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Question 1
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A 12-year-old boy comes to his GP complaining of a limp. He has a swollen right knee with clinical synovitis but no effusion. He is growing normally and has been generally healthy, except for experiencing diarrhoea and vomiting last week. There are no signs of joint issues in his other joints.
What condition is most likely causing his symptoms?Your Answer: Reactive arthritis
Explanation:Reactive Arthritis in Children
Reactive arthritis is the most common form of arthritis in children and is often associated with recent illness. In this case, the child presents with large-joint oligoarthritis following gastroenteritis. While it may also be associated with genitourinary infection, treating the infection does not alter the course of the joint disease. The child should be given analgesia and observed for arthritis elsewhere.
Although this may be a new presentation of enteropathic arthritis or JIA, the child’s lack of chronic disease symptoms reduces the likelihood of these diagnoses. Gout is extremely rare in children, except for in rare metabolic conditions. Septic arthritis must also be considered, but the child is likely to be systemically unwell with features of infection.
In summary, reactive arthritis is the most likely diagnosis in this case of paediatric arthritis following recent illness. It is important to monitor the child’s symptoms and consider other potential diagnoses if necessary.
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This question is part of the following fields:
- Rheumatology
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Question 2
Incorrect
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A previously healthy 8-year-old girl comes to the GP with a recent onset limp. She experiences tenderness in her right leg during all hip movements. Blood tests reveal no abnormalities. An MRI scan shows an irregular femoral head. What is the probable underlying diagnosis?
Your Answer: Slipped upper femoral epiphysis
Correct Answer: Legg-Calve-Perthes disease
Explanation:Idiopathic Osteonecrosis of the Femoral Head in Children
Idiopathic osteonecrosis of the femoral head, also known as Perthes disease, is a condition that primarily affects boys between the ages of 5 and 11. It is characterized by pain in the hip during movement and difficulty bearing weight. Unlike septic arthritis, the child is not systemically unwell. The cause of Perthes disease is unknown, although trauma may sometimes be a contributing factor.
Examination findings can help localize the pathology to the hip, and irregularities in the femoral head may be visible on x-ray. However, MRI is the preferred imaging modality. Treatment options depend on the extent of the affected area. If less than 50% of the head is affected, bed rest and analgesia may be sufficient. If more than 50% is affected, surgery may be necessary.
Other conditions that can cause a limping child include caisson disease, septic arthritis, sickle cell disease, and slipped upper femoral epiphysis (SUFE). However, each of these conditions has distinct characteristics that can help differentiate them from Perthes disease. For example, caisson disease is associated with nitrogen decompression sickness after diving, while SUFE tends to occur in teenagers and involves a fracture through the growth plate with a displaced femoral head.
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This question is part of the following fields:
- Rheumatology
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Question 3
Incorrect
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A 10-year-old girl comes to the clinic with a painful left ankle following a fall. An x-ray reveals a fracture that runs through the tibial growth plate and metaphysis. What Salter-Harris fracture classification does this injury fall under?
Your Answer: III
Correct Answer: II
Explanation:Type II Salter-Harris Fractures
The Salter-Harris classification system is a way to categorize fractures that involve the growth plate or physis. These types of fractures are common in children and teenagers whose growth plates are still open. Type II Salter-Harris fractures are the most common, accounting for 75% of all growth plate fractures. This type of fracture involves a defect that runs through the growth plate and then the metaphysis.
To put it simply, a Type II Salter-Harris fracture occurs when a bone breaks through the growth plate and into the surrounding bone tissue. This type of fracture is often caused by a sudden impact or trauma to the affected area. It is important to diagnose and treat Type II fractures promptly to prevent any long-term complications, such as growth abnormalities or joint problems.
In summary, Type II Salter-Harris fractures are a common type of growth plate fracture that involves a defect running through the growth plate and then the metaphysis. These fractures can have long-term consequences if not treated properly, making prompt diagnosis and treatment essential.
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This question is part of the following fields:
- Rheumatology
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Question 4
Incorrect
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A 30-year-old patient presents with complaints of recurrent bloody diarrhoea and symptoms of iritis. On examination, there is a painful nodular erythematous eruption on the shin and anal tags are observed. What diagnostic test would you recommend to confirm the diagnosis?
