephritis. These complications can occur due to an autoimmune reaction triggered by antigen/antibody complex formation or from cell damage caused by bacterial exotoxins.
When assessing a patient with a sore throat, the clinician should inquire about the duration and severity of the illness, as well as associated symptoms such as fever, malaise, headache, and joint pain. It is important to identify any red flags and determine if the patient is immunocompromised. Previous non-suppurative complications of Group A beta-hemolytic streptococcus infection should also be considered, as there is an increased risk of further complications with subsequent infections.
Red flags that may indicate a more serious condition include severe pain, neck stiffness, or difficulty swallowing. These symptoms may suggest epiglottitis or a retropharyngeal abscess, which require immediate attention.
To determine the likelihood of a streptococcal infection and the need for antibiotic treatment, two scoring systems can be used: CENTOR and FeverPAIN. The CENTOR criteria include tonsillar exudate, tender anterior cervical lymphadenopathy or lymphadenitis, history of fever, and absence of cough. The FeverPAIN criteria include fever, purulence, rapid onset of symptoms, severely inflamed tonsils, and absence of cough or coryza. Based on the scores from these criteria, the likelihood of a streptococcal infection can be estimated, and appropriate management can be undertaken. can
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This question is part of the following fields:
- Ear, Nose & Throat
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Question 87
Incorrect
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A 62 year old male comes to the emergency department with a chief complaint of experiencing dizziness upon movement. The patient states that the symptoms began today when he got up from bed. He describes the dizzy spells as a sensation of the room spinning and they typically last for around 30 seconds. The patient also mentions feeling nauseous during these episodes. There are no reported issues with hearing loss or tinnitus.
What is the most probable diagnosis?Your Answer:
Correct Answer: Benign paroxysmal positional vertigo
Explanation:BPPV is a condition where dizziness and vertigo occur suddenly when the position of the head is changed. This is a common symptom of benign paroxysmal positional vertigo, which is characterized by episodes of vertigo triggered by head movements.
Further Reading:
Benign paroxysmal positional vertigo (BPPV) is a common cause of vertigo, characterized by sudden dizziness and vertigo triggered by changes in head position. It typically affects individuals over the age of 55 and is less common in younger patients. BPPV is caused by dysfunction in the inner ear, specifically the detachment of otoliths (calcium carbonate particles) from the utricular otolithic membrane. These loose otoliths move through the semicircular canals, triggering a sensation of movement and resulting in conflicting sensory inputs that cause vertigo.
The majority of BPPV cases involve otoliths in the posterior semicircular canal, followed by the inferior semicircular canal. BPPV in the anterior semicircular canals is rare. Clinical features of BPPV include vertigo triggered by head position changes, such as rolling over in bed or looking upwards, accompanied by nausea. Episodes of vertigo typically last 10-20 seconds and can be diagnosed through positional nystagmus, which is a specific eye movement, observed during diagnostic maneuvers like the Dix-Hallpike maneuver.
Hearing loss and tinnitus are not associated with BPPV. The prognosis for BPPV is generally good, with spontaneous resolution occurring within a few weeks to months. Symptomatic relief can be achieved through the Epley maneuver, which is successful in around 80% of cases, or patient home exercises like the Brandt-Daroff exercises. Medications like Betahistine may be prescribed but have limited effectiveness in treating BPPV.
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This question is part of the following fields:
- Ear, Nose & Throat
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Question 88
Incorrect
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A 35-year-old woman from East Africa presents with haematuria. Urine specimens are sent, and a diagnosis of schistosomiasis is made.
What is the SINGLE most likely causative organism?Your Answer:
Correct Answer: Schistosoma haematobium
Explanation:Schistosomiasis, also known as bilharzia, is a tropical disease caused by parasitic trematodes (flukes) of the Schistosoma type. The transmission of this disease occurs when water becomes contaminated with faeces or urine containing eggs, and a specific freshwater snail serves as the intermediate host. Human contact with water inhabited by the intermediate host snail is necessary for transmission to occur.
There are five species of Schistosoma that can cause human disease: S. japonicum, S. mansoni, S. haematobium, S. intercalatum, and S. mekongi. Among these, S. japonicum and S. mansoni are the most significant causes of intestinal schistosomiasis, while S. haematobium is the primary cause of urogenital schistosomiasis.
Urogenital schistosomiasis occurs when adult worms migrate from their initial site in the liver to the vesical plexus. The presence of blood in the urine, known as haematuria, is a characteristic sign of urogenital schistosomiasis. In women, this condition may manifest with genital and vaginal lesions, as well as dyspareunia. pathology in the seminal vesicles and prostate. Advanced cases of urogenital schistosomiasis can result in fibrosis of the ureter and bladder, as well as kidney damage. Complications such as bladder cancer and infertility are also recognized in association with this disease.
