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Question 1
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A 50-year-old man presents to the emergency department with a 24-hour history of worsening right knee pain and limited mobility. He reports falling off his bike a few days ago but did not experience any knee pain until yesterday. Upon examination, the right knee appears red and hot with only 20º of flexion and a small effusion. The patient has a history of a conservatively treated ACL rupture in the other knee.
The patient's vital signs are as follows: heart rate 100 beats/min, respiratory rate 18/min, saturations 98% on room air, blood pressure 102/67 mmHg, and temperature 37.9ºC. Blood tests reveal a hemoglobin level of 145 g/L, platelets of 500 * 109/L, a white cell count of 13.6 * 109/L, a sodium level of 142 mmol/L, a potassium level of 5.0 mmol/L, a urea level of 4.0 mmol/L, a creatinine level of 110 µmol/L, and a CRP level of 130 mg/L. X-ray results show no obvious bony injury.
What is the most appropriate next step in managing this patient?Your Answer: Urgent orthopaedic review
Explanation:Septic arthritis is most commonly observed in adults’ knees, which presents as sudden joint pain and immobility, accompanied by fever and elevated inflammatory markers. Urgent orthopaedic evaluation is necessary for aspiration and potential washout, as untreated septic arthritis can lead to joint destruction within hours to days. Discharging the patient with oral antibiotics or physiotherapy is not recommended. Administering colchicine is not appropriate as there is no history of gout or pseudogout, and X-ray results do not indicate chondrocalcinosis. Ordering an MRI knee scan may delay appropriate treatment and will not impact management.
Septic Arthritis in Adults: Causes, Symptoms, and Treatment
Septic arthritis is a condition that occurs when bacteria infect a joint, leading to inflammation and pain. The most common organism that causes septic arthritis in adults is Staphylococcus aureus, but in young adults who are sexually active, Neisseria gonorrhoeae is the most common organism. The infection usually spreads through the bloodstream from a distant bacterial infection, such as an abscess. The knee is the most common location for septic arthritis in adults. Symptoms include an acute, swollen joint, restricted movement, warmth to the touch, and fever.
To diagnose septic arthritis, synovial fluid sampling is necessary and should be done before administering antibiotics if necessary. Blood cultures may also be taken to identify the cause of the infection. Joint imaging may also be used to confirm the diagnosis.
Treatment for septic arthritis involves intravenous antibiotics that cover Gram-positive cocci. Flucloxacillin or clindamycin is recommended if the patient is allergic to penicillin. Antibiotic treatment is typically given for several weeks, and patients are usually switched to oral antibiotics after two weeks. Needle aspiration may be used to decompress the joint, and arthroscopic lavage may be required in some cases.
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This question is part of the following fields:
- Musculoskeletal
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Question 2
Incorrect
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A 55-year-old patient complains of a painful swollen left knee that has not improved after a week of rest. The patient denies any history of injury. Upon examination, a moderate-sized effusion is observed. A plain radiograph reveals the following findings: some joint space loss and linear calcification of the articular cartilage. What is the probable diagnosis?
Your Answer: Osteoarthritis
Correct Answer: Pseudogout
Explanation:Chondrocalcinosis is a useful indicator for differentiating between pseudogout and gout.
The presence of chondrocalcinosis can be observed in an x-ray, which helps to distinguish between pseudogout and gout. In older individuals, joint space loss and osteoarthritic-like changes are common and may be caused by pseudogout.
Pseudogout, also known as acute calcium pyrophosphate crystal deposition disease, is a type of microcrystal synovitis that occurs when calcium pyrophosphate dihydrate crystals are deposited in the synovium. This condition is more common in older individuals, but those under 60 years of age may develop it if they have underlying risk factors such as haemochromatosis, hyperparathyroidism, low magnesium or phosphate levels, acromegaly, or Wilson’s disease. The knee, wrist, and shoulders are the most commonly affected joints, and joint aspiration may reveal weakly-positively birefringent rhomboid-shaped crystals. X-rays may show chondrocalcinosis, which appears as linear calcifications of the meniscus and articular cartilage in the knee. Treatment involves joint fluid aspiration to rule out septic arthritis, as well as the use of NSAIDs or steroids, as with gout.
