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Question 1
Incorrect
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A 70-year-old woman is prescribed amlodipine 5mg once daily for hypertension. She has no significant medical history and her routine blood tests (including fasting glucose) and ECG were unremarkable.
What is the recommended target blood pressure for her while on amlodipine treatment?Your Answer: < 140/90 mmHg
Correct Answer:
Explanation:The recommended blood pressure target for individuals under 80 years old during a clinic reading is 140/90 mmHg. However, the Quality and Outcomes Framework (QOF) indicator for GPs practicing in England specifies a slightly higher target of below 150/90 mmHg.
Hypertension, or high blood pressure, is a common condition that can lead to serious health problems if left untreated. The National Institute for Health and Care Excellence (NICE) has published updated guidelines for the management of hypertension in 2019. Some of the key changes include lowering the threshold for treating stage 1 hypertension in patients under 80 years old, allowing the use of angiotensin receptor blockers instead of ACE inhibitors, and recommending the use of calcium channel blockers or thiazide-like diuretics in addition to ACE inhibitors or angiotensin receptor blockers.
Lifestyle changes are also important in managing hypertension. Patients should aim for a low salt diet, reduce caffeine intake, stop smoking, drink less alcohol, eat a balanced diet rich in fruits and vegetables, exercise more, and lose weight.
Treatment for hypertension depends on the patient’s blood pressure classification. For stage 1 hypertension with ABPM/HBPM readings of 135/85 mmHg or higher, treatment is recommended for patients under 80 years old with target organ damage, established cardiovascular disease, renal disease, diabetes, or a 10-year cardiovascular risk equivalent to 10% or greater. For stage 2 hypertension with ABPM/HBPM readings of 150/95 mmHg or higher, drug treatment is recommended regardless of age.
The first-line treatment for patients under 55 years old or with a background of type 2 diabetes mellitus is an ACE inhibitor or angiotensin receptor blocker. Calcium channel blockers are recommended for patients over 55 years old or of black African or African-Caribbean origin. If a patient is already taking an ACE inhibitor or angiotensin receptor blocker, a calcium channel blocker or thiazide-like diuretic can be added.
If blood pressure remains uncontrolled with the optimal or maximum tolerated doses of four drugs, NICE recommends seeking expert advice or adding a fourth drug. Blood pressure targets vary depending on age, with a target of 140/90 mmHg for patients under 80 years old and 150/90 mmHg for patients over 80 years old. Direct renin inhibitors, such as Aliskiren, may be used in patients who are intolerant of other antihypertensive drugs, but their role is currently limited.
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This question is part of the following fields:
- Cardiovascular Health
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Question 2
Correct
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An 80-year-old man presents with persistent atrial fibrillation. He has a past medical history of hypertension and type 2 diabetes, both of which are being treated with oral agents. He has no contraindications to any antithrombotic treatments and has come to discuss his risk of stroke and the need for antithrombotic treatment. What is the first-line antithrombotic treatment that should be considered in this case?
Your Answer: Warfarin
Explanation:Understanding the CHA2DS2-VASc Score for Atrial Fibrillation Treatment
The CHA2DS2-VASc score is a validated scoring system used by clinicians to determine the most appropriate antithrombotic treatment for patients with atrial fibrillation. It takes into account various risk factors, including congestive heart failure, hypertension, age, diabetes mellitus, prior stroke or TIA, vascular disease, and sex category. Patients scoring two or more should be considered for warfarinisation, provided there are no contraindications.
In this case, the patient scores one point for hypertension and one point for diabetes, making him eligible for warfarinisation. However, it is also important to assess his bleeding risk using the HAS BLED score, as newer anticoagulants like Dabigatran and rivoroxiban may be more appropriate. The CHA2DS2-VASc score is recommended over the CHADS2 score, as it provides a more detailed assessment of risk factors.
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This question is part of the following fields:
- Cardiovascular Health
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Question 3
Correct
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An 80-year-old woman presents with a leg ulcer above the right medial malleolus. Compression bandaging is being considered as a treatment option. Without diabetes, what is the minimum ankle-brachial pressure index (ABPI) recommended by SIGN guidelines to ensure the safety of compression bandaging?
Your Answer: 0.8
Explanation:It is safe to use compression therapy for patients with leg ulcers who have an ABPI of 0.8 or higher.
Ankle-Brachial Pressure Index for Evaluating Peripheral Arterial Disease
The ankle-brachial pressure index (ABPI) is a diagnostic tool used to evaluate peripheral arterial disease (PAD). It measures the ratio of systolic blood pressure in the lower leg to that in the arms. A lower blood pressure in the legs, resulting in an ABPI of less than 1, is an indicator of PAD. This test is particularly useful in evaluating patients with suspected PAD, such as a male smoker who presents with intermittent claudication.
In addition, it is important to determine the ABPI in patients with leg ulcers. Compression bandaging is often used to treat venous ulcers, but it can be harmful in patients with PAD as it further restricts blood supply to the foot. Therefore, ABPIs should always be measured in patients with leg ulcers to determine if compression bandaging is appropriate.
The interpretation of ABPI values is as follows: a value greater than 1.2 may indicate calcified, stiff arteries, which can be seen in advanced age or PAD. A value between 1.0 and 1.2 is considered normal, while a value between 0.9 and 1.0 is acceptable. A value less than 0.9 is likely indicative of PAD, and values less than 0.5 indicate severe disease that requires urgent referral. The ABPI is a reliable test, with values less than 0.90 having a sensitivity of 90% and a specificity of 98% for PAD. Compression bandaging is generally considered acceptable if the ABPI is greater than or equal to 0.8.
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This question is part of the following fields:
- Cardiovascular Health
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Question 4
Incorrect
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A 40-year-old man has a mid-diastolic murmur best heard at the apex. There is no previous history of any abnormal cardiac findings.