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This question is part of the following fields:
- Urology
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Question 89
Incorrect
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A 35 year old female presents to the emergency department following a motor vehicle collision. Which system should be utilized to evaluate the potential for cervical spine injury?
Your Answer:
Correct Answer: Canadian C-spine rules
Explanation:When a 35-year-old female comes to the emergency department after a motor vehicle collision, it is important to assess the potential for cervical spine injury. To do this, the Canadian C-spine rules should be utilized. These rules provide a systematic approach to determine whether imaging, such as X-rays, is necessary to evaluate the cervical spine. The Canadian C-spine rules take into account various factors such as the patient’s age, mechanism of injury, and presence of certain symptoms or physical findings. By following these rules, healthcare professionals can effectively evaluate the potential for cervical spine injury and determine the appropriate course of action for further assessment and management.
Further Reading:
When assessing for cervical spine injury, it is recommended to use the Canadian C-spine rules. These rules help determine the risk level for a potential injury. High-risk factors include being over the age of 65, experiencing a dangerous mechanism of injury (such as a fall from a height or a high-speed motor vehicle collision), or having paraesthesia in the upper or lower limbs. Low-risk factors include being involved in a minor rear-end motor vehicle collision, being comfortable in a sitting position, being ambulatory since the injury, having no midline cervical spine tenderness, or experiencing a delayed onset of neck pain. If a person is unable to actively rotate their neck 45 degrees to the left and right, their risk level is considered low. If they have one of the low-risk factors and can actively rotate their neck, their risk level remains low.
If a high-risk factor is identified or if a low-risk factor is identified and the person is unable to actively rotate their neck, full in-line spinal immobilization should be maintained and imaging should be requested. Additionally, if a patient has risk factors for thoracic or lumbar spine injury, imaging should be requested. However, if a patient has low-risk factors for cervical spine injury, is pain-free, and can actively rotate their neck, full in-line spinal immobilization and imaging are not necessary.
NICE recommends CT as the primary imaging modality for cervical spine injury in adults aged 16 and older, while MRI is recommended as the primary imaging modality for children under 16.
Different mechanisms of spinal trauma can cause injury to the spine in predictable ways. The majority of cervical spine injuries are caused by flexion combined with rotation. Hyperflexion can result in compression of the anterior aspects of the vertebral bodies, stretching and tearing of the posterior ligament complex, chance fractures (also known as seatbelt fractures), flexion teardrop fractures, and odontoid peg fractures. Flexion and rotation can lead to disruption of the posterior ligament complex and posterior column, fractures of facet joints, lamina, transverse processes, and vertebral bodies, and avulsion of spinous processes. Hyperextension can cause injury to the anterior column, anterior fractures of the vertebral body, and potential retropulsion of bony fragments or discs into the spinal canal. Rotation can result in injury to the posterior ligament complex and facet joint dislocation.
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This question is part of the following fields:
- Trauma
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Question 90
Incorrect
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A 45-year-old woman with no permanent address sustains a head injury after falling. As part of her evaluation, you order a complete set of blood tests and a CT scan of the head. The blood tests reveal abnormal liver function and macrocytic anemia. The CT scan of the head appears normal, but an MRI performed later shows small petechial hemorrhages in the mamillary bodies.
During her hospital stay, she receives a treatment that worsens her condition, leading to acute confusion. Upon examination, you observe an unsteady gait, peripheral neuropathy, and bilateral abducens nerve palsies.
Which medication should be urgently administered to this patient?Your Answer:
Correct Answer: Intravenous Pabrinex
Explanation:This patient has developed Wernicke’s encephalopathy, a condition that is associated with alcohol abuse and other causes of thiamine deficiency. It is important to note that the infusion of glucose-containing intravenous fluids without thiamine in a patient with chronic thiamine deficiency can trigger Wernicke’s encephalopathy. In this particular case, it seems that this is what has occurred.
Wernicke’s encephalopathy is typically characterized by a triad of symptoms, which include acute confusion, ophthalmoplegia, and ataxia. Additionally, other possible features of this condition may include papilloedema, hearing loss, apathy, dysphagia, memory impairment, and hypothermia. It is also common for peripheral neuropathy, primarily affecting the legs, to occur in the majority of cases.
This condition is characterized by the presence of acute capillary haemorrhages, astrocytosis, and neuronal death in the upper brainstem and diencephalon. These abnormalities can be visualized through MRI scanning, although CT scanning is not very useful for diagnosis.
