A 27-year-old woman visits her GP for a routine health examination before beginning a new job. During the examination, thyroid function tests are conducted on her serum, which reveal elevated thyroid-stimulating hormone (TSH), reduced total thyroxine (T4), reduced free T4, and reduced triiodothyronine (T3) uptake. What is the most probable clinical manifestation that this patient will exhibit?
For which medical condition is Pioglitazone prescribed?
A 38-year-old woman comes to her doctor with concerns about weight gain and irregular periods. She reports feeling fatigued and sad. There are several purple stretch marks on her stomach and bruises on her legs. Blood tests show normal thyroid hormone levels and an elevated amount of cortisol being produced. If this patient has adrenal hyperactivity, what other symptoms might she experience?
You are asked to review a 27-year-old man who has had two episodes of pancreatitis. On reviewing his notes, the surgeons noticed that he appeared to have had a serum calcium of 3.2 mmol/l when it was checked at the general practice surgery a few weeks before the latest episode. Urinary calcium excretion is markedly reduced.
Which of the following diagnoses fits best with this clinical picture?
A 42-year-old man comes to the clinic complaining of gynaecomastia.
What is the most probable reason for his gynaecomastia?
Which gland produces thyroid stimulating hormone (TSH) in the endocrine system?
A 50-year-old woman presents with symptoms of lethargy, weight gain, dry hair and skin, cold intolerance, constipation and low mood. What is the most probable diagnosis?
What are the potential adverse effects of using recombinant human growth hormone (rhGH) therapy?
A 35-year-old woman comes to the Endocrinology Clinic complaining of bruising, striae, acne and hirsutism. During the examination, the patient seems lethargic and depressed, with centripetal obesity and proximal myopathy. Her blood pressure is 165/106 mmHg and blood tests show Na+ 136 mmol/l, K+ 2.8 mmol/l and random glucose 8.2 mmol/l. The doctor orders a low-dose dexamethasone test and a 24-hour urinary cortisol test. What is the most common cause of Cushing syndrome?
A 25-year-old woman visits her GP complaining of sweating, tremors, and palpitations that have been ongoing for 6 weeks. The patient is currently 7 months pregnant and has no significant medical history. Upon examination, the patient has bulging eyes, a heart rate of 110 bpm, and a small goitre. The following laboratory results were obtained:
– Free T4: 42 pmol/l (normal range: 11-22 pmol/l)
– Free T3: 16 pmol/l (normal range: 3.5-5 pmol/l)
– Thyroid stimulating hormone (TSH): <0.01 µU/l (normal range: 0.17-3.2 µU/l)
– TSH receptor antibody (TRAb): 20 U/l (normal range: <0.9 U/l)
What treatment should be recommended for this patient?