Select from the list the single most likely explanation of this murmur.Your Answer: Mitral incompetence
Correct Answer: Physiological
Explanation:Systolic Murmurs in Pregnancy: Causes and Characteristics
During pregnancy, the increased blood volume and flow through the heart can result in the appearance of innocent murmurs. In fact, a study found that 93.2% of healthy pregnant women had a systolic murmur at some point during pregnancy. These murmurs are typically systolic, may have a diastolic component, and can occur at any stage of pregnancy. They are often located at the second left intercostal space or along the left sternal border, but can radiate widely. If there is any doubt, referral for cardiological assessment is recommended.
Aortic stenosis produces a specific type of systolic murmur that begins shortly after the first heart sound and ends just before the second heart sound. It is best heard in the second right intercostal space. Mitral murmurs, on the other hand, are best heard at the apex and can radiate to the axilla. Mitral incompetence produces a pansystolic murmur of even intensity throughout systole, while mitral valve prolapse produces a mid-systolic click. A ventricular septal defect produces a harsh systolic murmur that is best heard along the left sternal edge.
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This question is part of the following fields:
- Cardiovascular Health
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Question 5
Correct
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A 67-year-old man presents with a recent diagnosis of angina pectoris. He is currently on aspirin, simvastatin, atenolol, and nifedipine, but is still experiencing frequent use of his GTN spray. What would be the most suitable course of action for further management?
Your Answer: Add isosorbide mononitrate MR and refer to cardiology for consideration of PCI or CABG
Explanation:According to NICE guidelines, if a patient needs a third anti-anginal medication, they should be referred for evaluation of a more permanent solution such as PCI or CABG. Although ACE inhibitors may be beneficial for certain patients with stable angina, they would not alleviate his angina symptoms.
Angina pectoris can be managed through lifestyle changes, medication, percutaneous coronary intervention, and surgery. In 2011, NICE released guidelines for the management of stable angina. Medication is an important aspect of treatment, and all patients should receive aspirin and a statin unless there are contraindications. Sublingual glyceryl trinitrate can be used to abort angina attacks. NICE recommends using either a beta-blocker or a calcium channel blocker as first-line treatment, depending on the patient’s comorbidities, contraindications, and preferences. If a calcium channel blocker is used as monotherapy, a rate-limiting one such as verapamil or diltiazem should be used. If used in combination with a beta-blocker, a longer-acting dihydropyridine calcium channel blocker like amlodipine or modified-release nifedipine should be used. Beta-blockers should not be prescribed concurrently with verapamil due to the risk of complete heart block. If initial treatment is ineffective, medication should be increased to the maximum tolerated dose. If a patient is still symptomatic after monotherapy with a beta-blocker, a calcium channel blocker can be added, and vice versa. If a patient cannot tolerate the addition of a calcium channel blocker or a beta-blocker, long-acting nitrate, ivabradine, nicorandil, or ranolazine can be considered. If a patient is taking both a beta-blocker and a calcium-channel blocker, a third drug should only be added while awaiting assessment for PCI or CABG.
Nitrate tolerance is a common issue for patients who take nitrates, leading to reduced efficacy. NICE advises patients who take standard-release isosorbide mononitrate to use an asymmetric dosing interval to maintain a daily nitrate-free time of 10-14 hours to minimize the development of nitrate tolerance. However, this effect is not seen in patients who take once-daily modified-release isosorbide mononitrate.
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This question is part of the following fields:
- Cardiovascular Health
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Question 6
Incorrect
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You see a 65-year-old gentleman who you have recently diagnosed with heart failure and an ejection fraction of 35%. You have titrated him up to the maximum dose of ACE-I and his renal function, sodium and potassium have all remained within normal limits for the past three months.
According to NICE, how often should he now have his treatment monitored?Your Answer:
Correct Answer: No further monitoring required
Explanation:Monitoring ACE-I Treatment
According to NICE guidelines, it is recommended to monitor ACE-I treatment every 6 months once the maximum tolerated dose has been reached. This ensures that the treatment is still effective and that any potential side effects are identified and managed promptly. Additionally, it is important to review the treatment if the person becomes acutely unwell. This allows for adjustments to be made to the treatment plan as needed. Regular monitoring and review of ACE-I treatment can help improve patient outcomes and prevent complications.
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This question is part of the following fields:
- Cardiovascular Health
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Question 7
Incorrect
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Mrs Maple is an 80-year-old woman who takes warfarin for atrial fibrillation. You have prescribed a new medication for her as treatment for an infection. A repeat INR was taken 3 days after starting her treatment. The level was 6.5.
Which of the following medications is most likely to have caused this?Your Answer:
Correct Answer: Fluconazole
Explanation:When taking warfarin, it is important to monitor INR levels carefully when also taking fluconazole due to their interaction. Fluconazole can cause an increase in INR. However, medications such as amikacin, vancomycin, clindamycin, and nitrofurantoin do not affect INR levels.
Interactions of Warfarin
Warfarin is a commonly used anticoagulant medication that requires careful monitoring due to its interactions with other drugs and medical conditions. Some general factors that can potentiate warfarin include liver disease, drugs that inhibit platelet function such as NSAIDs, and cranberry juice. Additionally, drugs that either inhibit or induce the P450 system can affect the metabolism of warfarin and alter the International Normalized Ratio (INR), which measures the effectiveness of the medication.
Drugs that induce the P450 system, such as antiepileptics and barbiturates, can decrease the INR, while drugs that inhibit the P450 system, such as antibiotics and SSRIs, can increase the INR. Other factors that can affect the metabolism of warfarin include chronic alcohol intake, smoking, and certain medical conditions. It is important for healthcare providers to be aware of these interactions and monitor patients closely to ensure safe and effective use of warfarin.
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This question is part of the following fields:
- Cardiovascular Health
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Question 8
Incorrect
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Which of the following is not a common side effect of amiodarone therapy?