If left untreated, most patients with Wernicke’s encephalopathy will go on to develop a Korsakoff psychosis. This condition is characterized by retrograde amnesia, an inability to form new memories, disordered time perception, and confabulation.
Patients who are suspected to have Wernicke’s encephalopathy should be promptly treated with parenteral thiamine (such as Pabrinex) for a minimum of 5 days. Following the parenteral therapy, oral thiamine should be administered.
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This question is part of the following fields:
- Neurology
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Question 91
Incorrect
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A 45-year-old woman was involved in a car accident where her car collided with a tree at high speed. She was not wearing a seatbelt and was thrown forward onto the steering wheel of her car. She has bruising over her anterior chest wall and is experiencing chest pain. Her chest X-ray in the emergency room reveals evidence of a traumatic aortic injury.
Which of the following fractures are most indicative of this injury?Your Answer:
Correct Answer: 1st and 2nd ribs
Explanation:Traumatic aortic rupture, also known as traumatic aortic disruption or transection, occurs when the aorta is torn or ruptured due to physical trauma. This condition often leads to sudden death because of severe bleeding. Motor vehicle accidents and falls from great heights are the most common causes of this injury.
The patients with the highest chances of survival are those who have an incomplete tear near the ligamentum arteriosum of the proximal descending aorta, close to where the left subclavian artery branches off. The presence of an intact adventitial layer or contained mediastinal hematoma helps maintain continuity and prevents immediate bleeding and death. If promptly identified and treated, survivors of these injuries can recover. In cases where traumatic aortic rupture leads to sudden death, approximately 50% of patients have damage at the aortic isthmus, while around 15% have damage in either the ascending aorta or the aortic arch.
Initial chest X-rays may show signs consistent with a traumatic aortic injury. However, false-positive and false-negative results can occur, and sometimes there may be no abnormalities visible on the X-ray. Some of the possible X-ray findings include a widened mediastinum, hazy left lung field, obliteration of the aortic knob, fractures of the 1st and 2nd ribs, deviation of the trachea to the right, presence of a pleural cap, elevation and rightward shift of the right mainstem bronchus, depression of the left mainstem bronchus, obliteration of the space between the pulmonary artery and aorta, and deviation of the esophagus or NG tube to the right.
A helical contrast-enhanced CT scan of the chest is the preferred initial investigation for suspected blunt aortic injury. It has proven to be highly accurate, with close to 100% sensitivity and specificity. CT scanning should be performed liberally, as chest X-ray findings can be unreliable. However, hemodynamically unstable patients should not be placed in a CT scanner. If the CT results are inconclusive, aortography or trans-oesophageal echo can be performed for further evaluation.
Immediate surgical intervention is necessary for these injuries. Endovascular repair is the most common method used and has excellent short-term outcomes. Open repair may also be performed depending on the circumstances. It is important to control heart rate and blood pressure during stabilization to reduce the risk of rupture. Pain should be managed with appropriate analgesic
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This question is part of the following fields:
- Trauma
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Question 92
Incorrect
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A 35-year-old man with a known history of alcohol dependency (consuming over 1L of whisky daily) and liver cirrhosis comes to the hospital with worsening ascites and abdominal pain. He is experiencing encephalopathy and has had multiple episodes of diarrhea today. His vital signs are as follows: heart rate of 116, blood pressure of 100/68, and a temperature of 38.9oC. Upon examination, he has significant ascites and generalized abdominal tenderness.
What is the most likely diagnosis in this case?Your Answer:
Correct Answer: Spontaneous bacterial peritonitis
Explanation:Spontaneous bacterial peritonitis (SBP) is a sudden bacterial infection of the fluid in the abdomen. It typically occurs in patients with high blood pressure in the portal vein, and about 70% of cases are seen in patients with severe liver disease. In any given year, around 30% of patients with fluid buildup in the abdomen will develop SBP.
SBP can present with a wide range of symptoms, so it’s important to be vigilant when caring for patients with fluid buildup in the abdomen, especially if there is a sudden decline in their condition. Some patients may not show any symptoms at all.
Common clinical features of SBP include fever (80% of cases), abdominal pain (70% of cases), worsening or unexplained confusion due to liver dysfunction, diarrhea, nausea and vomiting, and bowel obstruction.
There are several factors that increase the risk of developing SBP, including severe liver disease (Child-Pugh class C), gastrointestinal bleeding, urinary tract infection, excessive growth of bacteria in the intestines, presence of indwelling lines such as central venous catheters or urinary catheters, previous episodes of SBP, and low levels of protein in the fluid buildup in the abdomen.