Your Answer: HLA B-27
Correct Answer: Colonoscopy
Explanation:Inflammatory Bowel Disease with Crohn’s Disease Suggestion
The patient’s symptoms and physical examination suggest inflammatory bowel disease, with anal skin tags indicating a possible diagnosis of Crohn’s disease. Other symptoms consistent with this diagnosis include iritis and a skin rash that may be erythema nodosum. To confirm the diagnosis, a colonoscopy with biopsies would be the initial investigation. While serum ACE levels can aid in diagnosis, they are often elevated in conditions other than sarcoidosis.
Overall, the patient’s symptoms and physical examination point towards inflammatory bowel disease, with Crohn’s disease as a possible subtype. Further testing is necessary to confirm the diagnosis and rule out other conditions.
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This question is part of the following fields:
- Rheumatology
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Question 5
Correct
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A 14-year-old boy with juvenile idiopathic arthritis is visiting the eye clinic for a screening.
What is the purpose of his visit and what complication is he being screened for?Your Answer: Chronic anterior uveitis
Explanation:Complications of Juvenile Idiopathic Arthritis
Patients with Juvenile Idiopathic Arthritis (JIA) are regularly screened for chronic anterior uveitis, which can lead to scarring and blindness if left untreated. However, this condition may be asymptomatic in some cases, making annual screening using a slit-lamp essential.
One of the long-term complications of JIA is the development of flexion contractures of joints due to persistent joint inflammation. This occurs because pain is partly related to increased intra-articular pressure, which is at its lowest when joints are held at 30-50 degrees.
While corticosteroids may be used to manage joint inflammation, they are used sparingly in children due to the risk of cataract development. Conjunctivitis is not typically associated with JIA, but reactive arthritis. Keratitis, on the other hand, tends to be an infective process caused by bacteria or viruses.
Lastly, pterygium is an overgrowth of the conjunctiva towards the iris and is often seen in individuals exposed to windy or dusty conditions, such as surfers.
In summary, JIA can lead to various complications, including chronic anterior uveitis, joint contractures, and cataract development. Regular screening and management are crucial to prevent long-term damage.
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This question is part of the following fields:
- Rheumatology
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Question 6
Correct
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An 8-year-old girl comes to the doctor complaining of leg pains. She cries at night and her mother has to massage the painful areas to soothe her. Upon examination, there are no visible abnormalities. What is the probable diagnosis?
Your Answer: Idiopathic pains
Explanation:Idiopathic Limb Pains in Children
Idiopathic limb pains, also known as growing pains, are a common occurrence in children between the ages of 3 and 9. These pains typically occur in the lower limbs and can be quickly settled with comforting. It is important to note that these pains are not associated with any abnormalities found during examination and the child should be growing normally.
However, it is important to distinguish idiopathic limb pains from other conditions that may cause similar symptoms. Acute lymphoblastic leukaemia, for example, may cause limb pain due to bone marrow infiltration. Children with this condition may also exhibit signs of bone marrow failure and be systemically unwell.
Langerhans histiocytosis is another condition that can cause painful bone lesions. This proliferative disorder of antigen presenting cells may be localised or systemic and can be difficult to diagnose. The systemic form of the condition may also present with a widespread eczematous rash and fevers.
Non-accidental injury may also present with recurrent pains, but evidence of an injury would be expected. Primary bone malignancy is more common in teenage years and typically presents with unremitting pain, growth failure, weight loss, or pathological fractures.
In summary, while idiopathic limb pains are relatively easy to settle and associated with a normal examination, it is important to consider other potential conditions that may cause similar symptoms. Proper diagnosis and treatment can help ensure the best possible outcome for the child.
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This question is part of the following fields:
- Rheumatology
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Question 7
Correct
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A 58-year-old female patient with chronic rheumatoid arthritis visits her GP complaining of symptoms related to keratoconjunctivitis sicca. What is a straightforward test that can be performed to confirm this diagnosis?