Your Answer:
Correct Answer: Hypokalaemia
Explanation:Adverse Effects and Drug Interactions of Amiodarone
Amiodarone is a medication used to treat irregular heartbeats. However, its use can lead to several adverse effects. One of the most common adverse effects is thyroid dysfunction, which can manifest as either hypothyroidism or hyperthyroidism. Other adverse effects include corneal deposits, pulmonary fibrosis or pneumonitis, liver fibrosis or hepatitis, peripheral neuropathy, myopathy, photosensitivity, a slate-grey appearance, thrombophlebitis, injection site reactions, bradycardia, and lengthening of the QT interval.
It is also important to note that amiodarone can interact with other medications. For example, it can decrease the metabolism of warfarin, leading to an increased INR. Additionally, it can increase digoxin levels. Therefore, it is crucial to monitor patients closely for adverse effects and drug interactions when using amiodarone. Proper management and monitoring can help minimize the risks associated with this medication.
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This question is part of the following fields:
- Cardiovascular Health
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Question 9
Incorrect
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A 56-year-old man presents with a racing heart. He states that this started while he was mowing the lawn but subsided after he drank a glass of cold lemonade. However, his symptoms have returned. On physical examination, his pulse is regular and measures 150 bpm. An ECG reveals a narrow complex tachycardia with P waves linked to each QRS complex.
What is the probable diagnosis? Choose ONE answer only.Your Answer:
Correct Answer: Atrioventricular (AV) nodal re-entrant tachycardia
Explanation:Differentiating AV Nodal Re-entrant Tachycardia from Other Arrhythmias: An ECG Analysis
AV nodal re-entrant tachycardia is a type of arrhythmia that causes recurrent palpitations lasting for minutes to hours. Patients may also experience chest pain, shortness of breath, and syncope. The heart rate is usually between 150-250 bpm, and the rhythm is regular with narrow QRS complexes. Vagal manoeuvres can terminate the episode. However, it is essential to differentiate AV nodal re-entrant tachycardia from other arrhythmias, such as atrial fibrillation, atrial flutter, torsades de pointes, and ventricular tachycardia. An ECG analysis can help in this regard.
Atrial fibrillation is characterised by irregular ventricular complexes with an absence of P waves. In contrast, atrial flutter shows a saw-tooth pattern with the absence of P waves. Torsades de pointes is a rare form of polymorphic ventricular tachycardia that causes a gradual change in the amplitude and twisting of the QRS complexes around the isoelectric line. It is associated with a prolonged QT interval. Ventricular tachycardia, on the other hand, is characterised by broad complexes on ECG.
In conclusion, an ECG analysis is crucial in differentiating AV nodal re-entrant tachycardia from other arrhythmias. It helps in providing accurate diagnosis and appropriate treatment to the patients.
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This question is part of the following fields:
- Cardiovascular Health
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Question 10
Incorrect
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A 58-year-old woman presents to the General Practitioner for a consultation. She has recently been discharged from hospital after an episode of non-ST-elevation acute coronary syndrome. She has no other significant medical conditions.
Which of the following is the most appropriate antiplatelet therapy?Your Answer:
Correct Answer: Clopidogrel 75 mg od in combination with aspirin 75 mg od for 12 months, then aspirin 75 mg od alone
Explanation:Antiplatelet Therapy for Non-ST-Elevation Acute Coronary Syndrome
The National Institute for Health and Care Excellence recommends dual therapy with aspirin and other antiplatelet for 12 months, followed by aspirin alone, for antiplatelet therapy after a non-ST-elevation acute coronary syndrome. However, the use of clopidogrel with aspirin increases the risk of bleeding, and there is no evidence of benefit beyond 12 months of the last event.
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This question is part of the following fields:
- Cardiovascular Health
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Question 11
Incorrect
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A 67-year-old lady with mitral valve disease and atrial fibrillation is on warfarin therapy. Recently, her INR levels have decreased, leading to an increase in the warfarin dosage. What new treatments could be responsible for this change?
Your Answer:
Correct Answer: St John's wort
Explanation:Drug Interactions with Warfarin
Drugs that are metabolized in the liver can induce hepatic microsomal enzymes, which can affect the metabolism of other drugs. In the case of warfarin, an anticoagulant medication, certain drugs can either enhance or reduce its effectiveness.
St. John’s wort is an enzyme inducer and can increase the metabolism of warfarin, making it less effective. On the other hand, allopurinol can interact with warfarin to enhance its anticoagulant effect. Similarly, amiodarone inhibits the metabolism of coumarins, which can lead to an enhanced anticoagulant effect.
Clarithromycin, a drug that inhibits CYP3A isozyme, can enhance the anticoagulant effect of coumarins, including warfarin. This is because warfarin is metabolized by the same CYP3A isozyme as clarithromycin. Finally, sertraline may also interact with warfarin to enhance its anticoagulant effect.
In summary, it is important to be aware of potential drug interactions when taking warfarin, as they can either enhance or reduce its effectiveness. Patients should always inform their healthcare provider of all medications they are taking to avoid any potential adverse effects.
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This question is part of the following fields:
- Cardiovascular Health
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Question 12
Incorrect
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A 22 year old man is being investigated by a cardiologist for prolonged QT-syndrome. He visits your clinic with a 4 day history of cough with thick, green sputum, fever, and fatigue. During examination, his temperature is found to be 39ºC, oxygen saturation is 96% on air, and crackles are heard at the base of his left lung. Which medication should be avoided in treating his condition?
Your Answer:
Correct Answer: Erythromycin
Explanation:The normal corrected QT interval for males is below 430 ms and for females it is below 450 ms. Long QT syndrome (LQTS) is a rare condition that can be inherited or acquired, causing delayed repolarisation of the ventricles and increasing the risk of ventricular tachyarrhythmias. This can result in syncope, cardiac arrest, or sudden death. LQTS can be detected incidentally on an ECG, after a cardiac event such as syncope or cardiac arrest, or following the sudden death of a family member.