To diagnose SBP, a procedure called abdominal paracentesis is performed to collect fluid from the abdomen. The following findings on fluid analysis strongly suggest SBP: total white blood cell count in the fluid greater than 500 cells/µL, total neutrophil count in the fluid greater than 250 cells/µL, lactate level in the fluid higher than 25 mg/dL, pH of the fluid below 7.35, and presence of bacteria on Gram-stain.
Patients with SBP should be admitted to the hospital and treated with broad-spectrum antibiotics. The preferred antibiotic is an intravenous third-generation cephalosporin, such as Ceftriaxone. If the patient is allergic to beta-lactam antibiotics, ciprofloxacin can be considered as an alternative. Administration of intravenous albumin has been shown to reduce the risk of kidney failure and death.
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This question is part of the following fields:
- Gastroenterology & Hepatology
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Question 93
Incorrect
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A 14-year-old girl comes in with a sudden onset of a painful throat that has been bothering her for the past day. She has no history of coughing or cold symptoms. During the examination, her temperature is measured at 38.5°C, and there is visible exudate on her right tonsil, which also appears to be swollen and red. No anterior cervical lymph nodes can be felt. What is her FeverPAIN Score for assessing her sore throat?
Your Answer:
Correct Answer: 5
Explanation:Two scoring systems are suggested by NICE to aid in the evaluation of sore throat: The Centor Clinical Prediction Score and The FeverPAIN Score.
The FeverPAIN score was developed from a study involving 1760 adults and children aged three and above. The score was tested in a trial that compared three prescribing strategies: empirical delayed prescribing, using the score to guide prescribing, or a combination of the score with the use of a near-patient test (NPT) for streptococcus. Utilizing the score resulted in faster symptom resolution and a reduction in the prescription of antibiotics (both reduced by one third). The inclusion of the NPT did not provide any additional benefit.
The score comprises of five factors, each of which is assigned one point: Fever (Temp >38°C) in the last 24 hours, Purulence, Attended rapidly in under three days, Inflamed tonsils, and No cough or coryza.
Based on the score, the recommendations are as follows:
– Score 0-1 = 13-18% likelihood of streptococcus infection, antibiotics are not recommended.
– Score 2-3 = 34-40% likelihood of streptococcus infection, consider delayed prescribing of antibiotics (3-5 day ‘backup prescription’).
– Score 4-5 = 62-65% likelihood of streptococcus infection, use immediate antibiotics if severe, or a 48-hour short ‘backup prescription.’ -
This question is part of the following fields:
- Ear, Nose & Throat
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Question 94
Incorrect
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A 32-year-old woman is brought to the Emergency Department by ambulance due to 'severe palpitations.' Her heart rate is 180 bpm, and her rhythm strip is suggestive of supraventricular tachycardia. You plan to administer adenosine.
Which of the following is NOT a contraindication to the use of adenosine?Your Answer:
Correct Answer: History of heart transplant
Explanation:Adenosine is a type of purine nucleoside that is primarily utilized in the diagnosis and treatment of paroxysmal supraventricular tachycardia. Its main mechanism of action involves stimulating A1-adenosine receptors and opening acetylcholine-sensitive potassium channels. This leads to hyperpolarization of the cell membrane in the atrioventricular (AV) node and slows down conduction in the AV node by inhibiting calcium channels.
When administering adenosine, it is given rapidly through an intravenous bolus, followed by a saline flush. The initial dose for adults is 6 mg, and if necessary, additional doses of 12 mg or 18 mg can be given at 1-2 minute intervals until the desired effect is observed. It is important to note that the latest ALS guidelines recommend 18 mg for the third dose, while the BNF/NICE guidelines suggest 12 mg.
One of the advantages of adenosine is its very short half-life, which is less than 10 seconds. This means that its effects are rapid, typically occurring within 10 seconds. However, the duration of action is also short, lasting only 10-20 seconds. Due to its short half-life, any side effects experienced are usually brief. These side effects may include a sense of impending doom, facial flushing, dyspnea, chest discomfort, and a metallic taste.
There are certain contraindications to the use of adenosine. These include 2nd or 3rd degree AV block, sick sinus syndrome, long QT syndrome, severe hypotension, decompensated heart failure, chronic obstructive lung disease, and asthma. It is important to exercise caution when administering adenosine to patients with a heart transplant, as they are particularly sensitive to its effects. In these cases, a reduced initial dose of 3 mg is recommended, followed by 6 mg and then 12 mg.
It is worth noting that the effects of adenosine can be potentiated by dipyridamole, a medication commonly used in combination with adenosine. Therefore, the dose of adenosine should be adjusted and reduced in patients who are also taking dipyridamole.
