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  • Question 1 - A 67-year-old man presents with anaemia and weight loss. Upon endoscopy, a gastric...

    Correct

    • A 67-year-old man presents with anaemia and weight loss. Upon endoscopy, a gastric tumour is revealed, later established as an adenocarcinoma. The patient refuses any treatment and claims that his condition is not influencing the quality of his life. Clinical examination has nothing particularly interesting to show and the patient seems to be conscious of his decision, regardless of the likely curative nature of surgery. What is the single most appropriate management?

      Your Answer: Respect his wishes and book a follow-up appointment for four weeks

      Explanation:

      The patient seems to be conscious about his decision, which should be respected. According to Mental Capacity Act 2005, a person who makes an unwise decision should not be treated as unable to make a decision.

    • This question is part of the following fields:

      • Clinical Sciences
      22.8
      Seconds
  • Question 2 - Which of the following drugs is NOT used in the treatment of MRSA?...

    Incorrect

    • Which of the following drugs is NOT used in the treatment of MRSA?

      Your Answer: Teicoplanin

      Correct Answer: Ceftriaxone

      Explanation:

      Cephalosporins, such as ceftriaxone, do not cover methicillin-resistant staph aureus. They do cover some gram positives and gram negatives. Vancomycin and teicoplanin given intravenously have good coverage of MRSA and other gram positive bacteria. Rifampicin and doxycycline, although not the best treatment, can be used for outpatients if there are no systemic signs of illness.

    • This question is part of the following fields:

      • Infectious Diseases
      7.1
      Seconds
  • Question 3 - A 15-year-old child with learning difficulties is referred to the endocrine clinic for...

    Correct

    • A 15-year-old child with learning difficulties is referred to the endocrine clinic for review. His lab results show hypocalcaemia and increased serum concentration of parathyroid hormone. On examination, there is subcutaneous calcification and a short fifth metacarpal in each hand. What is the treatment of choice in this case?

      Your Answer: Calcium and vitamin D supplementation

      Explanation:

      This child has pseudo hypoparathyroidism. It is a heterogeneous group of rare endocrine disorders characterized by normal renal function and resistance to the action of parathyroid hormone (PTH), manifesting with hypocalcaemia, hyperphosphatemia, and increased serum concentration of PTH.
      Patients with pseudo hypoparathyroidism type 1a present with a characteristic phenotype collectively called Albright hereditary osteodystrophy (AHO). The constellation of findings includes the following:
      Short stature
      Stocky habitus
      Obesity
      Developmental delay
      Round face
      Dental hypoplasia
      Brachymetacarpals
      Brachymetatarsals
      Soft tissue calcification/ossification
      The goals of therapy are to maintain serum total and ionized calcium levels within the reference range to avoid hypercalcaemia and to suppress PTH levels to normal. This is important because elevated PTH levels in patients with PHP can cause increased bone remodelling and lead to hyper-parathyroid bone disease.
      The goals of pharmacotherapy are to correct calcium deficiency, to prevent complications, and to reduce morbidity. Intravenous calcium is the initial treatment for all patients with severe symptomatic hypocalcaemia. Administration of oral calcium and 1alpha-hydroxylated vitamin D metabolites, such as calcitriol, remains the mainstay of treatment and should be initiated in every patient with a diagnosis of pseudo hypoparathyroidism.

    • This question is part of the following fields:

      • Endocrinology
      13.9
      Seconds
  • Question 4 - A 15-year-old girl is referred to the paediatric unit with reduced urine output...

    Incorrect

    • A 15-year-old girl is referred to the paediatric unit with reduced urine output and lethargy. She has been passing bloody diarrhoea for the past four days. On admission she appears dehydrated. Bloods show the following: Na+ 142 mmol/L, K+ 4.8 mmol/L, Bicarbonate 22 mmol/L, Urea 10.1 mmol/L, Creatinine 176 µmol/L, Hb 10.4 g/dL, MCV 90 fl Plt 91 * 109/L, WBC 14.4 * 109/L, Given the likely diagnosis, which one of the following organisms is the most likely cause?

      Your Answer: Campylobacter

      Correct Answer: E. coli

      Explanation:

      The likely diagnosis in this case is Haemolytic Uremic Syndrome (HUS), which is generally seen in young children presenting with a triad of symptoms, namely: acute renal failure, microangiopathic haemolytic anaemia, and thrombocytopenia. The typical cause of HUS is ingestion of a strain of Escherichia coli.