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This question is part of the following fields:
- Musculoskeletal
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Question 3
Correct
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A 7 year-old girl from Sierra Leone presents with a 2 week history of painful left leg. She is homozygous for sickle cell disease. On examination the child is febrile at 39.8ºC and there is bony tenderness over the left tibial shaft. Investigations are:
Hb 6.9 g/dL
Blood culture Gram positive cocci
X-ray left tibia: Osteomyelitis - destruction of bony cortex with periosteal reaction.
What is the most likely responsible pathogen?Your Answer: Non-typhi Salmonella
Explanation:Non-typhi salmonella (NTS) is known to cause blood and bone infections, particularly in children with sickle cell disease and malaria. The exact reason for this susceptibility is not fully understood, but it may be due to the bacteria’s affinity for iron, which is made available through haemolysis. Other bacteria such as E.coli and P. aeruginosa are not commonly associated with sickle cell disease, and Staphylococcus aureus is a gram-positive coccus. Aplastic anaemia and parvovirus can be ruled out as causes, as the child’s haemoglobin level is normal and parvovirus does not cause osteomyelitis.
Understanding Osteomyelitis: Types, Causes, and Treatment
Osteomyelitis is a bone infection that can be classified into two types: haematogenous and non-haematogenous. Haematogenous osteomyelitis is caused by bacteria that enter the bloodstream and is usually monomicrobial. It is more common in children, with vertebral osteomyelitis being the most common form in adults. Risk factors include sickle cell anaemia, intravenous drug use, immunosuppression, and infective endocarditis. On the other hand, non-haematogenous osteomyelitis results from the spread of infection from adjacent soft tissues or direct injury to the bone. It is often polymicrobial and more common in adults, with risk factors such as diabetic foot ulcers, pressure sores, diabetes mellitus, and peripheral arterial disease.
Staphylococcus aureus is the most common cause of osteomyelitis, except in patients with sickle-cell anaemia where Salmonella species predominate. To diagnose osteomyelitis, MRI is the imaging modality of choice, with a sensitivity of 90-100%. Treatment for osteomyelitis involves a six-week course of flucloxacillin. Clindamycin is an alternative for patients who are allergic to penicillin.
In summary, osteomyelitis is a bone infection that can be caused by bacteria entering the bloodstream or spreading from adjacent soft tissues or direct injury to the bone. It is more common in children and adults with certain risk factors. Staphylococcus aureus is the most common cause, and MRI is the preferred imaging modality for diagnosis. Treatment involves a six-week course of flucloxacillin or clindamycin for penicillin-allergic patients.
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This question is part of the following fields:
- Musculoskeletal
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Question 4
Correct
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A 26-year-old construction worker visits his GP complaining of elbow swelling that has been present for three weeks. He reports that it started gradually and has no known triggers. The area is painful and warm to the touch, but he has no swelling in other parts of his body and feels generally well. The patient has a history of well-managed rheumatoid arthritis and is taking methotrexate, and has no other medical conditions. During the examination, the doctor detects a tender, soft, fluctuant mass on the back of the patient's elbow. Based on these findings, what is the most probable diagnosis?
Your Answer: Olecranon bursitis
Explanation:Olecranon bursitis is a condition that occurs when the olecranon bursa, a fluid-filled sac located over the olecranon process at the proximal end of the ulna, becomes inflamed. This bursa serves to reduce friction between the elbow joint and the surrounding soft tissues. Inflammation can be caused by trauma, infection, or systemic conditions such as rheumatoid arthritis or gout. It is also commonly known as student’s elbow due to the repetitive mild trauma of leaning on a desk using the elbows. The condition can be categorized as septic or non-septic depending on whether an infection is present.