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This question is part of the following fields:
- Cardiology
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Question 95
Incorrect
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A 60-year-old woman presents with worsening symptoms of shortness of breath. Upon examination of her cardiovascular system, you find a collapsing pulse. Her apex beat is hyperkinetic and displaced to the side. During auscultation, you detect an early diastolic murmur that is most pronounced when the patient is sitting forward and exhaling.
What is the SINGLE most probable diagnosis?Your Answer:
Correct Answer: Aortic regurgitation
Explanation:Aortic regurgitation is a condition where the aortic valve fails to close tightly, resulting in the backflow of blood from the aorta into the left ventricle during ventricular diastole. This valvular lesion presents with various clinical symptoms and signs.
The clinical symptoms of aortic regurgitation include exertional dyspnea, orthopnea, and paroxysmal nocturnal dyspnea. These symptoms are experienced by patients during physical activity, while lying flat, and during episodes of sudden nighttime breathlessness, respectively.
On the other hand, the clinical signs of aortic regurgitation can be observed during physical examination. These signs include a collapsing pulse, widened pulse pressure, hyperkinetic laterally displaced apex beat, and a thrill in the aortic area. Additionally, an early diastolic murmur can be heard, which is loudest at the lower left sternal edge when the patient is sitting forward and exhaling.
Aortic regurgitation is also associated with several eponymous signs, which are named after the physicians who first described them. These signs include Corrigan’s sign, which is characterized by visible and forceful neck pulsation. De Musset’s sign refers to head nodding in time with the heartbeat. Quincke’s sign is the observation of visible nail bed capillary pulsation. Duroziez’s sign is the presence of a diastolic murmur heard proximal to femoral artery compression. Traube’s sign is the perception of a pistol shot sound over the femoral arteries. The Lighthouse sign is the blanching and flushing of the forehead. Becker’s sign is the pulsation seen in retinal vessels. Rosenbach’s sign is the presence of a pulsatile liver. Lastly, Muller’s sign refers to pulsations of the uvula.
In summary, aortic regurgitation is a valvular lesion that leads to the incomplete closure of the aortic valve. It manifests with various clinical symptoms, signs, and eponymous findings, which can be identified through careful examination and observation.
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This question is part of the following fields:
- Cardiology
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Question 96
Incorrect
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A 25 year old patient is brought into the resuscitation bay by paramedics after being pulled from a lake. The patient initially had a core temperature of 29.2ºC. CPR is underway. The patient's core temperature is rechecked after warming measures are introduced and the core temperature has increased to 32.5ºC. What changes, if any, would you make to administration of adrenaline during CPR in a patient with a core temperature of 32.5ºC compared to someone with a normal core temperature?
Your Answer:
Correct Answer: Interval between doses doubled
Explanation:When performing CPR on patients with a core temperature of 30-35°C, it is recommended to double the interval between IV drug doses compared to what is used for normothermic patients. However, if the core temperature is above 35°C, standard drug protocols should be followed.
Further Reading:
Cardiopulmonary arrest is a serious event with low survival rates. In non-traumatic cardiac arrest, only about 20% of patients who arrest as an in-patient survive to hospital discharge, while the survival rate for out-of-hospital cardiac arrest is approximately 8%. The Resus Council BLS/AED Algorithm for 2015 recommends chest compressions at a rate of 100-120 per minute with a compression depth of 5-6 cm. The ratio of chest compressions to rescue breaths is 30:2.
After a cardiac arrest, the goal of patient care is to minimize the impact of post cardiac arrest syndrome, which includes brain injury, myocardial dysfunction, the ischaemic/reperfusion response, and the underlying pathology that caused the arrest. The ABCDE approach is used for clinical assessment and general management. Intubation may be necessary if the airway cannot be maintained by simple measures or if it is immediately threatened. Controlled ventilation is aimed at maintaining oxygen saturation levels between 94-98% and normocarbia. Fluid status may be difficult to judge, but a target mean arterial pressure (MAP) between 65 and 100 mmHg is recommended. Inotropes may be administered to maintain blood pressure. Sedation should be adequate to gain control of ventilation, and short-acting sedating agents like propofol are preferred. Blood glucose levels should be maintained below 8 mmol/l. Pyrexia should be avoided, and there is some evidence for controlled mild hypothermia but no consensus on this.
Post ROSC investigations may include a chest X-ray, ECG monitoring, serial potassium and lactate measurements, and other imaging modalities like ultrasonography, echocardiography, CTPA, and CT head, depending on availability and skills in the local department. Treatment should be directed towards the underlying cause, and PCI or thrombolysis may be considered for acute coronary syndrome or suspected pulmonary embolism, respectively.
Patients who are comatose after ROSC without significant pre-arrest comorbidities should be transferred to the ICU for supportive care. Neurological outcome at 72 hours is the best prognostic indicator of outcome.