    • This question is part of the following fields:

      • Nephrology
      20
      Seconds
  • Question 5 - The family of a 10-year-old boy was advised to take the boy to...

    Correct

    • The family of a 10-year-old boy was advised to take the boy to see an oncologist, for suspected lymphoma. The boy had lymphadenopathy on presentation. His mother says that he's had a fever, night sweats and has experienced weight loss. The boy underwent a lymph node biopsy at the oncologist which suggests Burkitt's lymphoma. Which oncogene are you expecting to see after molecular testing?

      Your Answer: c-MYC

      Explanation:

      Burkitt lymphoma is a germinal centre B-cell-derived cancer that was instrumental in the identification of MYC as an important human oncogene more than three decades ago. Recently, new genomics technologies have uncovered several additional oncogenic mechanisms that cooperate with MYC to create this highly aggressive cancer.

    • This question is part of the following fields:

      • Clinical Sciences
      11
      Seconds
  • Question 6 - A 27-year-old gentleman presents with a 2 year history of involuntary neck movements....

    Incorrect

    • A 27-year-old gentleman presents with a 2 year history of involuntary neck movements. There is no history of trauma. He is on no drugs. There is no relevant family history. On examination he has an episodic right torticollis. The rest of his neurological examination is normal. MRI of his cervical spine is normal. The neurologist in the Movement Disorders Clinic has diagnosed cervical dystonia. Which of the following treatments will be most beneficial?

      Your Answer: Baclofen

      Correct Answer: Botulinum toxin

      Explanation:

      Botulinum toxin is a neurotoxic protein from Clostridium botulinum that causes flaccid paralysis as it acts by preventing the release of Ach at the neuromuscular joint. It is the first-line treatment for cervical dystonia (torticollis) because the condition is a neurological disorder characterised by unusual muscle contractions of the neck. With the use of Botulinum toxin, the contractions would be released.

    • This question is part of the following fields:

      • Neurology
      12.2
      Seconds
  • Question 7 - A 28-year-old woman presents with intermittent episodes of diarrhoea, constipation, abdominal bloating and...

    Correct

    • A 28-year-old woman presents with intermittent episodes of diarrhoea, constipation, abdominal bloating and flatulence. Clinical examination is unremarkable. Faecal occult bloods are negative and haematological and biochemical investigations are unremarkable. Which of the following is the next most appropriate management step?

      Your Answer: Trial of dairy-free diet

      Explanation:

      The best next step is to try a dairy-free diet, many patients may develop this in their lifetime. IBS is a diagnosis of exclusion, and one would need to rule lactose intolerance out as a potential aetiology first. She is only 28, and without overt bleeding or signs/sxs/labs suggestive of obstruction or inflammation; colonoscopy, flex sig and a barium enema are not indicated.

    • This question is part of the following fields:

      • Gastroenterology
      10.1
      Seconds
  • Question 8 - A 22 year-old university graduate presented with progressive unsteadiness during walking over the...

    Correct

    • A 22 year-old university graduate presented with progressive unsteadiness during walking over the last year. She had been otherwise healthy apart from recent difficulty hearing her lecturer in classes. She took no prescription medication but had occasionally taken cocaine during her first year of college. She also admits to drinking up to 30 units of alcohol per week and smoked 10 cigarettes per day. Her parents were both well, but her father's sister had problems with walking before she died. Examination reveals normal tone and power throughout all four limbs. Reflexes were normal in the upper limbs but decreased at the knees and absent at the ankles. Coordination was normal in all four limbs but her gait was ataxic. Sensation in the upper limbs was normal but decreased vibratory sensation and proprioception was noted to the ankles bilaterally. What is the most likely diagnosis?

      Your Answer: Friedreich’s ataxia

      Explanation:

      Friedreich’s ataxia is an autosomal recessive disorder that usually begins before the end of the teens. It has an estimated prevalence in Europe of 1 in 50,000 and life expectancy is around 40–50 years. Neurological features include a progressive ataxia, cerebellar dysarthria, lower limb areflexia, decreased vibratory sensation and proprioception, and pyramidal weakness. Pes cavus and scoliosis are also both seen. Cardiomyopathy occurs in over 70% of cases. Less common features include optic atrophic, diabetes mellitus, and deafness.

    • This question is part of the following fields:

      • Neurology
      21.1
      Seconds
  • Question 9 - A 34 year old female presents to the clinic with skin tightness. On...