The condition is more common in men and typically presents between the ages of 30 and 60. Causes of olecranon bursitis include repetitive trauma, direct trauma, infection, gout, rheumatoid arthritis, and idiopathic reasons. Patients with non-septic olecranon bursitis typically present with swelling over the olecranon process, while some may also experience tenderness and erythema over the bursa. Patients with septic bursitis are more likely to have pain and fever.
Signs of olecranon bursitis include swelling over the posterior aspect of the elbow, tenderness on palpation of the swollen area, redness and warmth of the overlying skin, fever, skin abrasion overlying the bursa, effusions in other joints if associated with rheumatoid arthritis, and tophi if associated with gout. Movement at the elbow joint should be painless until the swollen bursa is compressed in full flexion.
Investigations are not always needed if a clinical diagnosis can be made and there is no concern about septic arthritis. However, if septic bursitis is suspected, aspiration of bursal fluid for microscopy and culture is essential. Purulent fluid suggests infection, while straw-colored bursal fluid favors a non-infective cause.
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This question is part of the following fields:
- Musculoskeletal
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Question 5
Incorrect
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A 35-year-old woman comes to the clinic with complaints of swelling, pain and stiffness in her fingers on both hands for the past few weeks. During examination, she is found to be afebrile and her fingers are generally swollen and sausage-shaped. Her nails are also pitted with onycholysis.
What is the most probable diagnosis for her condition?
Your Answer: Reactive arthritis
Correct Answer: Psoriatic arthritis
Explanation:Differentiating Types of Arthritis: A Brief Overview
Arthritis is a common condition that affects millions of people worldwide. However, not all types of arthritis are the same. Here is a brief overview of some of the most common types of arthritis and how they differ from each other.
Psoriatic Arthritis: This type of arthritis is often seen in people with psoriasis and is characterized by painful, swollen joints. Dactylitis, or swelling of the whole digit causing ‘sausage-shaped’ fingers or toes, is a common feature. Nail changes, such as pitting and onycholysis, are also associated with psoriatic arthritis.
Gonococcal Arthritis: This is a type of septic arthritis caused by the sexually transmitted infection Neisseria gonorrhoeae. It typically presents with fever, a rash, and an acutely swollen joint, but there is no nail involvement.
Osteoarthritis (OA): This is a disease of synovial joints in which there is a loss of cartilage. It is uncommon for OA to be diagnosed in anyone under the age of 45. Dactylitis and nail changes are not associated with OA.
Reactive Arthritis: This is a sterile arthritis occurring following an infection, usually either an acute gastrointestinal or sexually transmitted infection. The clinical features of dactylitis and nail changes described in this case are not associated with reactive arthritis.
Rheumatoid Arthritis (RA): This is an inflammatory condition that tends to affect the small joints of the hands but can affect any synovial joint. Nail changes are not usually associated with RA, and general swelling of the whole digit (dactylitis) is not a typical feature.
In conclusion, understanding the different types of arthritis and their unique features is important for accurate diagnosis and appropriate treatment.
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This question is part of the following fields:
- Musculoskeletal
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Question 6
Incorrect
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A high school student complains of painful mouth ulcers associated with pain and swelling in both hands. She has had several episodes of vasospasm in her fingers, with pallor, cyanosis and subsequent redness caused by reactive hyperaemia. Blood tests reveal anti-double-stranded (ds)DNA antibodies and antinuclear antibodies (ANAs).
Which of the following is the most likely diagnosis?
Your Answer: Behçet’s disease
Correct Answer: Systemic lupus erythematosus (SLE)
Explanation:Autoimmune Connective Tissue Diseases: Characteristics and Differences
Systemic lupus erythematosus (SLE), Sjögren syndrome, Behçet’s disease, granulomatosis with polyangiitis, and systemic sclerosis are all autoimmune connective tissue diseases with distinct characteristics. SLE is most prevalent in African-American women and presents with arthralgia, rashes, and fever. Sjögren syndrome is characterised by dry eyes and mouth, while Behçet’s disease is primarily characterised by recurrent mouth ulcers, genital ulceration, eye lesions, and cutaneous manifestations. Granulomatosis with polyangiitis predominantly affects the small vessels and presents with lesions involving the upper respiratory tract, lungs, and kidneys. Systemic sclerosis is a multisystem disease characterised by Raynaud’s phenomenon and either limited or diffuse cutaneous scleroderma. Understanding the differences between these diseases is crucial for accurate diagnosis and treatment.