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This question is part of the following fields:
- Environmental Emergencies
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Question 97
Incorrect
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A 4-year-old boy has been seen by one of your colleagues a few days earlier due to a persistent cough and fever that he has had for the past 10 days. The cough is a harsh, hacking cough and tends to occur in short bursts. Your colleague suspected a diagnosis of whooping cough and organized for a nasopharyngeal swab to be sent for culture.
You review the child today with his parents having received notification from the lab that the child has a confirmed diagnosis of whooping cough. He lives with his parents and has a younger sister who is 2 years old. The mother is currently 36 weeks pregnant. The sister is up-to-date with all of her vaccinations as per the current US vaccination schedule.
Which members of the household should receive chemoprophylaxis?Your Answer:
Correct Answer: The mother, father, and brother
Explanation:Whooping cough is a respiratory infection caused by the bacteria Bordetella pertussis. It is highly contagious and spreads to about 90% of close household contacts. Public Health England (PHE) has identified two priority groups for managing whooping cough contacts. Group 1 includes infants under one year who have received less than three doses of the pertussis vaccine and are at risk of severe infection. Group 2 includes pregnant women at 32 weeks or more, healthcare workers dealing with infants and pregnant women, individuals working with unvaccinated infants under 4 months old, and individuals living with unvaccinated infants under 4 months old.
According to current guidelines, antibiotic prophylaxis with a macrolide antibiotic like erythromycin should only be given to close contacts if the following criteria are met: the index case has had symptoms within the past 21 days and there is a close contact in one of the priority groups. If both criteria are met, all contacts, regardless of age and vaccination status, should be offered chemoprophylaxis. In this case, the mother falls into group 2, so the recommended action is to provide chemoprophylaxis to all household contacts, including the mother, father, and brother. Additionally, those who receive chemoprophylaxis should also consider immunization or a booster dose based on their current vaccination status.
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This question is part of the following fields:
- Respiratory
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Question 98
Incorrect
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You evaluate a 30-year-old female patient with sickle-cell disease. She presents with dyspnea and pain in her lower extremities.
Which ONE statement about sickle-cell disease is accurate?Your Answer:
Correct Answer: Cholelithiasis is a recognised complication
Explanation:HbAS is known as Sickle cell trait, while HbSS is the genotype for Sickle-cell disease. Sickle-shaped red blood cells have a shorter lifespan of 10-20 days compared to the normal red blood cells that live for 90-120 days. Cholelithiasis, a complication of sickle-cell disease, occurs due to excessive bilirubin production caused by the breakdown of red blood cells. The inheritance pattern of sickle-cell disease is autosomal recessive. The disease is caused by a point mutation in the beta-globin chain of hemoglobin, resulting in the substitution of glutamic acid with valine at the sixth position. Individuals with one normal hemoglobin gene and one sickle gene have the genotype HbAS, which is commonly referred to as Sickle Cell trait.
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This question is part of the following fields:
- Haematology
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Question 99
Incorrect
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Your consultant requests you to arrange a teaching session on secondary causes of hypertension. Which of the subsequent electrolyte abnormalities would be in line with a diagnosis of Conn's syndrome?
Your Answer:
Correct Answer: Hypokalaemia and hypernatraemia
Explanation:Patients with primary hyperaldosteronism typically present with hypertension and hypokalemia. This is due to the fact that aldosterone encourages the reabsorption of sodium and the excretion of potassium, leading to an imbalance in these electrolytes. Additionally, hypernatremia, or high levels of sodium in the blood, is often observed in these patients.
Further Reading:
Hyperaldosteronism is a condition characterized by excessive production of aldosterone by the adrenal glands. It can be classified into primary and secondary hyperaldosteronism. Primary hyperaldosteronism, also known as Conn’s syndrome, is typically caused by adrenal hyperplasia or adrenal tumors. Secondary hyperaldosteronism, on the other hand, is a result of high renin levels in response to reduced blood flow across the juxtaglomerular apparatus.
Aldosterone is the main mineralocorticoid steroid hormone produced by the adrenal cortex. It acts on the distal renal tubule and collecting duct of the nephron, promoting the reabsorption of sodium ions and water while secreting potassium ions.
The causes of hyperaldosteronism vary depending on whether it is primary or secondary. Primary hyperaldosteronism can be caused by adrenal adenoma, adrenal hyperplasia, adrenal carcinoma, or familial hyperaldosteronism. Secondary hyperaldosteronism can be caused by renal artery stenosis, reninoma, renal tubular acidosis, nutcracker syndrome, ectopic tumors, massive ascites, left ventricular failure, or cor pulmonale.