Long QT syndrome (LQTS) is a genetic condition that causes a delay in the ventricles’ repolarization. This delay can lead to ventricular tachycardia/torsade de pointes, which can cause sudden death or collapse. The most common types of LQTS are LQT1 and LQT2, which are caused by defects in the alpha subunit of the slow delayed rectifier potassium channel. A normal corrected QT interval is less than 430 ms in males and 450 ms in females.
There are various causes of a prolonged QT interval, including congenital factors, drugs, and other conditions. Congenital factors include Jervell-Lange-Nielsen syndrome and Romano-Ward syndrome. Drugs that can cause a prolonged QT interval include amiodarone, sotalol, tricyclic antidepressants, and selective serotonin reuptake inhibitors. Other factors that can cause a prolonged QT interval include electrolyte imbalances, acute myocardial infarction, myocarditis, hypothermia, and subarachnoid hemorrhage.
LQTS may be detected on a routine ECG or through family screening. Long QT1 is usually associated with exertional syncope, while Long QT2 is often associated with syncope following emotional stress, exercise, or auditory stimuli. Long QT3 events often occur at night or at rest and can lead to sudden cardiac death.
Management of LQTS involves avoiding drugs that prolong the QT interval and other precipitants if appropriate. Beta-blockers are often used, and implantable cardioverter defibrillators may be necessary in high-risk cases. It is important to note that sotalol may exacerbate LQTS.
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This question is part of the following fields:
- Cardiovascular Health
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Question 13
Incorrect
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An 80 year old woman presents to the clinic with a history of progressive dyspnea for the past four months. She reports experiencing left-sided chest pain and dizziness upon exertion, which subside with rest. During the physical examination, you detect an ejection systolic murmur that radiates to the carotids. What other clinical manifestation might you anticipate observing during the assessment?
Your Answer:
Correct Answer: Narrow pulse pressure
Explanation:Aortic stenosis is a condition characterized by the narrowing of the aortic valve, which can lead to various symptoms. These symptoms include chest pain, dyspnea, syncope or presyncope, and a distinct ejection systolic murmur that radiates to the carotids. Severe aortic stenosis can cause a narrow pulse pressure, slow rising pulse, delayed ESM, soft/absent S2, S4, thrill, duration of murmur, and left ventricular hypertrophy or failure. The condition can be caused by degenerative calcification, bicuspid aortic valve, William’s syndrome, post-rheumatic disease, or subvalvular HOCM.
Management of aortic stenosis depends on the severity of the condition and the presence of symptoms. Asymptomatic patients are usually observed, while symptomatic patients require valve replacement. Surgical AVR is the preferred treatment for young, low/medium operative risk patients, while TAVR is used for those with a high operative risk. Balloon valvuloplasty may be used in children without aortic valve calcification and in adults with critical aortic stenosis who are not fit for valve replacement. If the valvular gradient is greater than 40 mmHg and there are features such as left ventricular systolic dysfunction, surgery may be considered even if the patient is asymptomatic.
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This question is part of the following fields:
- Cardiovascular Health
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Question 14
Incorrect
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A 65-year-old man undergoes an abdominal ultrasound as part of investigations for persistent mildly abnormal liver function tests. The liver appears normal but he is found to have an abdominal aortic aneurysm (AAA).
Select from the list the single correct statement regarding an unruptured abdominal aortic aneurysm.Your Answer:
Correct Answer: Elective repair of an aneurysm has a significant mortality risk
Explanation:Unruptured Abdominal Aortic Aneurysm: Symptoms, Risks, and Treatment Options
Abdominal Aortic Aneurysm (AAA) is a condition that often goes unnoticed due to the lack of symptoms. It is usually discovered incidentally during abdominal examinations or scans. However, bimanual palpation of the supra-umbilical region can detect a significant number of aneurysms. While most patients do not experience any pain, severe lumbar pain may indicate an impending rupture. The risk of rupture increases with the size of the aneurysm, with an annual rupture rate of 0.5-1.5% for aneurysms between 4.0 and 5.5 cm, and 5-15% for those between 5.5 and 6.0 cm.
The natural history of a small AAA is gradual expansion, with an annual rate of approximately 10% of the initial arterial diameter. The mortality rate from a ruptured AAA is high, at 80%. However, elective repair can significantly reduce the risk of rupture. The overall mortality rate for elective repair in the UK is 2.4%, with a lower mortality rate for endovascular aneurysm repair (EVAR) than open surgery.
It is important for drivers to notify the DVLA of any AAA, as it may affect their ability to drive. Group 1 drivers should notify the DVLA of an aneurysm >6 cm, while >6.5 cm would disqualify them from driving. Group 2 drivers should notify the DVLA of an aneurysm of any size, and an aortic diameter >5.5 cm would disqualify them from driving.
In conclusion, while most patients with unruptured AAA do not experience any symptoms, it is important to be aware of the risks and treatment options. Early detection and elective repair can significantly reduce the risk of rupture and improve outcomes.
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This question is part of the following fields:
- Cardiovascular Health
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Question 15
Incorrect
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A 32-year-old man presents for an insurance medical. He has no significant medical history. During the examination, his BMI is 23 kg/m2, blood pressure is 110/70 mmHg, and auscultation of the heart reveals a mid-systolic click and a late systolic murmur (which are more pronounced when he stands up).
What is the most likely diagnosis based on these findings?Your Answer:
Correct Answer: Mitral valve prolapse
Explanation:Understanding Mitral Valve Prolapse: Symptoms, Causes, and Associated Conditions
Mitral valve prolapse is a condition where the leaflets of the mitral valve bulge in systole, affecting around 2-3% of the population. It can occur as an isolated entity or with heritable disorders of connective tissue. While most people are asymptomatic, some may experience symptoms such as anxiety, panic attacks, palpitations, syncope, or presyncope. The condition is also a risk factor for mitral regurgitation and carries a small risk of cerebral emboli and sudden death. Diagnosis is made through auscultation, with a mid-to-late systolic click and a late systolic murmur heard at the apex. Other heart conditions, such as atrial septal defect, aortic stenosis, mitral regurgitation, and mitral stenosis, have distinct murmurs that aid in diagnosis.