Your Answer: Schirmer's test
Explanation:Secondary Sjögren’s Syndrome in Rheumatological Patients
It is not uncommon for patients with rheumatological disease to develop secondary Sjögren’s syndrome, which is also known as keratoconjunctivitis sicca. This condition is characterized by a reduction in secretions, particularly in the salivary and lacrimal glands. One of the diagnostic tests used to identify this condition is the Schirmer’s test. This test is a simple procedure that measures the production of tears in the eyes. During the test, a strip of paper is placed under the eyelid of the patient, and after five minutes, the amount of moistness on the paper is measured. If the moistness is less than 5 mm, it is suggestive of Sjögren’s syndrome.
Overall, secondary Sjögren’s syndrome is a common condition that can occur in patients with rheumatological disease. The Schirmer’s test is a simple and effective way to diagnose this condition, and it can help healthcare professionals provide appropriate treatment to patients.
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This question is part of the following fields:
- Rheumatology
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Question 8
Incorrect
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What type of juvenile arthritis is most frequently seen?
Your Answer: Rheumatoid factor positive oligoarthritis
Correct Answer: Antinuclear antibody positive oligoarthritis
Explanation:Juvenile Idiopathic Arthritis (JIA) and its Characteristics
Juvenile Idiopathic Arthritis (JIA) is a condition characterized by persistent joint swelling in children under 16 years of age without any known cause. It is not the same as rheumatoid arthritis, as only 5% of JIA cases are rheumatoid factor positive polyarthritis. Instead, 60% of JIA cases are ANA+ oligoarthritis. Children with JIA may also experience systemic symptoms, such as chronic anterior uveitis, which requires regular screening. Chronic inflammation can lead to secondary amyloidosis, while poor growth, anorexia, and anaemia are common due to chronic disease and steroid therapy.
Overall, JIA is a complex condition that can have a significant impact on a child’s health and wellbeing. It is important for healthcare professionals to be aware of the various characteristics of JIA and to provide appropriate care and support to affected children and their families.
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This question is part of the following fields:
- Rheumatology
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Question 9
Incorrect
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A 27-year-old male presents with lower back pain and painful feet that feel like walking on pebbles. He has been generally healthy, but he recently returned from a trip to Corfu where he had a diarrheal illness. He admits to infrequently taking ecstasy but takes no other medication. On examination, he has limited movement and pain in the sacroiliac joints and soreness in the soles of his feet upon deep palpation. What is the most probable diagnosis?
Your Answer: Drug-induced arthropathy
Correct Answer: Reactive arthritis
Explanation:After a diarrhoeal illness, the patient may be at risk of developing reactive arthritis, which is a possible diagnosis for both sacroiliitis and plantar fasciitis. However, it is less likely to be related to inflammatory bowel disease (IBD) if there is only one acute episode of diarrhoea.
Sacroiliitis is a condition that affects the sacroiliac joint, which is located at the base of the spine where it connects to the pelvis. It causes inflammation and pain in the lower back, buttocks, and legs. Plantar fasciitis, on the other hand, is a condition that affects the plantar fascia, a thick band of tissue that runs along the bottom of the foot. It causes pain and stiffness in the heel and arch of the foot.
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This question is part of the following fields:
- Rheumatology
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Question 10
Correct
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A 70-year-old male complains of increasing pain and swelling in his left knee over the past three days. He has a medical history of hypertension and takes bendroflumethiazide and lisinopril. Upon examination, his left knee is swollen, red, and tender, and he experiences limited mobility due to the pain. What is the most suitable test to perform for this patient?
Your Answer: Joint aspiration
Explanation:Differential Diagnosis of Monoarthropathy
Monoarthropathy can have various causes, and one of the possibilities is septic arthritis. To rule out this condition, joint aspiration is necessary, and the sample should be sent for microscopy and culture to detect the presence of crystals and organisms. Polymorphs and organisms are expected in septic arthritis, while negatively birefringent crystals are typical for gout, and positively birefringent crystals are seen in pseudogout. FBC and ESR are not useful for diagnosis, and although an x-ray may show osteoarthritis changes, it is not the primary investigation.
Bendroflumethiazide can increase urate levels and trigger acute gout, but urate concentrations may remain normal during an acute gout attack. Therefore, it is essential to consider all possible causes of monoarthropathy and perform the appropriate tests to make an accurate diagnosis.
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This question is part of the following fields:
- Rheumatology
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