Clinical features of hyperaldosteronism include hypertension, hypokalemia, metabolic alkalosis, hypernatremia, polyuria, polydipsia, headaches, lethargy, muscle weakness and spasms, and numbness. It is estimated that hyperaldosteronism is present in 5-10% of patients with hypertension, and hypertension in primary hyperaldosteronism is often resistant to drug treatment.
Diagnosis of hyperaldosteronism involves various investigations, including U&Es to assess electrolyte disturbances, aldosterone-to-renin plasma ratio (ARR) as the gold standard diagnostic test, ECG to detect arrhythmia, CT/MRI scans to locate adenoma, fludrocortisone suppression test or oral salt testing to confirm primary hyperaldosteronism, genetic testing to identify familial hyperaldosteronism, and adrenal venous sampling to determine lateralization prior to surgery.
Treatment of primary hyperaldosteronism typically involves surgical adrenalectomy for patients with unilateral primary aldosteronism. Diet modification with sodium restriction and potassium supplementation may also be recommended.
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This question is part of the following fields:
- Endocrinology
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Question 100
Incorrect
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A 3-year-old girl presents with stridor and a barking cough. Her mother reports that she has had a slight cold for a few days and her voice had been hoarse. Her vital signs are as follows: temperature 38.1°C, heart rate 135, respiratory rate 30, oxygen saturation 97% on room air. Her chest examination is unremarkable, but you observe the presence of stridor at rest.
What is the SINGLE most probable diagnosis?Your Answer:
Correct Answer: Croup
Explanation:Croup, also known as laryngo-tracheo-bronchitis, is typically caused by the parainfluenza virus. Other viruses such as rhinovirus, influenza, and respiratory syncytial viruses can also be responsible. Before the onset of stridor, there is often a mild cold-like illness that lasts for 1-2 days. Symptoms usually reach their peak within 1-3 days, with the cough often being more troublesome at night. A milder cough may persist for another 7-10 days.
A distinctive feature of croup is a barking cough, but it does not indicate the severity of the condition. To reduce airway swelling, dexamethasone and prednisolone are commonly prescribed. If a child is experiencing vomiting, nebulized budesonide can be used as an alternative. However, it is important to note that steroids do not shorten the duration of the illness. In severe cases, nebulized adrenaline can be administered.
Hospitalization for croup is uncommon and typically reserved for children who are experiencing worsening respiratory distress or showing signs of drowsiness or agitation.
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This question is part of the following fields:
- Respiratory
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Question 101
Incorrect
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A 65 year old is brought to the emergency department due to confusion and mild fever. It is suspected that the patient has a urinary tract infection. The patient's family member informs you that the patient takes warfarin for atrial fibrillation but is unsure if they have taken it correctly due to confusion. An INR test is conducted and the result comes back as 8.2.
What would be the most suitable course of action?Your Answer:
Correct Answer: Give vitamin K 1 mg by mouth
Explanation:When the INR (International Normalized Ratio) is above 8 but there is no sign of bleeding, the usual approach is to stop administering warfarin and instead provide oral vitamin K. If the INR is below 8 and there is no evidence of bleeding, it is appropriate to discontinue warfarin. However, if there is evidence of bleeding or the INR exceeds 8, reversal agents are administered. In cases where the INR is greater than 8 without any bleeding, oral vitamin K is typically prescribed at a dosage of 1-5 mg.
Further Reading:
Management of High INR with Warfarin
Major Bleeding:
– Stop warfarin immediately.
– Administer intravenous vitamin K 5 mg.
– Administer 25-50 u/kg four-factor prothrombin complex concentrate.
– If prothrombin complex concentrate is not available, consider using fresh frozen plasma (FFP).
– Seek medical attention promptly.INR > 8.0 with Minor Bleeding:
– Stop warfarin immediately.
– Administer intravenous vitamin K 1-3mg.
– Repeat vitamin K dose if INR remains high after 24 hours.
– Restart warfarin when INR is below 5.0.
– Seek medical advice if bleeding worsens or persists.INR > 8.0 without Bleeding:
– Stop warfarin immediately.
– Administer oral vitamin K 1-5 mg using the intravenous preparation orally.
– Repeat vitamin K dose if INR remains high after 24 hours.
– Restart warfarin when INR is below 5.0.
– Seek medical advice if any symptoms or concerns arise.INR 5.0-8.0 with Minor Bleeding:
– Stop warfarin immediately.
– Administer intravenous vitamin K 1-3mg.
– Restart warfarin when INR is below 5.0.
– Seek medical advice if bleeding worsens or persists.INR 5.0-8.0 without Bleeding:
– Withhold 1 or 2 doses of warfarin.