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This question is part of the following fields:
- Cardiovascular Health
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Question 16
Incorrect
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An 85-year-old man is seen in the hypertension clinic with a blood pressure reading of 144/86 mmHg, consistent with recent readings. His annual blood work shows:
- Na+ 141 mmol/l
- K+ 4.1 mmol/l
- Urea 7.2 mmol/l
- Creatinine 95 µmol/l
- HbA1c 39 mmol/mol (5.7%)
- Total cholesterol 4.3 mmol/l
- HDL 1.0 mmol/l
He is currently taking ramipril 10 mg od, indapamide MR 1.5 mg od, amlodipine 10 mg od, and simvastatin 20 mg on. As his healthcare provider, which change, if any, should you discuss with the patient?Your Answer:
Correct Answer: No changes to the medication are indicated
Explanation:Given the patient’s age of over 80 years, a clinic reading of less than 150/90 mmHg is deemed acceptable, and thus, no modifications to his current antihypertensive medications are necessary.
Hypertension, or high blood pressure, is a common condition that can lead to serious health problems if left untreated. The National Institute for Health and Care Excellence (NICE) has published updated guidelines for the management of hypertension in 2019. Some of the key changes include lowering the threshold for treating stage 1 hypertension in patients under 80 years old, allowing the use of angiotensin receptor blockers instead of ACE inhibitors, and recommending the use of calcium channel blockers or thiazide-like diuretics in addition to ACE inhibitors or angiotensin receptor blockers.
Lifestyle changes are also important in managing hypertension. Patients should aim for a low salt diet, reduce caffeine intake, stop smoking, drink less alcohol, eat a balanced diet rich in fruits and vegetables, exercise more, and lose weight.
Treatment for hypertension depends on the patient’s blood pressure classification. For stage 1 hypertension with ABPM/HBPM readings of 135/85 mmHg or higher, treatment is recommended for patients under 80 years old with target organ damage, established cardiovascular disease, renal disease, diabetes, or a 10-year cardiovascular risk equivalent to 10% or greater. For stage 2 hypertension with ABPM/HBPM readings of 150/95 mmHg or higher, drug treatment is recommended regardless of age.
The first-line treatment for patients under 55 years old or with a background of type 2 diabetes mellitus is an ACE inhibitor or angiotensin receptor blocker. Calcium channel blockers are recommended for patients over 55 years old or of black African or African-Caribbean origin. If a patient is already taking an ACE inhibitor or angiotensin receptor blocker, a calcium channel blocker or thiazide-like diuretic can be added.
If blood pressure remains uncontrolled with the optimal or maximum tolerated doses of four drugs, NICE recommends seeking expert advice or adding a fourth drug. Blood pressure targets vary depending on age, with a target of 140/90 mmHg for patients under 80 years old and 150/90 mmHg for patients over 80 years old. Direct renin inhibitors, such as Aliskiren, may be used in patients who are intolerant of other antihypertensive drugs, but their role is currently limited.
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This question is part of the following fields:
- Cardiovascular Health
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Question 17
Incorrect
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A 72-year-old man who rarely visits the clinic presents with several weeks of orthopnoea, paroxysmal nocturnal dyspnoea, and swollen ankles. His wife brings him in for examination. On assessment, he has bilateral basal crepitations and a resting heart rate of 110 beats per minute. An ECG shows sinus rhythm. Echocardiography confirms a diagnosis of heart failure. Despite receiving optimal doses of an ACE inhibitor and furosemide, he remains symptomatic and tachycardic.
Which of the following statements is the most accurate regarding his further management?Your Answer:
Correct Answer: He should be started on a beta-blocker
Explanation:The Importance of Beta-Blockers in Heart Failure Management
Heart failure is a serious condition that affects millions of people worldwide. Current guidance recommends the use of beta-blockers in all patients with symptomatic heart failure and an LVEF ≤40%, where tolerated and not contra-indicated. Beta-blockers have been shown to increase ejection fraction, improve exercise tolerance, and reduce morbidity, mortality, and hospital admissions.
It is important to note that beta-blockers should be initiated even if a patient is already stabilized on other drugs. While diuretics can be used to control initial oedema, the mainstay of treatment for heart failure is ACE inhibitors and beta-blockade. Digoxin and spironolactone have a place in heart failure management, but they are not first or second line treatments.
For severe heart failure, biventricular pacing with an implantable defibrillator can be useful. Overall, the use of beta-blockers is crucial in the management of heart failure and should be considered in all eligible patients.
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This question is part of the following fields:
- Cardiovascular Health
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Question 18
Incorrect
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A 68-year-old woman has weight loss and heat intolerance.
Investigations:
Free T4 32.9 pmol/L (9.8-23.1)
TSH <0.02 mU/L (0.35-5.50)
Free T3 11.1 pmol/L (3.5-6.5)
She is taking medication for atrial fibrillation, ischaemic heart disease and type 2 diabetes.
Which drug is most likely to be responsible for these results?Your Answer:
Correct Answer: Digoxin
Explanation:Amiodarone and Thyroid Function
Amiodarone is a medication commonly used to treat heart rhythm disorders. However, it can also cause abnormalities in thyroid function tests. This can result in both hypothyroidism and hyperthyroidism. Hypothyroidism may occur due to interference with the conversion of thyroxine (T4) to tri-iodothyronine (T3). On the other hand, hyperthyroidism may be caused by thyroiditis or the donation of iodine, as amiodarone contains a large amount of iodine.