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This question is part of the following fields:
- Musculoskeletal
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Question 7
Incorrect
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A 25-year-old female complains of ankle pain after twisting it during a game of basketball. What is the least significant factor to consider when determining if an x-ray is necessary?
Your Answer: Cannot walk 4 steps immediately after the injury and now
Correct Answer: Swelling immediately after the injury and now
Explanation:Ottawa Rules for Ankle Injuries
The Ottawa Rules provide a guideline for determining whether an ankle x-ray is necessary after an injury. These rules have a sensitivity approaching 100%, meaning they are highly accurate. An ankle x-ray is only required if there is pain in the malleolar zone and one of the following findings: bony tenderness at the lateral malleolar zone or medial malleolar zone, or inability to walk four weight-bearing steps immediately after the injury and in the emergency department.
The lateral malleolar zone is from the tip of the lateral malleolus to include the lower 6 cm of the posterior border of the fibular, while the medial malleolar zone is from the tip of the medial malleolus to the lower 6 cm of the posterior border of the tibia. These rules help healthcare professionals determine whether an ankle x-ray is necessary, which can save time and resources. It is important to note that there are also Ottawa rules available for foot and knee injuries. By following these guidelines, healthcare professionals can provide efficient and effective care for ankle injuries.
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This question is part of the following fields:
- Musculoskeletal
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Question 8
Correct
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A 29-year-old male complains of experiencing low back pain and stiffness for a few months now, with the worst symptoms occurring in the mornings. He reports that exercise helps alleviate the pain, but prolonged sitting at his desk exacerbates it. During the examination, there is limited lumbar flexion, and a pelvic X-ray reveals sacroiliitis. What is the best initial approach to managing this condition?
Your Answer: Ibuprofen
Explanation:Ankylosing spondylitis, a spondyloarthropathy associated with HLA-B27 and commonly seen in men aged 20-30, can be managed with exercise regimes and NSAIDs as the first line of treatment. Pelvic X-rays are helpful in identifying subchondral erosions and sclerosis in the commonly affected sacroiliac joints. Physiotherapy and NSAIDs like ibuprofen are recommended as the initial management. Intra-articular corticosteroid injections are useful for unilateral joint symptoms, while methotrexate may be considered for peripheral joint involvement. Paracetamol can be used in conjunction with NSAIDs if needed, but ibuprofen should be the first-line option.
Investigating and Managing Ankylosing Spondylitis
Ankylosing spondylitis is a type of spondyloarthropathy that is associated with HLA-B27. It is more commonly seen in males aged 20-30 years old. Inflammatory markers such as ESR and CRP are usually elevated, but normal levels do not necessarily rule out ankylosing spondylitis. HLA-B27 is not a reliable diagnostic tool as it can also be positive in normal individuals. The most effective way to diagnose ankylosing spondylitis is through a plain x-ray of the sacroiliac joints. However, if the x-ray is negative but suspicion for AS remains high, an MRI can be obtained to confirm the diagnosis.
Management of ankylosing spondylitis involves regular exercise, such as swimming, and the use of NSAIDs as the first-line treatment. Physiotherapy can also be helpful. Disease-modifying drugs used for rheumatoid arthritis, such as sulphasalazine, are only useful if there is peripheral joint involvement. Anti-TNF therapy, such as etanercept and adalimumab, should be given to patients with persistently high disease activity despite conventional treatments, according to the 2010 EULAR guidelines. Ongoing research is being conducted to determine whether anti-TNF therapies should be used earlier in the course of the disease. Spirometry may show a restrictive defect due to a combination of pulmonary fibrosis, kyphosis, and ankylosis of the costovertebral joints.