– Reduce subsequent maintenance dose.
– Monitor INR closely and seek medical advice if any concerns arise.Note: In cases of intracranial hemorrhage, prothrombin complex concentrate should be considered as it is faster acting than fresh frozen plasma (FFP).
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This question is part of the following fields:
- Haematology
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Question 102
Incorrect
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A 32-year-old woman presents with symptoms of painful urination and frequent urination. She is currently 16 weeks pregnant. A urine dipstick test reveals the presence of blood, protein, white blood cells, and nitrites. Based on her history of chronic kidney disease and an eGFR of 38 ml/minute, you diagnose her with a urinary tract infection (UTI) and decide to prescribe antibiotics. However, there are no culture or sensitivity results available. Which of the following antibiotics would be the most appropriate choice in this situation?
Your Answer:
Correct Answer: Cefalexin
Explanation:For the treatment of pregnant women with lower urinary tract infections (UTIs), it is recommended to provide them with an immediate prescription for antibiotics. It is important to consider their previous urine culture and susceptibility results, as well as any prior use of antibiotics that may have contributed to the development of resistant bacteria. Before starting antibiotics, it is advised to obtain a midstream urine sample from pregnant women and send it for culture and susceptibility testing.
Once the microbiological results are available, it is necessary to review the choice of antibiotic. If the bacteria are found to be resistant, it is recommended to switch to a narrow-spectrum antibiotic whenever possible. The choice of antibiotics for pregnant women aged 12 years and over is summarized below:
First-choice:
– Nitrofurantoin 100 mg modified-release taken orally twice daily for 3 days, if the estimated glomerular filtration rate (eGFR) is above 45 ml/minute.Second-choice (if there is no improvement in lower UTI symptoms with the first-choice antibiotic for at least 48 hours, or if the first-choice is not suitable):
– Amoxicillin 500 mg taken orally three times daily for 7 days (only if culture results are available and show susceptibility).
– Cefalexin 500 mg taken twice daily for 7 days.For alternative second-choice antibiotics, it is recommended to consult a local microbiologist and choose the appropriate antibiotics based on the culture and sensitivity results.
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This question is part of the following fields:
- Urology
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Question 103
Incorrect
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A 42-year-old carpenter presents with a sudden onset of severe pain in his left wrist. He recently started taking bendroflumethiazide to help with his ankle swelling. He is overweight with a BMI of 36 kg/m2 and admits to drinking a few beers most nights. He describes the pain as unbearable and it was at its worst in the first 8-10 hours. On examination, his left wrist is swollen, hot, and extremely tender. The skin over the area is red.
What is the most likely diagnosis for this patient?Your Answer:
Correct Answer: Gout
Explanation:Gout is a form of arthritis that causes a swollen, tender, red, and hot joint. Initially, it was believed to primarily affect wealthy individuals due to dietary connections, but it is now becoming more prevalent and is estimated to impact around 1-2% of the Western population. This increase may be attributed to longer lifespans and changes in our eating habits. Additionally, there is a positive correlation between the rising rates of metabolic disease and gout.
While gout commonly affects the metatarsal-phalangeal joint of the big toe (approximately 50% of cases), it can also impact other joints such as the fingers, wrists, knees, and ankles. The pain experienced during an episode is often excruciating, and these episodes typically last about a week. Approximately half of the patients experience a recurrence within a year.
Hyperuricemia is the underlying cause of gout. Uric acid, a byproduct of purine metabolism, is typically eliminated through the kidneys. However, in about 90% of cases, hyperuricemia occurs due to the under-excretion of urate, while the remaining 10% is caused by overproduction. Elevated urate levels increase the likelihood of crystal formation. Measuring uric acid levels in the blood can be misleading, as some individuals with high levels do not develop gout, and levels can be normal during an attack. The crystallization process is complex and more likely to occur in cooler temperatures (which is why the feet are often affected, and symptoms worsen at night), during acidosis, and when there are rapid fluctuations in uric acid levels.
Diagnosing gout is primarily based on clinical evaluation. If there is a rapid onset of severe pain, swelling, and tenderness that reaches its peak within 6-12 hours, accompanied by redness, it strongly suggests crystal inflammation. The presence of monosodium urate crystals in synovial fluid or tophi confirms the diagnosis. When these crystals are examined under polarized light, they exhibit negative birefringence. Since gout symptoms can be mistaken for septic arthritis, if there is uncertainty in the diagnosis and the joint has been aspirated, it should also be sent for gram-staining.
Tophi are painless, hard lumps that develop when hyperuricemia persists for an extended period. They often appear on the elbows and ears.
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This question is part of the following fields:
- Musculoskeletal (non-traumatic)
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