Aside from thyroid issues, amiodarone can also lead to other side effects such as pulmonary fibrosis and photosensitivity reactions. It is important to monitor thyroid function tests regularly when taking amiodarone and to report any symptoms of thyroid dysfunction to a healthcare provider.
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This question is part of the following fields:
- Cardiovascular Health
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Question 19
Incorrect
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A 45-year-old male presents at your clinic following a recent admission at the cardiac unit of the local general hospital. He suffered a myocardial (MI) infarction three weeks ago and has been recovering well physically, but he cries a lot of the time.
You find evidence of low mood, anhedonia and sleep disturbance.
The man feels hopeless about the future and has fleeting thoughts of suicide. He has suffered from depression in the past which responded well to antidepressant treatment.
Which antidepressant would you choose from the following based on its demonstrated safety post-myocardial infarction?Your Answer:
Correct Answer: Sertraline
Explanation:Sertraline for Depression in Patients with Recent MI or Unstable Angina
Sertraline is a medication that is both effective and well-tolerated for treating depression in patients who have recently experienced a myocardial infarction (MI) or unstable angina. In addition to its antidepressant properties, sertraline has been found to inhibit platelet aggregation. This makes it a valuable treatment option for patients who are at risk for blood clots and other cardiovascular complications. With its dual benefits, sertraline can help improve both the mental and physical health of patients who have experienced a cardiac event.
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This question is part of the following fields:
- Cardiovascular Health
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Question 20
Incorrect
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A 68-year-old man with lung cancer is diagnosed with deep vein thrombosis. He is seen in the hospital clinic and prescribed a direct oral anticoagulant (DOAC). What would be the best course of treatment?
Your Answer:
Correct Answer: Continue on the DOAC for 3-6 months
Explanation:In 2020, NICE revised their guidance to suggest the use of DOACs for individuals with active cancer who have VTE. Prior to this, low molecular weight heparin was the recommended treatment.
Deep vein thrombosis (DVT) is a serious condition that requires prompt diagnosis and management. The National Institute for Health and Care Excellence (NICE) updated their guidelines in 2020, recommending the use of direct oral anticoagulants (DOACs) as first-line treatment for most people with VTE, including as interim anticoagulants before a definite diagnosis is made. They also recommend the use of DOACs in patients with active cancer, as opposed to low-molecular weight heparin as was previously recommended. Routine cancer screening is no longer recommended following a VTE diagnosis.
If a patient is suspected of having a DVT, a two-level DVT Wells score should be performed to assess the likelihood of the condition. If a DVT is ‘likely’ (2 points or more), a proximal leg vein ultrasound scan should be carried out within 4 hours. If the result is positive, then a diagnosis of DVT is made and anticoagulant treatment should start. If the result is negative, a D-dimer test should be arranged. If a proximal leg vein ultrasound scan cannot be carried out within 4 hours, a D-dimer test should be performed and interim therapeutic anticoagulation administered whilst waiting for the proximal leg vein ultrasound scan (which should be performed within 24 hours).
The cornerstone of VTE management is anticoagulant therapy. The big change in the 2020 guidelines was the increased use of DOACs. Apixaban or rivaroxaban (both DOACs) should be offered first-line following the diagnosis of a DVT. Instead of using low-molecular weight heparin (LMWH) until the diagnosis is confirmed, NICE now advocate using a DOAC once a diagnosis is suspected, with this continued if the diagnosis is confirmed. If neither apixaban or rivaroxaban are suitable, then either LMWH followed by dabigatran or edoxaban OR LMWH followed by a vitamin K antagonist (VKA, i.e. warfarin) can be used.
All patients should have anticoagulation for at least 3 months. Continuing anticoagulation after this period is partly determined by whether the VTE was provoked or unprovoked. If the VTE was provoked, the treatment is typically stopped after the initial 3 months (3 to 6 months for people with active cancer). If the VTE was
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This question is part of the following fields:
- Cardiovascular Health
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Question 21
Incorrect
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What is the most useful investigation to differentiate between the types of cardiomyopathy from the given list?
Your Answer:
Correct Answer: Echocardiogram
Explanation:Understanding the Four Types of Cardiomyopathy
Cardiomyopathy is a group of heart muscle disorders that affect the structure and function of the heart. There are four major types of cardiomyopathy: dilated, hypertrophic, restrictive, and arrhythmogenic right ventricular cardiomyopathy. Each type is characterized by specific features such as ventricular dilation, hypertrophy, restrictive filling, and fibro-fatty changes in the right ventricular myocardium.
While dilated and hypertrophic cardiomyopathies are the most common types, a familial cause has been identified in a significant percentage of patients with these conditions. On the other hand, restrictive cardiomyopathy is usually not familial.
To diagnose cardiomyopathy, a full cardiological assessment is necessary. Transthoracic Doppler echocardiography can confirm the diagnosis of hypertrophic cardiomyopathy, distinguish between restrictive cardiomyopathy and constrictive pericarditis, and assess the severity of ventricular dysfunction in dilated cardiomyopathies. Coronary angiography can help exclude coronary artery disease as the cause of dilated cardiomyopathy.
A normal ECG is uncommon in any form of cardiomyopathy, and cardiomegaly on a chest X-ray may be present in all types. Brain natriuretic peptide is a marker of ventricular dysfunction but cannot differentiate between cardiomyopathies.
In summary, understanding the different types of cardiomyopathy and their diagnostic tools is crucial in managing and treating this group of heart muscle disorders.
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This question is part of the following fields:
- Cardiovascular Health
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Question 22
Incorrect
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A 67-year-old man presents with shortness of breath.
An ECG shows atrial fibrillation (AF).
He takes digoxin, furosemide, and lisinopril.
What further drug would improve this patient's outcome?Your Answer:
Correct Answer: Abciximab
Explanation:Prophylactic Therapy for AF Patients with Heart Failure
The risk of embolic events in patients with heart failure and AF is high, with the risk of stroke increasing up to five-fold in non-rheumatic AF. The most appropriate prophylactic therapy for these patients is with an anticoagulant, such as warfarin.