    Correct

    • A 34 year old female presents to the clinic with skin tightness. On examination she has sclerodactyly, thickened skin of the shoulders and bi-basal crepitations. Her HRCT chest shows ground glass changes. Raynaud phenomenon is suspected and she is started on a monthly dose of IV cyclophosphamide (1 gm/month) for 6 months and a daily dose of 10 mg of oral prednisolone. However, she returned over a period of few weeks after developing exertional dyspnoea, pedal oedema and feeling unwell. On examination, JVP is raised, there is marked pedal oedema and bi basal crepitations on chest auscultation. Urine dipstick shows haematuria (++) and proteinuria (++). What in your opinion is the most likely cause of her deteriorating renal function?

      Your Answer: Scleroderma renal crisis

      Explanation:

      Scleroderma renal crisis (SRC) is a rare but severe complication in patients with systemic sclerosis (SSc). It is characterized by malignant hypertension, microangiopathic haemolytic anaemia with schistocytes and oligo/anuric acute renal failure. SRC occurs in 5% of patients with systemic scleroderma, particularly in the first years of disease evolution and in the diffuse form. Patients may develop symptoms of fluid overload.

    • This question is part of the following fields:

      • Rheumatology
      22.3
      Seconds
  • Question 10 - A 60-year old female suddenly started seeing a curtain-like shadow in her field...

    Incorrect

    • A 60-year old female suddenly started seeing a curtain-like shadow in her field of vision with flashes of lights and subsequent loss of vision, which prompted her to visit her ophthalmologist. What do you think is the most appropriate treatment in this case?

      Your Answer: Peripheral iridectomy

      Correct Answer:

      Explanation:

      Flashes of light, presence of floaters and loss of vision (often described as a black curtain closing in on the visual field) are symptoms that strongly indicate retinal detachment. The fundoscopy findings of retinal tears support this diagnosis. Therefore, surgery of retina must be done to treat this patient.

    • This question is part of the following fields:

      • Ophthalmology
      12.7
      Seconds
  • Question 11 - Which of the following is true of Koplik’s spots? ...

    Incorrect

    • Which of the following is true of Koplik’s spots?

      Your Answer: Located opposite the incisor teeth

      Correct Answer: Are diagnostic of measles

      Explanation:

      Koplik’s spots are pathopneumonic for MEASLES. They are blue/white spots, small, occurring on the buccal mucosa. They typically occur next to premolars, not opposite to the incisors. They are not related to fever height. They are not on the hands. They usually occur BEFORE the rash.

    • This question is part of the following fields:

      • Infectious Diseases
      20.2
      Seconds
  • Question 12 - Choose the best source of folic acid: ...

    Incorrect

    • Choose the best source of folic acid:

      Your Answer: Red meat

      Correct Answer: Liver

      Explanation:

      Beef liver is one of the best sources of folic acid, amongst others like green vegetables and nuts.

    • This question is part of the following fields:

      • Clinical Sciences
      2.8
      Seconds
  • Question 13 - Which of the following statements regarding psoriasis is incorrect? ...

    Correct

    • Which of the following statements regarding psoriasis is incorrect?

      Your Answer: Mediated by type 2 helper T cells

      Explanation:

      Psoriasis is a long-lasting autoimmune disease characterized by patches of skin typically red, dry, itchy, and scaly. Psoriasis can affect the nails and produces a variety of changes in the appearance of finger and toe nails including pitting and onycholysis. Nail psoriasis occurs in 40–45% of people with psoriasis affecting the skin and has a lifetime incidence of 80–90% in those with psoriatic arthritis. Psoriasis is mediated by type 1 helper T cells which are involved in the cell mediated response.

    • This question is part of the following fields:

      • Dermatology
      3.6
      Seconds
  • Question 14 - A 55 yr. old male with a history of myocardial infarction 4 years...

    Incorrect

    • A 55 yr. old male with a history of myocardial infarction 4 years ago, was admitted with a history of fever for the past 2 weeks. On investigation, his echocardiography revealed a small vegetation around the mitral valve. His blood culture was positive for Streptococcus viridans. Which of the following is the most appropriate antibiotic therapy?

      Your Answer: IV vancomycin + benzylpenicillin

      Correct Answer: IV benzylpenicillin

      Explanation:

      According to the American Heart Association (AHA) penicillin-susceptible S viridans, S bovis, and other streptococci (MIC of penicillin of ≤0.1 mcg/mL) should be treated with penicillin G or ceftriaxone or penicillin G + a gentamicin combination or vancomycin (if allergy to penicillin).