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This question is part of the following fields:
- Musculoskeletal
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Question 9
Incorrect
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A 49-year-old man comes to the GP complaining of pain in his right elbow. He reports that the pain began last week after he painted the walls of his house. During the examination, it is observed that the pain intensifies when he resists wrist extension and supinates his forearm while the elbow is extended. What is the probable diagnosis?
Your Answer: Medial epicondylitis
Correct Answer: Lateral epicondylitis
Explanation:The most likely cause of elbow pain in this individual is lateral epicondylitis, which is commonly known as ‘tennis’ elbow. It is aggravated by wrist extension and supination of the forearm, although other activities can also trigger it. Cubital tunnel syndrome is not the correct answer as it presents with ulnar nerve compression and paraesthesia in the ulnar nerve distribution, which is exacerbated when the elbow is flexed for extended periods of time. Medial epicondylitis, also known as ‘golfer’s’ elbow, is not the correct answer either as the pain is aggravated by wrist flexion and pronation, and there are no other associated features. Olecranon bursitis is also not the correct answer as it presents with a swelling over the olecranon, and may also have associated pain, warmth, and erythema, and typically affects middle-aged male patients.
Understanding Lateral Epicondylitis
Lateral epicondylitis, commonly known as tennis elbow, is a condition that often occurs after engaging in activities that the body is not accustomed to, such as painting or playing tennis. It is most prevalent in individuals aged 45-55 years and typically affects the dominant arm. The primary symptom of this condition is pain and tenderness localized to the lateral epicondyle. The pain is often exacerbated by wrist extension against resistance with the elbow extended or supination of the forearm with the elbow extended. Episodes of lateral epicondylitis can last between 6 months and 2 years, with patients experiencing acute pain for 6-12 weeks.
To manage lateral epicondylitis, it is essential to avoid muscle overload and engage in simple analgesia. Steroid injections and physiotherapy are also viable options for managing the condition. By understanding the symptoms and management options for lateral epicondylitis, individuals can take the necessary steps to alleviate pain and discomfort associated with this condition.
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This question is part of the following fields:
- Musculoskeletal
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Question 10
Correct
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A 35-year-old footballer presents with persistent pain in his left knee that began abruptly during a game. During the physical examination, you instruct the patient to lie down and flex his knee. As you internally rotate his foot, he experiences discomfort and you detect a clicking sensation. The patient inquires about the procedure, and you clarify that you are performing McMurray's test, a specialized examination for knee joint issues. What is the probable reason for his knee pain?
Your Answer: Meniscal tear
Explanation:A positive McMurray test is indicative of a meniscal tear, which is typically caused by twisting of the knee. During the test, the knee is flexed while the sole of the foot is held, and one hand is placed on the medial side of the knee to pull it towards a varus position. The other hand is used to internally rotate the leg while extending the knee. If the patient experiences pain or a clicking sensation, the test is considered positive. On the other hand, a positive draw test is a sign of an anterior cruciate ligament tear, which is also commonly caused by twisting of the knee.
Knee problems are common among older adults, and it is important to be aware of the key features of each condition. Osteoarthritis of the knee is often seen in patients over 50 years of age who are overweight. This condition can cause severe pain, intermittent swelling, crepitus, and limited movement. Infrapatellar bursitis, also known as Clergyman’s knee, is associated with kneeling, while prepatellar bursitis, or Housemaid’s knee, is associated with more upright kneeling. Anterior cruciate ligament injuries may be caused by twisting of the knee, and patients may have heard a popping noise. Rapid onset of knee effusion and a positive draw test are also common features. Posterior cruciate ligament injuries may be caused by anterior force applied to the proximal tibia, such as during a car accident. Collateral ligament injuries can cause tenderness over the affected ligament and knee effusion. Meniscal lesions may be caused by twisting of the knee and can cause locking and giving-way, as well as tenderness along the joint line.
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This question is part of the following fields:
- Musculoskeletal
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