According to studies, for every 1,000 patients with AF who are treated with warfarin for one year, 30 strokes are prevented at the expense of six major bleeds. On the other hand, for every 1,000 patients with AF who are treated with aspirin for one year, only 12.5 strokes are prevented at the expense of six major bleeds.
It is important to note that NICE guidelines on Atrial fibrillation (CG180) recommend warfarin, not aspirin, as the preferred prophylactic therapy for AF patients with heart failure.
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This question is part of the following fields:
- Cardiovascular Health
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Question 23
Incorrect
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A 45-year-old woman is newly diagnosed with ankylosing spondylitis. An echocardiogram shows a valvular anomaly.
What is the most probable diagnosis?Your Answer:
Correct Answer: Aortic regurgitation
Explanation:Cardiovascular Complications in Ankylosing Spondylitis
Ankylosing spondylitis is a chronic inflammatory disease that primarily affects the spine and sacroiliac joints. However, it can also lead to cardiovascular complications. The most common complication is aortic regurgitation, which occurs due to inflammation of the ascending aorta. On the other hand, mitral regurgitation is not typically associated with ankylosing spondylitis and is usually caused by congenital conditions or cardiomyopathies. Aortic stenosis is also not commonly associated with ankylosing spondylitis, as it is usually caused by age-related calcification or congenital bicuspid valve. Similarly, mitral stenosis is more commonly associated with rheumatic heart disease than ankylosing spondylitis. Tricuspid stenosis is a rare cardiac defect that is usually associated with rheumatic fever. Therefore, it is important for individuals with ankylosing spondylitis to be aware of the potential cardiovascular complications and to seek medical attention if any symptoms arise.
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This question is part of the following fields:
- Cardiovascular Health
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Question 24
Incorrect
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Which of the following patients is most likely to have their actual risk of cardiovascular disease underestimated by QRISK2?
Your Answer:
Correct Answer: A 54-year-old man with a history of schizophrenia who takes olanzapine
Explanation:Patients with a serious mental health disorder and those taking antipsychotics may have their cardiovascular disease risk underestimated by QRISK2.
Management of Hyperlipidaemia: NICE Guidelines
Hyperlipidaemia, or high levels of lipids in the blood, is a major risk factor for cardiovascular disease (CVD). In 2014, the National Institute for Health and Care Excellence (NICE) updated their guidelines on lipid modification, which caused controversy due to the recommendation of statins for a significant proportion of the population over the age of 60. The guidelines suggest a systematic strategy to identify people over 40 years who are at high risk of CVD, using the QRISK2 CVD risk assessment tool. A full lipid profile should be checked before starting a statin, and patients with very high cholesterol levels should be investigated for familial hyperlipidaemia. The new guidelines recommend offering a statin to people with a QRISK2 10-year risk of 10% or greater, with atorvastatin 20 mg offered first-line. Special situations, such as type 1 diabetes mellitus and chronic kidney disease, are also addressed. Lifestyle modifications, including a cardioprotective diet, physical activity, weight management, alcohol intake, and smoking cessation, are important in managing hyperlipidaemia.
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This question is part of the following fields:
- Cardiovascular Health
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Question 25
Incorrect
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Which treatment for hypercholesterolaemia in primary prevention trials has been shown to reduce all cause mortality?
Your Answer:
Correct Answer: Statins
Explanation:Lipid Management in Primary Care
Lipid management is a common scenario in primary care, and NICE has produced guidance on Lipid modification (CG181) in the primary and secondary prevention of cardiovascular disease. The use of statins in primary prevention is supported by clinical trial data, with WOSCOPS (The West of Scotland Coronary Prevention Study) being a landmark trial. This study looked at statin versus placebo in men aged 45-65 with no coronary disease and a cholesterol >4 mmol/L, showing a reduction in all-cause mortality by 22% in the statin arm for a 20% total cholesterol reduction.
Other study data also supports the use of statins as primary prevention of coronary artery disease. The NICE Clinical Knowledge Summary on lipid modification – CVD prevention recommends Atorvastatin at 20 mg for primary prevention and 80 mg for secondary prevention. Risk is assessed using the QRISK2 calculator. Overall, lipid management is an important aspect of primary care, and healthcare professionals should be familiar with the latest guidance and clinical trial data to provide optimal care for their patients.
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This question is part of the following fields:
- Cardiovascular Health
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Question 26
Incorrect
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A 62-year-old man has recently started taking a new medication for his hypertension. He has noticed swelling in his ankles and wonders if it could be a side effect of the medication. Which drug is most likely responsible for his symptoms?
Your Answer:
Correct Answer: Amlodipine
Explanation:Understanding Amlodipine: A Calcium-Channel Blocker and its Side-Effects
Amlodipine is a medication that belongs to the class of calcium-channel blockers. It works by inhibiting the inward displacement of calcium ions through the slow channels of active cell membranes. The primary effect of amlodipine is to relax vascular smooth muscle and dilate peripheral and coronary arteries. However, this medication is also associated with some side-effects due to its vasodilatory properties.
Common side-effects of amlodipine include flushing and headache, which usually subside after a few days. Another common side-effect is ankle swelling, which only partially responds to diuretics. In some cases, ankle swelling may be severe enough to warrant discontinuation of the drug. On the other hand, oedema is uncommon with losartan and not reported for any of the other options.
If you experience oedema due to calcium-channel blockers, it is important to manage it properly. Please refer to the external links for more information on how to manage this side-effect.
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This question is part of the following fields:
- Cardiovascular Health
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Question 27
Incorrect
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A 63-year-old man is taking warfarin for atrial fibrillation.