    • This question is part of the following fields:

      • Cardiology
      14.6
      Seconds
  • Question 15 - A 50-year-old male is brought to the emergency department following a suicide attempt....

    Correct

    • A 50-year-old male is brought to the emergency department following a suicide attempt. He was found at home with an empty bottle of paracetamol by his side. Still conscious, a history was obtained from him to assess his risk of further attempts. Which of the following is considered to be the strongest risk factor for successful suicide?

      Your Answer: Addiction to opiates

      Explanation:

      Among the given options, an addiction to opiates is considered the strongest risk factor for committing suicide.

      Other options:
      Being a female – Being male is one of the most significant risk factors for suicide.
      Being married – Having family support is an important protective factor for suicide.
      Having five children – Having children at home is thought to be a protective factor.
      Having never seen a general practitioner – Having a chronic mental or physical condition is however a risk factor for suicide.

      Risk factors of suicide:
      There are several factors shown to be associated with an increased risk of suicide:
      Male sex
      History of deliberate self-harm
      Alcohol or drug misuse
      History of mental illness (depression, schizophrenia)
      History of chronic disease
      Advancing age
      Unemployment or social isolation/living alone
      Being unmarried, divorced or widowed
      Previous attempt to commit suicide.

      Signs pointing towards suicidal intension:
      Efforts to avoid discovery
      Planning
      Leaving a written note
      Final acts such as sorting out finances
      Violent method

      Protective factors against suicide:
      Family support
      Having children at home
      Religious belief

    • This question is part of the following fields:

      • Psychiatry
      13.6
      Seconds
  • Question 16 - A 23-year-old man is referred to the pneumologist with a suspicion of bronchiectasis....

    Incorrect

    • A 23-year-old man is referred to the pneumologist with a suspicion of bronchiectasis. History reveals he's been having recurrent pulmonary infections his whole life together with difficulties gaining weight. He's a non-smoker with a clear family history and he admits inhalers haven't helped him in the past. He is finally suspected of having cystic fibrosis. What is the normal function of the cystic fibrosis transmembrane regulator?

      Your Answer: Potassium channel

      Correct Answer: Chloride channel

      Explanation:

      Chloride channels are involved in a diverse set of functions in normal physiology and acquired diseases. Additionally, there are genetic diseases caused by mutations in chloride channels (channelopathies) — the most common being cystic fibrosis, which has a prevalence of 1 in 2,000 Caucasians.

    • This question is part of the following fields:

      • Clinical Sciences
      18
      Seconds
  • Question 17 - A woman is prescribed docetaxel as part of her chemotherapy for breast cancer....

    Incorrect

    • A woman is prescribed docetaxel as part of her chemotherapy for breast cancer. What is the mechanism of action of docetaxel?

      Your Answer: Inhibits RNA synthesis

      Correct Answer: Prevents microtubule disassembly

      Explanation:

      The principal mechanism of action of taxanes (e.g. docetaxel) is the prevention of microtubule disassembly.

      Other aforementioned options are ruled out because:

      1. Doxorubicin: stabilizes DNA topoisomerase II complex and inhibits DNA and RNA synthesis.

      2. Vincristine, vinblastine: inhibits formation of microtubules.

      3. Cisplatin: causes cross-linking in DNA.

    • This question is part of the following fields:

      • Haematology & Oncology
      6.2
      Seconds
  • Question 18 - A 60 yr. old man presented with severe central chest pain for the...

    Correct

    • A 60 yr. old man presented with severe central chest pain for the last 2 hours. He was on insulin for diabetes mellitus and he was dependent on haemodialysis because of end stage renal failure. He had undergone haemodialysis 48 hours prior to this presentation. His ECG showed an acute inferior myocardial infarction. Despite thrombolysis and other appropriate treatment, he continued to have chest pain after 6 hours from the initial presentation. His blood pressure was 88/54 mmHg and he had bibasal crepitations. His investigation results are given below. Serum sodium 140 mmol/l (137-144), Serum potassium 6.6 mmol/l (3.5-4.9), Serum urea 50 mmol/l (2.5-7.5), Serum creatinine 940 μmol/l (60-110), Haemoglobin 10.2g/dl (13.0-18.0), Troponin T >24 g/l (<0.04), Left ventricular ejection fraction was 20%. What is the most appropriate management for this patient?

      Your Answer: Coronary angiography and rescue PCI

      Explanation:

      According to the history the patient has cardiogenic shock and pulmonary oedema. On-going ischaemia is indicated by persisting symptoms. So the most appropriate management is coronary angiography and rescue PCI. There are no indications for blood transfusion at this moment and it will aggravate the pulmonary oedema. Haemodialysis, beta blockers and furosemide cannot be given due to low blood pressure.

    • This question is part of the following fields:

      • Cardiology
      23.2
      Seconds
  • Question 19 - A 65-year-old complains of fatigue, headache and blurred vision in the left eye....

    Incorrect

    • A 65-year-old complains of fatigue, headache and blurred vision in the left eye. Moreover, she is unable to comb her hair. What is the most probable diagnosis?

      Your Answer: Amaurosis fugax

      Correct Answer: Temporal arteritis

      Explanation:

      The patient is in a suitable age for developing temporal arteritis and the fact that she’s unable to comb her hair indicates scalp tenderness or proximal muscle weakness. A high ESR together with increased CRP supports the diagnosis. Temporal artery biopsy is also useful to establish the diagnosis.

    • This question is part of the following fields:

      • Ophthalmology
      7.1
      Seconds
  • Question 20 - A 78-year-old male with long-standing Alzheimer's disease is being reviewed in your clinic....

    Correct

    • A 78-year-old male with long-standing Alzheimer's disease is being reviewed in your clinic. Which among the following is true regarding memantine, a drug which has been approved for the management of dementia in the UK?

      Your Answer: It is an NMDA-receptor agonist

      Explanation:

      Memantine is an antagonist of the NMDA (N-Methyl-D-Aspartate)-receptor subtype of glutamate receptor. It is used to slow the neurotoxicity thought to be involved in Alzheimer’s disease and other neurodegenerative diseases.

      Drug interactions:
      When given concomitantly with other NMDA-receptor antagonists (e.g., ketamine, amantadine) increase the risk of psychosis.
      Dopamine agonists, L-dopa, and anticholinergics enhance effects of memantine.
      Antispasmodics (e.g., baclofen)  enhance effects, as memantine has some antispasmodic effects.
      Drugs excreted by cationic transporters in the kidney (e.g. quinine, cimetidine, ranitidine) reduce excretion.

      Common adverse effects include dizziness, headache, confusion, diarrhoea, and constipation.

    • This question is part of the following fields:

      • Pharmacology
      7.4
      Seconds
  • Question 21 - A 44-year-old hairdresser with a history of myasthenia gravis is admitted to the...

    Incorrect

    • A 44-year-old hairdresser with a history of myasthenia gravis is admitted to the Emergency Department. She is currently taking pyridostigmine, but there has been a significant worsening of her symptoms following antibiotic treatment for a chest infection. On examination she is dyspnoeic and cyanotic with quiet breath sounds in both lungs. Other than respiratory support, what are the two other treatments of choice?

      Your Answer: IV methylprednisolone or intravenous immunoglobulins

      Correct Answer: Plasmapheresis or intravenous immunoglobulins

      Explanation:

      This patient is having a myasthenic crisis. Opinions vary as to whether plasmapheresis or intravenous immunoglobulins should be given first-line. Plasmapheresis usually works much faster, but is more costly due to equipment.
      Myasthenia gravis is an autoimmune disorder resulting in insufficient functioning acetylcholine receptors. Antibodies to acetylcholine receptors are seen in 85-90% of cases. Myasthenia gravis is more common in women (2:1).

    • This question is part of the following fields:

      • Neurology
      14.3
      Seconds
  • Question 22 - A 41 year old man who has had two episodes of pneumonia in...

    Incorrect

    • A 41 year old man who has had two episodes of pneumonia in succession and an episode of haemoptysis is observed to have paroxysms of coughing and increasing wheezing. A single lesion which is well-defined is seen in the lower right lower lobe on a chest x-ray. There is no necrosis but biopsy shows numerous abnormal cells, occasional nuclear pleomorphism and absent mitoses. Which diagnosis fits the clinical presentation?