Select the single ideal target INR from the options.Your Answer:
Correct Answer: 2.5
Explanation:Recommended INR Levels for Anticoagulation Therapy
Anticoagulation therapy is used to prevent blood clots in individuals with certain medical conditions. The target level for the majority of indications is an INR (international normalized ratio) of 2.5. However, for individuals who are already receiving warfarin and have recurrent deep vein thrombosis or pulmonary embolism, a higher INR of 3.5 is recommended. Additionally, for patients with mechanical prosthetic heart valves, the recommended INR level ranges from 3.0 to 3.5 depending on the type of valve. It is important to closely monitor INR levels and adjust the dosage of anticoagulation therapy as needed to prevent complications.
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This question is part of the following fields:
- Cardiovascular Health
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Question 28
Incorrect
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A 72-year-old bus driver comes to you for consultation after undergoing an abdominal ultrasound scan as part of a routine health check. The scan reveals an abdominal aortic aneurysm (AAA) measuring 4 cm, and he has no symptoms.
What is the most suitable course of action?Your Answer:
Correct Answer: Refer for annual ultrasound surveillance
Explanation:Recommended Actions for Patients with Abdominal Aortic Aneurysm
Patients with an abdominal aortic aneurysm (AAA) require careful monitoring and appropriate actions to prevent complications. Here are some recommended actions based on the size of the AAA and the patient’s condition:
Annual ultrasound surveillance: Asymptomatic patients with an AAA measuring 3.0–4.4 cm should undergo annual ultrasound monitoring to detect any changes in size or shape. This can help identify the need for further intervention, such as surgery or endovascular repair. In addition, patients should be advised to quit smoking, control their blood pressure, and take statins and antiplatelet therapy as needed.
Refer for follow-up ultrasound in three months: If the AAA measures between 4.5 and 5.4 cm, a follow-up ultrasound should be arranged in three months to monitor any progression. This can help determine the optimal timing for intervention and prevent rupture or dissection.
Advise the patient to inform the DVLA and cease driving: Patients who have an AAA and hold a Group 2 driving license must notify the Driver and Vehicle Licensing Agency (DVLA) and stop driving if the aneurysm diameter is larger than 5.5 cm. This is to ensure the safety of the patient and other road users.
Arrange a repeat scan in one year: The recommended screening interval for AAA is determined by its size, with a maximum interval of one year. Therefore, patients with an AAA measuring more than 5.5 cm or with rapid growth should undergo repeat scans every six months to one year to monitor any changes.
Monitor all patients with an AAA: Regardless of symptoms, all patients with an AAA measuring more than 3 cm require monitoring and appropriate actions to prevent complications. If the patient develops symptoms such as pain, they may need additional investigation and possible intervention to prevent rupture or dissection.
By following these recommended actions, patients with an AAA can receive timely and appropriate care to prevent complications and improve their outcomes.
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This question is part of the following fields:
- Cardiovascular Health
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Question 29
Incorrect
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A 55-year-old man presents to the surgery with intermittent palpitations, occurring for approximately 60 minutes every five to six days.
Careful questioning reveals no clear precipitating factors, and he is otherwise an infrequent attender to the surgery. On examination, his BP is 140/80 mmHg, his pulse irregular at 100 bpm, but otherwise cardiovascular and respiratory examination is unremarkable.
You arrange for an ECG the following day with the practice nurse, which is normal.
What is the next most appropriate step?Your Answer:
Correct Answer: Arrange an event recorder ECG
Explanation:Recommended Investigation for Diagnosis of Heart Condition
The recommended investigation for confirming the diagnosis of the heart condition in this scenario is an event recorder electrocardiogram (ECG). This is because symptomatic episodes are more than 24 hours apart, making a 24-hour ambulatory ECG less likely to confirm the diagnosis. While echocardiography may be useful in evaluating atrial fibrillation, a diagnosis must first be made.
It is important to note that there is no indication of haemodynamic compromise in this scenario, so acute admission is not necessary. By conducting the appropriate investigation, healthcare professionals can accurately diagnose and treat the heart condition.
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This question is part of the following fields:
- Cardiovascular Health
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Question 30
Incorrect
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A 56-year-old man collapses after complaining of palpitations and is admitted to the Emergency Department (ED). He is found to be in ventricular tachycardia and is successfully cardioverted. Further investigations reveal an underlying long QT syndrome, and an implantable cardioverter-defibrillator (ICD) is inserted. The man works as an HGV driver. What advice should be given regarding his ability to drive HGV vehicles?
Your Answer:
Correct Answer: Permanent bar
Explanation:Regardless of the circumstances, the loss of HGV licence is indicated by ICD.
DVLA Guidelines for Cardiovascular Disorders and Driving
The DVLA has specific guidelines for individuals with cardiovascular disorders who wish to drive a car or motorcycle. For those with hypertension, driving is permitted unless the treatment causes unacceptable side effects, and there is no need to notify the DVLA. However, if the individual has Group 2 Entitlement, they will be disqualified from driving if their resting blood pressure consistently measures 180 mmHg systolic or more and/or 100 mm Hg diastolic or more.
Individuals who have undergone elective angioplasty must refrain from driving for one week, while those who have undergone CABG or acute coronary syndrome must wait four weeks before driving. If an individual experiences angina symptoms at rest or while driving, they must cease driving altogether. Pacemaker insertion requires a one-week break from driving, while implantable cardioverter-defibrillator (ICD) implantation results in a six-month driving ban if implanted for sustained ventricular arrhythmia. If implanted prophylactically, the individual must cease driving for one month, and Group 2 drivers are permanently barred from driving with an ICD.
Successful catheter ablation for an arrhythmia requires a two-day break from driving, while an aortic aneurysm of 6 cm or more must be reported to the DVLA. Licensing will be permitted subject to annual review, but an aortic diameter of 6.5 cm or more disqualifies patients from driving. Finally, individuals who have undergone a heart transplant must refrain from driving for six weeks, but there is no need to notify the DVLA.
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This question is part of the following fields:
- Cardiovascular Health
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