      Your Answer: Small cell carcinoma of the bronchus

      Correct Answer: Bronchial carcinoid

      Explanation:

      Bronchial carcinoids are uncommon, slow growing, low-grade, malignant neoplasms, comprising 1-2% of all primary lung cancers.
      It is believed to be derived from surface of bronchial glandular epithelium. Mostly located centrally, they produce symptoms and signs of bronchial obstruction such as localized wheeze, non resolving recurrent pneumonitis, cough, chest pain, and fever. Haemoptysis is present in approximately 50% of the cases due to their central origin and hypervascularity.
      Central bronchial carcinoids are more common than the peripheral type and are seen as endobronchial nodules or hilar/perihilar mass closely related to the adjacent bronchus. Chest X-ray may not show the central lesion depending on how small it is.

    • This question is part of the following fields:

      • Respiratory
      22
      Seconds
  • Question 23 - A 23-year-old student commences chemotherapy for B-type acute lymphoblastic leukaemia. She suffers from...

    Incorrect

    • A 23-year-old student commences chemotherapy for B-type acute lymphoblastic leukaemia. She suffers from vomiting, but 36 hours later her condition worsens and her bloods reveal a corrected calcium of 2.0 mmol/l and serum potassium of 6.7 mmol/l. Which of the following options is the best way to avoid this problem from occurring?

      Your Answer: Furosemide and allopurinol pre-chemotherapy

      Correct Answer: Hydration and allopurinol pre-chemotherapy

      Explanation:

      This case is most likely tumour lysis syndrome, often occurring immediately after starting chemotherapy because the tumour cells are killed and their contents are released into the bloodstream. After treating lymphomas or leukaemia, there is a sudden hypocalcaemia, hyperphosphatemia, and hyperkalaemia

    • This question is part of the following fields:

      • Nephrology
      9
      Seconds
  • Question 24 - A 26 year old male presents with right sided elbow and wrist pain...

    Correct

    • A 26 year old male presents with right sided elbow and wrist pain and left sided knee and ankle pain that has persisted for about two weeks. He recently returned from a trip to Thailand that last for two weeks. The patient admits to having unprotected sex while on holiday. Examination reveals swelling and tenderness of tendons around joints but no inflammation of the joints. A vesiculopustular skin rash is also observed. What is the most likely cause?

      Your Answer: Gonococcal arthritis

      Explanation:

      Patients with disseminated gonococcal arthritis may present with dermatitis-arthritis syndrome (60%) of with localized septic arthritis. (40%). Arthritis-dermatitis syndrome includes the classic triad of dermatitis, tenosynovitis, and migratory polyarthritis. Gout usually involves a singe joint and does not cause vesicopustular skin rash. Reactive arthritis has ocular symptoms (conjunctivitis), urethritis, and arthritis. Fungal arthritis occurs rarely and it may occur after a surgical infection or fungal spread hematogenously. it presents with tender, red, hot and swollen joint with loss of range of motion.

    • This question is part of the following fields:

      • Rheumatology
      32.1
      Seconds
  • Question 25 - A 50 yr. old male patient presented with acute chest pain and a...

    Correct

    • A 50 yr. old male patient presented with acute chest pain and a non ST elevation myocardial infarction (NSTEMI) was diagnosed. He was threated with aspirin 300mg and 2 puffs of glyceral trin (GTN) spray. According to NICE guidelines, which of the following categories of patients should receive clopidogrel?

      Your Answer: All patients

      Explanation:

      According to NICE guidelines (2013) all people who have had an acute MI treatment should be offered with ACE inhibitor, dual antiplatelet therapy (aspirin plus a second antiplatelet agent), a beta-blocker and a statin.

    • This question is part of the following fields:

      • Cardiology
      14.4
      Seconds
  • Question 26 - A 38-year-old female is referred to the dermatologist for a rash on both...

    Correct

    • A 38-year-old female is referred to the dermatologist for a rash on both her elbows. The rash is red, is papulovesicular in nature, and looks like it has many small blisters. The dermatologist diagnoses her with dermatitis herpetiformis. Which HLA haplotype is this associated with?

      Your Answer: HLA-DR3

      Explanation:

      Dermatitis herpetiformis (DH), or Duhring’s disease, is a chronic blistering skin condition,characterised by blisters filled with a watery fluid. Despite its name, it is neither related to nor caused by herpes virus: the name means that it is a skin inflammation having an appearance similar to herpes.
      Dermatitis herpetiformis is characterized by intensely itchy, chronic papulovesicular eruptions, usually distributed symmetrically on extensor surfaces (buttocks, back of neck, scalp, elbows, knees, back, hairline, groin, or face)
      Dermatitis herpetiformis is an autoimmune condition associated with HLA-DR3.
      HLA-A3 is associated with haemochromatosis. HLA-B5 is most commonly associated with Behcet’s disease. HLA-DR4 is associated with both type 1 diabetes mellitus and rheumatoid arthritis. HLA-B27 is most commonly associated with several diseases, most commonly ankylosing spondylitis.

    • This question is part of the following fields:

      • Clinical Sciences
      49.1
      Seconds
  • Question 27 - A 57-year-old man, who suffers from biventricular cardiac failure, comes to his doctor...

    Incorrect

    • A 57-year-old man, who suffers from biventricular cardiac failure, comes to his doctor for a review. His symptoms are currently well controlled; he is taking Ramipril 10mg, Spironolactone 25mg, Bisoprolol 10mg, and Furosemide 40mg. His main complaint is of painful gynaecomastia that he says has developed over the past 6 months. Physical exam reveals a blood pressure of 125/80 mmHg and no residual signs of cardiac failure. Renal function is unchanged from 6 months earlier, with stable creatinine at 125 µmol/l. Which of the following is the most appropriate next step?

      Your Answer: Check is prolactin level

      Correct Answer: Change the spironolactone to eplerenone

      Explanation:

      Spironolactone is an aldosterone antagonist diuretic that is well-known to cause gynaecomastia because it increases testosterone clearance and oestradiol production. The patient’s primary complaint of gynaecomastia should immediately prompt discontinuation of spironolactone and replacement with Eplerenone, which lacks the antiandrogenic effects, and thus there is less risk of gynaecomastia.

    • This question is part of the following fields:

      • Nephrology
      14.6
      Seconds
  • Question 28 - A 38-year-old woman returns from a summer holiday with a dry cough. Her...

    Incorrect

    • A 38-year-old woman returns from a summer holiday with a dry cough. Her CXR shows bilateral consolidated areas. Which antibiotic would you suggest?

      Your Answer: Clarithromycin

      Correct Answer: Ciprofloxacin

      Explanation:

      Ciprofloxacin is a well-established broad-spectrum fluoroquinolone antibiotic that penetrates well into the lung tissues.

    • This question is part of the following fields:

      • Infectious Diseases
      6
      Seconds
  • Question 29 - A 26 year old woman is 32 weeks pregnant. She has a history...

    Incorrect

    • A 26 year old woman is 32 weeks pregnant. She has a history of Sjogren Syndrome. The foetus would be at a risk for which of the following?

      Your Answer: Hydrops fetalis

      Correct Answer: All correct

      Explanation:

      Women with Sjögren syndrome are likely to experience more complications during pregnancy than women without an autoimmune disease as the anti-Ro and anti-La antibodies cross the placenta and lead to various life threatening complications. Studies show a high incidence of poor fetal outcomes for these patients. Congenital heart block, neonatal lupus, congestive cardiac failure, hydrops fetalis can all be caused as a result of Sjogren syndrome.

    • This question is part of the following fields:

      • Rheumatology
      7.3
      Seconds
  • Question 30 - A 48 yr. old male presented with exertional angina for 2 weeks. He...

    Correct

    • A 48 yr. old male presented with exertional angina for 2 weeks. He has no significant past medical history or cardiac risk factors except a total cholesterol of 5.8 mmol/L. He has been already started on aspirin. Which of the following is the most suitable drug combination for him?

      Your Answer: B-blocker and statin

      Explanation:

      Beta blockers and calcium channel blockers have proven prognostic benefits. Nitrates don’t have any proven prognostic benefits. A statin is indicated for a patient with angina and cholesterol level of 5.5 to 8.5 to prevent risk of myocardial infarction. So the preferred combination from the given answers is beta blocker + statin.

    • This question is part of the following fields:

      • Cardiology
      48.1
      Seconds

SESSION STATS - PERFORMANCE PER SPECIALTY

Clinical Sciences (3/5) 60%
Infectious Diseases (0/3) 0%
Endocrinology (1/1) 100%
Nephrology (0/3) 0%
Neurology (1/3) 33%
Gastroenterology (1/1) 100%
Rheumatology (2/3) 67%
Ophthalmology (0/2) 0%
Dermatology (1/1) 100%
Cardiology (3/4) 75%
Psychiatry (1/1) 100%
Haematology & Oncology (0/1) 0%
Pharmacology (1/1) 100%
Respiratory (0/1) 0%
Passmed